Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway

References

• El-Sheikh AAK, Greupink R, Wortelboer HM, et al. Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4. Transl Res. 2013;162(6):398–409. doi:10.1016/j.trsl.2013.08.003
   PubMed Web of Science ®Google Scholar
• Smeets PH, van Aubel RA, Wouterse AC, van den Heuvel JJ, Russel FG. Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol. 2004;15(11):2828–2835. doi:10.1097/01.ASN.0000143473.64430.AC
   PubMed Web of Science ®Google Scholar
• Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000;57(4):760–768. doi:10.1124/mol.57.4.760
   PubMed Web of Science ®Google Scholar
• El-Sheikh AA, van den Heuvel JJ, Koenderink JB, Russel FG. Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007;320(1):229–235. doi:10.1124/jpet.106.110379
   PubMed Web of Science ®Google Scholar
• Zhou Y, Du B, Kan M, et al. Drug elimination alteration in acute lymphoblastic leukemia mediated by renal transporters and glomerular filtration. Pharm Res. 2020;37(8):158. doi:10.1007/s11095-020-02896-8
   PubMed Web of Science ®Google Scholar
• Oladimeji PO, Chen T. PXR: more than just a master xenobiotic receptor. Mol Pharmacol. 2018;93(2):119–127. doi:10.1124/mol.117.110155
   PubMedGoogle Scholar
• Chai X, Zeng S, Xie W. Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond. Expert Opin Drug Metab Toxicol. 2013;9(3):253–266. doi:10.1517/17425255.2013.754010
   PubMed Web of Science ®Google Scholar
• Evers R, Piquette-Miller M, Polli JW, et al. Disease-associated changes in drug transporters may impact the pharmacokinetics and/or toxicity of drugs: a white paper from the international transporter consortium. Clin Pharmacol Ther. 2018;104(5):900–915. doi:10.1002/cpt.1115
   PubMed Web of Science ®Google Scholar
• Meyer Zu Schwabedissen HE, Kim RB. Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms. Mol Pharm. 2009;6(6):1644–1661. doi:10.1021/mp9000298
   PubMedGoogle Scholar
• Teng S, Piquette-Miller M. The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. J Pharmacol Exp Ther. 2005;312(2):841–848. doi:10.1124/jpet.104.076141
   PubMed Web of Science ®Google Scholar
• Hartmann G, Cheung AK, Piquette-Miller M. Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002;303(1):273–281. doi:10.1124/jpet.102.039404
   PubMed Web of Science ®Google Scholar
• Abualsunun WA, Piquette-Miller M. STAT3 is involved in IL-6-mediated downregulation of hepatic transporters in mice. J Pharm Pharm Sci. 2018;21(1s):325s–334s. doi:10.18433/jpps30241
   PubMedGoogle Scholar
• El-Gohary GM, Azzam HM, Ahmed OI, El-Shokry MH. Pro-inflammatory cytokines and depression in patients with acute leukemia. Egypt J Immunol. 2008;15(1):13–24.
   PubMedGoogle Scholar
• Yoon JY, Lafarge S, Dawe D, et al. Association of interleukin-6 and interleukin-8 with poor prognosis in elderly patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2012;53(9):1735–1742. doi:10.3109/10428194.2012.666662
   PubMed Web of Science ®Google Scholar
• Soegaard SH, Rostgaard K, Skogstrand K, Wiemels JL, Schmiegelow K, Hjalgrim H. Neonatal inflammatory markers are associated with childhood B-cell precursor acute lymphoblastic leukemia. Cancer Res. 2018;78(18):5458–5463. doi:10.1158/0008-5472.CAN-18-0831
   PubMed Web of Science ®Google Scholar
• Horacek JM, Kupsa T, Vasatova M, Jebavy L, Zak P. Serum cytokine and adhesion molecule profile differs in newly diagnosed acute myeloid and lymphoblastic leukemia. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015;159(2):299–301. doi:10.5507/bp.2014.051
   PubMed Web of Science ®Google Scholar
• Yang Q, Doshi U, Li N, Li AP. Effects of culture duration on gene expression of P450 isoforms, uptake and efflux transporters in primary hepatocytes cultured in the absence and presence of interleukin-6: implications for experimental design for the evaluation of downregulatory effects of biotherapeutics. Curr Drug Metab. 2012;13(7):938–946. doi:10.2174/138920012802138570
   PubMed Web of Science ®Google Scholar
• Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol. 2007;7(1):41–51. doi:10.1038/nri1995
   PubMed Web of Science ®Google Scholar
• Yu H, Lee H, Herrmann A, Buettner R, Jove R. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer. 2014;14(11):736–746. doi:10.1038/nrc3818
   PubMed Web of Science ®Google Scholar
• Bene MC, Castoldi G, Knapp W, et al. Proposals for the immunological classification of acute leukemias. European group for the immunological characterization of leukemias (EGIL). Leukemia. 1995;9(10):1783–1786.
   PubMed Web of Science ®Google Scholar
• Gonzalez Garcia JR, Meza-Espinoza JP. Use of the international system for human cytogenetic nomenclature (ISCN). Blood. 2006;108(12):3952–3953. author reply 3953. doi:10.1182/blood-2006-06-031351
   PubMed Web of Science ®Google Scholar
• Gao C, Zhao XX, Li WJ, et al. Clinical features, early treatment responses, and outcomes of pediatric acute lymphoblastic leukemia in China with or without specific fusion transcripts: a single institutional study of 1004 patients. Am J Hematol. 2012;87(11):1022–1027. doi:10.1002/ajh.23307
   PubMed Web of Science ®Google Scholar
• Chakraborty D, Sumova B, Mallano T, et al. Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis. Nat Commun. 2017;8(1):1130. doi:10.1038/s41467-017-01236-6
   PubMedGoogle Scholar
• Norelli M, Camisa B, Barbiera G, et al. Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells. Nat Med. 2018;24(6):739–748. doi:10.1038/s41591-018-0036-4
   PubMed Web of Science ®Google Scholar
• Wu R, Liu X, Yin J, et al. IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice. Metabolism. 2018;83:18–24. doi:10.1016/j.metabol.2018.01.002
   PubMed Web of Science ®Google Scholar
• Guo P, Wang X, Liu L, Belinsky MG, Kruh GD, Gallo JM. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2007;43(5):1789–1795. doi:10.1016/j.jpba.2006.12.034
   PubMed Web of Science ®Google Scholar
• Morgan ET, Goralski KB, Piquette-Miller M, et al. Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metab Dispos. 2008;36(2):205–216. doi:10.1124/dmd.107.018747
   PubMed Web of Science ®Google Scholar
• Merrell MD, Nyagode BA, Clarke JD, Cherrington NJ, Morgan ET. Selective and cytokine-dependent regulation of hepatic transporters and bile acid homeostasis during infectious colitis in mice. Drug Metab Dispos. 2014;42(4):596–602. doi:10.1124/dmd.113.055525
   PubMed Web of Science ®Google Scholar
• Yang J, Yan B. Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Toxicol Sci. 2007;95(1):13–22. doi:10.1093/toxsci/kfl120
   PubMed Web of Science ®Google Scholar
• Kawauchi S, Nakamura T, Horibe S, et al. Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers. Biopharm Drug Dispos. 2016;37(9):522–532. doi:10.1002/bdd.2042
   PubMed Web of Science ®Google Scholar
• Teng S, Piquette-Miller M. Regulation of transporters by nuclear hormone receptors: implications during inflammation. Mol Pharm. 2008;5(1):67–76. doi:10.1021/mp700102q
   PubMedGoogle Scholar
• Denson LA, Bohan A, Held MA, Boyer JL. Organ-specific alterations in RAR alpha: rXRalpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis. Gastroenterology. 2002;123(2):599–607. doi:10.1053/gast.2002.34758
   PubMed Web of Science ®Google Scholar