Colocalization with MMP-7 in the Distal Colon is Crucial for Syndecan-2 Shedding in Dextran Sulfate Sodium-Induced Colitis Mice

References

• Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454:428–435. doi:10.1038/nature07201
   PubMed Web of Science ®Google Scholar
• Kotas ME, Medzhitov R. Homeostasis, inflammation, and disease susceptibility. Cell. 2015;160:816–827. doi:10.1016/j.cell.2015.02.010
   PubMed Web of Science ®Google Scholar
• Todoric J, Antonucci L, Karin M. Targeting inflammation in cancer prevention and therapy. Cancer Prev Res. 2016;9:895–905. doi:10.1158/1940-6207.CAPR-16-0209
   PubMed Web of Science ®Google Scholar
• Kamekura R, Nava P, Feng M, et al. Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier. Mol Biol Cell. 2015;26:3165–3177. doi:10.1091/mbc.e15-03-0147
   PubMed Web of Science ®Google Scholar
• Guinea-Viniegra J, Zenz R, Scheuch H, et al. TNFalpha shedding and epidermal inflammation are controlled by Jun proteins. Genes Dev. 2009;23:2663–2674. doi:10.1101/gad.543109
   PubMed Web of Science ®Google Scholar
• Gomez MI, Sokol SH, Muir AB, et al. Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling. J Immunol. 2005;175:1930–1936. doi:10.4049/jimmunol.175.3.1930
   PubMed Web of Science ®Google Scholar
• Hayashida K, Bartlett A, Chen Y, et al. Molecular and cellular mechanisms of ectodomain shedding. Anat Rec. 2010;293(6):925–937. doi:10.1002/ar.20757
   Google Scholar
• Ribeiro AS, Albergaria A, Sousa B, et al. Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells. Oncogene. 2010;29:392–402. doi:10.1038/onc.2009.338
   PubMed Web of Science ®Google Scholar
• Mannello F, Tonti G, Medda V, et al. Increased shedding of soluble fragments of P-cadherin in nipple aspirate fluids from women with breast cancer. Cancer Sci. 2008;99:2160–2169. doi:10.1111/j.1349-7006.2008.00921.x
   PubMed Web of Science ®Google Scholar
• Gordon KJ, Dong M, Chislock EM, et al. Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression. Carcinogenesis. 2008;29:252–262. doi:10.1093/carcin/bgm249
   PubMed Web of Science ®Google Scholar
• Finger EC, Turley RS, Dong M, et al. TbetaRIII suppresses non-small cell lung cancer invasiveness and tumorigenicity. Carcinogenesis. 2008;29:528–535. doi:10.1093/carcin/bgm289
   PubMed Web of Science ®Google Scholar
• Elderbroom JL, Huang JJ, Gatza CE, et al. Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion. Mol Biol Cell. 2014;25:2320–2332. doi:10.1091/mbc.e13-09-0524
   PubMed Web of Science ®Google Scholar
• Götte M. Syndecans in inflammation. FASEB J. 2003;17:575–591. doi:10.1096/fj.02-0739rev
   PubMed Web of Science ®Google Scholar
• Hayashida K, Parks W, Park PW. Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines. Blood. 2009;114:3033–3043. doi:10.1182/blood-2009-02-204966
   PubMed Web of Science ®Google Scholar
• Xu J, Park PW, Kheradmand F, et al. Endogenous attenuation of allergic lung inflammation by syndecan-1. J Immunol. 2014;174:5758–5765. doi:10.4049/jimmunol.174.9.5758
   Google Scholar
• Wang X, Chen Y, Song Y, et al. Activated Syndecan-1 shedding contributes to mice colitis induced by dextran sulfate sodium. Dig Dis Sci. 2010;56:1047–1056. doi:10.1007/s10620-010-1398-8
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang Z, Liu J, et al. Cell surface-anchored syndecan-1 ameliorates intestinal inflammation and neutrophil transmigration in ulcerative colitis. J Cell Mol Med. 2017;21:13–25. doi:10.1111/jcmm.12934
   PubMed Web of Science ®Google Scholar
• Wu H, Zhou Q, Xie J, et al. Syndecan-4 shedding is involved in the oxidative stress and inflammatory responses in left atrial tissue with valvular atrial fibrillation. Int J Clin Exp Pathol. 2015;8:6387–6396.
   PubMed Web of Science ®Google Scholar
• Tan X, Khalil N, Tesarik C, et al. Th1 cytokine-induced syndecan-4 shedding by airway smooth muscle cells is dependent on mitogen-activated protein kinases. Am J Physiol Lung Cell Mol Physiol. 2012;302:700–710. doi:10.1152/ajplung.00167.2011
   PubMed Web of Science ®Google Scholar
• Choi S, Chung H, Hong H, et al. Inflammatory hypoxia induces syndecan-2 expression through IL-1β-mediated FOXO3a activation in colonic epithelia. FASEB J. 2017;31:1516–1530. doi:10.1096/fj.201601098R
   PubMed Web of Science ®Google Scholar
• Choi S, Choi Y, Jun E, et al. Shed syndecan-2 enhances tumorigenic activities of colon cancer cells. Oncotarget. 2015;6:3874–3886. doi:10.18632/oncotarget.2885
   PubMedGoogle Scholar
• Clasper S, Vekemans S, Fiore M, et al. Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 (fibroglycan) on human activated macrophages can regulate fibroblast growth factor action. J Biol Chem. 1999;274:24113–24123. doi:10.1074/jbc.274.34.24113
   PubMed Web of Science ®Google Scholar
• Teix T, Nieto-blanco P, Vilella R, et al. Syndecan-2 and −4 expressed on activated primary human CD4+ lymphocytes can regulate T cell activation. Mol Immunol. 2008;45(10):2905–2919. doi:10.1016/j.molimm.2008.01.033
   PubMed Web of Science ®Google Scholar
• Hong H, Song HK, Hwang ES, et al. Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation. FASEB J. 2019;10:11381–11395. doi:10.1096/fj.201900561R
   Google Scholar
• Kwon M, Hong E, Choi Y, et al. Interleukin-1α promotes extracellular shedding of syndecan-2 via induction of matrix metalloproteinase-7 expression. Biochem Biophys Res Commun. 2014;446(2):487–492. doi:10.1016/j.bbrc.2014.02.142
   PubMed Web of Science ®Google Scholar
• Wang L, An J, Song S, et al. Electroacupuncture preserves intestinal barrier integrity through modulating the gut microbiota in DSS-induced chronic colitis. Life Sci. 2020;15:261–118473.
   Google Scholar
• Royal JM, Reeves MA, Matoba N. Repeated oral administration of a KDEL-tagged recombinant cholera toxin B subunit effectively mitigates DSS colitis despite a robust. Immunogenic Response Toxins. 2019;11(12):678.
   Google Scholar
• Lee Y, Park J, Cheon D, et al. Processing of syndecan-2 by matrix metalloproteinase-14 and effect of its cleavage on VEGF-induced tube formation of HUVECs. Biochem J. 2017;474:3719–3732. doi:10.1042/BCJ20170340
   PubMed Web of Science ®Google Scholar
• Choi S, Kim J, Park J, et al. The matrix metalloproteinase-7 regulates the extracellular shedding of syndecan-2 from colon cancer cells. Biochem Biophys Res Commun. 2012;417(4):1260–1264. doi:10.1016/j.bbrc.2011.12.120
   PubMed Web of Science ®Google Scholar
• Grivennikov S, Karin E, Terzic J, et al. IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis associated cancer. Cancer Cell. 2009;15(2):103–113. doi:10.1016/j.ccr.2009.01.001
   PubMed Web of Science ®Google Scholar
• Lee JH, Park H, Chung H, et al. Syndecan-2 regulates the migratory potential of melanoma cells. J Biol Chem. 2009;284:27167–27175. doi:10.1074/jbc.M109.034678
   PubMed Web of Science ®Google Scholar
• Park H, Kim Y, Lim Y, et al. Syndecan-2 mediates adhesion and proliferation of colon carcinoma cells. J Biol Chem. 2002;277(33):29730–29736. doi:10.1074/jbc.M202435200
   PubMed Web of Science ®Google Scholar