The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation

References

• Yeung YT, Aziz F, Guerrero-Castilla A, Arguelles S. Signaling pathways in inflammation and anti-inflammatory therapies. Curr Pharm Des. 2018;24(14):1449–1484. doi:10.2174/1381612824666180327165604
   PubMed Web of Science ®Google Scholar
• Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013;9(1):30. doi:10.1186/1710-1492-9-30
   PubMed Web of Science ®Google Scholar
• Wang H, Yang G, Wang S, Zheng X, Zhang W, Li Y. The most commonly treated acupuncture indications in the United States: a cross-sectional study. Am J Chin Med. 2018;1–33. doi:10.1142/S0192415X18500738
   Web of Science ®Google Scholar
• Chousterman BG, Swirski FK, Weber GF. Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 2017;39(5):517–528. doi:10.1007/s00281-017-0639-8
   PubMed Web of Science ®Google Scholar
• Yang G, Hu RY, Deng AJ, Huang Y, Li J. Effects of electro-acupuncture at zusanli, guanyuan for sepsis patients and its mechanism through immune regulation. Chin J Integr Med. 2016;22(3):219–224. doi:10.1007/s11655-016-2462-9
   PubMed Web of Science ®Google Scholar
• Liu S, Wang ZF, Su YS, et al. Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture. Neuron. 2020;108(3):436–450.e7. doi:10.1016/j.neuron.2020.07.015
   PubMed Web of Science ®Google Scholar
• McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365(23):2205–2219. doi:10.1056/NEJMra1004965
   PubMed Web of Science ®Google Scholar
• Yang F, Gong Y, Yu N, et al. ST36 Acupuncture Alleviates the Inflammation of Adjuvant-Induced Arthritic Rats by Targeting Monocyte/Macrophage Modulation. Evid Based Complement Alternat Med. 2021;2021:9430501. doi:10.1155/2021/9430501
   PubMed Web of Science ®Google Scholar
• Dong ZQ, Zhu J, Lu DZ, Chen Q, Xu YL. Effect of Electroacupuncture in “Zusanli” and “Kunlun” Acupoints on TLR4 Signaling Pathway of Adjuvant Arthritis Rats. Am J Ther. 2018;25(3):e314–e319. doi:10.1097/MJT.0000000000000477
   PubMed Web of Science ®Google Scholar
• Du ZH, Zhang CW, Xie WX, et al. Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis. Evid Based Complement Alternat Med. 2019;2019:4617464. doi:10.1155/2019/4617464
   PubMed Web of Science ®Google Scholar
• Xu Y, Hong S, Zhao X, et al. Acupuncture Alleviates Rheumatoid Arthritis by Immune-Network Modulation. Am J Chin Med. 2018;46(5):997–1019. doi:10.1142/S0192415X18500520
   PubMed Web of Science ®Google Scholar
• Yu ML, Wei RD, Zhang T, et al. Electroacupuncture Relieves Pain and Attenuates Inflammation Progression Through Inducing IL-10 Production in CFA-Induced Mice. Inflammation. 2020;43(4):1233–1245. doi:10.1007/s10753-020-01203-2
   PubMed Web of Science ®Google Scholar
• Su C, Chen Y, Chen Y, et al. Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats. Mol Med Rep. 2019;20(5):4101–4110. doi:10.3892/mmr.2019.10674
   PubMed Web of Science ®Google Scholar
• Torres-Rosas R, Yehia G, Peña G, et al. Dopamine mediates vagal modulation of the immune system by electroacupuncture. Nat Med. 2014;20(3):291–295. doi:10.1038/nm.3479
   PubMed Web of Science ®Google Scholar
• Chen Y, Lei Y, Mo LQ, et al. Electroacupuncture pretreatment with different waveforms prevents brain injury in rats subjected to cecal ligation and puncture via inhibiting microglial activation, and attenuating inflammation, oxidative stress and apoptosis. Brain Res Bull. 2016;127:248–259. doi:10.1016/j.brainresbull.2016.10.009
   PubMed Web of Science ®Google Scholar
• Zhang L, Huang Z, Shi X, et al. Protective Effect of Electroacupuncture at Zusanli on Myocardial Injury in Septic Rats. Evid Based Complement Alternat Med. 2018;2018:6509650. doi:10.1155/2018/6509650
   PubMed Web of Science ®Google Scholar
• Xie DP, Zhou GB, Chen RL, et al. Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen. Evid Based Complement Alternat Med. 2020;2020:1914031. doi:10.1155/2020/1914031
   PubMed Web of Science ®Google Scholar
• Hartenstein V, Martinez P. Structure, development and evolution of the digestive system. Cell Tissue Res. 2019;377(3):289–292. doi:10.1007/s00441-019-03102-x
   PubMed Web of Science ®Google Scholar
• Song S, An J, Li Y, Liu S. Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1β and promoting Nrf2/HO-1. Mol Immunol. 2019;106:143–152. doi:10.1016/j.molimm.2018.12.023
   PubMed Web of Science ®Google Scholar
• Liu GH, Liu HM, Chen YS, Lee TY. Effect of Electroacupuncture in Mice with Dextran Sulfate Sodium-Induced Colitis and the Influence of Gut Microbiota. Evid Based Complement Alternat Med. 2020;2020:2087903. doi:10.1155/2020/2087903
   PubMed Web of Science ®Google Scholar
• Deng J, Yang S, Yuan Q, et al. Acupuncture Ameliorates Postoperative Ileus via IL-6-miR-19a-KIT Axis to Protect Interstitial Cells of Cajal. Am J Chin Med. 2017;45(4):737–755. doi:10.1142/S0192415X17500392
   PubMed Web of Science ®Google Scholar
• Song YF, Pei LX, Chen L, et al. Electroacupuncture Relieves Irritable Bowel Syndrome by Regulating IL-18 and Gut Microbial Dysbiosis in a Trinitrobenzene Sulfonic Acid-Induced Post-Inflammatory Animal Model. Am J Chin Med. 2020;48(1):77–90. doi:10.1142/S0192415X20500044
   PubMed Web of Science ®Google Scholar
• Meng X, Guo X, Zhang J, et al. Acupuncture on ST36, CV4 and KI1 Suppresses the Progression of Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. Metabolites. 2019;9(12). doi:10.3390/metabo9120299
   PubMed Web of Science ®Google Scholar
• Ma B, Li P, An H, Song Z. Electroacupuncture Attenuates Liver Inflammation in Nonalcoholic Fatty Liver Disease Rats. Inflammation. 2020;43(6):2372–2378. doi:10.1007/s10753-020-01306-w
   PubMed Web of Science ®Google Scholar
• Liang S, Ma HY, Zhong Z, et al. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019;156(4):1156–1172.e6. doi:10.1053/j.gastro.2018.11.019
   PubMed Web of Science ®Google Scholar
• Lee YJ, Rong JZ, Kim YW, et al. Acupuncture inhibits liver injury induced by morphine plus Acetaminophen through antioxidant system. EUR J INTEGR MED. 2016;8(3):204–212. doi:10.1016/j.eujim.2015.12.009
   Web of Science ®Google Scholar
• Wang YL, Su YS, He W, Jing XH. Electroacupuncture relieved visceral and referred hindpaw hypersensitivity in colitis rats by inhibiting tyrosine hydroxylase expression in the sixth lumbar dorsal root ganglia. Neuropeptides. 2019;77:101957. doi:10.1016/j.npep.2019.101957
   PubMed Web of Science ®Google Scholar
• Yang NN, Ye Y, Tian ZX, et al. Effects of electroacupuncture on the intestinal motility and local inflammation are modulated by acupoint selection and stimulation frequency in postoperative ileus mice. Neurogastroenterol Motil. 2020;32(5):e13808. doi:10.1111/nmo.13808
   PubMed Web of Science ®Google Scholar
• Ramires CC, Balbinot DT, Cidral-Filho FJ, Dias DV, Dos Santos AR, da Silva MD. Acupuncture reduces peripheral and brainstem cytokines in rats subjected to lipopolysaccharide-induced inflammation. Acupunct Med. 2021;39(4):376–384. doi:10.1177/0964528420938379
   PubMed Web of Science ®Google Scholar
• Li Y, Chen Y, Zhang X, et al. Protective effect of electro-acupuncture on liver ischemia-reperfusion injury in rats. Exp Ther Med. 2018;16(2):1373–1380. doi:10.3892/etm.2018.6287
   PubMed Web of Science ®Google Scholar
• Xiong J, Qi W, Yang H, et al. Acupuncture Treatment for Cough-Variant Asthma: a Meta-Analysis. Evid Based Complement Alternat Med. 2021;2021:6694936. doi:10.1155/2021/6694936
   PubMedGoogle Scholar
• Fernández-Jané C, Vilaró J, Fei Y, et al. Filiform needle acupuncture for COPD: a systematic review and meta-analysis. Complement Ther Med. 2019;47:102182. doi:10.1016/j.ctim.2019.08.016
   PubMed Web of Science ®Google Scholar
• Seidman MD, Gurgel RK, Lin SY, et al. Clinical practice guideline: allergic rhinitis executive summary. Otolaryngol Head Neck Surg. 2015;152(2):197–206. doi:10.1177/0194599814562166
   PubMed Web of Science ®Google Scholar
• McCullough AR, Pollack AJ, Plejdrup Hansen M, et al. Antibiotics for acute respiratory infections in general practice: comparison of prescribing rates with guideline recommendations. Med J Aust. 2017;207(2):65–69. doi:10.5694/mja16.01042
   PubMed Web of Science ®Google Scholar
• Feng D, Zhou H, Jin X, et al. Electroacupuncture Pretreatment Alleviates LPS-Induced Acute Respiratory Distress Syndrome via Regulating the PPAR Gamma/NF-Kappa B Signaling Pathway. Evid Based Complement Alternat Med. 2020;2020:4594631. doi:10.1155/2020/4594631
   PubMed Web of Science ®Google Scholar
• Lou Y, Yu Q, Xu K, et al. Electroacupuncture pre‑conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF-κB in rats. Mol Med Rep. 2020;22(4):3225–3232. doi:10.3892/mmr.2020.11429
   PubMed Web of Science ®Google Scholar
• Gong LR, Kan YX, Lian Y, et al. Electroacupuncture Attenuates Limb Ischemia-Reperfusion-Induced Lung Injury Via p38 Mitogen-Activated Protein Kinase-Nuclear Factor Erythroid-2-Related Factor-2/Heme Oxygenase Pathway. J Surg Res. 2020;246:170–181. doi:10.1016/j.jss.2019.08.021
   PubMed Web of Science ®Google Scholar
• Huang D, Chen M, Wang Z, Hou L, Yu W. Electroacupuncture Pretreatment Attenuates Inflammatory Lung Injury After Cardiopulmonary Bypass by Suppressing NLRP3 Inflammasome Activation in Rats. Inflammation. 2019;42(3):895–903. doi:10.1007/s10753-018-0944-y
   PubMed Web of Science ®Google Scholar
• Dhar R, Zhang L, Li Y, et al. Electroacupuncture ameliorates cardiopulmonary bypass induced apoptosis in lung via ROS/Nrf2/NLRP3 inflammasome pathway. Life Sci. 2019;238:116962. doi:10.1016/j.lfs.2019.116962
   PubMed Web of Science ®Google Scholar
• Ma W, Li Z, Lu Z, et al. Protective Effects of Acupuncture in Cardiopulmonary Bypass-Induced Lung Injury in Rats. Inflammation. 2017;40(4):1275–1284. doi:10.1007/s10753-017-0570-0
   PubMed Web of Science ®Google Scholar
• Lauterbach MA, Hanke JE, Serefidou M, et al. Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. Immunity. 2019;51(6):997–1011.e7. doi:10.1016/j.immuni.2019.11.009
   PubMed Web of Science ®Google Scholar
• Li J, Wu S, Tang H, et al. Long-term effects of acupuncture treatment on airway smooth muscle in a rat model of smoke-induced chronic obstructive pulmonary disease. Acupunct Med. 2016;34(2):107–113. doi:10.1136/acupmed-2014-010674
   PubMed Web of Science ®Google Scholar
• Lambrecht BN, Hammad H. Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology. Annu Rev Immunol. 2012;30:243–270. doi:10.1146/annurev-immunol-020711-075021
   PubMed Web of Science ®Google Scholar
• Dong M, Wang WQ, Chen J, et al. Acupuncture Regulates the Balance of CD4(+) T Cell Subtypes in Experimental Asthma Mice. Chin J Integr Med. 2019;25(8):617–624. doi:10.1007/s11655-018-3055-6
   PubMed Web of Science ®Google Scholar
• Zhou L, Hong J, Wan Z, Lu X, Shao Y. Effects of electroacupuncture combined with interleukin‑10 on chronic sinusitis in mice. Mol Med Rep. 2019;20(2):1952–1958. doi:10.3892/mmr.2019.10375
   PubMed Web of Science ®Google Scholar
• Dong M, Ma C, Wang WQ, Chen J, Wei Y. Regulation of the IL-33/ST2 pathway contributes to the anti-inflammatory effect of acupuncture in the ovalbumin-induced murine asthma model. Acupunct Med. 2018;36(5):319–326. doi:10.1136/acupmed-2017-011377
   PubMed Web of Science ®Google Scholar
• Vivier E, Artis D, Colonna M, et al. Innate Lymphoid Cells: 10 Years On. Cell. 2018;174(5):1054–1066. doi:10.1016/j.cell.2018.07.017
   PubMed Web of Science ®Google Scholar
• Cui J, Dong M, Yi L, et al. Acupuncture inhibited airway inflammation and group 2 innate lymphoid cells in the lung in an ovalbumin-induced murine asthma model. Acupunct Med. 2021;39(3):217–225. doi:10.1177/0964528420924033
   PubMed Web of Science ®Google Scholar
• Nurwati I, Purwanto B, Mudigdo A, Saputra K, Prasetyo DH, Muthmainah M. Improvement in inflammation and airway remodelling after acupuncture at BL13 and ST36 in a mouse model of chronic asthma. Acupunct Med. 2019;37(4):228–236. doi:10.1177/0964528418818705
   PubMed Web of Science ®Google Scholar
• Kwon HS, Koh SH. Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener. 2020;9(1):42. doi:10.1186/s40035-020-00221-2
   PubMed Web of Science ®Google Scholar
• Yang QQ, Zhou JW. Neuroinflammation in the central nervous system: symphony of glial cells. Glia. 2019;67(6):1017–1035. doi:10.1002/glia.23571
   PubMed Web of Science ®Google Scholar
• Li L, Acioglu C, Heary RF, Elkabes S. Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases. Brain Behav Immun. 2021;91:740–755. doi:10.1016/j.bbi.2020.10.007
   PubMed Web of Science ®Google Scholar
• Zhu XL, Chen X, Wang W, et al. Electroacupuncture pretreatment attenuates spinal cord ischemia-reperfusion injury via inhibition of high-mobility group box 1 production in a LXA(4) receptor-dependent manner. Brain Res. 2017;1659:113–120. doi:10.1016/j.brainres.2017.01.008
   PubMed Web of Science ®Google Scholar
• Lu J, Shao RH, Jin SY, Hu L, Tu Y, Guo JY. Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression. Brain Res Bull. 2017;128:106–112. doi:10.1016/j.brainresbull.2016.11.010
   PubMed Web of Science ®Google Scholar
• Ye Y, Yang Y, Chen C, et al. Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway. Stem Cells Int. 2017;2017:5841814. doi:10.1155/2017/5841814
   PubMed Web of Science ®Google Scholar
• Cai GF, Sun ZR, Zhuang Z, et al. Cross electro-nape-acupuncture ameliorates cerebral hemorrhage-induced brain damage by inhibiting necroptosis. World J Clin Cases. 2020;8(10):1848–1858. doi:10.12998/wjcc.v8.i10.1848
   PubMed Web of Science ®Google Scholar
• Li Y, Yin C, Li X, et al. Electroacupuncture Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Rats via Suppressing TLR4 Signaling and TRPV1 Upregulation in Sensory Neurons. Int J Mol Sci. 2019;20(23). doi:10.3390/ijms20235917
   Web of Science ®Google Scholar
• Zhou X, Lu W, Wang Y, Li J, Luo Y. A20-Binding Inhibitor of NF-κB 1 Ameliorates Neuroinflammation and Mediates Antineuroinflammatory Effect of Electroacupuncture in Cerebral Ischemia/Reperfusion Rats. Evid Based Complement Alternat Med. 2020;2020:6980398. doi:10.1155/2020/6980398
   PubMed Web of Science ®Google Scholar
• Liu R, Xu NG, Yi W, Ji C. Electroacupuncture Attenuates Inflammation after Ischemic Stroke by Inhibiting NF-κB-Mediated Activation of Microglia. Evid Based Complement Alternat Med. 2020;2020:8163052. doi:10.1155/2020/8163052
   PubMed Web of Science ®Google Scholar
• Liu W, Wang X, Yang S, et al. Electroacupuncture improves motor impairment via inhibition of microglia-mediated neuroinflammation in the sensorimotor cortex after ischemic stroke. Life Sci. 2016;151:313–322. doi:10.1016/j.lfs.2016.01.045
   PubMed Web of Science ®Google Scholar
• Jiang J, Luo Y, Qin W, et al. Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats. Front Mol Neurosci. 2017;10:363. doi:10.3389/fnmol.2017.00363
   PubMed Web of Science ®Google Scholar
• Hu Q, Zheng X, Li X, et al. Electroacupuncture Alleviates Mechanical Allodynia in a Rat Model of Complex Regional Pain Syndrome Type-I via Suppressing Spinal CXCL12/CXCR4 Signaling. J Pain. 2020;21(9–10):1060–1074. doi:10.1016/j.jpain.2020.01.007
   PubMed Web of Science ®Google Scholar
• Wang L, Yang JW, Lin LT, et al. Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-κB Signaling Pathway. Oxid Med Cell Longev. 2020;2020:8253904. doi:10.1155/2020/8253904
   PubMed Web of Science ®Google Scholar
• Liu W, Wang X, Zheng Y, et al. Electroacupuncture inhibits inflammatory injury by targeting the miR-9-mediated NF-κB signaling pathway following ischemic stroke. Mol Med Rep. 2016;13(2):1618–1626. doi:10.3892/mmr.2015.4745
   PubMed Web of Science ®Google Scholar
• Wang Y, Jiang H, Meng H, et al. Antidepressant Mechanism Research of Acupuncture: insights from a Genome-Wide Transcriptome Analysis of Frontal Cortex in Rats with Chronic Restraint Stress. Evid Based Complement Alternat Med. 2017;2017:1676808. doi:10.1155/2017/1676808
   PubMed Web of Science ®Google Scholar
• Liu XY, Dai XH, Zou W, et al. Acupuncture through Baihui (DU20) to Qubin (GB7) mitigates neurological impairment after intracerebral hemorrhage. Neural Regen Res. 2018;13(8):1425–1432. doi:10.4103/1673-5374.235298
   PubMed Web of Science ®Google Scholar
• Badimon A, Strasburger HJ, Ayata P, et al. Negative feedback control of neuronal activity by microglia. Nature. 2020;586(7829):417–423. doi:10.1038/s41586-020-2777-8
   PubMed Web of Science ®Google Scholar
• Peng J, Liu Y, Umpierre AD, et al. Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice. Mol Brain. 2019;12(1):71. doi:10.1186/s13041-019-0492-x
   PubMed Web of Science ®Google Scholar
• Zhao L, Liu L, Xu X, et al. Electroacupuncture Inhibits Hyperalgesia by Alleviating Inflammatory Factors in a Rat Model of Migraine. J Pain Res. 2020;13:75–86. doi:10.2147/JPR.S225431
   PubMed Web of Science ®Google Scholar
• Huang J, You X, Liu W, et al. Electroacupuncture ameliorating post-stroke cognitive impairments via inhibition of peri-infarct astroglial and microglial/macrophage P2 purinoceptors-mediated neuroinflammation and hyperplasia. BMC Complement Altern Med. 2017;17(1):480. doi:10.1186/s12906-017-1974-y
   PubMedGoogle Scholar
• Wang X, Li Z, Li C, Wang Y, Yu S, Ren L. Electroacupuncture with Bushen Jiannao improves cognitive deficits in senescence-accelerated mouse prone 8 mice by inhibiting neuroinflammation. J Tradit Chin Med. 2020;40(5):812–819. doi:10.19852/j.cnki.jtcm.2020.05.011
   PubMed Web of Science ®Google Scholar
• Cai M, Lee JH, Yang EJ. Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer’s disease animal model. J Neuroinflammation. 2019;16(1):264. doi:10.1186/s12974-019-1665-3
   PubMed Web of Science ®Google Scholar
• Jiang J, Ding N, Wang K, Li Z. Electroacupuncture Could Influence the Expression of IL-1β and NLRP3 Inflammasome in Hippocampus of Alzheimer’s Disease Animal Model. Evid Based Complement Alternat Med. 2018;2018:8296824. doi:10.1155/2018/8296824
   PubMed Web of Science ®Google Scholar
• Yu J, Min D, Bai Y, Qu L, Zou T, Wang S. Electroacupuncture alleviates Parkinson disease and regulates the expression of brain-gut peptides. Exp Anim. 2020;69(4):448–460. doi:10.1538/expanim.19-0153
   PubMed Web of Science ®Google Scholar
• Dumitrescu L, Popescu-Olaru I, Cozma L, et al. Oxidative Stress and the Microbiota-Gut-Brain Axis. Oxid Med Cell Longev. 2018;2018:2406594. doi:10.1155/2018/2406594
   PubMed Web of Science ®Google Scholar
• Du SQ, Wang XR, Zhu W, et al. Acupuncture inhibits TXNIP-associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats. CNS Neurosci Ther. 2018;24(1):39–46. doi:10.1111/cns.12773
   PubMed Web of Science ®Google Scholar
• Zhu MM, Lin JH, Qing P, et al. Manual acupuncture relieves microglia-mediated neuroinflammation in a rat model of traumatic brain injury by inhibiting the RhoA/ROCK2 pathway. Acupunct Med. 2020;38(6):426–434. doi:10.1177/0964528420912248
   PubMed Web of Science ®Google Scholar
• Frantz AL, Regner GG, Pflüger P, et al. Manual acupuncture improves parameters associated with oxidative stress and inflammation in PTZ-induced kindling in mice. Neurosci Lett. 2017;661:33–40. doi:10.1016/j.neulet.2017.09.044
   PubMed Web of Science ®Google Scholar
• Zhang K, Liu R, Gao Y, Ma W, Shen W. Electroacupuncture Relieves LPS-Induced Depression-Like Behaviour in Rats Through IDO-Mediated Tryptophan-Degrading Pathway. Neuropsychiatr Dis Treat. 2020;16:2257–2266. doi:10.2147/NDT.S274778
   PubMed Web of Science ®Google Scholar
• Long M, Wang Z, Zheng D, et al. Electroacupuncture Pretreatment Elicits Neuroprotection Against Cerebral Ischemia-Reperfusion Injury in Rats Associated with Transient Receptor Potential Vanilloid 1-Mediated Anti-Oxidant Stress and Anti-Inflammation. Inflammation. 2019;42(5):1777–1787. doi:10.1007/s10753-019-01040-y
   PubMed Web of Science ®Google Scholar
• Kong Y, Li S, Zhang M, et al. Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats. J Mol Neurosci. 2021;71(9):1863–1875. doi:10.1007/s12031-020-01770-x
   PubMed Web of Science ®Google Scholar
• Cristino L, Bisogno T, Di Marzo V. Cannabinoids and the expanded endocannabinoid system in neurological disorders. Nat Rev Neurol. 2020;16(1):9–29. doi:10.1038/s41582-019-0284-z
   PubMed Web of Science ®Google Scholar
• Zhang H, He S, Hu Y, Zheng H. Antagonism of cannabinoid receptor 1 attenuates the anti-inflammatory effects of electroacupuncture in a rodent model of migraine. Acupunct Med. 2016;34(6):463–470. doi:10.1136/acupmed-2016-011113
   PubMed Web of Science ®Google Scholar
• Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376(9746):1094–1108. doi:10.1016/S0140-6736(10)60826-4
   PubMed Web of Science ®Google Scholar
• Wang X, Hunter D, Xu J, Ding C. Metabolic triggered inflammation in osteoarthritis. Osteoarthritis Cartilage. 2015;23(1):22–30. doi:10.1016/j.joca.2014.10.002
   PubMed Web of Science ®Google Scholar
• Tolboom TC, van der Helm-van Mil AH, Nelissen RG, Breedveld FC, Toes RE, Huizinga TW. Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis. Arthritis Rheum. 2005;52(7):1999–2002. doi:10.1002/art.21118
   PubMed Web of Science ®Google Scholar
• Moradi B, Rosshirt N, Tripel E, et al. Unicompartmental and bicompartmental knee osteoarthritis show different patterns of mononuclear cell infiltration and cytokine release in the affected joints. Clin Exp Immunol. 2015;180(1):143–154. doi:10.1111/cei.12486
   PubMed Web of Science ®Google Scholar
• Klein-Wieringa IR, de Lange-brokaar BJ, Yusuf E, et al. Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: a Comparison between the Synovium and the Infrapatellar Fat Pad. J Rheumatol. 2016;43(4):771–778. doi:10.3899/jrheum.151068
   PubMed Web of Science ®Google Scholar
• Feldmann M, Brennan FM, Maini RN. Rheumatoid arthritis. Cell. 1996;85(3):307–310. doi:10.1016/s0092-8674(00)81109-5
   PubMed Web of Science ®Google Scholar
• Choy EH, Isenberg DA, Garrood T, et al. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum. 2002;46(12):3143–3150. doi:10.1002/art.10623
   PubMed Web of Science ®Google Scholar
• Li B, Jing L, Jia L, et al. Acupuncture reduces pain in rats with osteoarthritis by inhibiting MCP2/CCR2 signaling pathway. Exp Biol Med (Maywood). 2020;245(18):1722–1731. doi:10.1177/1535370220952342
   PubMed Web of Science ®Google Scholar
• Wu GW, Chen J, Huang YM, et al. Electroacupuncture Delays Cartilage Degeneration by Modulating Nuclear Factor-κB Signaling Pathway. Chin J Integr Med. 2019;25(9):677–683. doi:10.1007/s11655-018-2916-8
   PubMed Web of Science ®Google Scholar
• Xie LL, Zhao YL, Yang J, et al. Electroacupuncture Prevents Osteoarthritis of High-Fat Diet-Induced Obese Rats. Biomed Res Int. 2020;2020:9380965. doi:10.1155/2020/9380965
   PubMed Web of Science ®Google Scholar
• Chen H, Shao X, Li L, et al. Electroacupuncture serum inhibits TNF‑α‑mediated chondrocyte inflammation via the Ras‑Raf‑MEK1/2‑ERK1/2 signaling pathway. Mol Med Rep. 2017;16(5):5807–5814. doi:10.3892/mmr.2017.7366
   PubMed Web of Science ®Google Scholar
• Wang Z, Chen M, Wang B, et al. Electroacupuncture Alleviates Osteoarthritis by Suppressing NLRP3 Inflammasome Activation in Guinea Pigs. Evid Based Complement Alternat Med. 2020;2020:5476064. doi:10.1155/2020/5476064
   PubMed Web of Science ®Google Scholar
• Almeida Mdos S, Oliveira LP, Vieira CP, Guerra Fda R, Pimentel ER. Birefringence of collagen fibres in rat calcaneal tendons treated with acupuncture during three phases of healing. Acupunct Med. 2016;34(1):27–32. doi:10.1136/acupmed-2015-010845
   PubMed Web of Science ®Google Scholar
• Su Z, Hu L, Cheng J, et al. Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy. J Appl Physiol. 2016;120(4):426–436. doi:10.1152/japplphysiol.00175.2015
   PubMed Web of Science ®Google Scholar
• Mehana EE, Khafaga AF, El-Blehi SS. The role of matrix metalloproteinases in osteoarthritis pathogenesis: an updated review. Life Sci. 2019;234:116786. doi:10.1016/j.lfs.2019.116786
   PubMed Web of Science ®Google Scholar
• Yuan XC, Wang Q, Su W, et al. Electroacupuncture potentiates peripheral CB2 receptor-inhibited chronic pain in a mouse model of knee osteoarthritis. J Pain Res. 2018;11:2797–2808. doi:10.2147/JPR.S171664
   PubMed Web of Science ®Google Scholar
• Zhang T, Yang WX, Wang YL, et al. Electroacupuncture preconditioning attenuates acute myocardial ischemia injury through inhibiting NLRP3 inflammasome activation in mice. Life Sci. 2020;248:117451. doi:10.1016/j.lfs.2020.117451
   PubMed Web of Science ®Google Scholar
• Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract. 2014;105(2):141–150. doi:10.1016/j.diabres.2014.04.006
   PubMed Web of Science ®Google Scholar
• Lan D, Xu N, Sun J, et al. Electroacupuncture mitigates endothelial dysfunction via effects on the PI3K/Akt signalling pathway in high fat diet-induced insulin-resistant rats. Acupunct Med. 2018;36(3):162–169. doi:10.1136/acupmed-2016-011253
   PubMed Web of Science ®Google Scholar
• Luo D, Liu L, Liang FX, Yu ZM, Chen R. Electroacupuncture: a Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity Rats. Evid Based Complement Alternat Med. 2018;2018:5302049. doi:10.1155/2018/5302049
   PubMed Web of Science ®Google Scholar
• Liaw JJ, Peplow PV. Differential Effect of Electroacupuncture on Inflammatory Adipokines in Two Rat Models of Obesity. J Acupunct Meridian Stud. 2016;9(4):183–190. doi:10.1016/j.jams.2016.02.002
   PubMedGoogle Scholar
• Liaw JJ, Peplow PV. Effect of Electroacupuncture on Inflammation in the Obese Zucker Fatty Rat Model of Metabolic Syndrome. J Acupunct Meridian Stud. 2016;9(2):73–79. doi:10.1016/j.jams.2015.08.004
   PubMedGoogle Scholar
• Liaw JJ, Peplow PV. Effects of Electroacupuncture on Pro-/Anti-inflammatory Adipokines in Serum and Adipose Tissue in Lean and Diet-induced Obese Rats. J Acupunct Meridian Stud. 2016;9(2):65–72. doi:10.1016/j.jams.2015.06.011
   PubMedGoogle Scholar
• Ye Y, Birnbaum Y, Widen SG, et al. Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy. Cardiovasc Drugs Ther. 2020;34(6):835–848. doi:10.1007/s10557-020-07043-4
   PubMed Web of Science ®Google Scholar
• Tian L, Song S, Zhu B, Liu S. Electroacupuncture at ST-36 Protects Interstitial Cells of Cajal via Sustaining Heme Oxygenase-1 Positive M2 Macrophages in the Stomach of Diabetic Mice. Oxid Med Cell Longev. 2018;2018:3987134. doi:10.1155/2018/3987134
   PubMed Web of Science ®Google Scholar
• Tang HY, Wang FJ, Ma JL, Wang H, Shen GM, Jiang AJ. Acupuncture attenuates the development of diabetic peripheral neuralgia by regulating P2X4 expression and inflammation in rat spinal microglia. J Physiol Sci. 2020;70(1):45. doi:10.1186/s12576-020-00769-8
   PubMed Web of Science ®Google Scholar
• Chen L, Sun HX, Xia YB, et al. Electroacupuncture decreases the progression of ovarian hyperstimulation syndrome in a rat model. Reprod Biomed Online. 2016;32(5):538–544. doi:10.1016/j.rbmo.2016.02.006
   PubMed Web of Science ®Google Scholar
• Chen L, Huang X, Wang L, et al. Electroacupuncture Reduces Oocyte Number and Maintains Vascular Barrier Against Ovarian Hyperstimulation Syndrome by Regulating CD200. Front Cell Dev Biol. 2021;9:648578. doi:10.3389/fcell.2021.648578
   PubMed Web of Science ®Google Scholar
• Kim D, Bae CH, Jun YL, Jeon H, Koo S, Kim S. Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups. Chin J Integr Med. 2017;23(12):943–947. doi:10.1007/s11655-017-2827-8
   PubMed Web of Science ®Google Scholar
• Langevin HM, Yandow JA. Relationship of acupuncture points and meridians to connective tissue planes. Anat Rec. 2002;269(6):257–265. doi:10.1002/ar.10185
   PubMedGoogle Scholar
• Zhang K, Zhao X, Ding S, et al. Applying Complex Network and Cell-Cell Communication Network Diagram Methods to Explore the Key Cytokines and Immune Cells in Local Acupoint Involved in Acupuncture Treating Inflammatory Pain. Evid Based Complement Alternat Med. 2020;2020:2585960. doi:10.1155/2020/2585960
   PubMed Web of Science ®Google Scholar
• Park JY, Park JJ, Jeon S, et al. From peripheral to central: the role of ERK signaling pathway in acupuncture analgesia. J Pain. 2014;15(5):535–549. doi:10.1016/j.jpain.2014.01.498
   PubMed Web of Science ®Google Scholar
• Zhang K, Zhao X, Yang T, et al. Initiation of Acupoint Molecular Mechanisms for Manual Acupuncture Analgesia-Nuclear Factor κB Signaling Pathway. Chin J Integr Med. 2020. doi:10.1007/s11655-020-3435-6
   Web of Science ®Google Scholar
• Goldman N, Chen M, Fujita T, et al. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 2010;13(7):883–888. doi:10.1038/nn.2562
   PubMed Web of Science ®Google Scholar
• Zhang RY, Zhu BF, Wang LK, et al. Electroacupuncture alleviates inflammatory pain via adenosine suppression and its mediated substance P expression. Arq Neuropsiquiatr. 2020;78(10):617–623. doi:10.1590/0004-282X20200078
   PubMed Web of Science ®Google Scholar
• Chen T, Xiong Y, Long M, et al. Electro-acupuncture Pretreatment at Zusanli (ST36) Acupoint Attenuates Lipopolysaccharide-Induced Inflammation in Rats by Inhibiting Ca(2+) Influx Associated with Cannabinoid CB2 Receptors. Inflammation. 2019;42(1):211–220. doi:10.1007/s10753-018-0885-5
   PubMed Web of Science ®Google Scholar
• Gong Y, Li N, Lv Z, et al. The neuro-immune microenvironment of acupoints-initiation of acupuncture effectiveness. J Leukoc Biol. 2020;108(1):189–198. doi:10.1002/JLB.3AB0420-361RR
   PubMed Web of Science ®Google Scholar
• Zhang ZJ, Wang XM, McAlonan GM. Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture. Evid Based Complement Alternat Med. 2012;2012:429412. doi:10.1155/2012/429412
   PubMed Web of Science ®Google Scholar
• Li N, Li M, Lu Z, et al. Exosome Is an Important Novel Way of Acupuncture Information Transmission. World J Tradit Chin Med. 2020;6(04):377–383.
   Google Scholar
• Chen B, Li MY, Guo Y, Zhao X, Lim HC. Mast cell-derived exosomes at the stimulated acupoints activating the neuro-immune regulation. Chin J Integr Med. 2017;23(11):878–880. doi:10.1007/s11655-016-2269-8
   PubMed Web of Science ®Google Scholar
• Lin W, Jia D, Fu C, Zheng Y, Lin Z. Electro-Acupuncture on ST36 and SP6 Acupoints Ameliorates Lung Injury via Sciatic Nerve in a Rat Model of Limb Ischemia-Reperfusion. J Inflamm Res. 2020;13:465–470. doi:10.2147/JIR.S264093
   PubMed Web of Science ®Google Scholar
• Wang JJ, Ming Q, Liu XD, et al. Electro-acupuncture of Foot YangMing regulates gastric activity possibly through mediation of the dorsal vagal complex. Am J Chin Med. 2007;35(3):455–464. doi:10.1142/S0192415X07004977
   PubMed Web of Science ®Google Scholar
• Lim HD, Kim MH, Lee CY, Namgung U. Anti-Inflammatory Effects of Acupuncture Stimulation via the Vagus Nerve. PLoS One. 2016;11(3):e0151882. doi:10.1371/journal.pone.0151882
   PubMed Web of Science ®Google Scholar
• Takahashi T. Mechanism of acupuncture on neuromodulation in the gut–a review. Neuromodulation. 2011;14(1):8–12; discussion 12. doi:10.1111/j.1525-1403.2010.00295.x
   Web of Science ®Google Scholar
• Salazar TE, Richardson MR, Beli E, et al. Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells. Stem Cells. 2017;35(5):1303–1315. doi:10.1002/stem.2613
   PubMed Web of Science ®Google Scholar
• Lee CH, Jung HS, Lee TY, et al. Studies of the central neural pathways to the stomach and Zusanli (ST36). Am J Chin Med. 2001;29(2):211–220. doi:10.1142/S0192415X01000241
   PubMed Web of Science ®Google Scholar
• Lim HD, Kim KJ, Jo BG, Park JY, Namgung U. Acupuncture stimulation attenuates TNF-α production via vagal modulation in the concanavalin A model of hepatitis. Acupunct Med. 2020;38(6):417–425. doi:10.1177/0964528420907338
   PubMed Web of Science ®Google Scholar
• Jie X, Li X, Song JQ, Wang D, Wang JH. Anti-inflammatory and autonomic effects of electroacupuncture in a rat model of diet-induced obesity. Acupunct Med. 2018;36(2):103–109. doi:10.1136/acupmed-2016-011223
   PubMed Web of Science ®Google Scholar
• Hawkins BT, Egleton RD, Davis TP. Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors. Am J Physiol Heart Circ Physiol. 2005;289(1):H212–9.
   PubMed Web of Science ®Google Scholar
• Liu PR, Zhou Y, Zhang Y, Diao S. Electroacupuncture alleviates surgery-induced cognitive dysfunction by increasing α7-nAChR expression and inhibiting inflammatory pathway in aged rats. Neurosci Lett. 2017;659:1–6. doi:10.1016/j.neulet.2017.08.043
   PubMed Web of Science ®Google Scholar
• Liu J, Li C, Peng H, et al. Electroacupuncture attenuates learning and memory impairment via activation of α7nAChR-mediated anti-inflammatory activity in focal cerebral ischemia/reperfusion injured rats. Exp Ther Med. 2017;14(2):939–946. doi:10.3892/etm.2017.4622
   PubMed Web of Science ®Google Scholar
• Wang Z, Hou L, Yang H, et al. Electroacupuncture Pretreatment Attenuates Acute Lung Injury Through α7 Nicotinic Acetylcholine Receptor-Mediated Inhibition of HMGB1 Release in Rats After Cardiopulmonary Bypass. Shock. 2018;50(3):351–359. doi:10.1097/SHK.0000000000001050
   PubMed Web of Science ®Google Scholar
• Geng Y, Chen D, Zhou J, Jiang H, Zhang H. Role of Cholinergic Anti-Inflammatory Pathway in Treatment of Intestinal Ischemia-Reperfusion Injury by Electroacupuncture at Zusanli. Evid Based Complement Alternat Med. 2017;2017:6471984. doi:10.1155/2017/6471984
   PubMed Web of Science ®Google Scholar
• Jiang T, Wu M, Zhang Z, et al. Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats. Mol Med. 2019;25(1):22. doi:10.1186/s10020-019-0091-4
   PubMedGoogle Scholar
• Ma Z, Zhang Z, Bai F, Jiang T, Yan C, Wang Q. Electroacupuncture Pretreatment Alleviates Cerebral Ischemic Injury Through α7 Nicotinic Acetylcholine Receptor-Mediated Phenotypic Conversion of Microglia. Front Cell Neurosci. 2019;13:537. doi:10.3389/fncel.2019.00537
   PubMed Web of Science ®Google Scholar
• Chi L, Du K, Liu D, Bo Y, Li W. Electroacupuncture brain protection during ischemic stroke: a role for the parasympathetic nervous system. J Cereb Blood Flow Metab. 2018;38(3):479–491. doi:10.1177/0271678X17697988
   PubMed Web of Science ®Google Scholar
• Cao Y, Wang L, Lin LT, et al. Acupuncture attenuates cognitive deficits through α7nAChR mediated anti-inflammatory pathway in chronic cerebral hypoperfusion rats. Life Sci. 2021;266:118732. doi:10.1016/j.lfs.2020.118732
   PubMed Web of Science ®Google Scholar
• Han D, Liu Z, Wang G, Zhang Y, Wu Z. Electroacupuncture Improves Cognitive Deficits through Increasing Regional Cerebral Blood Flow and Alleviating Inflammation in CCI Rats. Evid Based Complement Alternat Med. 2017;2017:5173168. doi:10.1155/2017/5173168
   PubMed Web of Science ®Google Scholar
• Wang Y, Xue M, Xia Y, Jiang Q, Huang Z, Huang C. Electroacupuncture treatment upregulates α7nAChR and inhibits JAK2/STAT3 in dorsal root ganglion of rat with spared nerve injury. J Pain Res. 2019;12:1947–1955. doi:10.2147/JPR.S203867
   PubMed Web of Science ®Google Scholar
• Wang Y, Xia YY, Xue M, Jiang Q, Huang Z, Huang C. Electroacupuncture ameliorates mechanical hypersensitivity by down-regulating spinal Janus kinase 2/signal transducer and activation of transcription 3 and interleukin 6 in rats with spared nerve injury. Acupunct Med. 2021;39(4):358–366. doi:10.1177/0964528420938376
   PubMed Web of Science ®Google Scholar
• Pera T, Penn RB. Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway. Curr Opin Pharmacol. 2014;16:72–81. doi:10.1016/j.coph.2014.03.005
   PubMed Web of Science ®Google Scholar
• Soler X, Ramsdell J. Anticholinergics/antimuscarinic drugs in asthma. Curr Allergy Asthma Rep. 2014;14(12):484. doi:10.1007/s11882-014-0484-y
   PubMed Web of Science ®Google Scholar
• Cavallotti C, Tonnarini G, Andrea V, Cavallotti D. Cholinergic staining of bronchus- associated lymphoid tissue. Neuroimmunomodulation. 2005;12(3):141–145. doi:10.1159/000084845
   PubMed Web of Science ®Google Scholar
• Degano B, Prévost MC, Berger P, et al. Estradiol decreases the acetylcholine-elicited airway reactivity in ovariectomized rats through an increase in epithelial acetylcholinesterase activity. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1849–1854. doi:10.1164/ajrccm.164.10.2102009
   PubMed Web of Science ®Google Scholar
• Montalbano AM, Di Sano C, Chiappara G, et al. Cigarette smoke and non-neuronal cholinergic system in the airway epithelium of COPD patients. J Cell Physiol. 2018;233(8):5856–5868. doi:10.1002/jcp.26377
   PubMed Web of Science ®Google Scholar
• Zhang XF, Xiang SY, Geng WY, et al. Electro-acupuncture regulates the cholinergic anti-inflammatory pathway in a rat model of chronic obstructive pulmonary disease. J Integr Med. 2018;16(6):418–426. doi:10.1016/j.joim.2018.10.003
   PubMed Web of Science ®Google Scholar
• Liu YL, Zhang LD, Ma TM, et al. Feishu Acupuncture Inhibits Acetylcholine Synthesis and Restores Muscarinic Acetylcholine Receptor M2 Expression in the Lung When Treating Allergic Asthma. Inflammation. 2018;41(3):741–750. doi:10.1007/s10753-017-0726-y
   PubMed Web of Science ®Google Scholar
• Li Y, Xu G, Hu S, et al. Electroacupuncture alleviates intestinal inflammation and barrier dysfunction by activating dopamine in a rat model of intestinal ischaemia. Acupunct Med. 2021;39(3):208–216. doi:10.1177/0964528420922232
   PubMed Web of Science ®Google Scholar
• Liu S, Wang Z, Su Y, et al. A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis. Nature. 2021;598(7882):641–645. doi:10.1038/s41586-021-04001-4
   PubMed Web of Science ®Google Scholar
• Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve–an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev. 2000;52(4):595–638.
   PubMed Web of Science ®Google Scholar
• Xia CM, Colomb DG Jr, Akbarali HI, Qiao LY. Prolonged sympathetic innervation of sensory neurons in rat thoracolumbar dorsal root ganglia during chronic colitis. Neurogastroenterol Motil. 2011;23(8):801–e339. doi:10.1111/j.1365-2982.2011.01728.x
   PubMed Web of Science ®Google Scholar
• Chen YJ, Gao YL, Lu WW, Gao W. Influence of acupuncture on the expression of VIP, SP, NKA and NKB, cAMP/cGMP and HE content and treatment of bronchial asthma in rats[J]. Cell Mol Biol. 2020;66(5):29–35. doi:10.14715/cmb/2020.66.5.6
   PubMed Web of Science ®Google Scholar
• Xiao LY, Wang XR, Yang JW, et al. Acupuncture Prevents the Impairment of Hippocampal LTP Through β1-AR in Vascular Dementia Rats. Mol Neurobiol. 2018;55(10):7677–7690. doi:10.1007/s12035-018-0943-x
   PubMed Web of Science ®Google Scholar
• Yang JW, Ye Y, Wang XR, et al. Acupuncture Attenuates Renal Sympathetic Activity and Blood Pressure via Beta-Adrenergic Receptors in Spontaneously Hypertensive Rats. Neural Plast. 2017;2017:8696402. doi:10.1155/2017/8696402
   PubMed Web of Science ®Google Scholar
• Lu M, He Y, Gong M, et al. Role of Neuro-Immune Cross-Talk in the Anti-obesity Effect of Electro-Acupuncture. Front Neurosci. 2020;14:151. doi:10.3389/fnins.2020.00151
   PubMed Web of Science ®Google Scholar
• Rosas-Ballina M, Olofsson PS, Ochani M, et al. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science. 2011;334(6052):98–101. doi:10.1126/science.1209985
   PubMed Web of Science ®Google Scholar
• Vida G, Peña G, Deitch EA, Ulloa L. α7-cholinergic receptor mediates vagal induction of splenic norepinephrine. J Immunol. 2011;186(7):4340–4346. doi:10.4049/jimmunol.1003722
   PubMed Web of Science ®Google Scholar
• Bratton BO, Martelli D, McKinley MJ, Trevaks D, Anderson CR, McAllen RM. Neural regulation of inflammation: no neural connection from the vagus to splenic sympathetic neurons. Exp Physiol. 2012;97(11):1180–1185. doi:10.1113/expphysiol.2011.061531
   PubMed Web of Science ®Google Scholar
• Pavlov VA, Tracey KJ. Neural circuitry and immunity. Immunol Res. 2015;63(1–3):38–57. doi:10.1007/s12026-015-8718-1
   PubMed Web of Science ®Google Scholar
• Abe C, Inoue T, Inglis MA, et al. C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. Nat Neurosci. 2017;20(5):700–707. doi:10.1038/nn.4526
   PubMed Web of Science ®Google Scholar
• Wei Y, Dong M, Zhong L, et al. Regulation of hypothalamic-pituitary-adrenal axis activity and immunologic function contributed to the anti-inflammatory effect of acupuncture in the OVA-induced murine asthma model. Neurosci Lett. 2017;636:177–183. doi:10.1016/j.neulet.2016.11.001
   PubMed Web of Science ®Google Scholar
• Shi P, Sun LL, Lee YS, Tu Y. Electroacupuncture regulates the stress-injury-repair chain of events after cerebral ischemia/reperfusion injury. Neural Regen Res. 2017;12(6):925–930. doi:10.4103/1673-5374.208574
   PubMed Web of Science ®Google Scholar
• Forsythe P, Bienenstock J, Kunze WA. Vagal pathways for microbiome-brain-gut axis communication. Adv Exp Med Biol. 2014;817:115–133. doi:10.1007/978-1-4939-0897-4_5
   PubMed Web of Science ®Google Scholar
• Jang JH, Yeom MJ, Ahn S, et al. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease. Brain Behav Immun. 2020;89:641–655. doi:10.1016/j.bbi.2020.08.015
   PubMed Web of Science ®Google Scholar
• Li L, Lu J, Sun Y, Jin X. Acupuncture protects from 6-OHDA-induced neuronal damage by balancing the ratio of DMT1/Fpn1. Saudi J Biol Sci. 2019;26(8):1948–1955. doi:10.1016/j.sjbs.2019.07.003
   PubMed Web of Science ®Google Scholar
• Zhu S, Li L, Li Y, Cao W. Macrophage related cytokine expressions in depression mouse model induced by chronic unpredictable mild stress. Pak J Pharm Sci. 2017;30(5(Supplementary)):1951–1955.
   PubMed Web of Science ®Google Scholar
• Yu Z. Neuromechanism of acupuncture regulating gastrointestinal motility. World J Gastroenterol. 2020;26(23):3182–3200. doi:10.3748/wjg.v26.i23.3182
   PubMed Web of Science ®Google Scholar