Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

References

• Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015;385(9966):430–440. doi:10.1016/s0140-6736(14)61698-6
   PubMed Web of Science ®Google Scholar
• Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–2128. doi:10.1016/S0140-6736(12)61728-0
   PubMed Web of Science ®Google Scholar
• Wang H, Liddell CA, Coates MM, et al. Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9947):957–979. doi:10.1016/S0140-6736(14)60497-9
   PubMed Web of Science ®Google Scholar
• Scheer CS, Fuchs C, Gründling M, et al. Impact of antibiotic administration on blood culture positivity at the beginning of sepsis: a prospective clinical cohort study. Clin Microbiol Infect. 2019;25(3):326–331. doi:10.1016/j.cmi.2018.05.016
   PubMed Web of Science ®Google Scholar
• Lamy B, Dargère S, Arendrup MC, Parienti JJ, Tattevin P. How to optimize the use of blood cultures for the diagnosis of bloodstream infections? A state-of-the art. Front Microbiol. 2016;7:697. doi:10.3389/fmicb.2016.00697
   PubMed Web of Science ®Google Scholar
• Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390(10104):1770–1780. doi:10.1016/s0140-6736(17)31002-4
   PubMed Web of Science ®Google Scholar
• Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018;9:754. doi:10.3389/fimmu.2018.00754
   PubMed Web of Science ®Google Scholar
• Povoa P, Almeida E, Moreira P, et al. C-reactive protein as an indicator of sepsis. Intensive Care Med. 1998;24(10):1052–1056. doi:10.1007/s001340050715
   PubMed Web of Science ®Google Scholar
• Stocker M, van Herk W, El Helou S, et al. C-reactive protein, procalcitonin, and white blood count to rule out neonatal early-onset sepsis within 36 hours: a secondary analysis of the neonatal procalcitonin intervention study. Clin Infect Dis. 2020. doi:10.1093/cid/ciaa876
   PubMed Web of Science ®Google Scholar
• Wang HE, Shapiro NI, Safford MM, et al. High-sensitivity C-reactive protein and risk of sepsis. PLoS One. 2013;8(7):e69232. doi:10.1371/journal.pone.0069232
   PubMed Web of Science ®Google Scholar
• Hofer N, Zacharias E, Muller W, Resch B. An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology. 2012;102(1):25–36. doi:10.1159/000336629
   PubMed Web of Science ®Google Scholar
• Khan F. C-reactive protein as a screening biomarker in neonatal sepsis. J Coll Physicians Surg Pak. 2019;29(10):951–953. doi:10.29271/jcpsp.2019.10.951
   PubMed Web of Science ®Google Scholar
• de Stoppelaar SF, van’t Veer C, van der Poll T. The role of platelets in sepsis. Thromb Haemost. 2014;112(4):666–677. doi:10.1160/TH14-02-0126
   PubMed Web of Science ®Google Scholar
• Greco E, Lupia E, Bosco O, Vizio B, Montrucchio G. Platelets and multi-organ failure in sepsis. Int J Mol Sci. 2017;18(10):2200. doi:10.3390/ijms18102200
   PubMed Web of Science ®Google Scholar
• Russwurm S, Vickers J, Meier-Hellmann A, et al. Platelet and leukocyte activation correlate with the severity of septic organ dysfunction. Shock. 2002;17(4):263–268. doi:10.1097/00024382-200204000-00004
   PubMed Web of Science ®Google Scholar
• Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci. 2013;13(2):333–338. doi:10.4314/ahs.v13i2.19
   PubMed Web of Science ®Google Scholar
• Claushuis TA, van Vught LA, Scicluna BP, et al. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood. 2016;127(24):3062–3072. doi:10.1182/blood-2015-11-680744
   PubMed Web of Science ®Google Scholar
• Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2–8. doi:10.1097/01.Pcc.0000149131.72248.E6
   PubMedGoogle Scholar
• Li T, Dong G, Zhang M, et al. Association of neutrophil-lymphocyte ratio and the presence of neonatal sepsis. J Immunol Res. 2020;2020:7650713. doi:10.1155/2020/7650713
   PubMed Web of Science ®Google Scholar
• Iroh Tam PY, Bendel CM. Diagnostics for neonatal sepsis: current approaches and future directions. Pediatr Res. 2017;82(4):574–583. doi:10.1038/pr.2017.134
   PubMed Web of Science ®Google Scholar
• Sharma D, Farahbakhsh N, Shastri S, Sharma P. Biomarkers for diagnosis of neonatal sepsis: a literature review. J Matern Fetal Neonatal Med. 2018;31(12):1646–1659. doi:10.1080/14767058.2017.1322060
   PubMed Web of Science ®Google Scholar
• Opal SM, Wittebole X. Biomarkers of Infection and Sepsis. Crit Care Clin. 2020;36(1):11–22. doi:10.1016/j.ccc.2019.08.002
   PubMed Web of Science ®Google Scholar
• Li T, Zhang Z, Li X, et al. Neutrophil extracellular traps: signaling properties and disease relevance. Mediators Inflamm. 2020;2020:9254087. doi:10.1155/2020/9254087
   PubMed Web of Science ®Google Scholar
• Ruan L, Chen GY, Liu Z, et al. The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review. Crit Care. 2018;22(1):316. doi:10.1186/s13054-018-2236-1
   PubMedGoogle Scholar
• Omran A, Maaroof A, Saleh MH, Abdelwahab A. Salivary C-reactive protein, mean platelet volume and neutrophil lymphocyte ratio as diagnostic markers for neonatal sepsis. J Pediatr. 2018;94(1):82–87. doi:10.1016/j.jped.2017.03.006
   Google Scholar
• Liu Y, Zhao L, Wu Z. Accuracy of C-reactive protein test for neonatal septicemia: a diagnostic meta-analysis. Med Sci Monit. 2019;25:4076–4081. doi:10.12659/MSM.916968
   PubMed Web of Science ®Google Scholar
• Li T, Li X, Wei Y, et al. Predictive value of C-reactive protein-to-albumin ratio for neonatal sepsis. J Inflamm Res. 2021;14:3207–3215. doi:10.2147/JIR.S321074
   PubMed Web of Science ®Google Scholar
• Eschborn S, Weitkamp JH. Procalcitonin versus C-reactive protein: review of kinetics and performance for diagnosis of neonatal sepsis. J Perinatol. 2019;39(7):893–903. doi:10.1038/s41372-019-0363-4
   PubMed Web of Science ®Google Scholar
• Gremmel T, Frelinger AL, Michelson AD. Platelet physiology. Semin Thromb Hemost. 2016;42(3):191–204. doi:10.1055/s-0035-1564835
   PubMed Web of Science ®Google Scholar
• Hvas AM. Platelet function in thrombosis and hemostasis. Semin Thromb Hemost. 2016;42(3):183–184. doi:10.1055/s-0036-1572329
   PubMedGoogle Scholar
• Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating platelets as mediators of immunity, inflammation, and thrombosis. Circ Res. 2018;122(2):337–351. doi:10.1161/CIRCRESAHA.117.310795
   PubMed Web of Science ®Google Scholar
• Thomas MR, Storey RF. The role of platelets in inflammation. Thromb Haemost. 2015;114(3):449–458. doi:10.1160/TH14-12-1067
   PubMed Web of Science ®Google Scholar
• Morrell CN, Aggrey AA, Chapman LM, Modjeski KL. Emerging roles for platelets as immune and inflammatory cells. Blood. 2014;123(18):2759–2767. doi:10.1182/blood-2013-11-462432
   PubMed Web of Science ®Google Scholar
• Elzey BD, Tian J, Jensen RJ, et al. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity. 2003;19(1):9–19. doi:10.1016/s1074-7613(03)00177-8
   PubMed Web of Science ®Google Scholar
• Semple JW, Italiano JE, Freedman J. Platelets and the immune continuum. Nat Rev Immunol. 2011;11(4):264–274. doi:10.1038/nri2956
   PubMed Web of Science ®Google Scholar
• Sonmez O, Sonmez M. Role of platelets in immune system and inflammation. Porto Biomed J. 2017;2(6):311–314. doi:10.1016/j.pbj.2017.05.005
   PubMedGoogle Scholar
• Thiery-Antier N, Binquet C, Vinault S, et al. Is thrombocytopenia an early prognostic marker in septic shock? Crit Care Med. 2016;44(4):764–772. doi:10.1097/CCM.0000000000001520
   PubMed Web of Science ®Google Scholar
• Zhao L, Zhao L, Wang YY, et al. Platelets as a prognostic marker for sepsis: a cohort study from the MIMIC-III database. Medicine. 2020;99(45):e23151. doi:10.1097/MD.0000000000023151
   PubMed Web of Science ®Google Scholar