Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality Worldwide for 36 cancers in 185 Countries. A Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Britt KL, Cuzick J, Phillips KA. Key steps for effective breast cancer prevention. Nat Rev Cancer. 2020;20(8):417–436. doi:10.1038/s41568-020-0266-x
   PubMed Web of Science ®Google Scholar
• Thorat MA, Balasubramanian R. Breast cancer prevention in high-risk women. Best Pract Res Clin Obstet Gynaecol. 2020;65:18–31. doi:10.1016/j.bpobgyn.2019.11.006
   PubMed Web of Science ®Google Scholar
• Paluch-Shimon S, Cardoso F, Partridge AH, et al. ESO-ESMO 4th international consensus guidelines for breast cancer in young women (BCY4). Annals Oncol. 2020;31(6):674–696. doi:10.1016/j.annonc.2020.03.284
   PubMed Web of Science ®Google Scholar
• Jin G, Lv J, Yang M, et al. Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study. Lancet Oncol. 2020;21(10):1378–1386. doi:10.1016/S1470-2045(20)30460-5
   PubMed Web of Science ®Google Scholar
• Carr PR, Weigl K, Edelmann D, et al. Estimation of absolute risk of colorectal cancer based on healthy lifestyle, genetic risk, and colonoscopy status in a population-based study. Gastroenterology. 2020;159(1):129–138.e129. doi:10.1053/j.gastro.2020.03.016
   PubMed Web of Science ®Google Scholar
• Johnson KE, Siewert KM, Klarin D, et al. The relationship between circulating lipids and breast cancer risk: a Mendelian randomization study. PLoS Med. 2020;17(9):e1003302. doi:10.1371/journal.pmed.1003302
   PubMed Web of Science ®Google Scholar
• McLaughlin SA, Brunelle CL, Breast Cancer-Related TA. Lymphedema: risk factors, screening, management, and the impact of locoregional treatment. J Clin Oncol. 2020;38(20):2341–2350. doi:10.1200/JCO.19.02896
   PubMed Web of Science ®Google Scholar
• Caffa I, Spagnolo V, Vernieri C, et al. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020;583(7817):620–624. doi:10.1038/s41586-020-2502-7
   PubMed Web of Science ®Google Scholar
• Corn KC, Windham MA, Rafat M. Lipids in the tumor microenvironment: from cancer progression to treatment. Prog Lipid Res. 2020;80:101055. doi:10.1016/j.plipres.2020.101055
   PubMed Web of Science ®Google Scholar
• Bleve A, Durante B, Sica A, Consonni FM. Lipid metabolism and cancer immunotherapy: immunosuppressive myeloid cells at the crossroad. Int J Mol Sci. 2020;21(16):5845. doi:10.3390/ijms21165845
   PubMed Web of Science ®Google Scholar
• Guo R, Chen Y, Borgard H, et al. The function and mechanism of lipid molecules and their roles in the diagnosis and prognosis of breast cancer. Molecules. 2020;25(20):4864. doi:10.3390/molecules25204864
   PubMed Web of Science ®Google Scholar
• Pang B, Zhu Y, Ni J, et al. Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis. Theranostics. 2020;10(5):2309–2326. doi:10.7150/thno.39486
   PubMed Web of Science ®Google Scholar
• Mukherjee A, Chiang CY, Daifotis HA, et al. Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance. Cancer Res. 2020;80(8):1748–1761. doi:10.1158/0008-5472.CAN-19-1999
   PubMed Web of Science ®Google Scholar
• Auciello FR, Bulusu V, Oon C, et al. A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discov. 2019;9(5):617–627. doi:10.1158/2159-8290.CD-18-1212
   PubMed Web of Science ®Google Scholar
• Wu L, Zhang X, Zheng L, et al. RIPK3 orchestrates fatty acid metabolism in tumor-associated macrophages and hepatocarcinogenesis. Cancer Immunol Res. 2020;8(5):710–721. doi:10.1158/2326-6066.CIR-19-0261
   PubMed Web of Science ®Google Scholar
• Wang J, Shidfar A, Ivancic D, et al. Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer. Int J Cancer. 2017;140(11):2484–2497. doi:10.1002/ijc.30680
   PubMed Web of Science ®Google Scholar
• Balaban S, Shearer RF, Lee LS, et al. Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer Metab. 2017;5(1):1. doi:10.1186/s40170-016-0163-7
   PubMed Web of Science ®Google Scholar
• Marino N, German R, Rao X, et al. Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis. NPJ Breast Cancer. 2020;6(1):50. doi:10.1038/s41523-020-00191-8
   PubMed Web of Science ®Google Scholar
• Havas KM, Milchevskaya V, Radic K, et al. Metabolic shifts in residual breast cancer drive tumor recurrence. J Clin Invest. 2017;127(6):2091–2105. doi:10.1172/JCI89914
   PubMed Web of Science ®Google Scholar
• Sirois I, Aguilar-Mahecha A, Lafleur J, et al. A unique morphological phenotype in chemoresistant triple-negative breast cancer reveals metabolic reprogramming and PLIN4 expression as a molecular vulnerability. Mol Cancer Res. 2019;17(12):2492–2507. doi:10.1158/1541-7786.MCR-19-0264
   PubMed Web of Science ®Google Scholar
• Jin X, Demere Z, Nair K, et al. A metastasis map of human cancer cell lines. Nature. 2020;588(7837):331–336. doi:10.1038/s41586-020-2969-2
   PubMed Web of Science ®Google Scholar
• Heer E, Harper A, Escandor N, Sung H, McCormack V, Fidler-Benaoudia MM. Global burden and trends in premenopausal and postmenopausal breast cancer: a population-based study. Lancet Global Health. 2020;8(8):e1027–e1037. doi:10.1016/S2214-109X(20)30215-1
   PubMed Web of Science ®Google Scholar
• Demark-Wahnefried W, Rogers LQ, Gibson JT, et al. Randomized trial of weight loss in primary breast cancer: impact on body composition, circulating biomarkers and tumor characteristics. Int J Cancer. 2020;146(10):2784–2796. doi:10.1002/ijc.32637
   PubMed Web of Science ®Google Scholar
• Hultsch S, Kankainen M, Paavolainen L, et al. Association of tamoxifen resistance and lipid reprogramming in breast cancer. BMC Cancer. 2018;18(1):850. doi:10.1186/s12885-018-4757-z
   PubMed Web of Science ®Google Scholar
• Chen Q, Meng X, Liao Q, Chen M. Versatile interactions and bioinformatics analysis of noncoding RNAs. Brief Bioinform. 2019;20(5):1781–1794. doi:10.1093/bib/bby050
   PubMed Web of Science ®Google Scholar
• Yan X, He B, Hu L, Gao J, Chen S, Jiang G. Insight into the endocrine disrupting effect and cell response to butyltin compounds in H295R cell: evaluated with proteomics and bioinformatics analysis. Sci Total Environ. 2018;628:1489–1496. doi:10.1016/j.scitotenv.2018.02.165
   PubMed Web of Science ®Google Scholar
• Chang JW, Kuo WH, Lin CM, et al. Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway. Oncogene. 2018;37(30):4137–4150. doi:10.1038/s41388-018-0253-9
   PubMed Web of Science ®Google Scholar
• Kao KJ, Chang KM, Hsu HC, Huang AT. Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. BMC Cancer. 2011;11(1):143. doi:10.1186/1471-2407-11-143
   PubMed Web of Science ®Google Scholar
• Shahid M, Mubeen A, Tse J, et al. Branched chain in situ hybridization for albumin as a marker of hepatocellular differentiation: evaluation of manual and automated in situ hybridization platforms. Am J Surg Pathol. 2015;39(1):25–34. doi:10.1097/PAS.0000000000000343
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. doi:10.1093/nar/gkv007
   PubMed Web of Science ®Google Scholar
• Hasegawa M, Takahashi H, Rajabi H, et al. Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells. Oncotarget. 2016;7(11):11756–11769. doi:10.18632/oncotarget.7598
   PubMedGoogle Scholar
• Yi S, Zhang H, Gong L, et al. Deep sequencing and bioinformatic analysis of lesioned sciatic nerves after crush injury. PLoS One. 2015;10(12):e0143491. doi:10.1371/journal.pone.0143491
   PubMed Web of Science ®Google Scholar
• Cai B, Ma W, Ding F, et al. The long noncoding RNA CAREL controls cardiac regeneration. J Am Coll Cardiol. 2018;72(5):534–550. doi:10.1016/j.jacc.2018.04.085
   PubMed Web of Science ®Google Scholar
• Jin L, Qin C, Qi X, Hong T, Yang X, Zhu X. Clinicopathological significance of Sox10 expression in triple-negative breast carcinoma; 2020.
   Google Scholar
• Hu J, Song K, Zhang J, Zhang Y, Tan BZ. Effects of menstrual blood‑derived stem cells on endometrial injury repair. Mol Med Rep. 2019;19(2):813–820. doi:10.3892/mmr.2018.9744
   PubMed Web of Science ®Google Scholar
• Chen F, Pan SX, Feng HL. [Distribution and content of transforming growth factor-β1 and vascular endothelial growth factor in each layer of concentrated growth factors]. Beijing da Xue Xue Bao Yi Xue Ban. 2016;48(5):860–865. Chinese.
   PubMedGoogle Scholar
• Andrade Wde C, Silva LF, Coelho MC, Tannuri AC, Alves VA, Tannuri U. Effects of the administration of pentoxifylline and prednisolone on the evolution of portal fibrogenesis secondary to biliary obstruction in growing animals: immunohistochemical analysis of the expression of TGF-β and VEGF. Clinics. 2012;67(12):1455–1461. doi:10.6061/clinics/2012(12)17
   PubMed Web of Science ®Google Scholar
• Liao X, Zhu G, Huang R, et al. Identification of potential prognostic microRNA biomarkers for predicting survival in patients with hepatocellular carcinoma. Cancer Manag Res. 2018;10:787–803. doi:10.2147/CMAR.S161334
   PubMed Web of Science ®Google Scholar
• Liao X, Liu X, Yang C, et al. Distinct diagnostic and prognostic values of minichromosome maintenance gene expression in patients with hepatocellular carcinoma. J Cancer. 2018;9(13):2357–2373. doi:10.7150/jca.25221
   PubMed Web of Science ®Google Scholar
• Zhang C, Zheng Y, Li X, Hu X, Qi F, Luo J. Genome-wide mutation profiling and related risk signature for prognosis of papillary renal cell carcinoma. Ann Transl Med. 2019;7(18):427. doi:10.21037/atm.2019.08.113
   PubMed Web of Science ®Google Scholar
• Heagerty PJ, Zheng Y. Survival model predictive accuracy and ROC curves. Biometrics. 2005;61(1):92–105. doi:10.1111/j.0006-341X.2005.030814.x
   PubMed Web of Science ®Google Scholar
• Lin P, He RQ, Ma FC, et al. Systematic analysis of survival-associated alternative splicing signatures in gastrointestinal pan-adenocarcinomas. EBioMedicine. 2018;34:46–60. doi:10.1016/j.ebiom.2018.07.040
   PubMed Web of Science ®Google Scholar
• Sun D, Tian L, Zhu Y, et al. Subunits of ARID1 serve as novel biomarkers for the sensitivity to immune checkpoint inhibitors and prognosis of advanced non-small cell lung cancer. Mol Med. 2020;26(1):78. doi:10.1186/s10020-020-00208-9
   PubMed Web of Science ®Google Scholar
• Liu Y, Wu L, Ao H, et al. Prognostic implications of autophagy-associated gene signatures in non-small cell lung cancer. Aging. 2019;11(23):11440–11462. doi:10.18632/aging.102544
   PubMedGoogle Scholar
• Liu GM, Zeng HD, Zhang CY, Xu JW. Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma. Cancer Cell Int. 2019;19(1):138. doi:10.1186/s12935-019-0858-2
   PubMed Web of Science ®Google Scholar
• He Z, Wang C, Xue H, Zhao R, Li G. Identification of a metabolism-related risk signature associated with clinical prognosis in glioblastoma using integrated bioinformatic analysis. Front Oncol. 2020;10:1631. doi:10.3389/fonc.2020.01631
   PubMed Web of Science ®Google Scholar
• Wang N, Gu Y, Li L, et al. Circular RNA circMYO9B facilitates breast cancer cell proliferation and invasiveness via upregulating FOXP4 expression by sponging miR-4316. Arch Biochem Biophys. 2018;653:63–70. doi:10.1016/j.abb.2018.04.017
   PubMed Web of Science ®Google Scholar
• Jørgensen KJ, Paludan-Müller AS. Breast cancer screening and diagnosis. Ann Intern Med. 2020;172(12):838–839. doi:10.7326/L20-0253
   PubMed Web of Science ®Google Scholar
• Fhu CW, Ali A. Fatty acid synthase: an emerging target in cancer. Molecules. 2020;25(17):17. doi:10.3390/molecules25173935
   Web of Science ®Google Scholar
• Kim JA. Peroxisome metabolism in cancer. Cells. 2020;9:7. doi:10.3390/cells9071692
   Web of Science ®Google Scholar
• Zeleznik OA, Clish CB, Kraft P, Avila-Pacheco J, Eliassen AH, Tworoger SS. Circulating lysophosphatidylcholines, phosphatidylcholines, ceramides, and sphingomyelins and ovarian cancer risk: a 23-year prospective study. J Natl Cancer Inst. 2020;112(6):628–636. doi:10.1093/jnci/djz195
   PubMedGoogle Scholar
• Feng WW, Kurokawa M. Lipid metabolic reprogramming as an emerging mechanism of resistance to kinase inhibitors in breast cancer. Cancer Drug Resist. 2020;3(1). doi:10.20517/cdr.22019.20100
   PubMedGoogle Scholar
• Yang L, Cui X, Zhang N, et al. Comprehensive lipid profiling of plasma in patients with benign breast tumor and breast cancer reveals novel biomarkers. Anal Bioanal Chem. 2015;407(17):5065–5077. doi:10.1007/s00216-015-8484-x
   PubMed Web of Science ®Google Scholar
• Hammad LA, Wu G, Saleh MM, et al. Elevated levels of hydroxylated phosphocholine lipids in the blood serum of breast cancer patients. Rapid Commun Mass Spectrom. 2009;23(6):863–876. doi:10.1002/rcm.3947
   PubMed Web of Science ®Google Scholar
• Kim H, Min HK, Kong G, Moon MH. Quantitative analysis of phosphatidylcholines and phosphatidylethanolamines in urine of patients with breast cancer by nanoflow liquid chromatography/tandem mass spectrometry. Anal Bioanal Chem. 2009;393(6–7):1649–1656. doi:10.1007/s00216-009-2621-3
   PubMed Web of Science ®Google Scholar
• Min HK, Kong G, Moon MH. Quantitative analysis of urinary phospholipids found in patients with breast cancer by nanoflow liquid chromatography-tandem mass spectrometry: II. Negative ion mode analysis of four phospholipid classes. Anal Bioanal Chem. 2010;396(3):1273–1280. doi:10.1007/s00216-009-3292-9
   PubMed Web of Science ®Google Scholar
• Vagia E, Mahalingam D, Cristofanilli M. The landscape of targeted therapies in TNBC. Cancers. 2020;12(4):916. doi:10.3390/cancers12040916
   PubMed Web of Science ®Google Scholar
• Keenan TE, Tolaney SM. Role of immunotherapy in triple-negative breast cancer. J Natl Compr Cancer Netw. 2020;18(4):479–489. doi:10.6004/jnccn.2020.7554
   PubMed Web of Science ®Google Scholar
• Park SY, Choi JH, Nam JS. Targeting cancer stem cells in triple-negative breast cancer. Cancers. 2019;11(7):965. doi:10.3390/cancers11070965
   PubMed Web of Science ®Google Scholar
• Dees S, Ganesan R, Singh S, Grewal IS. Bispecific antibodies for triple negative breast cancer. Trends Cancer. 2021;7(2):162–173. doi:10.1016/j.trecan.2020.09.004
   PubMed Web of Science ®Google Scholar
• Garrido-Castro AC, Lin NU, Polyak K. Insights into molecular classifications of triple-negative breast cancer: improving patient selection for treatment. Cancer Discov. 2019;9(2):176–198. doi:10.1158/2159-8290.CD-18-1177
   PubMed Web of Science ®Google Scholar
• Huynh MM, Pambid MR, Jayanthan A, Dorr A, Los G, Dunn SE. The Dawn of targeted therapies for triple negative breast cancer (TNBC): a snapshot of investigational drugs in Phase I and II trials. Expert Opin Investig Drugs. 2020;29(11):1199–1208. doi:10.1080/13543784.2020.1818067
   PubMed Web of Science ®Google Scholar
• Tacconi EM, Badie S, De Gregoriis G, et al. Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. EMBO Mol Med. 2019;11(7):e9982. doi:10.15252/emmm.201809982
   PubMed Web of Science ®Google Scholar
• Keung MY, Wu Y, Badar F, Vadgama JV. Response of breast cancer cells to PARP inhibitors is independent of BRCA status. J Clin Med. 2020;9:4. doi:10.3390/jcm9040940
   Web of Science ®Google Scholar
• Arun B, Akar U, Gutierrez-Barrera AM, Hortobagyi GN, Ozpolat B. The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells. Int J Oncol. 2015;47(1):262–268. doi:10.3892/ijo.2015.3003
   PubMed Web of Science ®Google Scholar
• Chen XQ, Zhang F, Su QC, Zeng C, Xiao FH, Peng Y. Methylome and transcriptome analyses reveal insights into the epigenetic basis for the good survival of hypomethylated ER-positive breast cancer subtype. Clin Epigenetics. 2020;12(1):16. doi:10.1186/s13148-020-0811-1
   PubMed Web of Science ®Google Scholar
• Kisková T, Kassayová M. Resveratrol action on lipid metabolism in cancer. Int J Mol Sci. 2019;20(11):2704. doi:10.3390/ijms20112704
   PubMed Web of Science ®Google Scholar
• Xu H, Zhou S, Tang Q, Xia H, Bi F. Cholesterol metabolism: new functions and therapeutic approaches in cancer. Biochim Biophys Acta Rev Cancer. 2020;1874(1):188394. doi:10.1016/j.bbcan.2020.188394
   PubMed Web of Science ®Google Scholar
• Ondruskova N, Cechova A, Hansikova H, Honzik T, Jaeken J. Congenital disorders of glycosylation: still “hot” in 2020. Biochim Biophys Acta Gen Subj. 2021;1865(1):129751. doi:10.1016/j.bbagen.2020.129751
   PubMed Web of Science ®Google Scholar
• Guillaumond F, Bidaut G, Ouaissi M, et al. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112(8):2473–2478. doi:10.1073/pnas.1421601112
   PubMed Web of Science ®Google Scholar
• Christodoulatos GS, Spyrou N, Kadillari J, Psallida S, Dalamaga M. The role of adipokines in breast cancer: current evidence and perspectives. Curr Obes Rep. 2019;8(4):413–433. doi:10.1007/s13679-019-00364-y
   PubMed Web of Science ®Google Scholar
• Ke ZB, Wu YP, Huang P, et al. Identification of novel genes in testicular cancer microenvironment based on ESTIMATE algorithm-derived immune scores. J Cell Physiol. 2021;236(1):706–713. doi:10.1002/jcp.29898
   PubMed Web of Science ®Google Scholar
• Graney PL, Tavakol DN, Chramiec A, Ronaldson-Bouchard K, Vunjak-Novakovic G. Engineered models of tumor metastasis with immune cell contributions. I Science. 2021;24(3):102179.
   Google Scholar
• Bosch M, Sánchez-álvarez M, Fajardo A, et al. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science. 2020;370(6514):eaay8085. doi:10.1126/science.aay8085
   PubMed Web of Science ®Google Scholar
• Li Z, Liu H, Luo X. Lipid droplet and its implication in cancer progression. Am J Cancer Res. 2020;10(12):4112–4122.
   PubMed Web of Science ®Google Scholar
• Wright HJ, Hou J, Xu B, et al. CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation. Proc Natl Acad Sci U S A. 2017;114(32):E6556–E6565. doi:10.1073/pnas.1703791114
   PubMed Web of Science ®Google Scholar
• Kwong SC, Jamil AHA, Rhodes A, Taib NA, Chung I. Metabolic role of fatty acid binding protein 7 in mediating triple-negative breast cancer cell death via PPAR-α signaling. J Lipid Res. 2019;60(11):1807–1817. doi:10.1194/jlr.M092379
   PubMed Web of Science ®Google Scholar
• Apaya MK, Hsiao PW, Yang YC, Shyur LF. Deregulating the CYP2C19/epoxy-eicosatrienoic acid-associated FABP4/FABP5 signaling network as a therapeutic approach for metastatic triple-negative breast cancer. Cancers. 2020;12(1):199. doi:10.3390/cancers12010199
   PubMed Web of Science ®Google Scholar
• Kao TJ, Wu CC, Phan NN, et al. Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer. Aging. 2021;13(14):17970. doi:10.18632/aging.203345
   PubMedGoogle Scholar
• Zhou N, Chen X, Xi J, et al. Novel genomic targets of valosin-containing protein in protecting pathological cardiac hypertrophy. Sci Rep. 2020;10(1):18098. doi:10.1038/s41598-020-75128-z
   PubMed Web of Science ®Google Scholar
• Chang TJ, Wang WC, Hsiung CA, et al. Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: a SAPPHIRe Cohort Study. Sci Rep. 2018;8(1):10574. doi:10.1038/s41598-018-28891-z
   PubMed Web of Science ®Google Scholar
• Brandsma CA, Guryev V, Timens W, et al. Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1. Thorax. 2020;75(2):180–183. doi:10.1136/thoraxjnl-2019-213200
   PubMed Web of Science ®Google Scholar
• Mei J, Xing Y, Lv J, et al. Construction of an immune-related gene signature for prediction of prognosis in patients with cervical cancer. Int Immunopharmacol. 2020;88:106882. doi:10.1016/j.intimp.2020.106882
   PubMed Web of Science ®Google Scholar
• Gong C, Hu Y, Zhou M, et al. Identification of specific modules and hub genes associated with the progression of gastric cancer. Carcinogenesis. 2019;40(10):1269–1277. doi:10.1093/carcin/bgz040
   PubMed Web of Science ®Google Scholar
• Aakula A, Kohonen P, Leivonen SK, et al. Systematic identification of microRNAs that impact on proliferation of prostate cancer cells and display changed expression in tumor tissue. Eur Urol. 2016;69(6):1120–1128. doi:10.1016/j.eururo.2015.09.019
   PubMed Web of Science ®Google Scholar
• Cho WC, Jang JE, Kim KH, Yoo BC, Ku JL. SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines. Int J Oncol. 2020;56(5):1140–1151. doi:10.3892/ijo.2020.5006
   PubMed Web of Science ®Google Scholar
• Zhu S, Xiang X, Xu X, Gao S, Mai K, Ai Q. TIR domain-containing adaptor-inducing interferon-β (TRIF) participates in antiviral immune responses and hepatic lipogenesis of large yellow croaker (larimichthys crocea). Front Immunol. 2019;10:2506. doi:10.3389/fimmu.2019.02506
   PubMed Web of Science ®Google Scholar
• Yokoyama S, Cai Y, Murata M, et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death. eLife. 2018;7. doi:10.7554/eLife.37854
   Web of Science ®Google Scholar
• Igal RA. Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis. 2010;31(9):1509–1515. doi:10.1093/carcin/bgq131
   PubMed Web of Science ®Google Scholar
• Gharbaran R. Advances in the molecular functions of syndecan-1 (SDC1/CD138) in the pathogenesis of malignancies. Crit Rev Oncol Hematol. 2015;94(1):1–17. doi:10.1016/j.critrevonc.2014.12.003
   PubMed Web of Science ®Google Scholar
• Spinler K, Bajaj J, Ito T, et al. A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. Nat Commun. 2020;11(1):5998. doi:10.1038/s41467-020-19782-x
   PubMed Web of Science ®Google Scholar
• Stow JL, Hung Y, Wall AA. Macropinocytosis: insights from immunology and cancer. Curr Opin Cell Biol. 2020;65:131–140. doi:10.1016/j.ceb.2020.06.005
   PubMed Web of Science ®Google Scholar
• Betriu N, Bertran-Mas J, Andreeva A, Semino CE. Syndecans and pancreatic ductal adenocarcinoma. Biomolecules. 2021;11(3):3. doi:10.3390/biom11030349
   Web of Science ®Google Scholar
• Hollósi P, Váncza L, Karászi K, et al. Syndecan-1 promotes hepatocyte-like differentiation of hepatoma cells targeting Ets-1 and AP-1. Biomolecules. 2020;10(10):10. doi:10.3390/biom10101356
   Web of Science ®Google Scholar
• Reszegi A, Karászi K, Tóth G, et al. Overexpression of human syndecan-1 protects against the diethylnitrosamine-induced hepatocarcinogenesis in mice. Cancers. 2021;13(7):7. doi:10.3390/cancers13071548
   Web of Science ®Google Scholar
• Chen J, Tang J, Chen W, et al. Effects of syndecan-1 on the expression of syntenin and the migration of U251 glioma cells. Oncol Lett. 2017;14(6):7217–7224. doi:10.3892/ol.2017.7170
   PubMed Web of Science ®Google Scholar
• Sundberg EL, Deng Y, Burd CG. Syndecan-1 mediates sorting of soluble lipoprotein lipase with sphingomyelin-rich membrane in the golgi apparatus. Dev Cell. 2019;51(3):387–398.e384. doi:10.1016/j.devcel.2019.08.014
   PubMed Web of Science ®Google Scholar
• Gharbaran R, Goy A, Tanaka T, et al. Fibroblast growth factor-2 (FGF2) and syndecan-1 (SDC1) are potential biomarkers for putative circulating CD15+/CD30+ cells in poor outcome Hodgkin lymphoma patients. J Hematol Oncol. 2013;6(1):62. doi:10.1186/1756-8722-6-62
   PubMed Web of Science ®Google Scholar
• Lu W, Li N, Liao F. Identification of key genes and pathways in pancreatic cancer gene expression profile by integrative analysis. Genes. 2019;10(8):8. doi:10.3390/genes10080612
   Web of Science ®Google Scholar
• Bowlt Blacklock K, Birand Z, Biasoli D, et al. Identification of molecular genetic contributants to canine cutaneous mast cell tumour metastasis by global gene expression analysis. PLoS One. 2018;13(12):e0208026. doi:10.1371/journal.pone.0208026
   PubMed Web of Science ®Google Scholar
• Rodriguez CP, Wu QV, Voutsinas J, et al. A phase II trial of pembrolizumab and vorinostat in recurrent metastatic head and neck squamous cell carcinomas and salivary gland cancer. Clin Cancer Res. 2020;26(4):837–845. doi:10.1158/1078-0432.CCR-19-2214
   PubMed Web of Science ®Google Scholar
• Yang M, Al Zaharna M, Chen YS, Li L, Cheung HY. In vitro antioxidant activities and anti-proliferative properties of the functional herb Abrus cantoniensis and its main alkaloid abrine. Food Funct. 2014;5(9):2268–2277. doi:10.1039/C4FO00217B
   PubMed Web of Science ®Google Scholar
• Chen KC, Chen CY. In silico identification of potent PPAR-γ agonists from traditional Chinese medicine: a bioactivity prediction, virtual screening, and molecular dynamics study. eCAM. 2014;2014:192452. doi:10.1155/2014/192452
   Web of Science ®Google Scholar
• Laskar S, Espino O, Bandyopadhyay D. Isolation, solid-state structure determination, in silico and in vitro anticancer evaluation of an indole amino acid Alkaloid L-Abrine. Curr Cancer Drug Targets. 2019;19(9):707–715. doi:10.2174/1568009619666190111111937
   PubMed Web of Science ®Google Scholar
• Lee WY, Chen KC, Chen HY, Chen CY. Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancers. Biomed Res Int. 2014;2014:364625. doi:10.1155/2014/364625
   PubMed Web of Science ®Google Scholar
• García-Tojal J, García-Orad A, Díaz AA, et al. Biological activity of complexes derived from pyridine-2-carbaldehyde thiosemicarbazone. Structure of. J Inorg Biochem. 2001;84(3–4):271–278. doi:10.1016/S0162-0134(01)00184-2
   PubMed Web of Science ®Google Scholar
• Hancock CN, Stockwin LH, Han B, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011;50(1):110–121. doi:10.1016/j.freeradbiomed.2010.10.696
   PubMed Web of Science ®Google Scholar