The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study

References

• Rossaint J, Zarbock A. Perioperative inflammation and its modulation by anesthetics. Anesth Analg. 2018;126(3):1058–1067. doi:10.1213/ANE.0000000000002484
   PubMed Web of Science ®Google Scholar
• Frangogiannis NG. The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol. 2014;11(5):255–265. doi:10.1038/nrcardio.2014.28
   PubMed Web of Science ®Google Scholar
• Hilfiker-Kleiner D, Shukla P, Klein G, et al. Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction. Circulation. 2010;122(2):145–155. doi:10.1161/CIRCULATIONAHA.109.933127
   PubMed Web of Science ®Google Scholar
• Boehm O, Baumgarten G, Hoeft A. Epidemiology of the high-risk population: perioperative risk and mortality after surgery. Curr Opin Crit Care. 2015;21(4):322–327. doi:10.1097/MCC.0000000000000221
   PubMed Web of Science ®Google Scholar
• Cai J, Pardali E, Sánchez-Duffhues G, Ten Dijke P. BMP signaling in vascular diseases. FEBS Lett. 2012;586(14):1993–2002. doi:10.1016/j.febslet.2012.04.030
   PubMed Web of Science ®Google Scholar
• Cole AE, Murray SS, Xiao J. Bone morphogenetic protein 4 signalling in neural stem and progenitor cells during development and after injury. Stem Cells Int. 2016;2016.
   Web of Science ®Google Scholar
• de Vinuesa AG, Abdelilah-Seyfried S, Knaus P, Zwijsen A, Bailly S. BMP signaling in vascular biology and dysfunction. Cytokine Growth Factor Rev. 2016;27:65–79. doi:10.1016/j.cytogfr.2015.12.005
   PubMed Web of Science ®Google Scholar
• Yin W, Jo H, Voit EO. Systems analysis of the role of bone morphogenic protein 4 in endothelial inflammation. Ann Biomed Eng. 2010;38(2):291–307. doi:10.1007/s10439-009-9822-y
   PubMed Web of Science ®Google Scholar
• Noseda M, Peterkin T, Simões FC, Patient R, Schneider MD. Cardiopoietic factors: extracellular signals for cardiac lineage commitment. Circ Res. 2011;108(1):129–152. doi:10.1161/CIRCRESAHA.110.223792
   PubMed Web of Science ®Google Scholar
• Qian S-W, Wu M-Y, Wang Y-N, et al. BMP4 facilitates beige fat biogenesis via regulating adipose tissue macrophages. J Mol Cell Biol. 2019;11(1):14–25. doi:10.1093/jmcb/mjy011
   PubMed Web of Science ®Google Scholar
• Helbing T, Arnold L, Wiltgen G, et al. Endothelial BMP4 regulates leukocyte diapedesis and promotes inflammation. Inflammation. 2017;40(6):1862–1874. doi:10.1007/s10753-017-0627-0
   PubMed Web of Science ®Google Scholar
• Hanna A, Frangogiannis NG. The role of the TGF-β superfamily in myocardial infarction. Front Cardiovasc Med. 2019;6:140. doi:10.3389/fcvm.2019.00140
   PubMed Web of Science ®Google Scholar
• Wang D, Prakash J, Nguyen P, et al. Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A. J Biol Chem. 2012;287(33):28067–28077. doi:10.1074/jbc.M112.379487
   PubMed Web of Science ®Google Scholar
• Jo H, Song H, Mowbray A. Role of NADPH oxidases in disturbed flow-and BMP4-induced inflammation and atherosclerosis. Antioxid Redox Signal. 2006;8(9–10):1609–1619. doi:10.1089/ars.2006.8.1609
   PubMed Web of Science ®Google Scholar
• Zimmerman LB, De Jesús-escobar JM, Harland RM. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell. 1996;86(4):599–606. doi:10.1016/S0092-8674(00)80133-6
   PubMed Web of Science ®Google Scholar
• Kloen P, Lauzier D, Hamdy RC. Co-expression of BMPs and BMP-inhibitors in human fractures and non-unions. Bone. 2012;51(1):59–68. doi:10.1016/j.bone.2012.03.032
   PubMed Web of Science ®Google Scholar
• Rajski M, Saaf A, Buess M. BMP2 response pattern in human lung fibroblasts predicts outcome in lung adenocarcinomas. BMC Med Genomics. 2015;8(1):1–12. doi:10.1186/s12920-015-0090-4
   PubMedGoogle Scholar
• Chattopadhyay T, Singh RR, Gupta S, Surolia A. Bone morphogenetic protein‐7 (BMP‐7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway. Biofactors. 2017;43(2):195–209. doi:10.1002/biof.1334
   PubMed Web of Science ®Google Scholar
• Youn J-Y, Zhou J, Cai H. Bone morphogenic protein 4 mediates NOX1-dependent eNOS uncoupling, endothelial dysfunction, and COX2 induction in type 2 diabetes mellitus. Mol Endocrinol. 2015;29(8):1123–1133. doi:10.1210/ME.2014-1313
   PubMedGoogle Scholar
• Wu T, Ling Q-Y, Zhong C, et al. Expression of BMP4 in myocardium and vascular tissue of obese mice. J Inflamm. 2015;12(1):1–6. doi:10.1186/s12950-015-0047-6
   Google Scholar
• Mukaka MM. A guide to appropriate use of correlation coefficient in medical research. Malawi Med J. 2012;24(3):69–71.
   PubMed Web of Science ®Google Scholar
• Csiszar A, Labinskyy N, Jo H, Ballabh P, Ungvari Z. Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2008;295(2):H569–H577. doi:10.1152/ajpheart.00180.2008
   PubMed Web of Science ®Google Scholar
• Martínez VG, Rubio C, Martínez-Fernández M, et al. BMP4 induces M2 macrophage polarization and favors tumor progression in bladder cancer. Clin Cancer Res. 2017;23(23):7388–7399. doi:10.1158/1078-0432.CCR-17-1004
   PubMed Web of Science ®Google Scholar
• Valencia J, Fernández-Sevilla L, Fraile-Ramos A, et al. Acute lymphoblastic leukaemia cells impair dendritic cell and macrophage differentiation: role of BMP4. Cells. 2019;8(7):722. doi:10.3390/cells8070722
   PubMed Web of Science ®Google Scholar
• Kariyawasam HH, Xanthou G, Barkans J, Aizen M, Kay AB, Robinson DS. Basal expression of bone morphogenetic protein receptor is reduced in mild asthma. Am J Respir Crit Care Med. 2008;177(10):1074–1081. doi:10.1164/rccm.200709-1376OC
   PubMed Web of Science ®Google Scholar
• Kim CW, Song H, Kumar S, et al. Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells. Arterioscler Thromb Vasc Biol. 2013;33(6):1350–1359. doi:10.1161/ATVBAHA.112.300287
   PubMed Web of Science ®Google Scholar
• Kercheva M, Gusakova AM, Ryabova TR, Suslova TE, Kzhyshkowska J, Ryabov VV. Serum levels of bone morphogenetic proteins 2 and 4 in patients with acute myocardial infarction. Cells. 2020;9(10):2179. doi:10.3390/cells9102179
   PubMed Web of Science ®Google Scholar
• Arnold L, Weberbauer M, Herkel M, et al. Endothelial BMP4 promotes leukocyte rolling and adhesion and is elevated in patients after survived out-of-hospital cardiac arrest. Inflammation. 2020;43(6):2379–2391. doi:10.1007/s10753-020-01307-9
   PubMed Web of Science ®Google Scholar
• Penn M, Mausner-Fainberg K, Golan M, Karni A. High serum levels of BMP-2 correlate with BMP-4 and BMP-5 levels and induce reduced neuronal phenotype in patients with relapsing-remitting multiple sclerosis. J Neuroimmunol. 2017;310:120–128. doi:10.1016/j.jneuroim.2017.07.008
   PubMed Web of Science ®Google Scholar
• Eligini S, Stella Barbieri S, Cavalca V, et al. Diversity and similarity in signaling events leading to rapid Cox-2 induction by tumor necrosis factor-α and phorbol ester in human endothelial cells. Cardiovasc Res. 2005;65(3):683–693. doi:10.1016/j.cardiores.2004.10.024
   PubMed Web of Science ®Google Scholar
• Wong WT, Tian XY, Chen Y, et al. Bone morphogenic Protein-4 impairs endothelial function through oxidative stress–dependent cyclooxygenase-2 upregulation: implications on hypertension. Circ Res. 2010;107(8):984–991. doi:10.1161/CIRCRESAHA.110.222794
   PubMed Web of Science ®Google Scholar
• Sorescu GP, Sykes M, Weiss D, et al. Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. J Biol Chem. 2003;278(33):31128–31135. doi:10.1074/jbc.M300703200
   PubMed Web of Science ®Google Scholar
• Sorescu GP, Song H, Tressel SL, et al. Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Circ Res. 2004;95(8):773–779. doi:10.1161/01.RES.0000145728.22878.45
   PubMed Web of Science ®Google Scholar
• Sun B, Sheng Y, Huo R, et al. Bone morphogenetic protein-4 contributes to the down-regulation of Kv4. 3 K+ channels in pathological cardiac hypertrophy. Biochem Biophys Res Commun. 2013;436(4):591–594. doi:10.1016/j.bbrc.2013.05.113
   PubMed Web of Science ®Google Scholar