Advanced search
Publication Cover
Journal of Inflammation Research Volume 14, 2021 - Issue
Submit an article Journal homepage
68
Views
1
CrossRef citations to date
0
Altmetric
Original Research

Linagliptin Inhibits Interleukin-6 Production Through Toll-Like Receptor 4 Complex and Lipopolysaccharide-Binding Protein Independent Pathway in vitro Model

Hiroshi Saito1 JA Hiroshima Genneral Hospital, Hatsukaichi City, Hiroshima, JapanORCID Iconhttps://orcid.org/0000-0002-5184-9181View further author information
ORCID Icon,
Yuya Nakamura2 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan;3 Saiyu Soka Hospital, Soka City, Saitama, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6156-5975View further author information
ORCID Icon,
Masahiro Inagaki2 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan;4 Faculty of Arts and Sciences at Fujiyoshida, Showa University, Fujiyoshida City, Yamanashi, JapanView further author information
,
Shiho Yamadera5 Department of Hospital Pharmaceutics, Showa University School of Pharmacy, Shinagawa-ku, Tokyo, JapanView further author information
,
Hideo Misawa2 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan;3 Saiyu Soka Hospital, Soka City, Saitama, JapanView further author information
,
Naoki Sato2 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan;6 Department of Research Center, Tanabe Pharmacy Inc., Chuo-ku, Tokyo, JapanView further author information
,
Tatsunori Oguchi2 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, JapanView further author information
,
Takae Inagaki7 Graduate School of Nursing and Rehabilitation Science, Yokohama City, Kanagawa, JapanView further author information
,
Yuya Tsuji2 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, JapanView further author information
,
Mayumi Tsuji2 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, JapanView further author information
,
Isao Ohsawa3 Saiyu Soka Hospital, Soka City, Saitama, JapanView further author information
,
Hiromichi Gotoh3 Saiyu Soka Hospital, Soka City, Saitama, JapanView further author information
&
Yuji Kiuchi2 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0001-7198-3735View further author information
ORCID Icon show all
Pages 5681-5686 | Published online: 02 Nov 2021

References

  • Nakamura Y, Hasegawa H, Tsuji M, et al. Linagliptin inhibits lipopolysaccharide-stimulated interleukin-6 production, intranuclear p65 expression, and p38 mitogen-activated protein kinase phosphorylation in human umbilical vein endothelial cells. Ren Replace The. 2016;2:17. doi:10.1186/s41100-016-0030-6
  • Nakamura Y, Inagaki M, Tsuji M, et al. Linagliptin has wide-ranging anti-inflammatory points of action in human umbilical vein endothelial cells. Jpn Clin Med. 2016;7:27–32. doi:10.4137/JCM.S39317
  • Yamadera S, Nakamura Y, Inagaki M, et al. Linagliptin inhibits lipopolysaccharide induced inflammation in human U937 monocytes. Inflamm Regen. 2018;38:13. doi:10.1186/s41232-018-0071-z
  • Sato N, Nakamura Y, Yamadera S, et al. Linagliptin inhibits lipopolysaccharide-induced inflammation concentration-dependently and-independently. J Inflamm Res. 2019;12:285–291. doi:10.2147/JIR.S221761
  • Wright SD, Ramos RA, Tobias PS, et al. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 1990;249:1431–1433.
  • Nishijima M, Hara-Kuge S, Takasuka N, et al. Identification of a biochemical lesion, and characteristic response to lipopolysaccharide (LPS) of a cultured macrophage-like cell mutant with defective LPSbinding. J Biochem. 1994;116:1082–1087. doi:10.1093/oxfordjournals.jbchem.a124631
  • Weinstein SL, June CH, DeFranco AL. Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14. J Immunol. 1993;151:3829–3838.
  • Yamamoto Y, Harashima A, Saito H, et al. Septic shock is associated with receptor for advanced glycation end products (RAGE) ligation of LPS. J Immunol. 2011;186:3248–3257. doi:10.4049/jimmunol.1002253
  • Jerala R. Structural biology of the LPS recognition. Int J Med Microbiol. 2007;297:353–363. doi:10.1016/j.ijmm.2007.04.001
  • Zweigner J, Schumann RR, Weber JR. The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes Infect. 2006;8:946–952. doi:10.1016/j.micinf.2005.10.006
  • Stenvinkel P, Heimbürger O, Lindholm B, et al. Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant. 2000;15:953–960. doi:10.1093/ndt/15.7.953
  • Jiao H, Zhang Y, Yan Z, et al. Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation. J Immunol. 2013;191:6191–6199. doi:10.4049/jimmunol.1300873
  • Hiromura M, Nohtomi K, Mori Y, et al. Caveolin-1, a binding protein of CD26, is essential for the anti-inflammatory effects of dipeptidyl peptidase-4 inhibitors on human and mouse macrophages. Biochem Biophys Res Commun. 2018;495:223–229. doi:10.1016/j.bbrc.2017.11.016
  • Boehringer Ingelheim Pharmaceuticals, Inc. Tradjenta (linagliptin) tablets. Available from: http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Tradjenta/Tradjenta.pdf. Accessed May 1, 2021.
  • Tachado SD, Li X, Bole M, et al. MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV+ persons. Blood. 2010;115:3606–3615. doi:10.1182/blood-2009-10-250787

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.