Methylglyoxal Exacerbates Lipopolysaccharide-Induced Acute Lung Injury via RAGE-Induced ROS Generation: Protective Effects of Metformin

References

• Bellani G, Laffey JG, Pham T, et al.; LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315(8):788–800. doi:10.1001/jama.2016.0291
   PubMed Web of Science ®Google Scholar
• Liu H, Yu X, Yu S, Kou J. Molecular mechanisms in lipopolysaccharide-induced pulmonary endothelial barrier dysfunction. Int Immunopharmacol. 2015;29(2):937–946. doi:10.1016/j.intimp.2015.10.010
   PubMed Web of Science ®Google Scholar
• Lee L, Downey GP. Neutrophil activation and acute lung injury. Curr Opinion Crit Care. 2001;7(1):1–7. doi:10.1097/00075198-200102000-00001
   PubMedGoogle Scholar
• Han S, Mallampalli RK. The acute respiratory distress syndrome: from mechanism to translation. J Immunol. 2015;194(3):855–860. doi:10.4049/jimmunol.1402513
   PubMed Web of Science ®Google Scholar
• Righetti RF, Dos Santos TM, Camargo LDN, et al. Protective effects of anti-IL17 on acute lung injury induced by LPS in mice. Front Pharmacol. 2018;9:1021. doi:10.3389/fphar.2018.01021
   PubMed Web of Science ®Google Scholar
• Fukunaga K, Kohli P, Bonnans C, Fredenburgh LE, Levy BD. Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. J Immunol. 2005;174(8):5033–5039. doi:10.4049/jimmunol.174.8.5033
   PubMed Web of Science ®Google Scholar
• Jinzhou Z, Tao H, Wensheng C, et al. Cyclooxygenase-2 suppresses polymorphonuclear neutrophil apoptosis after acute lung injury. J Trauma. 2008;64(4):1055–1060. doi:10.1097/TA.0b013e318047c07c
   PubMedGoogle Scholar
• Schalkwijk CG, Stehouwer CDA. Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases. Physiol Rev. 2020;100(1):407–461. doi:10.1152/physrev.00001.2019
   PubMed Web of Science ®Google Scholar
• Hanssen NMJ, Westerink J, Scheijen JLJM, van der Graaf Y, Stehouwer CDA, Schalkwijk CG. Higher plasma methylglyoxal levels are associated with incident cardiovascular disease and mortality in individuals with type 2 diabetes. Diabetes Care. 2018;41(8):1689–1695. doi:10.2337/dc18-0159
   PubMed Web of Science ®Google Scholar
• Odani H, Shinzato T, Matsumoto Y, Usami J, Maeda K. Increase in three alpha, beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction. Biochem Biophys Res Commun. 1999;256(1):89–93. doi:10.1006/bbrc.1999.0221
   PubMed Web of Science ®Google Scholar
• Lapolla A, Flamini R, Dalla Vedova A, et al. Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC/MS method. Clin Chem Lab Med. 2003;41(9):1166–1173. doi:10.1515/CCLM.2003.180
   PubMed Web of Science ®Google Scholar
• Ogawa S, Nakayama K, Nakayama M, et al. Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure. Hypertension. 2010;56(3):471–476. doi:10.1161/HYPERTENSIONAHA.110.156786
   PubMed Web of Science ®Google Scholar
• Senda M, Ogawa S, Nako K, Okamura M, Sakamoto T, Ito S. The strong relation between post-hemodialysis blood methylglyoxal levels and post-hemodialysis blood glucose concentration rise. Clin Exp Nephrol. 2015;19(3):527–533. doi:10.1007/s10157-014-1018-6
   PubMed Web of Science ®Google Scholar
• Sukkar MB, Ullah MA, Gan WJ, et al. RAGE: a new frontier in chronic airways disease. Br J Pharmacol. 2012;167(6):1161–1176. doi:10.1111/j.1476-5381.2012.01984.x
   PubMed Web of Science ®Google Scholar
• de la Cruz-ares S, Cardelo MP, Gutiérrez-Mariscal FM, et al. Endothelial dysfunction and advanced glycation end products in patients with newly diagnosed versus established diabetes: from the CORDIOPREV Study. Nutrients. 2020;12(1):238. doi:10.3390/nu12010238
   PubMed Web of Science ®Google Scholar
• Gutierrez-Mariscal FM, Cardelo MP, de la Cruz S, et al. Reduction in circulating advanced glycation end products by Mediterranean diet is associated with increased likelihood of type 2 diabetes remission in patients with coronary heart disease: from the Cordioprev Study. Mol Nutr Food Res. 2021;65(1):e1901290. doi:10.1002/mnfr.201901290
   PubMed Web of Science ®Google Scholar
• Tang Y, Zhao Y, Wang P, Sang S. Simultaneous determination of multiple reactive carbonyl species in high fat diet-induced metabolic disordered mice and the inhibitory effects of rosemary on carbonyl stress. J Agric Food Chem. 2021;69(3):1123–1131. doi:10.1021/acs.jafc.0c07748
   PubMed Web of Science ®Google Scholar
• Kimzey MJ, Kinsky OR, Yassine HN, et al. Site specific modification of the human plasma proteome by methylglyoxal. Toxicol Appl Pharmacol. 2015;289(2):155–162. doi:10.1016/j.taap.2015.09.029
   PubMed Web of Science ®Google Scholar
• Ahmed N, Thornalley PJ. Advanced glycation endproducts: what is their relevance to diabetic complications? Diabetes Obes Metab. 2007;9(3):233–245. doi:10.1111/j.1463-1326.2006.00595.x
   PubMed Web of Science ®Google Scholar
• Checa J, Aran JM. Reactive oxygen species: drivers of physiological and pathological processes. J Inflamm Res. 2020;13:1057–1073. doi:10.2147/JIR.S275595
   PubMed Web of Science ®Google Scholar
• Berlanga J, Cibrian D, Guillén I, et al. Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds. Clin Sci. 2005;109(1):83–95. doi:10.1042/CS20050026
   Web of Science ®Google Scholar
• Sena CM, Matafome P, Crisóstomo J, et al. Methylglyoxal promotes oxidative stress and endothelial dysfunction. Pharmacol Res. 2012;65(5):497–506. doi:10.1016/j.phrs.2012.03.004
   PubMed Web of Science ®Google Scholar
• Crisóstomo J, Matafome P, Santos-Silva D, et al. Methylglyoxal chronic administration promotes diabetes-like cardiac ischaemia disease in Wistar normal rats. Nutr Metab Cardiovasc Dis. 2013;23(12):1223–1230. doi:10.1016/j.numecd.2013.01.005
   PubMed Web of Science ®Google Scholar
• de Oliveira MG, Medeiros ML, Tavares EBG, Mónica FZ, Antunes E. Methylglyoxal, a reactive glucose metabolite, induces bladder overactivity in addition to inflammation in mice. Front Physiol. 2020;11:290. doi:10.3389/fphys.2020.00290
   PubMed Web of Science ®Google Scholar
• Kothari V, Galdo JA, Mathews ST. Hypoglycemic agents and potential anti-inflammatory activity. J Inflamm Res. 2016;9:27–38. doi:10.2147/JIR.S86917
   PubMed Web of Science ®Google Scholar
• Battah S, Ahmed N, Thornalley PJ. Kinetics and mechanism of the reaction of metformin with methylglyoxal. Int Congr Ser. 2002;1245:355–356. doi:10.1016/S0531-5131(02)00889-0
   Google Scholar
• Kinsky OR, Hargraves TL, Anumol T, et al. Metformin scavenges methylglyoxal to form a novel imidazolinone metabolite in humans. Chem Res Toxicol. 2016;29(2):227–234. doi:10.1021/acs.chemrestox.5b00497
   PubMed Web of Science ®Google Scholar
• Ruggiero-Lopez D, Lecomte M, Moinet G, Patereau G, Lagarde M, Wiernsperger N. Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of advanced glycation end product formation. Biochem Pharmacol. 1999;58(11):1765–1773. doi:10.1016/S0006-2952(99)00263-4
   PubMed Web of Science ®Google Scholar
• Kender Z, Fleming T, Kopf S, et al. Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes. Exp Clin Endocrinol Diabetes. 2014;122(5):316–319. doi:10.1055/s-0034-1371818
   PubMed Web of Science ®Google Scholar
• Brings S, Fleming T, De Buh S, et al. A scavenger peptide prevents methylglyoxal induced pain in mice. Biochim Biophys Acta Mol Basis. 2017;1863(3):654–662. doi:10.1016/j.bbadis.2016.12.001
   PubMed Web of Science ®Google Scholar
• Beisswenger PJ, Howell SK, Touchette AD, Lal S, Szwergold BS. Metformin reduces systemic methylglyoxal levels in type 2 diabetes. Diabetes. 1999;48(1):198–202. doi:10.2337/diabetes.48.1.198
   PubMed Web of Science ®Google Scholar
• McCallister JW, Adkins EJ, O’Brien JM Jr. Obesity and acute lung injury. Clin Chest Med. 2009;30(3):495–508. doi:10.1016/j.ccm.2009.05.008
   PubMed Web of Science ®Google Scholar
• Gong MN, Bajwa EK, Thompson BT, Christiani DC. Body mass index is associated with the development of acute respiratory distress syndrome. Thorax. 2010;65(1):44–50. doi:10.1136/thx.2009.117572
   PubMed Web of Science ®Google Scholar
• Stapleton RD, Suratt BT. Obesity and nutrition in acute respiratory distress syndrome. Clin Chest Med. 2014;35(4):655–671. doi:10.1016/j.ccm.2014.08.005
   PubMed Web of Science ®Google Scholar
• Medeiros ML, de Oliveira MG, Tavares EG, et al. Long-term methylglyoxal intake aggravates murine Th2-mediated airway eosinophil infiltration. Int Immunopharmacol. 2020;81:106254.
   PubMed Web of Science ®Google Scholar
• Calixto MC, Lintomen L, André DM, et al. Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. PLoS One. 2013;8(10):e76786. doi:10.1371/journal.pone.0076786
   PubMed Web of Science ®Google Scholar
• Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med. 2011;17(3–4):293–307. doi:10.2119/molmed.2010.00138
   PubMed Web of Science ®Google Scholar
• Pittet JF, Mackersie RC, Martin TR, Matthay MA. Biological markers of acute lung injury: prognostic and pathogenetic significance. Am J Respir Crit Care Med. 1997;155(4):1187–1205. doi:10.1164/ajrccm.155.4.9105054
   PubMed Web of Science ®Google Scholar
• Kabir K, Gelinas JP, Chen M, et al. Characterization of a murine model of endotoxin-induced acute lung injury. Shock. 2002;17(4):300–303. doi:10.1097/00024382-200204000-00010
   PubMed Web of Science ®Google Scholar
• Ding Q, Liu GQ, Zeng YY, et al. Role of IL-17 in LPS-induced acute lung injury: an in vivo study. Oncotarget. 2017;8(55):93704–93711. doi:10.18632/oncotarget.21474
   PubMedGoogle Scholar
• Neumann C, Scheffold A, Rutz S. Functions and regulation of T cell-derived interleukin-10. Semin Immunol. 2019;44:101344. doi:10.1016/j.smim.2019.101344
   PubMed Web of Science ®Google Scholar
• Couper KN, Blount DG, Riley EM. IL-10: the master regulator of immunity to infection. J Immunol. 2008;180(9):5771–5777. doi:10.4049/jimmunol.180.9.5771
   PubMed Web of Science ®Google Scholar
• Delbin MA, Davel AP, Couto GK, et al. Interaction between advanced glycation end products formation and vascular responses in femoral and coronary arteries from exercised diabetic rats. PLoS One. 2012;7:e53318.
   PubMed Web of Science ®Google Scholar
• Hudson BI, Lippman ME. Targeting RAGE signaling in inflammatory disease. Annu Rev Med. 2018;69(1):349–364. doi:10.1146/annurev-med-041316-085215
   PubMed Web of Science ®Google Scholar
• Sanders KA, Delker DA, Huecksteadt T, et al. RAGE is a critical mediator of pulmonary oxidative stress, alveolar macrophage activation and emphysema in response to cigarette smoke. Sci Rep. 2019;9(1):1–16. doi:10.1038/s41598-018-36163-z
   PubMedGoogle Scholar
• Li J, Wang K, Huang B, et al. The receptor for advanced glycation end products mediates dysfunction of airway epithelial barrier in a lipopolysaccharides-induced murine acute lung injury model. Int Immunopharmacol. 2021;93:107419. doi:10.1016/j.intimp.2021.107419
   PubMed Web of Science ®Google Scholar
• Matafome P, Rodrigues T, Sena C, Seiça R. Methylglyoxal in metabolic disorders: facts, myths, and promises. Med Res Rev. 2017;37(2):368–403. doi:10.1002/med.21410
   PubMed Web of Science ®Google Scholar
• Tate M, Higgins GC, De Blasio MJ, et al. The mitochondria-targeted methylglyoxal sequestering compound, mitoGamide, is cardioprotective in the diabetic heart. Cardiovasc Drugs Ther. 2020;34(2):223. doi:10.1007/s10557-019-06929-2
   PubMed Web of Science ®Google Scholar