PADI6 Regulates Trophoblast Cell Migration-Invasion Through the Hippo/YAP1 Pathway in Hydatidiform Moles

References

• Wang Q, Fu J, Hu L, et al. Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia. Cochrane Database Syst Rev. 2017;9:CD007289. doi:10.1002/14651858.CD007289.pub3
   PubMedGoogle Scholar
• Rezaei M, Suresh B, Bereke E, et al. Novel pathogenic variants in NLRP7, NLRP5, and PADI6 in patients with recurrent hydatidiform moles and reproductive failure. Clin Genet. 2021;99(6):823–828. doi:10.1111/cge.13941
   PubMed Web of Science ®Google Scholar
• Kaneki E, Kobayashi H, Hirakawa T, Matsuda T, Kato H, Wake N. Incidence of postmolar gestational trophoblastic disease in androgenetic moles and the morphological features associated with low risk postmolar gestational trophoblastic disease. Cancer Sci. 2010;101(7):1717–1721. doi:10.1111/j.1349-7006.2010.01602.x
   PubMed Web of Science ®Google Scholar
• Kan M, Yamamoto E, Niimi K, et al. Gestational trophoblastic neoplasia and pregnancy outcome after routine second curettage for hydatidiform mole a Retrospective Observational Study. J Reprod Med. 2016;61(7–8):373–379.
   PubMed Web of Science ®Google Scholar
• Bebbere D, Masala L, Albertini DF, Ledda S. The subcortical maternal complex: multiple functions for one biological structure? J Assist Reprod Genet. 2016;33(11):1431–1438. doi:10.1007/s10815-016-0788-z
   PubMed Web of Science ®Google Scholar
• Li L, Baibakov B, Dean J. A subcortical maternal complex essential for preimplantation mouse embryogenesis. Dev Cell. 2008;15(3):416–425. doi:10.1016/j.devcel.2008.07.010
   PubMed Web of Science ®Google Scholar
• Lu X, Gao Z, Qin D, Li L. A maternal functional module in the mammalian oocyte-to-embryo transition. Trends Mol Med. 2017;23(11):1014–1023. doi:10.1016/j.molmed.2017.09.004
   PubMed Web of Science ®Google Scholar
• Alazami AM, Awad SM, Coskun S, et al. TLE6 mutation causes the earliest known human embryonic lethality. Genome Biol. 2015;16(1):240. doi:10.1186/s13059-015-0792-0
   PubMedGoogle Scholar
• Docherty LE, Rezwan FI, Poole RL, et al. Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans. Nat Commun. 2015;6(1):8086. doi:10.1038/ncomms9086
   PubMedGoogle Scholar
• Murdoch S, Djuric U, Mazhar B, et al. Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat Genet. 2006;38(3):300–302. doi:10.1038/ng1740
   PubMed Web of Science ®Google Scholar
• Parry DA, Logan CV, Hayward BE, et al. Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte. Am J Hum Genet. 2011;89(3):451–458. doi:10.1016/j.ajhg.2011.08.002
   PubMed Web of Science ®Google Scholar
• Maddirevula S, Coskun S, Awartani K, Alsaif H, Abdulwahab FM, Alkuraya FS. The human knockout phenotype of PADI6 is female sterility caused by cleavage failure of their fertilized eggs. Clin Genet. 2017;91(2):344–345. doi:10.1111/cge.12866
   PubMed Web of Science ®Google Scholar
• Xu Y, Shi Y, Fu J, et al. Mutations in PADI6 cause female infertility characterized by early embryonic arrest. Am J Hum Genet. 2016;99(3):744–752. doi:10.1016/j.ajhg.2016.06.024
   PubMed Web of Science ®Google Scholar
• Qian J, Nguyen NMP, Rezaei M, et al. Biallelic PADI6 variants linking infertility, miscarriages, and hydatidiform moles. Eur J Hum Genet. 2018;26(7):1007–1013. doi:10.1038/s41431-018-0141-3
   PubMed Web of Science ®Google Scholar
• Wright PW, Bolling LC, Calvert ME, et al. ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Dev Biol. 2003;256(1):73–88. doi:10.1016/s0012-1606(02)00126-4
   PubMed Web of Science ®Google Scholar
• Esposito G, Vitale AM, Leijten FP, et al. Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility. Mol Cell Endocrinol. 2007;273(1–2):25–31. doi:10.1016/j.mce.2007.05.005
   PubMed Web of Science ®Google Scholar
• Shaaban AM, Rezvani M, Haroun RR, et al. Gestational trophoblastic disease: clinical and imaging features. Radiographics. 2017;37(2):681–700. doi:10.1148/rg.2017160140
   PubMed Web of Science ®Google Scholar
• Abi Nahed R, Reynaud D, Borg AJ, et al. NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation. J Mol Med. 2019;97(3):355–367. doi:10.1007/s00109-018-01737-x
   PubMed Web of Science ®Google Scholar
• Moroishi T, Hansen CG, Guan KL. The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer. 2015;15(2):73–79. doi:10.1038/nrc3876
   PubMed Web of Science ®Google Scholar
• Ling HH, Kuo CC, Lin BX, Huang YH, Lin CW. Elevation of YAP promotes the epithelial-mesenchymal transition and tumor aggressiveness in colorectal cancer. Exp Cell Res. 2017;350(1):218–225. doi:10.1016/j.yexcr.2016.11.024
   PubMed Web of Science ®Google Scholar
• Sun M, Na Q, Huang L, et al. YAP is decreased in preeclampsia and regulates invasion and apoptosis of HTR-8/SVneo. Reprod Sci. 2018;25(9):1382–1393. doi:10.1177/1933719117746784
   PubMed Web of Science ®Google Scholar
• Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D. Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell. 2013;154(6):1342–1355. doi:10.1016/j.cell.2013.08.025
   PubMed Web of Science ®Google Scholar
• Ni L, Zheng Y, Hara M, Pan D, Luo X. Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling. Genes Dev. 2015;29(13):1416–1431. doi:10.1101/gad.264929.115
   PubMed Web of Science ®Google Scholar
• Bae JS, Kim SM, Lee H. The Hippo signaling pathway provides novel anti-cancer drug targets. Oncotarget. 2017;8(9):16084–16098. doi:10.18632/oncotarget.14306
   PubMedGoogle Scholar
• Sharma A, Yerra VG, Kumar A. Emerging role of Hippo signalling in pancreatic biology: YAP re-expression and plausible link to islet cell apoptosis and replication. Biochimie. 2017;133:56–65. doi:10.1016/j.biochi.2016.12.009
   PubMed Web of Science ®Google Scholar
• Liu CY, Zha ZY, Zhou X, et al. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem. 2010;285(48):37159–37169. doi:10.1074/jbc.M110.152942
   PubMed Web of Science ®Google Scholar
• Rose R, Rose M, Ottmann C. Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J Struct Biol. 2012;180(1):65–72. doi:10.1016/j.jsb.2012.05.010
   PubMed Web of Science ®Google Scholar
• Wang H, Xu P, Luo X, et al. Phosphorylation of yes-associated protein impairs trophoblast invasion and migration: implications for the pathogenesis of fetal growth restrictiondagger. Biol Reprod. 2020;103(4):866–879. doi:10.1093/biolre/ioaa112
   PubMed Web of Science ®Google Scholar
• Sasaki H. Roles and regulations of Hippo signaling during preimplantation mouse development. Dev Growth Differ. 2017;59(1):12–20. doi:10.1111/dgd.12335
   PubMed Web of Science ®Google Scholar
• Meinhardt G, Haider S, Kunihs V, et al. Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta. Proc Natl Acad Sci U S A. 2020;117(24):13562–13570. doi:10.1073/pnas.2002630117
   PubMed Web of Science ®Google Scholar
• Saha B, Ganguly A. TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: an implication in early human pregnancy loss. Proc Natl Acad Sci U S A. 2020;117(30):17864–17875. doi:10.1073/pnas.2002449117
   PubMed Web of Science ®Google Scholar
• Pollard TD, Cooper JA. Actin, a central player in cell shape and movement. Science. 2009;326(5957):1208–1212. doi:10.1126/science.1175862
   PubMed Web of Science ®Google Scholar
• Tang DD, Gerlach BD. The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration. Respir Res. 2017;18(1):54. doi:10.1186/s12931-017-0544-7
   PubMed Web of Science ®Google Scholar
• Wang H, Yao H, Yi B, et al. MicroRNA-638 inhibits human airway smooth muscle cell proliferation and migration through targeting cyclin D1 and NOR1. J Cell Physiol. 2018;234(1):369–381. doi:10.1002/jcp.26930
   PubMed Web of Science ®Google Scholar
• Garcin C, Straube A, Malliri A, Caswell P, Ballestrem C, Hurlstone A. Microtubules in cell migration. Essays Biochem. 2019;63(5):509–520. doi:10.1042/EBC20190016
   PubMed Web of Science ®Google Scholar