Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults

References

• Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412–423. doi:10.1093/ageing/afq034
   PubMed Web of Science ®Google Scholar
• Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol a Biol Sci Med Sci. 2008;63(8):829–834. doi:10.1093/gerona/63.8.829
   PubMed Web of Science ®Google Scholar
• Chen LK, Woo J, Assantachai P, et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc. 2020;21(3):300–307 e2. doi:10.1016/j.jamda.2019.12.012
   PubMed Web of Science ®Google Scholar
• Cawthon PM, Fox KM, Gandra SR, et al. Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults? J Am Geriatr Soc. 2009;57(8):1411–1419. doi:10.1111/j.1532-5415.2009.02366.x
   PubMed Web of Science ®Google Scholar
• Cawthon PM, Fox KM, Gandra SR, et al. Clustering of strength, physical function, muscle, and adiposity characteristics and risk of disability in older adults. J Am Geriatr Soc. 2011;59(5):781–787. doi:10.1111/j.1532-5415.2011.03389.x
   PubMed Web of Science ®Google Scholar
• Sternfeld B, Ngo L, Satariano WA, Tager IB. Associations of body composition with physical performance and self-reported functional limitation in elderly men and women. Am J Epidemiol. 2002;156(2):110–121. doi:10.1093/aje/kwf023
   PubMed Web of Science ®Google Scholar
• Meng P, Hu YX, Fan L, et al. Sarcopenia and sarcopenic obesity among men aged 80 years and older in Beijing: prevalence and its association with functional performance. Geriatr Gerontol Int. 2014;14(Suppl 1):29–35.
   PubMedGoogle Scholar
• Chang CI, Huang KC, Chan DC, et al. The impacts of sarcopenia and obesity on physical performance in the elderly. Obes Res Clin Pract. 2015;9(3):256–265.
   PubMed Web of Science ®Google Scholar
• Hamrick MW, McGee-Lawrence ME, Frechette DM. Fatty infiltration of skeletal muscle: mechanisms and comparisons with bone marrow adiposity. Front Endocrinol (Lausanne). 2016;7:69. doi:10.3389/fendo.2016.00069
   PubMed Web of Science ®Google Scholar
• Visser M, Goodpaster BH, Kritchevsky SB, et al. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci. 2005;60(3):324–333. doi:10.1093/gerona/60.3.324
   PubMed Web of Science ®Google Scholar
• Delmonico MJ, Harris TB, Visser M, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr. 2009;90(6):1579–1585. doi:10.3945/ajcn.2009.28047
   PubMed Web of Science ®Google Scholar
• Park HK, Ahima RS. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism. 2015;64(1):24–34. doi:10.1016/j.metabol.2014.08.004
   PubMed Web of Science ®Google Scholar
• Cameron AJ, Zimmet PZ, Shaw JE, et al. The metabolic syndrome: in need of a global mission statement. Diabet Med. 2009;26(3):306–309. doi:10.1111/j.1464-5491.2009.02681.x
   PubMed Web of Science ®Google Scholar
• Mantzoros CS, Magkos F, Brinkoetter M, et al. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab. 2011;301(4):E567–84. doi:10.1152/ajpendo.00315.2011
   PubMed Web of Science ®Google Scholar
• Lana A, Valdés-Bécares A, Buño A, et al. Serum leptin concentration is associated with incident frailty in older adults. Aging Dis. 2017;8(2):240–249. doi:10.14336/AD.2016.0819
   PubMed Web of Science ®Google Scholar
• Guerra B, Santana A, Fuentes T, et al. Leptin receptors in human skeletal muscle. J Appl Physiol (1985). 2007;102(5):1786–1792. doi:10.1152/japplphysiol.01313.2006
   PubMed Web of Science ®Google Scholar
• Dyck DJ, Heigenhauser GJ, Bruce CR. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol (Oxf). 2006;186(1):5–16. doi:10.1111/j.1748-1716.2005.01502.x
   PubMed Web of Science ®Google Scholar
• Minokoshi Y, Toda C, Okamoto S. Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle. Indian J Endocrinol Metab. 2012;16(Suppl 3):S562–8. doi:10.4103/2230-8210.105573
   PubMedGoogle Scholar
• Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation. 2001;104(25):3052–3056. doi:10.1161/hc5001.101061
   PubMed Web of Science ®Google Scholar
• Wannamethee SG, Lowe GDO, Rumley A, et al. Adipokines and risk of type 2 diabetes in older men. Diabetes Care. 2007;30(5):1200–1205. doi:10.2337/dc06-2416
   PubMed Web of Science ®Google Scholar
• Lana A, Struijk E, Guallar-Castillón P, et al. Leptin concentration and risk of impaired physical function in older adults: the seniors-ENRICA cohort. Age Ageing. 2016;45(6):819–826. doi:10.1093/ageing/afw142
   PubMed Web of Science ®Google Scholar
• Karvonen-Gutierrez CA, Zheng H, Mancuso P, et al. Higher leptin and adiponectin concentrations predict poorer performance-based physical functioning in midlife women: the Michigan study of women’s health across the nation. J Gerontol a Biol Sci Med Sci. 2016;71(4):508–514. doi:10.1093/gerona/glv123
   PubMed Web of Science ®Google Scholar
• Hsu BG, Wang C-H, Lai Y-H, et al. Elevated serum leptin levels are associated with low muscle strength and muscle quality in male patients undergoing chronic hemodialysis. Tzu Chi Med J. 2021;33(1):74–79. doi:10.4103/tcmj.tcmj_20_20
   PubMed Web of Science ®Google Scholar
• Lin YL, Wang CH, Lai YH, Kuo CH, Syu RJ, Hsu BG. Negative correlation between leptin serum levels and sarcopenia in hemodialysis patients. Int J Clin Exp Pathol. 2018;11(3):1715–1723.
   PubMed Web of Science ®Google Scholar
• Kao TW, Peng TC, Chen WL, Han DS, Chen CL, Yang WS. Impact of adiposity on muscle function and clinical events among elders with dynapenia, presarcopenia and sarcopenia: a community-based cross-sectional study. Aging (Albany NY). 2021;13:7247.
   PubMedGoogle Scholar
• Roubenoff R. Applications of bioelectrical impedance analysis for body composition to epidemiologic studies. Am J Clin Nutr. 1996;64(3):459S–462S. doi:10.1093/ajcn/64.3.459S
   PubMed Web of Science ®Google Scholar
• Qu NN, Li KJ. Study on the reliability and validity of international physical activity questionnaire (Chinese Version, IPAQ). Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25:265–268.
   PubMedGoogle Scholar
• Ervin RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003–2006. Natl Health Stat Report. 2009;5(13):1–7.
   Google Scholar
• Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–1645.
   PubMed Web of Science ®Google Scholar
• Valencak TG, Osterrieder A, Schulz TJ. Sex matters: the effects of biological sex on adipose tissue biology and energy metabolism. Redox Biol. 2017;12:806–813. doi:10.1016/j.redox.2017.04.012
   PubMed Web of Science ®Google Scholar
• Guerra B, Fuentes T, Delgado-Guerra S, et al. Gender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity. PLoS One. 2008;3(10):e3466. doi:10.1371/journal.pone.0003466
   PubMed Web of Science ®Google Scholar
• Rosenbaum M, Leibel RL. Clinical review 107: role of gonadal steroids in the sexual dimorphisms in body composition and circulating concentrations of leptin. J Clin Endocrinol Metab. 1999;84(6):1784–1789.
   PubMed Web of Science ®Google Scholar
• Kohara K, Ochi M, Tabara Y, et al. Leptin in sarcopenic visceral obesity: possible link between adipocytes and myocytes. PLoS One. 2011;6(9):e24633. doi:10.1371/journal.pone.0024633
   PubMed Web of Science ®Google Scholar
• Antony B, Jones G, Stannus O, Blizzard L, Ding C Body fat predicts an increase and limb muscle strength predicts a decrease in leptin in older adults over 2.6 years. Clin Endocrinol (Oxf). 2013;79(5):652–660.
   PubMed Web of Science ®Google Scholar
• Sainz N, Rodríguez A, Catalán V, et al. Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice. PLoS One. 2009;4(9):e6808. doi:10.1371/journal.pone.0006808
   PubMed Web of Science ®Google Scholar
• Hubbard RE, O’Mahony MS, Calver BL, et al. Nutrition, inflammation, and leptin levels in aging and frailty. J Am Geriatr Soc. 2008;56(2):279–284. doi:10.1111/j.1532-5415.2007.01548.x
   PubMed Web of Science ®Google Scholar
• Kara E, Ahbap E, Sahutoglu T, et al. Elevated serum leptin levels are associated with good nutritional status in non-obese chronic hemodialysis patients. Clin Nephrol. 2015;83(3):147–153. doi:10.5414/CN108409
   PubMed Web of Science ®Google Scholar
• Markaki A, Grammatikopoulou MG, Venihaki M, et al. Associations of adiponectin and leptin levels with protein-energy wasting, in end stage renal disease patients. Endocrinol Nutr. 2016;63(9):449–457. doi:10.1016/j.endonu.2016.07.003
   PubMedGoogle Scholar
• Yang J. Enhanced skeletal muscle for effective glucose homeostasis. Prog Mol Biol Transl Sci. 2014;121:133–163.
   PubMed Web of Science ®Google Scholar
• Straight CR, Brady AO, Evans EM. Muscle quality and relative adiposity are the strongest predictors of lower-extremity physical function in older women. Maturitas. 2015;80(1):95–99. doi:10.1016/j.maturitas.2014.10.006
   PubMed Web of Science ®Google Scholar
• Sainz N, Barrenetxe J, Moreno-Aliaga MJ, et al. Leptin resistance and diet-induced obesity: central and peripheral actions of leptin. Metabolism. 2015;64(1):35–46. doi:10.1016/j.metabol.2014.10.015
   PubMed Web of Science ®Google Scholar