Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells

References

• Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP. A molecular profile of the endothelial cell response to ionizing radiation. Radiat Res. 2016;186(2):141. doi:10.1667/RR14444.1
   PubMed Web of Science ®Google Scholar
• Kim SD, Yi JM, Park MT. Irradiated endothelial cells modulate the malignancy of liver cancer cells. Oncol Lett. 2019;17(2):2187–96. doi:10.3892/ol.2018.9833
   PubMed Web of Science ®Google Scholar
• Baskar R, Dai J, Wenlong N, Yeo R, Yeoh KW. Biological response of cancer cells to radiation treatment. Front Mol Biosci. 2014;1:24. doi:10.3389/fmolb.2014.00024.
   PubMed Web of Science ®Google Scholar
• Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 2012;9(3):193–199. doi:10.7150/ijms.3635
   PubMed Web of Science ®Google Scholar
• Borrego-Soto G, Ortiz-López R, Rojas-Martínez A. Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer. Genet Mol Biol. 2015;38(4):420–432. doi:10.1590/S1415-475738420150019
   PubMed Web of Science ®Google Scholar
• Rodriguez E, Chevalier J, El Ghoul H, Voldum-Clausen K, Mundy J, Petersen M. DNA damage as a consequence of NLR activation. PLoS Genet. 2018;14(2):e1007235. doi:10.1371/journal.pgen.1007235
   PubMed Web of Science ®Google Scholar
• Madeline Lederer LR, Wanke-Jellinek L, Veit M Stoecklein JA, et al. Pathway activation in immune cells radiation exposure induces inflammasome radiation exposure induces inflammasome pathway activation in immune cells. J Immunol. 2018. doi:10.4049/jimmunol.1303051
   Google Scholar
• West CM, Barnett GC. Genetics and genomics of radiotherapy toxicity: towards prediction. Genome Med. 2011;3(8):52. doi:10.1186/gm268
   PubMed Web of Science ®Google Scholar
• Gaidt MM, Hornung V. Pore formation by GSDMD is the effector mechanism of pyroptosis. EMBO J. 2016;35(20):2167–2169. doi:10.15252/embj.201695415
   PubMed Web of Science ®Google Scholar
• Zhou H, Jin C, Cui L, et al. HMGB1 contributes to the irradiation-induced endothelial barrier injury through receptor for advanced glycation endproducts (RAGE). J Cell Physiol. 2018;233(9):6714–21. doi:10.1002/jcp.26341
   PubMed Web of Science ®Google Scholar
• Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140(6):821–832. doi:10.1016/j.cell.2010.01.040
   PubMed Web of Science ®Google Scholar
• Lu B, Wang H, Andersson U, Tracey KJ. Regulation of HMGB1 release by inflammasomes. Protein Cell. 2013;4(3):163–167. doi:10.1007/s13238-012-2118-2
   PubMed Web of Science ®Google Scholar
• Rajendran P, Rengarajan T, Thangavel J, et al. The vascular endothelium and human diseases. Int J Biol Sci. 2013;9(10):1057–1069. doi:10.7150/ijbs.7502
   PubMed Web of Science ®Google Scholar
• Michiels C. Endothelial cell functions. J Cell Physiol. 2003;196(3):430–443. doi:10.1002/jcp.10333
   PubMed Web of Science ®Google Scholar
• Medici D, Shore EM, Lounev VY, Kaplan FS, Kalluri R, Olsen BR. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med. 2010;16(12):1400–1406. doi:10.1038/nm.2252
   PubMed Web of Science ®Google Scholar
• Lomax ME, Folkes LK, O’Neill P. Biological consequences of radiation-induced DNA damage: relevance to radiotherapy. Clin Oncol. 2013;25(10):578–585. doi:10.1016/j.clon.2013.06.007
   PubMed Web of Science ®Google Scholar
• Tsai SR, Hamblin MR. Biological effects and medical applications of infrared radiation. J Photochem Photobiol B Biol. 2017;170:197–207. doi:10.1016/j.jphotobiol.2017.04.014
   PubMed Web of Science ®Google Scholar
• Verma N, Tiku AB. Significance and nature of bystander responses induced by various agents. Mutat Res Rev Mutat Res. 2017;773:104–121. doi:10.1016/j.mrrev.2017.05.003
   PubMed Web of Science ®Google Scholar
• Sand J, Fenini G, Grossi S, et al. The NLRP1 inflammasome pathway is silenced in cutaneous squamous cell carcinoma. J Invest Dermatol. 2019;139(8):1788–1797.e6. doi:10.1016/j.jid.2019.01.025
   PubMed Web of Science ®Google Scholar
• Zhai Z, Liu W, Kaur M, et al. NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma. Oncogene. 2017;36(27):3820–3830. doi:10.1038/onc.2017.26
   PubMed Web of Science ®Google Scholar
• Zhai Z, Liu W, Luo Y, et al. 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma. J Invest Dermatol. 2016;136(5):S114. doi:10.1016/j.jid.2016.02.688
   Web of Science ®Google Scholar
• Zhiyu W, Wang N, Wang Q, et al. The inflammasome: an emerging therapeutic oncotarget for cancer prevention. Oncotarget. 2016;7(31):50766–50780. doi:10.18632/oncotarget.9391
   PubMedGoogle Scholar
• Lebeaupin C, Proics E, De Bieville CHD, et al. ER stress induces NLRP3 inflammasome activation and hepatocyte death. Cell Death Dis. 2015;6(9):e1879–e1879. doi:10.1038/cddis.2015.248
   PubMedGoogle Scholar
• Maier P, Hartmann L, Wenz F, Herskind C. Cellular pathways in response to ionizing radiation and their targetability for tumor radiosensitization. Int J Mol Sci. 2016;17(1):102. doi:10.3390/ijms17010102
   PubMed Web of Science ®Google Scholar
• Blyth BJ, Cole AJ, MacManus MP, Martin OA. Radiation therapy-induced metastasis: radiobiology and clinical implications. Clin Exp Metastasis. 2018;35(4):223–236. doi:10.1007/s10585-017-9867-5
   PubMed Web of Science ®Google Scholar
• Tsuchiya K, Nakajima S, Hosojima S, et al. Caspase-1 initiates apoptosis in the absence of gasdermin D. Nat Commun. 2019;10(1):1–9. doi:10.1038/s41467-019-09753-2
   PubMedGoogle Scholar
• Jia C, Zhang J, Chen H, et al. Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation. Cell Death Dis. 2019;10(10):1–6. doi:10.1038/s41419-019-2021-3
   Google Scholar