Neutrophil Extracellular Traps Augmented Alveolar Macrophage Pyroptosis via AIM2 Inflammasome Activation in LPS-Induced ALI/ARDS

References

• Fan E, Brodie D, Slutsky AS. Acute respiratory distress syndrome: advances in diagnosis and treatment. JAMA. 2018;319(7):698–710. doi:10.1001/jama.2017.21907
   PubMed Web of Science ®Google Scholar
• Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315(8):788–800. doi:10.1001/jama.2016.0291
   PubMed Web of Science ®Google Scholar
• Alessandri F, Pugliese F, Ranieri VM. The role of rescue therapies in the treatment of severe ARDS. Respir Care. 2018;63(1):92–101. doi:10.4187/respcare.05752
   PubMed Web of Science ®Google Scholar
• Hussell T, Bell TJ. Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol. 2014;14(2):81–93. doi:10.1038/nri3600
   PubMed Web of Science ®Google Scholar
• Wallach D, Kang TB, Dillon CP, Green DR. Programmed necrosis in inflammation: toward identification of the effector molecules. Science. 2016;352(6281):aaf2154. doi:10.1126/science.aaf2154
   PubMed Web of Science ®Google Scholar
• Fernandes-Alnemri T, Wu J, Yu JW, et al. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ. 2007;14(9):1590–1604. doi:10.1038/sj.cdd.4402194
   PubMed Web of Science ®Google Scholar
• Jorgensen I, Miao EA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev. 2015;265(1):130–142. doi:10.1111/imr.12287
   PubMed Web of Science ®Google Scholar
• Wu DD, Pan PH, Liu B, et al. Inhibition of alveolar macrophage pyroptosis reduces lipopolysaccharide-induced acute lung injury in mice. Chin Med J. 2015;128(19):2638–2645. doi:10.4103/0366-6999.166039
   PubMed Web of Science ®Google Scholar
• Wu D, Pan P, Su X, et al. Interferon regulatory factor-1 mediates alveolar macrophage pyroptosis during LPS-induced acute lung injury in mice. Shock. 2016;46(3):329–338. doi:10.1097/shk.0000000000000595
   PubMed Web of Science ®Google Scholar
• Dolinay T, Kim YS, Howrylak J, et al. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med. 2012;185(11):1225–1234. doi:10.1164/rccm.201201-0003OC
   PubMed Web of Science ®Google Scholar
• Jones HD, Crother TR, Gonzalez-Villalobos RA, et al. The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. Am J Respir Cell Mol Biol. 2014;50(2):270–280. doi:10.1165/rcmb.2013-0087OC
   PubMed Web of Science ®Google Scholar
• Kovarova M, Hesker PR, Jania L, et al. NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol. 2012;189(4):2006–2016. doi:10.4049/jimmunol.1201065
   PubMed Web of Science ®Google Scholar
• Brodsky IE, Medzhitov R. Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol. 2011;21(2):R72–5. doi:10.1016/j.cub.2010.12.008
   PubMed Web of Science ®Google Scholar
• Fink SL, Cookson BT. Pyroptosis and host cell death responses during Salmonella infection. Cell Microbiol. 2007;9(11):2562–2570. doi:10.1111/j.1462-5822.2007.01036.x
   PubMed Web of Science ®Google Scholar
• Zemans RL, Matthay MA. What drives neutrophils to the alveoli in ARDS? Thorax. 2017;72(1):1–3. doi:10.1136/thoraxjnl-2016-209170
   PubMed Web of Science ®Google Scholar
• Papayannopoulos V. Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol. 2018;18(2):134–147. doi:10.1038/nri.2017.105
   PubMed Web of Science ®Google Scholar
• Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532–1535. doi:10.1126/science.1092385
   PubMed Web of Science ®Google Scholar
• Huang H, Tohme S, Al-Khafaji AB, et al. Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology (Baltimore, Md). 2015;62(2):600–614. doi:10.1002/hep.27841
   PubMed Web of Science ®Google Scholar
• Behnen M, Leschczyk C, Moller S, et al. Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcgammaRIIIB and Mac-1. J Immunol. 2014;193(4):1954–1965. doi:10.4049/jimmunol.1400478
   PubMed Web of Science ®Google Scholar
• Chen K, Nishi H, Travers R, et al. Endocytosis of soluble immune complexes leads to their clearance by FcgammaRIIIB but induces neutrophil extracellular traps via FcgammaRIIA in vivo. Blood. 2012;120(22):4421–4431. doi:10.1182/blood-2011-12-401133
   PubMedGoogle Scholar
• Keshari RS, Jyoti A, Dubey M, et al. Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition. PLoS One. 2012;7(10):e48111. doi:10.1371/journal.pone.0048111
   PubMed Web of Science ®Google Scholar
• McDonald B, Davis RP, Kim SJ, et al. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood. 2017;129(10):1357–1367. doi:10.1182/blood-2016-09-741298
   PubMed Web of Science ®Google Scholar
• Narasaraju T, Yang E, Samy RP, et al. Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis. Am J Pathol. 2011;179(1):199–210. doi:10.1016/j.ajpath.2011.03.013
   PubMed Web of Science ®Google Scholar
• Li H, Zhou X, Tan H, et al. Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS. Oncotarget. 2018;9(2):1772–1784. doi:10.18632/oncotarget.22744
   PubMedGoogle Scholar
• Liu S, Su X, Pan P, et al. Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury. Sci Rep. 2016;6:37252. doi:10.1038/srep37252
   PubMed Web of Science ®Google Scholar
• Farrera C, Fadeel B. Macrophage clearance of neutrophil extracellular traps is a silent process. J Immunol. 2013;191(5):2647–2656. doi:10.4049/jimmunol.1300436
   PubMed Web of Science ®Google Scholar
• Warnatsch A, Ioannou M, Wang Q, Papayannopoulos V. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis. Science. 2015;349(6245):316–320. doi:10.1126/science.aaa8064
   PubMed Web of Science ®Google Scholar
• Riehl DR, Roewe J, Klebow S, et al. Neutrophil extracellular traps drive bleomycin-induced lung fibrosis by regulating TGFβ1-dependent interactions of platelets and macrophages. FASEB J. 2016;30(1_supplement):50.1. doi:10.1096/fasebj.30.1_supplement.50.1
   Google Scholar
• Chen L, Zhao Y, Lai D, et al. Neutrophil extracellular traps promote macrophage pyroptosis in sepsis. Cell Death Dis. 2018;9(6):597. doi:10.1038/s41419-018-0538-5
   PubMedGoogle Scholar
• Hu Z, Murakami T, Tamura H, et al. Neutrophil extracellular traps induce IL-1beta production by macrophages in combination with lipopolysaccharide. Int J Mol Med. 2017;39(3):549–558. doi:10.3892/ijmm.2017.2870
   PubMed Web of Science ®Google Scholar
• Li H, Pan P, Su X, et al. Neutrophil extracellular traps are pathogenic in ventilator-induced lung injury and partially dependent on TLR4. Biomed Res Int. 2017;2017:8272504. doi:10.1155/2017/8272504
   PubMed Web of Science ®Google Scholar
• Knight JS, Subramanian V, O’Dell AA, et al. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015;74(12):2199–2206. doi:10.1136/annrheumdis-2014-205365
   PubMed Web of Science ®Google Scholar
• Caudrillier A, Kessenbrock K, Gilliss BM, et al. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012;122(7):2661–2671. doi:10.1172/jci61303
   PubMed Web of Science ®Google Scholar
• Dicker AJ, Crichton ML, Pumphrey EG, et al. Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018;141(1):117–127. doi:10.1016/j.jaci.2017.04.022
   PubMed Web of Science ®Google Scholar
• Dai M, Pan P, Li H, et al. The antimicrobial cathelicidin peptide hlF(1-11) attenuates alveolar macrophage pyroptosis induced by Acinetobacter baumannii in vivo. Exp Cell Res. 2018;364(1):95–103. doi:10.1016/j.yexcr.2018.01.035
   PubMed Web of Science ®Google Scholar
• Casals C, Arias-Diaz J, Valino F, et al. Surfactant strengthens the inhibitory effect of C-reactive protein on human lung macrophage cytokine release. Am J Physiol Lung Cell Mol Physiol. 2003;284(3):L466–72. doi:10.1152/ajplung.00325.2002
   PubMed Web of Science ®Google Scholar
• Gea-Sorli S, Guillamat R, Serrano-Mollar A, Closa D. Activation of lung macrophage subpopulations in experimental acute pancreatitis. J Pathol. 2011;223(3):417–424. doi:10.1002/path.2814
   PubMed Web of Science ®Google Scholar
• Czaikoski PG, Mota JM, Nascimento DC, et al. Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis. PLoS One. 2016;11(2):e0148142. doi:10.1371/journal.pone.0148142
   PubMed Web of Science ®Google Scholar
• Lugrin J, Martinon F. Detection of ASC oligomerization by western blotting. Bio-Protocol. 2017;7(10):e2292. doi:10.21769/BioProtoc.2292
   PubMedGoogle Scholar
• Ryu JC, Kim MJ, Kwon Y, et al. Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2. Article. Mucosal Immunol. 2016;10:757. doi:10.1038/mi.2016.73
   PubMed Web of Science ®Google Scholar
• Chen KW, Gross CJ, Sotomayor FV, et al. The neutrophil NLRC4 inflammasome selectively promotes IL-1beta maturation without pyroptosis during acute Salmonella challenge. Cell Rep. 2014;8(2):570–582. doi:10.1016/j.celrep.2014.06.028
   PubMed Web of Science ®Google Scholar
• Máca J, Jor O, Holub M, et al. Past and present ARDS mortality rates: a Systematic Review. Respir Care. 2017;62(1):113–122. doi:10.4187/respcare.04716
   PubMed Web of Science ®Google Scholar
• Kallet R, Pirracchio R, Lipnick MS, Sinha P, Gomez A, Matthay MA. Mortality rate in ARDS is higher in those meeting NIH ARDSNet exclusion criteria. Respir Care. 2018;63(Suppl 10):3017278.
   Google Scholar
• Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol. 2010;10(6):427–439. doi:10.1038/nri2779
   PubMed Web of Science ®Google Scholar
• Yang W, Tao Y, Wu Y, et al. Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair. Nat Commun. 2019;10(1):1076. doi:10.1038/s41467-019-09046-8
   PubMedGoogle Scholar
• Prame Kumar K, Nicholls AJ, Wong CHY. Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease. Cell Tissue Res. 2018;371(3):551–565. doi:10.1007/s00441-017-2753-2
   PubMed Web of Science ®Google Scholar
• Sadatomo A, Inoue Y, Ito H, et al. Interaction of neutrophils with macrophages promotes IL-1β maturation and contributes to hepatic ischemia–reperfusion injury. J Immunol. 2017;199(9):3306–3315. doi:10.4049/jimmunol.1700717
   PubMed Web of Science ®Google Scholar
• Aktas G, Duman T, Atak B, et al. Irritable bowel syndrome is associated with novel inflammatory markers derived from hemogram parameters. journal article. Family Med Prim Care Rev. 2020;22(2):107–110. doi:10.5114/fmpcr.2020.95311
   Google Scholar
• Liu S, Yue Y, Pan P, et al. IRF-1 intervention in the classical ROS-dependent release of NETs during LPS-induced acute lung injury in mice. Inflammation. 2019;42(1):387–403. doi:10.1007/s10753-018-0903-7
   PubMed Web of Science ®Google Scholar
• Lazzaretto B, Fadeel B. Intra- and extracellular degradation of neutrophil extracellular traps by macrophages and dendritic cells. J Immunol. 2019;203(8):2276–2290. doi:10.4049/jimmunol.1800159
   PubMed Web of Science ®Google Scholar
• Josefs T, Barrett TJ, Brown EJ, et al. Neutrophil extracellular traps promote macrophage inflammation and impair atherosclerosis resolution in diabetic mice. JCI Insight. 2020;5(7):e134796. doi:10.1172/jci.insight.134796
   PubMed Web of Science ®Google Scholar
• Trachalaki A, Tsitoura E, Mastrodimou S, et al. Enhanced IL-1β release following NLRP3 and AIM2 inflammasome stimulation is linked to mtROS in airway macrophages in pulmonary fibrosis. Original Research. Front Immunol. 2021;12:2182. doi:10.3389/fimmu.2021.661811
   Web of Science ®Google Scholar
• Fidler TP, Xue C, Yalcinkaya M, et al. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Nature. 2021;592(7853):296–301. doi:10.1038/s41586-021-03341-5
   PubMed Web of Science ®Google Scholar
• Roth S, Cao J, Singh V, et al. Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity. 2021;54(4):648–659.e8. doi:10.1016/j.immuni.2021.02.004
   PubMed Web of Science ®Google Scholar
• Bai Y, Tong Y, Liu Y, Hu H. Self-dsDNA in the pathogenesis of systemic lupus erythematosus. Clin Exp Immunol. 2018;191(1):1–10. doi:10.1111/cei.13041
   PubMed Web of Science ®Google Scholar
• Sharma BR, Karki R, Kanneganti T-D. Role of AIM2 inflammasome in inflammatory diseases, cancer and infection. Eur J Immunol. 2019;49(11):1998–2011. doi:10.1002/eji.201848070
   PubMed Web of Science ®Google Scholar
• Bae JH, Jo S, Kim SJ, et al. Circulating cell-free mtDNA contributes to AIM2 inflammasome-mediated chronic inflammation in patients with Type 2 diabetes. Cells. 2019;8(4):328. doi:10.3390/cells8040328
   PubMed Web of Science ®Google Scholar
• Houthaeve G, Xiong R, Robijns J, et al. Targeted perturbation of nuclear envelope integrity with vapor nanobubble-mediated photoporation. ACS Nano. 2018;12(8):7791–7802. doi:10.1021/acsnano.8b01860
   PubMed Web of Science ®Google Scholar
• Luo Y, Xiong B, Liu H, et al. Koumine suppresses IL-1β secretion and attenuates inflammation associated with blocking ROS/NF-κB/NLRP3 axis in macrophages. Front Pharmacol. 2021;11:622074. doi:10.3389/fphar.2020.622074
   PubMed Web of Science ®Google Scholar