The Neutrophil-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Patients with Heart Failure

References

• Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129–2200. doi:10.1093/eurheartj/ehw128
   PubMed Web of Science ®Google Scholar
• Tognini S, Pasqualetti G, Calsolaro V, Polini A, Caraccio N, Monzani F. Cardiovascular risk and quality of life in elderly people with mild thyroid hormone deficiency. Front Endocrinol (Lausanne). 2014;5:153. doi:10.3389/fendo.2014.00153
   PubMed Web of Science ®Google Scholar
• He T, Mischak M, Clark AL, et al. Urinary peptides in heart failure: a link to molecular pathophysiology. Eur J Heart Fail. 2021;23:1875–1887. doi:10.1002/ejhf.2195
   PubMed Web of Science ®Google Scholar
• Savarese G, Lund LH. Global public health burden of heart failure. Card Fail Rev. 2017;3(1):7–11. doi:10.15420/cfr.2016:25:2
   PubMedGoogle Scholar
• Park JJ, Choi DJ. Current status of heart failure: global and Korea. Korean J Intern Med. 2020;35(3):487–497. doi:10.3904/kjim.2020.120
   PubMed Web of Science ®Google Scholar
• Adamo L, Rocha-Resende C, Prabhu SD, Mann DL. Publisher Correction: reappraising the role of inflammation in heart failure. Nat Rev Cardiol. 2021;18:735. doi:10.1038/s41569-021-00534-3
   PubMed Web of Science ®Google Scholar
• Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med. 2018;52:8–12. doi:10.1016/j.ejim.2018.04.014
   PubMed Web of Science ®Google Scholar
• Don BR, Kaysen G. Serum albumin: relationship to inflammation and nutrition. Semin Dial. 2004;17(6):432–437. doi:10.1111/j.0894-0959.2004.17603.x
   PubMed Web of Science ®Google Scholar
• Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett. 2008;582(13):1783–1787. doi:10.1016/j.febslet.2008.04.057
   PubMed Web of Science ®Google Scholar
• Uthamalingam S, Kandala J, Daley M, et al. Serum albumin and mortality in acutely decompensated heart failure. Am Heart J. 2010;160(6):1149–1155. doi:10.1016/j.ahj.2010.09.004
   PubMed Web of Science ®Google Scholar
• Horwich TB, Kalantar-Zadeh K, MacLellan RW, Fonarow GC. Albumin levels predict survival in patients with systolic heart failure. Am Heart J. 2008;155(5):883–889. doi:10.1016/j.ahj.2007.11.043
   PubMed Web of Science ®Google Scholar
• Gopal DM, Kalogeropoulos AP, Georgiopoulou VV, et al. Serum albumin concentration and heart failure risk the health, aging, and body composition study. Am Heart J. 2010;160(2):279–285. doi:10.1016/j.ahj.2010.05.022
   PubMed Web of Science ®Google Scholar
• Filippatos GS, Desai RV, Ahmed MI, et al. Hypoalbuminaemia and incident heart failure in older adults. Eur J Heart Fail. 2011;13(10):1078–1086. doi:10.1093/eurjhf/hfr088
   PubMed Web of Science ®Google Scholar
• Cui H, Ding X, Li W, Chen H, Li H. The neutrophil percentage to albumin ratio as a new predictor of in-hospital mortality in patients with ST-Segment elevation myocardial infarction. Med Sci Monit. 2019;25:7845–7852. doi:10.12659/MSM.917987
   PubMed Web of Science ®Google Scholar
• Wang B, Li D, Cheng B, Ying B, Gong Y. The neutrophil percentage-to-albumin ratio is associated with all-cause mortality in critically ill patients with acute kidney injury. Biomed Res Int. 2020;2020:5687672. doi:10.1155/2020/5687672
   PubMed Web of Science ®Google Scholar
• Gong Y, Li D, Cheng B, Ying B, Wang B. Increased neutrophil percentage-to-albumin ratio is associated with all-cause mortality in patients with severe sepsis or septic shock. Epidemiol Infect. 2020;148:e87. doi:10.1017/S0950268820000771
   PubMed Web of Science ®Google Scholar
• Tawfik B, Mokdad AA, Patel PM, Li HC, Huerta S. The neutrophil to albumin ratio as a predictor of pathological complete response in rectal cancer patients following neoadjuvant chemoradiation. Anticancer Drugs. 2016;27(9):879–883. doi:10.1097/CAD.0000000000000411
   PubMed Web of Science ®Google Scholar
• Liao YC, Ying HQ, Huang Y, et al. Role of chronic inflammatory ratios in predicting recurrence of resected patients with Stage I-III mucinous colorectal adenocarcinoma. Cancer Manag Res. 2021;13:3455–3464. doi:10.2147/CMAR.S303758
   PubMed Web of Science ®Google Scholar
• Peng Y, Xue Y, Wang J, et al. Association between neutrophil-to-albumin ratio and mortality in patients with cardiogenic shock: a retrospective cohort study. BMJ Open. 2020;10(10):e039860. doi:10.1136/bmjopen-2020-039860
   PubMed Web of Science ®Google Scholar
• Johnson AE, Pollard TJ, Shen L, et al. MIMIC-III, a freely accessible critical care database. Sci Data. 2016;3:160035. doi:10.1038/sdata.2016.35
   PubMed Web of Science ®Google Scholar
• Mann DL, Deswal A, Bozkurt B, Torre-Amione G. New therapeutics for chronic heart failure. Annu Rev Med. 2002;53:59–74. doi:10.1146/annurev.med.53.082901.104004
   PubMed Web of Science ®Google Scholar
• Packer M, Bristow MR, Cohn JN, et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N Engl J Med. 1996;334(21):1349–1355. doi:10.1056/NEJM199605233342101
   PubMed Web of Science ®Google Scholar
• Merit HF; International Steering Committee. Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL randomised intervention trial in congestive heart failure. Lancet. 1999;353(9169):2001–2007. doi:10.1016/S0140-6736(99)04440-2
   PubMed Web of Science ®Google Scholar
• FaBbender K, Mielke O. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet. 1999;353(9146):9–13. doi:10.1016/S0140-6736(98)11181-9
   PubMed Web of Science ®Google Scholar
• Van Linthout S, Tschope C. Inflammation - cause or consequence of heart failure or both? Curr Heart Fail Rep. 2017;14(4):251–265. doi:10.1007/s11897-017-0337-9
   PubMedGoogle Scholar
• Rullman E, Melin M, Mandic M, Gonon A, Fernandez-Gonzalo R, Gustafsson T. Circulatory factors associated with function and prognosis in patients with severe heart failure. Clin Res Cardiol. 2020;109(6):655–672. doi:10.1007/s00392-019-01554-3
   PubMed Web of Science ®Google Scholar
• Smith JA. Neutrophils, host defense, and inflammation: a double-edged sword. J Leukoc Biol. 1994;56(6):672–686. doi:10.1002/jlb.56.6.672
   PubMed Web of Science ®Google Scholar
• Niessner A, Hohensinner PJ, Rychli K, et al. Prognostic value of apoptosis markers in advanced heart failure patients. Eur Heart J. 2009;30(7):789–796. doi:10.1093/eurheartj/ehp004
   PubMed Web of Science ®Google Scholar
• Silvestre-Roig C, Braster Q, Ortega-Gomez A, Soehnlein O. Neutrophils as regulators of cardiovascular inflammation. Nat Rev Cardiol. 2020;17(6):327–340. doi:10.1038/s41569-019-0326-7
   PubMed Web of Science ®Google Scholar
• Bai B, Cheng M, Jiang L, Xu J, Chen H, Xu Y. High neutrophil to lymphocyte ratio and its gene signatures correlate with diastolic dysfunction in heart failure with preserved ejection fraction. Front Cardiovasc Med. 2021;8:614757. doi:10.3389/fcvm.2021.614757
   PubMed Web of Science ®Google Scholar
• Fuhrman MP, Charney P, Mueller CM. Hepatic proteins and nutrition assessment. J Am Diet Assoc. 2004;104(8):1258–1264. doi:10.1016/j.jada.2004.05.213
   PubMedGoogle Scholar
• De Feo P, Lucidi P. Liver protein synthesis in physiology and in disease states. Curr Opin Clin Nutr Metab Care. 2002;5(1):47–50. doi:10.1097/00075197-200201000-00009
   PubMed Web of Science ®Google Scholar
• Mitch WE. Malnutrition: a frequent misdiagnosis for hemodialysis patients. J Clin Invest. 2002;110(4):437–439. doi:10.1172/JCI16494
   PubMed Web of Science ®Google Scholar
• Pasini E, Aquilani R, Gheorghiade M, Dioguardi FS. Malnutrition, muscle wasting and cachexia in chronic heart failure: the nutritional approach. Ital Heart J. 2003;4(4):232–235.
   PubMedGoogle Scholar
• Liu M, Chan CP, Yan BP, et al. Albumin levels predict survival in patients with heart failure and preserved ejection fraction. Eur J Heart Fail. 2012;14(1):39–44. doi:10.1093/eurjhf/hfr154
   PubMed Web of Science ®Google Scholar
• Arques S, Ambrosi P. Human serum albumin in the clinical syndrome of heart failure. J Card Fail. 2011;17(6):451–458. doi:10.1016/j.cardfail.2011.02.010
   PubMed Web of Science ®Google Scholar
• Pasini E, Comini L, Dioguardi FS, et al. Hypoalbuminemia as a marker of protein metabolism disarrangement in patients with stable chronic heart failure. Minerva Med. 2020;111(3):226–238. doi:10.23736/S0026-4806.20.06244-8
   PubMed Web of Science ®Google Scholar