HMGB1-Induced Hepatocyte Pyroptosis Expanding Inflammatory Responses Contributes to the Pathogenesis of Acute-on-Chronic Liver Failure (ACLF)

References

• Xue R, Zhu X, Jia L, et al. Mitofusin2, a rising star in acute-on-chronic liver failure, triggers macroautophagy via the mTOR signalling pathway. J Cell Mol Med. 2019;23(11):7810–7818. doi:10.1111/jcmm.14658
   PubMed Web of Science ®Google Scholar
• Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association, Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. [Guideline for diagnosis and treatment of liver failure (2018)]. Chin J Clin Hepatol. 2019;35(1):38–44. Chinese. doi:10.3969/j.issn.1001-5256
   Google Scholar
• Hou W, Hao Y, Yang W, et al. The Jieduan-Niwan (JDNW) formula ameliorates hepatocyte apoptosis: a study of the inhibition of E2F1-mediated apoptosis signaling pathways in acute-on-chronic liver failure (ACLF) using rats. Drug Des Devel Ther. 2021;Volume 15:3845–3862. doi:10.2147/DDDT.S308713
   Web of Science ®Google Scholar
• Martin-Mateos R, Alvarez-Mon M, Albillos A. Dysfunctional immune response in acute-on-chronic liver failure: it takes two to tango. Front Immunol. 2019;10:973. doi:10.3389/fimmu.2019.00973
   PubMed Web of Science ®Google Scholar
• Moreau R. The pathogenesis of ACLF: the inflammatory response and immune function. Semin Liver Dis. 2016;36(2):133–140. doi:10.1055/s-0036-1583199
   PubMed Web of Science ®Google Scholar
• Tang Y, Zhao X, Antoine D, et al. Regulation of post-translational modifications of HMGB1 during immune responses. Antioxid Redox Signal. 2016;24(12):620–634. doi:10.1089/ars.2015.6409
   PubMed Web of Science ®Google Scholar
• Xu J, Jiang Y, Wang J, et al. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014;21(8):1229–1239. doi:10.1038/cdd.2014.40
   PubMed Web of Science ®Google Scholar
• Xu H, Li H, Qu Y, Zheng J, Lu J. High mobility group box 1 release from cholangiocytes in patients with acute-on-chronic liver failure. Exp Ther Med. 2014;8(4):1178–1184. doi:10.3892/etm.2014.1904
   PubMed Web of Science ®Google Scholar
• Hu Y, Hu D, Fu R. Correlation between high mobility group box-1 protein and chronic hepatitis B infection with severe hepatitis B and acute-on-chronic liver failure: a meta-analysis. Minerva Med. 2017;108(3):268–276. doi:10.23736/S0026-4806.16.04865-5
   PubMed Web of Science ®Google Scholar
• Dong W, Zhu Q, Yang B, et al. Polychlorinated biphenyl quinone induces Caspase 1-mediated pyroptosis through induction of pro-inflammatory HMGB1-TLR4-NLRP3-GSDMD Signal Axis. Chem Res Toxicol. 2019;32(6):1051–1057. doi:10.1021/acs.chemrestox.8b00376
   PubMed Web of Science ®Google Scholar
• Sun Z, Nyanzu M, Yang S, et al. VX765 attenuates pyroptosis and HMGB1/TLR4/NF-κB pathways to improve functional outcomes in TBI mice. Oxid Med Cell Longev. 2020;2020:7879629. doi:10.1155/2020/7879629
   PubMed Web of Science ®Google Scholar
• Jia C, Zhang J, Chen H, et al. Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation. Cell Death Dis. 2019;10(10):778. doi:10.1038/s41419-019-2021-3
   PubMedGoogle Scholar
• Hu X, Chen H, Xu H, et al. Role of pyroptosis in traumatic brain and spinal cord injuries. Int J Biol Sci. 2020;16(12):2042–2050. doi:10.7150/ijbs.45467
   PubMed Web of Science ®Google Scholar
• Li H, Zhao X, Cheng Y, et al. Gasdermin D-mediated hepatocyte pyroptosis expands inflammatory responses that aggravate acute liver failure by upregulating monocyte chemotactic protein 1/CC chemokine receptor-2 to recruit macrophages. World J Gastroenterol. 2019;25(44):6527–6540. doi:10.3748/wjg.v25.i44.6527
   PubMed Web of Science ®Google Scholar
• Fink SL, Cookson BT. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol. 2006;8(11):1812–1825. doi:10.1111/j.1462-5822.2006.00751.x
   PubMed Web of Science ®Google Scholar
• Deng J, Tan W, Luo Q, Lin L, Zheng L, Yang J. Long non-coding RNA MEG3 promotes renal tubular epithelial cell pyroptosis by regulating the miR-18a-3p/GSDMD pathway in lipopolysaccharide-induced acute kidney injury. Front Physiol. 2021;12:663216. doi:10.3389/fphys.2021.663216
   PubMed Web of Science ®Google Scholar
• Xue R, Yang J, Jia L, et al. Mitofusin2, as a protective target in the liver, controls the balance of apoptosis and autophagy in acute-on-chronic liver failure. Front Pharmacol. 2019;10:601. doi:10.3389/fphar.2019.00601
   PubMed Web of Science ®Google Scholar
• Thakur V, Sadanandan J, Chattopadhyay M. High-mobility group box 1 protein signaling in painful diabetic neuropathy. Int J Mol Sci. 2020;21(3):881. doi:10.3390/ijms21030881
   PubMed Web of Science ®Google Scholar
• Paudel YN, Angelopoulou E, Semple B, Piperi C, Othman I, Shaikh MF. Potential neuroprotective effect of the HMGB1 inhibitor glycyrrhizin in neurological disorders. ACS Chem Neurosci. 2020;11(4):485–500. doi:10.1021/acschemneuro.9b00640
   PubMed Web of Science ®Google Scholar
• Wannamaker W, Davies R, Namchuk M, et al. (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18. J Pharmacol Exp Ther. 2007;321(2):509–516. doi:10.1124/jpet.106.111344
   PubMed Web of Science ®Google Scholar
• Li F, Xu M, Wang M, et al. Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema. Respir Res. 2018;19(1):230. doi:10.1186/s12931-018-0931-8
   PubMed Web of Science ®Google Scholar
• Huang J, Huang X, Chen Z, Zheng Q, Sun R. Dose conversion among different animals and healthy volunteers in pharmacological study. Chin J Clin Pharmacol Ther. 2004;09:1069–1072.
   Google Scholar
• Schindelin J, Arganda-Carreras I, Frise E, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9(7):676–682. doi:10.1038/nmeth.2019
   PubMed Web of Science ®Google Scholar
• Triantafyllou E, Woollard KJ, McPhail MJW, Antoniades CG, Possamai LA. The role of monocytes and macrophages in acute and acute-on-chronic liver failure. Front Immunol. 2018;9:2948. doi:10.3389/fimmu.2018.02948
   PubMed Web of Science ®Google Scholar
• Yuan S, Liu Z, Xu Z, Liu J, Zhang J. High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies. J Hematol Oncol. 2020;13(1):91. doi:10.1186/s13045-020-00920-3
   PubMed Web of Science ®Google Scholar
• Kolios G, Valatas V, Kouroumalis E. Role of kupffer cells in the pathogenesis of liver disease. World J Gastroenterol. 2006;12(46):7413–7420. doi:10.3748/wjg.v12.i46.7413
   PubMed Web of Science ®Google Scholar
• Cao Z, Li F, Xiang X, et al. Circulating cell death biomarker: good candidates of prognostic indicator for patients with hepatitis B virus related acute-on-chronic liver failure. Sci Rep. 2015;5(1):14240. doi:10.1038/srep14240
   PubMedGoogle Scholar
• Zhou R, Zhao S, Zou M, et al. HMGB1 cytoplasmic translocation in patients with acute liver failure. BMC Gastroenterol. 2011;11(1):21. doi:10.1186/1471-230X-11-21
   PubMedGoogle Scholar
• Liu X, Lu B, Fu J, Zhu X, Song E, Song Y. Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells. J Hazard Mater. 2021;404(PtB):124050. doi:10.1016/j.jhazmat.2020.124050
   PubMedGoogle Scholar
• Xu Q, Zhao B, Ye Y, et al. Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke. J Neuroinflammation. 2021;18(1):123. doi:10.1186/s12974-021-02137-8
   PubMed Web of Science ®Google Scholar
• Kelley N, Jeltema D, Duan Y, He Y. The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci. 2019;20(13):3328. doi:10.3390/ijms20133328
   PubMed Web of Science ®Google Scholar
• Ghoneim ME, Abdallah DM, Shebl AM, El-Abhar HS. The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy. Toxicol Appl Pharmacol. 2020;409:115309. doi:10.1016/j.taap.2020.115309
   PubMed Web of Science ®Google Scholar
• Wang M, Chen X, Zhang Y. Biological functions of gasdermins in cancer: from molecular mechanisms to therapeutic potential. Front Cell Dev Biol. 2021;9:638710. doi:10.3389/fcell.2021.638710
   PubMed Web of Science ®Google Scholar
• Wang K, Sun Q, Zhong X, et al. Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis. Cell. 2020;180(5):941–955. doi:10.1016/j.cell.2020.02.002
   PubMed Web of Science ®Google Scholar
• Wang W, Zhang T. Caspase-1-mediated pyroptosis of the predominance for driving CD4+ T cells death: a nonlocal spatial mathematical model. Bull Math Biol. 2018;80(3):540–582. doi:10.1007/s11538-017-0389-8
   PubMed Web of Science ®Google Scholar
• Chevriaux A, Pilot T, Derangère V, et al. Cathepsin B is required for NLRP3 inflammasome activation in macrophages, through NLRP3 interaction. Front Cell Dev Biol. 2020;8:167. doi:10.3389/fcell.2020.00167
   PubMed Web of Science ®Google Scholar
• Wang J, Wang L, Zhang X, et al. Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis. Int Immunopharmacol. 2021;94:107496. doi:10.1016/j.intimp.2021.107496
   PubMed Web of Science ®Google Scholar
• Xia P, Pan Y, Zhang F, et al. Pioglitazone confers neuroprotection against ischemia-induced pyroptosis due to its inhibitory effects on HMGB-1/RAGE and Rac1/ROS pathway by activating PPAR-ɤ. Cell Physiol Biochem. 2018;45(6):2351–2368. doi:10.1159/000488183
   PubMedGoogle Scholar
• Yu P, Zhang X, Liu N, Tang L, Peng C, Chen X. Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther. 2021;6(1):128. doi:10.1038/s41392-021-00507-5
   PubMed Web of Science ®Google Scholar
• Wang L, Qin X, Liang J, Ge P. Induction of pyroptosis: a promising strategy for cancer treatment. Front Oncol. 2021;11:635774. doi:10.3389/fonc.2021.635774
   PubMed Web of Science ®Google Scholar