MiR-940 Serves as a Diagnostic Biomarker in Patients with Sepsis and Regulates Sepsis-Induced Inflammation and Myocardial Dysfunction

References

• Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–810. doi:10.1001/jama.2016.0287
   PubMed Web of Science ®Google Scholar
• Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644–1655. doi:10.1378/chest.101.6.1644
   PubMed Web of Science ®Google Scholar
• Napolitano LM. Sepsis 2018: definitions and Guideline Changes. Surg Infect (Larchmt). 2018;19(2):117–125. doi:10.1089/sur.2017.278
   PubMed Web of Science ®Google Scholar
• Ledderose C, Bao Y, Kondo Y, et al. Purinergic Signaling and the Immune Response in Sepsis: a Review. Clin Ther. 2016;38(5):1054–1065. doi:10.1016/j.clinthera.2016.04.002
   PubMed Web of Science ®Google Scholar
• Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL. Sepsis and septic shock. Nature Rev Dis Primers. 2016;2:16045. doi:10.1038/nrdp.2016.45
   PubMed Web of Science ®Google Scholar
• Papadopoulos P, Pistiki A, Theodorakopoulou M, et al. Immunoparalysis: clinical and immunological associations in SIRS and severe sepsis patients. Cytokine. 2017;92:83–92. doi:10.1016/j.cyto.2017.01.012
   PubMed Web of Science ®Google Scholar
• Howell MD, Davis AM. Management of Sepsis and Septic Shock. JAMA. 2017;317(8):847–848. doi:10.1001/jama.2017.0131
   PubMed Web of Science ®Google Scholar
• Li HM, Jang JH, Jung JS, et al. G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: cooperativity with Adenosine Receptor 2b. J Immunol. 2019;202(2):527–538. doi:10.4049/jimmunol.1700783
   PubMed Web of Science ®Google Scholar
• Liu W, Xu Y, Guan H, Meng H. Clinical potential of miR-940 as a diagnostic and prognostic biomarker in breast cancer patients. Cancer Biomarkers. 2018;22(3):487–493. doi:10.3233/cbm-171124
   PubMed Web of Science ®Google Scholar
• Ding D, Zhang Y, Yang R, et al. miR-940 Suppresses Tumor Cell Invasion and Migration via Regulation of CXCR2 in Hepatocellular Carcinoma. Biomed Res Int. 2016;2016:7618342. doi:10.1155/2016/7618342
   PubMed Web of Science ®Google Scholar
• Liu D, Tang ZY, Hu ZJ, Li WW, Yuan WN. MiR-940 regulates angiogenesis after cerebral infarction through VEGF. Eur Rev Med Pharmacol Sci. 2018;22(22):7899–7907. doi:10.26355/eurrev_201811_16416
   PubMed Web of Science ®Google Scholar
• Cao J, Liu Z, Zhang L, Li J. miR-940 regulates the inflammatory response of chondrocytes by targeting MyD88 in osteoarthritis. Mol Cell Biochem. 2019;461(1–2):183–193. doi:10.1007/s11010-019-03601-z
   PubMed Web of Science ®Google Scholar
• Xu T, Zhou Q, Che L, et al. Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients. Oncotarget. 2016;7(11):12414–12425. doi:10.18632/oncotarget.6966
   PubMed Web of Science ®Google Scholar
• Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc. 2009;4(1):31–36. doi:10.1038/nprot.2008.214
   PubMed Web of Science ®Google Scholar
• van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017;17(7):407–420. doi:10.1038/nri.2017.36
   PubMed Web of Science ®Google Scholar
• Wen JN, Li N, Guo CX, Shen N, He B. Performance and comparison of assessment models to predict 30-day mortality in patients with hospital-acquired pneumonia. Chin Med J. 2020;133(24):2947–2952. doi:10.1097/cm9.0000000000001252
   PubMed Web of Science ®Google Scholar
• Lendak DF, Mihajlović DM, Novakov-Mikić AS, Boban JM, Ubavić M, Sv B. APRIL and sTACI could be predictors of multiorgan dysfunction syndrome in sepsis. Virulence. 2018;9(1):946–953. doi:10.1080/21505594.2018.1462636
   PubMed Web of Science ®Google Scholar
• Li Y, Zhao Y, Qiu C, et al. Role of eotaxin-1/CCL11 in sepsis-induced myocardial injury in elderly patients. Aging. 2020;12(5):4463–4473. doi:10.18632/aging.102896
   PubMedGoogle Scholar
• Tavladaki T, Spanaki AM, Dimitriou H, et al. Similar Metabolic, Innate Immunity, and Adipokine Profiles in Adult and Pediatric Sepsis Versus Systemic Inflammatory Response Syndrome-A Pilot Study. Pediatr Critical Care Med. 2017;18(11):e494–e505. doi:10.1097/pcc.0000000000001300
   PubMed Web of Science ®Google Scholar
• Bracht H, Hafner S, Weiß M. [Sepsis Update: definition and Epidemiology]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie. 2019;54(1):10–20. doi:10.1055/a-0625-5492. German.
   PubMed Web of Science ®Google Scholar
• Fu Q, Yu W, Fu S, Chen E, Zhang S, Liang TB. Screening and identification of key gene in sepsis development: evidence from bioinformatics analysis. Medicine. 2020;99(27):e20759. doi:10.1097/md.0000000000020759
   PubMed Web of Science ®Google Scholar
• Testa U, Pelosi E, Castelli G, Labbaye C. miR-146 and miR-155: two Key Modulators of Immune Response and Tumor Development. Non-Coding RNA. 2017;3(3):22. doi:10.3390/ncrna3030022
   PubMedGoogle Scholar
• Meng L, Cao H, Wan C, Jiang L. MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1. Folia Histochemica Et Cytobiologica. 2019;57(4):168–178. doi:10.5603/FHC.a2019.0019
   PubMed Web of Science ®Google Scholar
• Chen C, Zhang L, Huang H, et al. Serum miR-126-3p level is down-regulated in sepsis patients. Int J Clin Exp Pathol. 2018;11(5):2605–2612.
   PubMed Web of Science ®Google Scholar
• Ma XF, Qin J, Guo XH. MiR-181-5p protects mice from sepsis via repressing HMGB1 in an experimental model. Eur Rev Med Pharmacol Sci. 2020;24(18):9712–9720. doi:10.26355/eurrev_202009_23063
   PubMed Web of Science ®Google Scholar
• Singh AK, Rooge SB, Varshney A, et al. Global microRNA expression profiling in the liver biopsies of hepatitis B virus-infected patients suggests specific microRNA signatures for viral persistence and hepatocellular injury. Hepatology. 2018;67(5):1695–1709. doi:10.1002/hep.29690
   PubMed Web of Science ®Google Scholar
• Briassoulis G, Briassoulis P, Miliaraki M, et al. Biomarker cruises in sepsis: who is the CAPTAIN? Discussion on “Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study. Intensive Care Med. 2019;45(1):132–133. doi:10.1007/s00134-018-5451-y
   PubMed Web of Science ®Google Scholar
• Spanaki AM, Tavladaki T, Dimitriou H, et al. Longitudinal Profiles of Metabolism and Bioenergetics Associated with Innate Immune Hormonal Inflammatory Responses and Amino-Acid Kinetics in Severe Sepsis and Systemic Inflammatory Response Syndrome in Children. JPEN J Parenter Enteral Nutr. 2018;42(6):1061–1074. doi:10.1002/jpen.1050
   PubMed Web of Science ®Google Scholar
• Lan C, Shi X, Guo N, Pei H, Zhang H. [Value of serum miR-155-5p and miR-133a-3p expression for the diagnosis and prognosis evaluation of sepsis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2016;28(8):694–698. doi:10.3760/cma.j.issn.2095-4352.2016.08.005. Chinese.
   PubMedGoogle Scholar
• Deng Q, Zhao T, Pan B, et al. Protective Effect of Tubastatin A in CLP-Induced Lethal Sepsis. Inflammation. 2018;41(6):2101–2109. doi:10.1007/s10753-018-0853-0
   PubMed Web of Science ®Google Scholar
• Briassoulis G, Briassouli E, Fitrolaki DM, et al. Heat shock protein 72 expressing stress in sepsis: unbridgeable gap between animal and human studies–a hypothetical “comparative” study. Biomed Res Int. 2014;2014:101023. doi:10.1155/2014/101023
   PubMed Web of Science ®Google Scholar
• Wang B, Shen PF, Qu YX, et al. miR-940 promotes spinal cord injury recovery by inhibiting TLR4/NF-κB pathway-mediated inflammation. Eur Rev Med Pharmacol Sci. 2019;23(8):3190–3197. doi:10.26355/eurrev_201904_17677
   PubMed Web of Science ®Google Scholar