Curcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a

References

• Tu C, He J, Wu B, et al. An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis. Cytokine. 2019;113:1–12. doi:10.1016/j.cyto.2018.06.019
   PubMed Web of Science ®Google Scholar
• Jiang Y, Tuan RS. Origin and function of cartilage stem/progenitor cells in osteoarthritis. Nat Rev Rheumatol. 2015;11(4):206–212. doi:10.1038/nrrheum.2014.200
   PubMed Web of Science ®Google Scholar
• Silverwood V, Blagojevic-Bucknall M, Jinks C, et al. Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015;23(4):507–515. doi:10.1016/j.joca.2014.11.019
   PubMed Web of Science ®Google Scholar
• Musumeci G, Aiello FC, Szychlinska MA, et al. Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression. Int J Mol Sci. 2015;16(12):6093–6112. doi:10.3390/ijms16036093
   PubMedGoogle Scholar
• O’Neill TW, McCabe PS, McBeth J. Update on the epidemiology, risk factors and disease outcomes of osteoarthritis. Best Pract Res Clin Rheumatol. 2018;32(2):312–326. doi:10.1016/j.berh.2018.10.007
   PubMed Web of Science ®Google Scholar
• Blanco FJ, Guitian R, Vazquez-Martul E, et al. Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum. 1998;41(2):284–289. doi:10.1002/1529-0131(199802)41:2<284::AID-ART12>3.0.CO;2-T
   PubMed Web of Science ®Google Scholar
• Kim HA, Lee YJ, Seong SC, et al. Apoptotic chondrocyte death in human osteoarthritis. J Rheumatol. 2000;27(2):455–462.
   PubMed Web of Science ®Google Scholar
• Wang Z, Hu J, Pan Y, et al. MiR-140-5p/miR-149 affects chondrocyte proliferation, apoptosis, and autophagy by targeting FUT1 in osteoarthritis. Inflammation. 2018;41(3):959–971. doi:10.1007/s10753-018-0750-6
   PubMed Web of Science ®Google Scholar
• Hwang HS, Kim HA. Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int J Mol Sci. 2015;16(11):26035–26054. doi:10.3390/ijms161125943
   PubMed Web of Science ®Google Scholar
• Carames B, Taniguchi N, Otsuki S, et al. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum. 2010;62(3):791–801. doi:10.1002/art.27305
   PubMed Web of Science ®Google Scholar
• Sasaki H, Takayama K, Matsushita T, et al. Autophagy modulates osteoarthritis-related gene expression in human chondrocytes. Arthritis Rheum. 2012;64(6):1920–1928. doi:10.1002/art.34323
   PubMed Web of Science ®Google Scholar
• Cooper KF. Till death do us part: the marriage of autophagy and apoptosis. Oxid Med Cell Longev. 2018;2018:4701275. doi:10.1155/2018/4701275
   PubMed Web of Science ®Google Scholar
• Malemud CJ. MicroRNAs and osteoarthritis. Cells. 2018;7(8):92. doi:10.3390/cells7080092
   PubMed Web of Science ®Google Scholar
• Papanagnou P, Stivarou T, Tsironi M. The role of miRNAs in common inflammatory arthropathies: osteoarthritis and gouty arthritis. Biomolecules. 2016;6(4):44. doi:10.3390/biom6040044
   PubMed Web of Science ®Google Scholar
• Abouheif MM, Nakasa T, Shibuya H, et al. Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro. Rheumatology (Oxford). 2010;49(11):2054–2060. doi:10.1093/rheumatology/keq247
   PubMed Web of Science ®Google Scholar
• Chen P, Chen F, Lei J, et al. Activation of the miR-34a-mediated SIRT1/mTOR signaling pathway by urolithin A attenuates D-galactose-induced brain aging in mice. Neurotherapeutics. 2019;16(4):1269–1282. doi:10.1007/s13311-019-00753-0
   PubMed Web of Science ®Google Scholar
• Chang TC, Wentzel EA, Kent OA, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007;26(5):745–752. doi:10.1016/j.molcel.2007.05.010
   PubMed Web of Science ®Google Scholar
• Feng SD, Mao Z, Liu C, et al. Simultaneous overexpression of miR-126 and miR-34a induces a superior antitumor efficacy in pancreatic adenocarcinoma. Onco Targets Ther. 2017;10:5591–5604. doi:10.2147/OTT.S149632
   PubMed Web of Science ®Google Scholar
• Dunn SL, Soul J, Anand S, et al. Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses. Osteoarthritis Cartilage. 2016;24(8):1431–1440. doi:10.1016/j.joca.2016.03.007
   PubMed Web of Science ®Google Scholar
• Pellicelli M, Picard C, Wang D, et al. E2F1 and TFDP1 regulate PITX1 expression in normal and osteoarthritic articular chondrocytes. PLoS One. 2016;11(11):e0165951. doi:10.1371/journal.pone.0165951
   PubMed Web of Science ®Google Scholar
• Li Y, Zeng C, Hu J, et al. Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression. J Hematol Oncol. 2018;11(1):89. doi:10.1186/s13045-018-0632-2
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang L, Yang L, et al. miR-34a/c induce caprine endometrial epithelial cell apoptosis by regulating circ-8073/CEP55 via the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways. J Cell Physiol. 2020;235(12):10051–10067. doi:10.1002/jcp.29821
   PubMed Web of Science ®Google Scholar
• Khan NM, Ansari MY, Haqqi TM. Sucrose, but not glucose, blocks IL1-beta-induced inflammatory response in human chondrocytes by inducing autophagy via AKT/mTOR pathway. J Cell Biochem. 2017;118(3):629–639. doi:10.1002/jcb.25750
   PubMed Web of Science ®Google Scholar
• Xue JF, Shi ZM, Zou J, et al. Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. Biomed Pharmacother. 2017;89:1252–1261. doi:10.1016/j.biopha.2017.01.130
   PubMed Web of Science ®Google Scholar
• Marchiani A, Rozzo C, Fadda A, et al. Curcumin and curcumin-like molecules: from spice to drugs. Curr Med Chem. 2014;21(2):204–222. doi:10.2174/092986732102131206115810
   PubMed Web of Science ®Google Scholar
• Wang J, Ma J, Gu JH, et al. Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1beta is mediated by curcumin via inhibition of NF-kappaB signaling in rat chondrocytes. Mol Med Rep. 2017;16(2):1837–1845. doi:10.3892/mmr.2017.6771
   PubMed Web of Science ®Google Scholar
• Clutterbuck AL, Allaway D, Harris P, et al. Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1beta-treated articular cartilage. F1000Res. 2013;2:147. doi:10.12688/f1000research.2-147.v1
   PubMedGoogle Scholar
• Dai Q, Zhou D, Xu L, et al. Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats. Drug Des Devel Ther. 2018;12:4095–4105. doi:10.2147/DDDT.S175763
   PubMed Web of Science ®Google Scholar
• Zhang G, Cao J, Yang E, et al. Curcumin improves age-related and surgically induced osteoarthritis by promoting autophagy in mice. Biosci Rep. 2018;38.
   Web of Science ®Google Scholar
• Zhu M, Zheng Z, Huang J, et al. Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells. J Cell Biochem. 2019;120(9):15616–15624. doi:10.1002/jcb.28828
   PubMed Web of Science ®Google Scholar
• Subramaniam D, Ponnurangam S, Ramamoorthy P, et al. Curcumin induces cell death in esophageal cancer cells through modulating notch signaling. PLoS One. 2012;7(2):e30590. doi:10.1371/journal.pone.0030590
   PubMed Web of Science ®Google Scholar
• Reyes C, Leyland KM, Peat G, et al. Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a Population-Based Cohort Study. Arthritis Rheum. 2016;68(8):1869–1875. doi:10.1002/art.39707
   PubMed Web of Science ®Google Scholar
• Dickson BM, Roelofs AJ, Rochford JJ, et al. The burden of metabolic syndrome on osteoarthritic joints. Arthritis Res Ther. 2019;21(1):289. doi:10.1186/s13075-019-2081-x
   PubMed Web of Science ®Google Scholar
• Kuroki H, Nakagawa Y, Mori K, et al. Acoustic stiffness and change in plug cartilage over time after autologous osteochondral grafting: correlation between ultrasound signal intensity and histological score in a rabbit model. Arthritis Res Ther. 2004;6(6):R492–504. doi:10.1186/ar1219
   PubMed Web of Science ®Google Scholar
• Feng K, Ge Y, Chen Z, et al. Curcumin inhibits the PERK-eIF2alpha-CHOP pathway through promoting SIRT1 expression in oxidative stress-induced rat chondrocytes and ameliorates osteoarthritis progression in a rat model. Oxid Med Cell Longev. 2019;2019:8574386. doi:10.1155/2019/8574386
   PubMed Web of Science ®Google Scholar
• Henrotin Y, Malaise M, Wittoek R, et al. Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a Double-Blind Multicenter Randomized Placebo Controlled Three-Arm Study. Arthritis Res Ther. 2019;21(1):179. doi:10.1186/s13075-019-1960-5
   PubMed Web of Science ®Google Scholar
• Zhou Y, Ming J, Deng M, et al. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-kappaB/HIF-2alpha axis. J Mol Med (Berl). 2020;98(10):1479–1491. doi:10.1007/s00109-020-01972-1
   PubMed Web of Science ®Google Scholar
• Collins KH, Paul HA, Reimer RA, et al. Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model. Osteoarthritis Cartilage. 2015;23(11):1989–1998. doi:10.1016/j.joca.2015.03.014
   PubMed Web of Science ®Google Scholar
• Rios JL, Bomhof MR, Reimer RA, et al. Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity. Sci Rep. 2019;9(1):3893. doi:10.1038/s41598-019-40601-x
   PubMedGoogle Scholar
• Tan L, Harper L, McNulty MA, et al. High-fat diet induces endoplasmic reticulum stress to promote chondrocyte apoptosis in mouse knee joints. FASEB J. 2020;34(4):5818–5826. doi:10.1096/fj.201902746R
   PubMed Web of Science ®Google Scholar
• Jiang M, He J, Gu H, et al. Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS3. Toxicol Appl Pharmacol. 2020;388:114871. doi:10.1016/j.taap.2019.114871
   PubMed Web of Science ®Google Scholar
• Zhang Z, Leong DJ, Xu L, et al. Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther. 2016;18(1):128. doi:10.1186/s13075-016-1025-y
   PubMedGoogle Scholar
• Henrotin Y, Priem F, Mobasheri A. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus. 2013;2(1):56. doi:10.1186/2193-1801-2-56
   PubMedGoogle Scholar
• Yang KY, Lin LC, Tseng TY, et al. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;853(1–2):183–189. doi:10.1016/j.jchromb.2007.03.010
   PubMed Web of Science ®Google Scholar
• Malemud CJ. Inhibition of MMPs and ADAM/ADAMTS. Biochem Pharmacol. 2019;165:33–40. doi:10.1016/j.bcp.2019.02.033
   PubMed Web of Science ®Google Scholar
• Bollmann M, Pinno K, Ehnold LI, et al. MMP-9 mediated Syndecan-4 shedding correlates with osteoarthritis severity. Osteoarthritis Cartilage. 2021;29(2):280–289. doi:10.1016/j.joca.2020.10.009
   PubMed Web of Science ®Google Scholar
• Chang JC, Christiansen BA, Murugesh DK, et al. SOST/Sclerostin improves posttraumatic osteoarthritis and inhibits MMP2/3 expression after injury. J Bone Miner Res. 2018;33(6):1105–1113. doi:10.1002/jbmr.3397
   PubMed Web of Science ®Google Scholar
• Yang L, Song X, Zhu J, et al. Tumor suppressor microRNA-34a inhibits cell migration and invasion by targeting MMP-2/MMP-9/FNDC3B in esophageal squamous cell carcinoma. Int J Oncol. 2017;51(1):378–388. doi:10.3892/ijo.2017.4015
   PubMed Web of Science ®Google Scholar
• Hou Q, Han S, Yang L, et al. The interplay of microRNA-34a, LGR4, EMT-associated factors, and MMP2 in regulating uveal melanoma cells. Invest Ophthalmol Vis Sci. 2019;60(13):4503–4510. doi:10.1167/iovs.18-26477
   PubMed Web of Science ®Google Scholar
• Liu H, Dong Y, Feng X, et al. MiR-34a promotes bone regeneration in irradiated bone defects by enhancing osteoblastic differentiation of mesenchymal stromal cells in rats. Stem Cell Res Ther. 2019;10(1):180. doi:10.1186/s13287-019-1285-y
   PubMedGoogle Scholar
• Wen F, An C, Wu X, et al. MiR-34a regulates mitochondrial content and fat ectopic deposition induced by resistin through the AMPK/PPARalpha pathway in HepG2 cells. Int J Biochem Cell Biol. 2018;94:133–145. doi:10.1016/j.biocel.2017.11.008
   PubMed Web of Science ®Google Scholar
• Si HB, Zeng Y, Liu SY, et al. Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats. Osteoarthritis Cartilage. 2017;25(10):1698–1707. doi:10.1016/j.joca.2017.06.002
   PubMed Web of Science ®Google Scholar
• Krajewska JB, Fichna J, Mosinska P. One step ahead: miRNA-34 in colon cancer-future diagnostic and therapeutic tool? Crit Rev Oncol Hematol. 2018;132:1–8. doi:10.1016/j.critrevonc.2018.09.006
   PubMed Web of Science ®Google Scholar
• Chao J, Guo Y, Li P, et al. Role of kallistatin treatment in aging and cancer by modulating miR-34a and miR-21 expression. Oxid Med Cell Longev. 2017;2017:5025610. doi:10.1155/2017/5025610
   PubMed Web of Science ®Google Scholar
• Denechaud PD, Fajas L, Giralt A. E2F1, a novel regulator of metabolism. Front Endocrinol (Lausanne). 2017;8:311. doi:10.3389/fendo.2017.00311
   PubMed Web of Science ®Google Scholar
• Ghorbani M, Themis M, Payne A. Genome wide classification and characterisation of CpG sites in cancer and normal cells. Comput Biol Med. 2016;68:57–66. doi:10.1016/j.compbiomed.2015.09.023
   PubMed Web of Science ®Google Scholar
• Handle F, Prekovic S, Helsen C, et al. Drivers of AR indifferent anti-androgen resistance in prostate cancer cells. Sci Rep. 2019;9(1):13786. doi:10.1038/s41598-019-50220-1
   PubMedGoogle Scholar
• Kent LN, Leone G. The broken cycle: E2F dysfunction in cancer. Nat Rev Cancer. 2019;19(6):326–338. doi:10.1038/s41568-019-0143-7
   PubMed Web of Science ®Google Scholar
• Wang L, Chen H, Wang C, et al. Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair. Proc Natl Acad Sci U S A. 2018;115(16):E3837–E3845. doi:10.1073/pnas.1720094115
   PubMed Web of Science ®Google Scholar
• Maiuri MC, Zalckvar E, Kimchi A, et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8(9):741–752. doi:10.1038/nrm2239
   PubMed Web of Science ®Google Scholar
• Rainey NE, Moustapha A, Petit PX. Curcumin, a multifaceted hormetic agent, mediates an intricate crosstalk between mitochondrial turnover, autophagy, and apoptosis. Oxid Med Cell Longev. 2020;2020:3656419. doi:10.1155/2020/3656419
   PubMed Web of Science ®Google Scholar
• Wang CI, Chen YY, Wang CL, et al. mTOR regulates proteasomal degradation and Dp1/E2F1- mediated transcription of KPNA2 in lung cancer cells. Oncotarget. 2016;7(18):25432–25442. doi:10.18632/oncotarget.8170
   PubMedGoogle Scholar
• Zou Z, Chen J, Liu A, et al. mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1. J Cell Biol. 2015;211(1):105–122. doi:10.1083/jcb.201411128
   PubMed Web of Science ®Google Scholar
• Wong P-M, Puente C, Ganley IG, et al. The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy. 2013;9(2):124–137. doi:10.4161/auto.23323
   PubMed Web of Science ®Google Scholar
• Kim J, Kundu M, Viollet B, et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011;13(2):132–141. doi:10.1038/ncb2152
   PubMed Web of Science ®Google Scholar
• Rabinowitz JD, White E. Autophagy and metabolism. Science. 2010;330(6009):1344–1348. doi:10.1126/science.1193497
   PubMed Web of Science ®Google Scholar