Anti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats

References

• Chiang CP, Chang JYF, Wang YP, Wu YH, Wu YC, Sun A. Recurrent aphthous stomatitis etiology, serum autoantibodies, anemia, hematinic deficiencies, and management. J Formosan Med Assoc. 2019;118:1279–1289. doi:10.1016/j.jfma.2018.10.023
   PubMed Web of Science ®Google Scholar
• Svalastog AL, Donev D, Kristoffersen NJ, Gajović S. Concepts and definitions of health and health-related values in the knowledge landscapes of the digital society. Croat Med J. 2017;58:431–435. doi:10.3325/cmj.2017.58.431
   PubMed Web of Science ®Google Scholar
• Fitzpatrick SG, Cohen DM, Clark AN. Ulcerated lesions of the oral mucosa: clinical and histologic review. Head Neck Pathol. 2019;13(1):91–102. doi:10.1007/s12105-018-0981-8
   PubMed Web of Science ®Google Scholar
• Waasdorp M, Krom BP, Bikker FJ, van Zuijlen PPM, Niessen FB, Gibbs S. The bigger picture: why oral mucosa heals better than skin. Biomolecules. 2021;11(1165):22. doi:10.3390/biom11081165
   Web of Science ®Google Scholar
• Cavalcante GM, Paula RJS, Souza LP, Sousa FB, Mota MRL, Alves APNN. Experimental model of traumatic ulcer in the cheek mucosa of rats. Acta Cirúrgica Brasileira. 2011;26(3):227–234. doi:10.1590/s0102-86502011000300012
   PubMed Web of Science ®Google Scholar
• Woo SB, Setterfield JF, Greenberg MS. Ulcerative, vesicular, and bullous lesions. In: Glick M, Greenberg MS, Lockhart PB, Challacombe SJ, editors. Burket’s Oral Medicine. 13th ed. Hoboken, NJ, USA: Wiley-Blackwell; 2021:35–84.
   Google Scholar
• De Bosscher K, Berghe WV, Haegeman G. Cross-talk between nuclear receptors and nuclear factor kappaB. Oncogene. 2006;25(51):6868–6886. doi:10.1038/sj.onc.1209935
   PubMed Web of Science ®Google Scholar
• Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023. doi:10.1038/sigtrans.2017.23
   PubMed Web of Science ®Google Scholar
• Oliveira BV, de Barros-silva PG, Nojosa JDS, et al. TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats. J Appl Oral Sci. 2016;24(3):278–290. doi:10.1590/1678-775720150481
   PubMed Web of Science ®Google Scholar
• Ferrer MD, Busquets-Cortés C, Capó X, et al. Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. Curr Med Chem. 2019;26(18):3225–3241. doi:10.2174/0929867325666180514112124
   PubMed Web of Science ®Google Scholar
• Wahyuni IS, Sufiawati I, Nittayananta W, Puspitasari IM, Levita J. Efficacy and safety of plant-based therapy on re-current aphthous stomatitis and oral mucositis in the past decade: a systematic review. J Herbmed Pharmacol. 2021;10(2):179–187. doi:10.34172/jhp.2021.19
   Google Scholar
• Umar MI, Asmawi MZ, Sadikun A, Altaf R, Iqbal MA. Review: phytochemistry and medicinal properties of Kaempferia galanga L. (Zingiberaceae) extracts. Afr J Pharm Pharmacol. 2011;5(14):1638–1647. doi:10.5897/AJPP11.388
   Google Scholar
• Wang SY, Zhao H, Xu HT, et al. Kaempferia galanga L.: progresses in phytochemistry, pharmacology, toxicology and ethnomedicinal uses. Front Pharmacol. 2021;12:675350. doi:10.3389/fphar.2021.675350
   PubMed Web of Science ®Google Scholar
• Kumar A. Phytochemistry, pharmacological activities and uses of traditional medicinal plant Kaempferia galanga L. - an overview. J Ethnopharmacol. 2020;10(253):112667. doi:10.1016/j.jep.2020.112667
   Web of Science ®Google Scholar
• Wahyuni IS, Sufiawati I, Nittayananta W, Levita J. Identification of ethyl para-methoxycinnamate and kaempferol in the ethanol extract of Kaempferia galanga L. rhizome as biomaterial for drug candidate using spectrophotometric and chromatographic analysis. Mater Sci Forum. 2021;1028:371–376. doi:10.4028/www.scientific.net/MSF.1028.371
   Google Scholar
• Wahyuni IS, Sufiawati I, Nittayananta W, Levita J. The determination of ethyl p-methoxycinnamate in Kaempferia galanga L. rhizome extract harvested in rainy and dry seasons. Int J App Pharm. 2021;13(4):132–135. doi:10.22159/ijap.2021.v13s4.43841
   PubMedGoogle Scholar
• Umar MI, Asmawi MZ, Sadikun A, et al. Bioactivity-guided isolation of Ethyl-p-methoxycinnamate, an anti-inflammatory constituent from Kaempferia galanga L. extracts. Molecules. 2012;17:8720–8734. doi:10.3390/molecules17078720
   PubMed Web of Science ®Google Scholar
• Umar MI, Asmawi MZ, Sadikun A, et al. Ethyl-p-methoxy cinnamate isolated from Kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-alpha, and angiogenesis by blocking endothelial functions. CLINICS. 2014;69(2):134–144. doi:10.6061/clinics/2014(02)10
   PubMed Web of Science ®Google Scholar
• Levita J, Wijaya LK, Celcilia S, Mutakin M. Inhibitory activity of Kaempferia galanga and Hibiscus sabdariffa on the rate of PGH2 formation. J Appl Sci. 2015;15(7):1032–1036. doi:10.3923/jas.2015.1032.1036
   Google Scholar
• Yao F, Huang Y, Wang Y, He X. Anti-inflammatory diarylheptanoids and phenolics from the rhizomes of kencur (Kaempferia galanga L.). Ind Crops Prod. 2018;125:454–461. doi:10.1016/j.indcrop.2018.09.026
   Web of Science ®Google Scholar
• Aroonrerk N, Kamkaen N. Anti-inflammatory activity of Quercus infectoria, Glycyrrhiza uralensis, Kaempferia galanga, and Coptis chinensis, the main components of Thai herbal remedies for aphthous ulcer. J Health Res. 2009;23(1):17–22.
   Google Scholar
• Kanjanapothi D, Panthong A, Lertprasertsuke N, et al. Toxicity of crude rhizome extract of Kaempferia galanga L. (Proh Hom). J Ethnopharmacol. 2004;90:359–365. doi:10.1016/j.jep.2003.10.020
   PubMed Web of Science ®Google Scholar
• Vittalrao AM, Shanbhag T, Kumari M, Bairy KL, Shenoy S. Evaluation of antiinflammatory and analgesic activities of alcoholic extract of Kaempferia galanga in rats. Indian J Physiol Pharmacol. 2011;55(1):13–24. PMID: 22315806.
   PubMedGoogle Scholar
• Riasari H, Rachmaniar R, Febriani Y. Effectiveness of anti-inflammatory plaster from Kencur (Kaempferia galanga L.) rhizome ethanol extract. Int J Pharm Sci Res. 2016;7(4):1746–1749. doi:10.13040/IJPSR.0975-8232
   Google Scholar
• Samodra G, Febrina D. Anti-inflammatory effects of Kaempferia galanga L. rhizome extract in carrageenan-induced female rats. Adv Health Sci Res. 2019;20(1):13–17. doi:10.2991/ahsr.k.200204.004
   Google Scholar
• Kang MH, Kim BH. Oral wound healing effects of acai berry water extracts in rat oral mucosa. Toxicol Res. 2018;34(2):97–102. doi:10.5487/TR.2018.34.2.097
   PubMed Web of Science ®Google Scholar
• Miao M, Peng M, Xing Z, Liu D. Effect of Shuangjinlian mixture on oral ulcer model in rat. Saudi J Biol Sci. 2019;26:790–794. doi:10.1016/j.sjbs.2019.02.005
   PubMed Web of Science ®Google Scholar
• Sari LM, Mubarak Z, Sari DK. Evaluation of clinical, histology, TNF-α, and collagen expressions on oral ulcer in rats after treatment with areca nut and chrysanthemum oral gel. F1000 Res. 2021;10:623. doi:10.12688/f1000research.54887.1
   Google Scholar
• Surboyo MDC, Mahdani FY, Ayuningtas NF, Santosh ABR, Ernawati DS, Mansur D. The cytotoxicity, anti-inflammation, anti-nociceptive and oral ulcer healing properties of coconut shell liquid smoke. J Herbmed Pharmacol. 2021;10(4):459–467. doi:10.34172/jhp.2021.53
   Google Scholar
• Syahruddin AN, Dahlan CK, Taslim NA. The effects of Kaempferia galanga L. extract on pain, stiffness and functional physic in patient with knee osteoarthritis: double blind randomized clinical trial. Int J Sci Healthcare Res. 2017;2(4):37–43.
   Google Scholar
• Tambunan LV, Lubis W. Effectiveness of Kaempferia galanga Linn Rhizome’s extract towards the healing of minor re-current aphthous stomatitis in RSGMP USU’s patients. Uip Heath Med. 2017;1(1):100–103. doi:10.7454/uiphm.v1i0.35
   Google Scholar
• Kischkel S, Brietzke A, Matschegewski C, Schmidt W, Eickner T, Grabow N. Application of 3R principles in small animal GLP testing of biomaterials. Curr Direct Biomed Eng. 2019;5(1):335–338. doi:10.1515/cdbme-2019-0084
   Google Scholar
• Mellor DJ. Updating animal welfare thinking: moving beyond the “five freedoms” towards “a life worth living”. Animals. 2016;6(21):1–20. doi:10.3390/ani6030021
   Web of Science ®Google Scholar
• Idrus E, Hartanti PD, Suniarti DF, Prasetyo SR, Wimardhani YS, Subarnbhesaj A. An experimental model of chemically-induced ulceration of the buccal mucosa of Mus musculus. Makara J Health Res. 2019;23(3):181–187. doi:10.7454/msk.v23i3.1158
   Web of Science ®Google Scholar
• Lesmana R, Goenawan H, Dewi FNA. Pedoman Penggunaan Tikus Sebagai Hewan Uji Laboratorium (Guidelines for the Use of Rats as Laboratory Test Animals). 1st ed. Jakarta, Indonesia: Penerbit Buku Kedokteran EGC; 2017:20–24.
   Google Scholar
• Yau YH, Potenza MN. Stress and eating behaviors. Minerva Endocrinol. 2013;38(3):255–267. PMID: 24126546; PMCID: PMC4214609.
   PubMed Web of Science ®Google Scholar
• Ridtitid W, Sae-wong C, Reanmongkol W, Wongnawa M. Antinociceptive activity of the methanolic extract of Kaempferia galanga Linn. in experimental animals. J Ethnopharmacol. 2008;118(2):225–230. doi:10.1016/j.jep.2008.04.002
   PubMed Web of Science ®Google Scholar
• Jagadish PC, Latha KP, Mudgal J, Nampurath GK. Extraction, characterization and evaluation of Kaempferia galanga L. (Zingiberaceae) rhizome extracts against acute and chronic inflammation in rats. J Ethnopharmacol. 2016;194:434–439. doi:10.1016/j.jep.2016.10.010
   PubMed Web of Science ®Google Scholar
• Elshamy AI, Mohamed TA, Essa AF, et al. Recent advances in Kaempferia phytochemistry and biological activity: a comprehensive review. Nutrients. 2019;11(10):2396. doi:10.3390/nu11102396
   PubMed Web of Science ®Google Scholar
• Sidhu G, Preuss CV. Triamcinolone. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2021. Available from: https://www.ncbi.nlm.nih.gov/books/NBK544309/. Accessed March 23, 2022.
   Google Scholar