Qing-Luo-Yin Alleviated Experimental Arthritis in Rats by Disrupting Immune Feedback Between Inflammatory T Cells and Monocytes: Key Evidences from Its Effects on Immune Cell Phenotypes

References

• Ponchel F, Vital EM, Kingsbury SR, El-Sherbiny Y. CD4+ T-cell subsets in rheumatoid arthritis. Int J Cl Rheum. 2012;7(1):37–53. doi:10.2217/ijr.11.69
   Google Scholar
• Thomas R, Turner M, Cope AP. High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis? Arthritis Res Ther. 2008;10(4):210. doi:10.1186/ar2446
   PubMed Web of Science ®Google Scholar
• Scherer HU, Häupl T, Burmester GR. The etiology of rheumatoid arthritis. J Autoimmun. 2020;110:102400. doi:10.1016/j.jaut.2019.102400
   PubMed Web of Science ®Google Scholar
• Schulze-Koops H, Kalden JR. The balance of Th1/Th2 cytokines in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2001;15(5):677–691. doi:10.1053/berh.2001.0187
   PubMed Web of Science ®Google Scholar
• Niu Q, Cai B, Huang ZC, Shi YY, Wang LL. Disturbed Th17/Treg balance in patients with rheumatoid arthritis. Rheumatol Int. 2012;32(9):2731–2736. doi:10.1007/s00296-011-1984-x
   PubMed Web of Science ®Google Scholar
• Takeuchi T. Revolutionary change in rheumatoid arthritis management with biological therapy. Keio J Med. 2011;60(3):75–81. doi:10.2302/kjm.60.75
   PubMedGoogle Scholar
• Roberts CA, Dickinson AK, Taams LS. The interplay between monocytes/macrophages and CD4+ T cell subsets in rheumatoid arthritis. Front Immunol. 2015;6:571. doi:10.3389/fimmu.2015.00571
   PubMed Web of Science ®Google Scholar
• Kawanaka N, Yamamura M, Aita T, et al. CD14+, CD16+ blood monocytes and joint inflammation in rheumatoid arthritis. Arthritis Rheumatol. 2010;46(10):2578–2586. doi:10.1002/art.10545
   Google Scholar
• Rossol M, Kraus S, Pierer M, Baerwald C, Wagner U. The CD14(bright) CD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population. Arthritis Rheum. 2012;64(3):671–677. doi:10.1002/art.33418
   PubMedGoogle Scholar
• De-brito NM, Da-costa HC, Simões RL, Barja-Fidalgo C. Lipoxin-induced phenotypic changes in CD115+LY6Chi monocytes tam precursors inhibits tumor development. Front Oncol. 2019;9:540. doi:10.3389/fonc.2019.00540
   PubMed Web of Science ®Google Scholar
• Yrlid U, Jenkins CD, MacPherson GG. Relationships between distinct blood monocyte subsets and migrating intestinal lymph dendritic cells in vivo under steady-state conditions. J Immunol. 2006;176(7):4155–4162. doi:10.4049/jimmunol.176.7.4155
   PubMed Web of Science ®Google Scholar
• Brühl H, Cihak J, Plachý J, et al. Targeting of Gr-1+, CCR2+ monocytes in collagen-induced arthritis. Arthritis Rheum. 2007;56(9):2975–2985. doi:10.1002/art.22854
   PubMedGoogle Scholar
• Davignon JL, Hayder M, Baron M, et al. Targeting monocytes/macrophages in the treatment of rheumatoid arthritis. Rheumatology. 2013;52(4):590–598. doi:10.1093/rheumatology/kes304
   PubMed Web of Science ®Google Scholar
• Hoes JN, Jacobs JWG, Buttgereit F, Bijlsma JWJ. Current view of glucocorticoid co-therapy with DMARDs in rheumatoid arthritis. Nat Rev Rheumatol. 2010;6(12):693–702. doi:10.1038/nrrheum.2010.179
   PubMed Web of Science ®Google Scholar
• Friedman B, Cronstein B. Methotrexate mechanism in treatment of rheumatoid arthritis. Joint Bone Spine. 2019;86(3):301–307. doi:10.1016/j.jbspin.2018.07.004
   PubMed Web of Science ®Google Scholar
• O’Dell JR, Mikuls TR, Taylor TH, et al. Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med. 2013;369(4):307–318. doi:10.1056/NEJMoa1303006
   PubMed Web of Science ®Google Scholar
• Nam JL, Takase-Minegishi K, Ramiro S, et al. Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2016 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2017;76(6):1108–1113. doi:10.1136/annrheumdis-2016-210713
   Web of Science ®Google Scholar
• An Y, Liu T, He D, et al. The usage of biological DMARDs and clinical remission of rheumatoid arthritis in China: a real-world large scale study. Clin Rheumatol. 2017;36(1):35–43. doi:10.1007/s10067-016-3424-5
   PubMed Web of Science ®Google Scholar
• Klareskog L, Gaubitz M, Rodriguez-Valverde V, et al. A long-term, open-label trial of the safety and efficacy of etanercept (Enbrel) in patients with rheumatoid arthritis not treated with other disease-modifying antirheumatic drugs. Ann Rheum Dis. 2006;65(12):1578–1584. doi:10.1136/ard.2005.038349
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Hirata S, Saleem B, Emery P. Discontinuation of biologics in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2013;31(Suppl.78):S22–S27.
   PubMedGoogle Scholar
• Singh JA, Cameron C, Noorbaloochi S, et al. Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis. Lancet. 2015;386(9990):258–265. doi:10.1016/S0140-6736(14)61704-9
   PubMed Web of Science ®Google Scholar
• Zhang B, Wang X, Li S. An integrative platform of TCM network pharmacology and its application on a herbal formula, Qing-Luo-Yin. Evid Based Complement Alternat Med. 2013;2013:456747. doi:10.1155/2013/456747
   PubMed Web of Science ®Google Scholar
• Wu ZY. A Metabolomics Study of Traditional Chinese Medicine Recipe “Qing Luo Yin” in Treating Heat-Induced Paralysis Syndrome [master’s dissertation]. Wuhu: Wannan Medical College; 2020:21–40.
   Google Scholar
• Li X, Tang Z, Wen L, Jiang C, Feng Q. Matrine: a review of its pharmacology, pharmacokinetics, toxicity, clinical application and preparation researches. J Ethnopharmacol. 2020;269(1):113682. doi:10.1016/j.jep.2020.113682
   PubMedGoogle Scholar
• Tang J, Raza A, Chen J, Xu H. A systematic review on the Sinomenine derivatives. Mini Rev Med Chem. 2018;18(11):906–917. doi:10.2174/1389557517666171123212557
   PubMed Web of Science ®Google Scholar
• Zou F, Wang L, Liu H, et al. Sophocarpine suppresses NF-κB-mediated inflammation both in vitro and in vivo and inhibits diabetic cardiomyopathy. Front Pharmacol. 2019;10:1219. doi:10.3389/fphar.2019.01219
   PubMed Web of Science ®Google Scholar
• Wu M, Ma C, Wu Y, Li S. Simultaneous LC analysis of five bioactive alkaloids in an anti-angiogenesis herbal formula, Qing-Luo-Yin. Chromatographia. 2008;68(s7–s8):579–585. doi:10.1365/s10337-008-0767-3
   Google Scholar
• Billiau A, Matthys P. Collagen-induced arthritis and related animal models: how much of their pathogenesis is auto-immune, how much is auto-inflammatory? Cytokine Growth Factor Rev. 2011;22(5–6):339–344. doi:10.1016/j.cytogfr.2011.11.003
   PubMed Web of Science ®Google Scholar
• Furuya T, Salstrom JL, McCall-Vining S, et al. Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci. Hum Mol Genet. 2000;9(15):2241–2250. doi:10.1093/oxfordjournals.hmg.a018915
   PubMed Web of Science ®Google Scholar
• Zuo J, Yin Q, Wang YW, et al. Inhibition of NF-κB pathway in fibroblast-like synoviocytes by α-mangostin implicated in protective effects on joints in rats suffering from adjuvant-induced arthritis. Int Immunopharmacol. 2018;56:78–89. doi:10.1016/j.intimp.2018.01.016
   PubMed Web of Science ®Google Scholar
• Psychogios N, Hau DD, Peng J, et al. The human serum metabolome. PLoS One. 2011;6(2):e16957. doi:10.1371/journal.pone.0016957
   PubMed Web of Science ®Google Scholar
• Pérez-Enciso M, Tenenhaus M. Prediction of clinical outcome with microarray data: a partial least squares discriminant analysis (PLS-DA) approach. Hum Genet. 2003;112(5–6):581–592. doi:10.1007/s00439-003-0921-9
   PubMed Web of Science ®Google Scholar
• Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics. 2011;27(3):431–432. doi:10.1093/bioinformatics/btq675
   PubMed Web of Science ®Google Scholar
• Ma HL, Liang S, Li J, et al. IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest. 2008;118(2):597–607. doi:10.1172/JCI33263
   PubMed Web of Science ®Google Scholar
• Daniela F. New Insights Into the Molecular and Cellular Requirements of Lymphocyte Development [doctoral thesis]. Basel: University of Basel, Faculty of Science; 2016:32–106.
   Google Scholar
• Sierra-Filardi E, Puig-Krger A, Blanco FJ, et al. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood. 2011;117(19):5092–5101. doi:10.1182/blood-2010-09-306993
   PubMed Web of Science ®Google Scholar
• Vishnyakova P, Poltavets A, Karpulevich E, et al. The response of two polar monocyte subsets to inflammation. Biomed Pharmacother. 2021;139(327):111614. doi:10.1016/j.biopha.2021.111614
   PubMedGoogle Scholar
• Rodgers LC, Cole J, Rattigan KM, et al. The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion. Rheumatology. 2020;59(4):869–878. doi:10.1093/rheumatology/kez378
   PubMed Web of Science ®Google Scholar
• Lotfi N, Zhang GX, Esmaeil N, Rostami A. Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes. Sci Rep-UK. 2020;10(1):1567. doi:10.1038/s41598-020-58131-2
   PubMed Web of Science ®Google Scholar
• Larysa BB, Valentina MK. Pyrazinamide effects on cartilage type II collagen amino acid composition. Int J Pept. 2012;2012:781785. doi:10.1155/2012/781785
   PubMedGoogle Scholar
• Rhoads JP, Major AS, Rathmell JC. Fine tuning of immunometabolism for the treatment of rheumatic diseases. Nat Rev Rheumatol. 2017;13(5):313–320. doi:10.1038/nrrheum.2017.54
   PubMed Web of Science ®Google Scholar
• Wang R, Li DF, Hu YF, et al. Qing-Luo-Yin alleviated monocytes/macrophages-mediated inflammation in rats with adjuvant-induced arthritis by disrupting their interaction with (pre)-adipocytes through PPAR-γ signaling. Drug Des Devel Ther. 2021;15:3105–3118. doi:10.2147/DDDT.S320599
   PubMed Web of Science ®Google Scholar
• Kiefer J, Zeller J, Bogner B, et al. An unbiased flow cytometry-based approach to assess subset-specific circulating monocyte activation and cytokine profile in whole blood. Front Immunol. 2021;12:641224. doi:10.3389/fimmu.2021.641224
   PubMed Web of Science ®Google Scholar
• Jia Y, Han S, Li J, et al. IRF8 is the target of SIRT1 for the inflammation response in macrophages. Innate Immun. 2017;23(2):188–195. doi:10.1177/1753425916683751
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhou L, Xu Y, et al. A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis. Nature. 2020;586(7829):434–439. doi:10.1038/s41586-020-2799-2
   PubMed Web of Science ®Google Scholar
• Li S, Lu AP, Wang YY, Li YD. Suppressive effects of a Chinese herbal medicine Qing-Luo-Yin extract on the angiogenesis of collagen-induced arthritis in rats. Am J Chin Med. 2003;31(5):713–720. doi:10.1142/S0192415X03001430
   PubMed Web of Science ®Google Scholar
• Guo W. Comparative Study On the Effect of Anti-Synovial Angiogenesis of Qingluoyin and Wenluoyin in Rheumatoid Arthritis [master’s dissertation] Beijing: China Academy of Chinese Medical Sciences; 2011:40–70.
   Google Scholar
• Jiang TT, Ji CF, Cheng XP, et al. α-Mangostin alleviated HIF-1α-mediated angiogenesis in rats with adjuvant-induced arthritis by suppressing aerobic glycolysis. Front Pharmacol. 2021. doi:10.3389/fphar.2021.785586
   Web of Science ®Google Scholar
• Zuo J, Wang X, Liu Y, et al. Integrating network pharmacology and metabolomics study on anti-rheumatic mechanisms and antagonistic effects against methotrexate-induced toxicity of Qing-Luo-Yin. Front Pharmacol. 2018;2018:01472. doi:10.3389/fphar.2018.01472
   Google Scholar
• Phillips JL, Azari P. Zinc transferrin. Enhancement of nucleic acid synthesis in phytohemagglutinin-stimulated human lymphocytes. Cell Immunol. 1974;10(1):31–37. doi:10.1016/0008-8749(74)90148-8
   PubMed Web of Science ®Google Scholar
• Wang QH, Li Y, Dou DY, et al. Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation. Int Immunopharmacol. 2021;98:107856. doi:10.1016/j.intimp.2021.107856
   PubMed Web of Science ®Google Scholar
• Li P, Zhao Y, Wu X, et al. Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription. Nucleic Acids Res. 2012;40(4):1609–1620. doi:10.1093/nar/gkr984
   PubMed Web of Science ®Google Scholar