miR-486-5p Serves as a Diagnostic Biomarker for Sepsis and Its Predictive Value for Clinical Outcomes

References

• Zheng X, Leung KS, Wong MH, et al. Long non-coding RNA pairs to assist in diagnosing sepsis. BMC Genomics. 2021;22(1):275. doi:10.1186/s12864-021-07576-4
   PubMed Web of Science ®Google Scholar
• Tang Y, Yang X, Shu H, et al. Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury. Hereditas. 2021;158(1):1–10. doi:10.1186/s41065-021-00176-y
   PubMed Web of Science ®Google Scholar
• Na L, Ding H, Xing E, et al. Lnc-MEG3 acts as a potential biomarker for predicting increased disease risk, systemic inflammation, disease severity, and poor prognosis of sepsis via interacting with miR-21. J Clin Lab Anal. 2020;34(4):e23123. doi:10.1002/jcla.23123
   PubMed Web of Science ®Google Scholar
• Tuzun F, Ozkan H, Cetinkaya M, et al. Is European Medicines Agency (EMA) sepsis criteria accurate for neonatal sepsis diagnosis or do we need new criteria? PLoS One. 2019;14(6):e0218002. doi:10.1371/journal.pone.0218002
   PubMed Web of Science ®Google Scholar
• Llobat L, Gourbault O. Role of MicroRNAs in human osteosarcoma: future perspectives. Biomedicines. 2021;9(5):463. doi:10.3390/biomedicines9050463
   PubMed Web of Science ®Google Scholar
• Wang D, Han L. Downregulation of miR-1184 serves as a diagnostic biomarker in neonatal sepsis and regulates LPS-induced inflammatory response by inhibiting IL-16 in monocytes. Exp Ther Med. 2021;21:350. doi:10.3892/etm.2021.9781
   PubMed Web of Science ®Google Scholar
• Zhang H, Che L, Wang Y, et al. Deregulated microRNA-22-3p in patients with sepsis-induced acute kidney injury serves as a new biomarker to predict disease occurrence and 28-day survival outcomes. Int Urol Nephrol. 2021. doi:10.1007/s11255-021-02784-z
   Web of Science ®Google Scholar
• Liu Z, Yang D, Gao J, et al. Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis. Theranostics. 2020;10(26):11963–11975. doi:10.7150/thno.50093
   PubMed Web of Science ®Google Scholar
• Liu HC, Han DS, Hsu CC, et al. Circulating MicroRNA-486 and MicroRNA-146a serve as potential biomarkers of sarcopenia in the older adults. BMC Geriatr. 2021;21(1):86. doi:10.1186/s12877-021-02040-0
   PubMed Web of Science ®Google Scholar
• Zheng X, Xu K, Zhu L, et al. MiR-486-5p act as a biomarker in endometrial carcinoma: promotes cell proliferation, migration, invasion by targeting MARK1. Onco Targets Ther. 2020;13:4843–4853. doi:10.2147/OTT.S246841
   PubMed Web of Science ®Google Scholar
• Ninawe A, Guru SA, Yadav P, et al. miR-486-5p: a prognostic biomarker for chronic myeloid leukemia. ACS Omega. 2021;6(11):7711–7718. doi:10.1021/acsomega.1c00035
   PubMed Web of Science ®Google Scholar
• Zheng C, Wu D, Shi S, et al. miR-34b-5p promotes renal cell inflammation and apoptosis by inhibiting aquaporin-2 in sepsis-induced acute kidney injury. Ren Fail. 2021;43(1):291–301. doi:10.1080/0886022X.2021.1871922
   PubMed Web of Science ®Google Scholar
• Cirillo F, Catellani C, Lazzeroni P, et al. MiRNAs regulating insulin sensitivity are dysregulated in Polycystic Ovary Syndrome (PCOS) ovaries and are associated with markers of inflammation and insulin sensitivity. Front Endocrinol. 2019;10:879. doi:10.3389/fendo.2019.00879
   PubMed Web of Science ®Google Scholar
• Luo Q, Zhu J, Zhang Q, et al. MicroRNA-486-5p promotes acute lung injury via inducing inflammation and apoptosis by targeting OTUD7B. Inflammation. 2020;43(3):975–984. doi:10.1007/s10753-020-01183-3
   PubMed Web of Science ®Google Scholar
• Vasilescu C, Rossi S, Shimizu M, et al. MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS One. 2009;4(10):e7405. doi:10.1371/journal.pone.0007405
   PubMed Web of Science ®Google Scholar
• Vandewalle J, Libert C. Glucocorticoids in sepsis: to be or not to be. Front Immunol. 2020;11:1318. doi:10.3389/fimmu.2020.01318
   PubMed Web of Science ®Google Scholar
• Shankar-Hari M, Phillips GS, Levy ML, et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):775–787. doi:10.1001/jama.2016.0289
   PubMed Web of Science ®Google Scholar
• Vincent JL, de Mendonca A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on “sepsis-related problems” of the European society of intensive care medicine. Crit Care Med. 1998;26(11):1793–1800. doi:10.1097/00003246-199811000-00016
   PubMed Web of Science ®Google Scholar
• Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801–810. doi:10.1001/jama.2016.0287
   PubMed Web of Science ®Google Scholar
• Fu H, Tie Y, Xu C, et al. Identification of human fetal liver miRNAs by a novel method. FEBS Lett. 2005;579(17):3849–3854. doi:10.1016/j.febslet.2005.05.064
   PubMed Web of Science ®Google Scholar
• Tahiri A, Leivonen SK, Lüders T, et al. Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors. Carcinogenesis. 2014;35(1):76–85. doi:10.1093/carcin/bgt333
   PubMed Web of Science ®Google Scholar
• Liu X, Chen X, Zeng K, et al. DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/beta-catenin signal pathways. Cell Death Dis. 2018;9(10):1037. doi:10.1038/s41419-018-1105-9
   PubMedGoogle Scholar
• Yi Y, Lu X, Chen J, et al. Downregulated miR-486-5p acts as a tumor suppressor in esophageal squamous cell carcinoma. Exp Ther Med. 2016;12(5):3411–3416. doi:10.3892/etm.2016.3783
   PubMed Web of Science ®Google Scholar
• Li C, Zheng X, Li W, et al. Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms. BMC Cancer. 2018;18(1):61. doi:10.1186/s12885-017-3753-z
   PubMed Web of Science ®Google Scholar
• Abou El-Khier NT, Zaki ME, Alkasaby NM. Study of MicroRNA-122 as a diagnostic biomarker of sepsis. Egypt J Immunol. 2019;26:105–116.
   PubMedGoogle Scholar
• Kong R, Gao J, Si Y, et al. Combination of circulating miR-19b-3p, miR-122-5p and miR-486-5p expressions correlates with risk and disease severity of knee osteoarthritis. Am J Transl Res. 2017;9:2852–2864.
   PubMed Web of Science ®Google Scholar
• Zhang J, Xu Z, Kong L, et al. miRNA-486-5p promotes COPD progression by targeting HAT1 to regulate the TLR4-triggered inflammatory response of alveolar macrophages. Int J Chron Obstruct Pulmon Dis. 2020;15:2991–3001. doi:10.2147/COPD.S280614
   PubMed Web of Science ®Google Scholar
• Lopez R, Vial C, Graf J, et al. Platelet count in patients with mild disease at admission is associated with progression to severe hantavirus cardiopulmonary syndrome. Viruses. 2019;11:693. doi:10.3390/v11080693
   PubMed Web of Science ®Google Scholar
• Guo S, Mao X, Liang M. The moderate predictive value of serial serum CRP and PCT levels for the prognosis of hospitalized community-acquired pneumonia. Respir Res. 2018;19:193. doi:10.1186/s12931-018-0877-x
   PubMed Web of Science ®Google Scholar
• Zhao D, Li S, Cui J, et al. Plasma miR-125a and miR-125b in sepsis: correlation with disease risk, inflammation, severity, and prognosis. J Clin Lab Anal. 2020;34(2):e23036. doi:10.1002/jcla.23036
   PubMed Web of Science ®Google Scholar
• Ling H, Li Q, Duan ZP, et al. LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1alpha/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury. Am J Physiol Cell Physiol. 2021;321(1):C117–C133. doi:10.1152/ajpcell.00394.2020
   PubMed Web of Science ®Google Scholar
• Li L, Liu M, Cao M, et al. Research progress on SIRT1 and sepsis. Histol Histopathol. 2019;34:1205–1215.
   PubMed Web of Science ®Google Scholar
• Chen L, Xie W, Wang L, et al. MiRNA-133a aggravates inflammatory responses in sepsis by targeting SIRT1. Int Immunopharmacol. 2020;88:106848. doi:10.1016/j.intimp.2020.106848
   PubMed Web of Science ®Google Scholar
• Guo T, Jiang ZB, Tong ZY, et al. Shikonin ameliorates LPS-induced cardiac dysfunction by SIRT1-dependent inhibition of NLRP3 inflammasome. Front Physiol. 2020;11:570441. doi:10.3389/fphys.2020.570441
   PubMed Web of Science ®Google Scholar
• Gao ZJ, Yuan WD, Yuan JQ, et al. miR-486-5p functions as an oncogene by targeting PTEN in non-small cell lung cancer. Pathol Res Pract. 2018;214(5):700–705. doi:10.1016/j.prp.2018.03.013
   PubMed Web of Science ®Google Scholar
• Sun XH, Wang X, Zhang Y, et al. Exosomes of bone-marrow stromal cells inhibit cardiomyocyte apoptosis under ischemic and hypoxic conditions via miR-486-5p targeting the PTEN/PI3K/AKT signaling pathway. Thromb Res. 2019;177:23–32. doi:10.1016/j.thromres.2019.02.002
   PubMed Web of Science ®Google Scholar