Predicting Mucosal Healing in Crohn’s Disease: A Nomogram Model Developed from a Retrospective Cohort

References

• D’Haens G, Kelly O, Battat R., et al. Development and validation of a test to monitor endoscopic activity in patients with Crohn’s disease based on serum levels of proteins. Gastroenterology. 2020;158(3):515–526 e10. doi:10.1053/j.gastro.2019.10.034
   PubMed Web of Science ®Google Scholar
• Ungaro RC, Yzet C, Bossuyt P, et al. Deep remission at 1 year prevents progression of early Crohn’s disease. Gastroenterology. 2020;159(1):139–147. doi:10.1053/j.gastro.2020.03.039
   PubMed Web of Science ®Google Scholar
• Ungaro RC, Aggarwal S, Topaloglu O, Lee WJ, Clark R, Colombel JF. Systematic review and meta-analysis: efficacy and safety of early biologic treatment in adult and paediatric patients with Crohn’s disease. Aliment Pharmacol Ther. 2020;51(9):831–842. doi:10.1111/apt.15685
   PubMed Web of Science ®Google Scholar
• Oliva S, Aloi M, Viola F, et al. A treat to target strategy using panenteric capsule endoscopy in pediatric patients with Crohn’s disease. Clin Gastroenterol Hepatol. 2019;17(10):2060–2067. doi:10.1016/j.cgh.2018.10.015
   PubMed Web of Science ®Google Scholar
• Panaccione R, Colombel JF, Travis SP, et al. Tight control for Crohn’s disease with Adalimumab-based treatment is cost-effective: an economic assessment of the CALM trial. Gut. 2020;69(4):658–664. doi:10.1136/gutjnl-2019-318256
   PubMed Web of Science ®Google Scholar
• Berg DR, Colombel JF, Ungaro R. The role of early biologic therapy in inflammatory bowel disease. Inflamm Bowel Dis. 2019;25(12):1896–1905. doi:10.1093/ibd/izz059
   PubMed Web of Science ®Google Scholar
• Cozijnsen MA, Ben Shoham A, Kang B, et al. Development and validation of the mucosal inflammation noninvasive index for pediatric Crohn’s disease. Clin Gastroenterol Hepatol. 2020;18(1):133–140. doi:10.1016/j.cgh.2019.04.012
   PubMed Web of Science ®Google Scholar
• Castiglione F, Imperatore N, Testa A, et al. One-year clinical outcomes with biologics in Crohn’s disease: transmural healing compared with mucosal or no healing. Aliment Pharmacol Ther. 2019;49(8):1026–1039. doi:10.1111/apt.15190
   PubMed Web of Science ®Google Scholar
• Shah SC, Colombel JF, Sands BE, Narula N. Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn’s disease. Aliment Pharmacol Ther. 2016;43(3):317–333. doi:10.1111/apt.13475
   PubMed Web of Science ®Google Scholar
• Barre A, Colombel JF, Ungaro R. Review article: predictors of response to vedolizumab and ustekinumab in inflammatory bowel disease. Aliment Pharmacol Ther. 2018;47(7):896–905. doi:10.1111/apt.14550
   PubMed Web of Science ®Google Scholar
• Colombel JF, Adedokun OJ, Gasink C, et al. Combination therapy with infliximab and azathioprine improves infliximab pharmacokinetic features and efficacy: a post hoc analysis. Clin Gastroenterol Hepatol. 2019;17(8):1525–1532. doi:10.1016/j.cgh.2018.09.033
   PubMed Web of Science ®Google Scholar
• Mao R, Qiu Y, Chen BL, et al. Factors associated with the achievement of mucosal healing in Crohn’s disease: the benefit of endoscopic monitoring in treating to target. Therap Adv Gastroenterol. 2017;10(6):453–463. doi:10.1177/1756283X17698089
   PubMed Web of Science ®Google Scholar
• Dulai PS, Boland BS, Singh S, et al. Development and validation of a scoring system to predict outcomes of vedolizumab treatment in patients with Crohn’s disease. Gastroenterology. 2018;155(3):687–695. doi:10.1053/j.gastro.2018.05.039
   PubMed Web of Science ®Google Scholar
• Ben-Horin S, Lahat A, Amitai MM, et al. Assessment of small bowel mucosal healing by video capsule endoscopy for the prediction of short-term and long-term risk of Crohn’s disease flare: a prospective cohort study. Lancet Gastroenterol Hepatol. 2019;4(7):519–528. doi:10.1016/S2468-1253(19)30088-3
   PubMed Web of Science ®Google Scholar
• Albshesh A, Ungar B, Ben-Horin S, Eliakim R, Kopylov U, Carter D. Terminal ileum thickness during maintenance therapy is a predictive marker of the outcome of infliximab therapy in Crohn disease. Inflamm Bowel Dis. 2020;26(10):1619–1625. doi:10.1093/ibd/izaa219
   PubMed Web of Science ®Google Scholar
• Tang N, Chen H, Chen R, Tang W, Zhang H. Combination of serological biomarkers and clinical features to predict mucosal healing in Crohn’s disease: a multicenter cohort study. BMC Gastroenterol. 2022;22(1):229. doi:10.1186/s12876-022-02304-y
   PubMed Web of Science ®Google Scholar
• Alkhatry M, Al-Rifai A, Annese V, et al. First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases: a 2020 Delphi consensus. World J Gastroenterol. 2020;26(43):6710–6769. doi:10.3748/wjg.v26.i43.6710
   PubMed Web of Science ®Google Scholar
• Cerrillo E, Moret I, Iborra M, et al. A nomogram combining fecal calprotectin levels and plasma cytokine profiles for individual prediction of postoperative Crohn’s disease recurrence. Inflamm Bowel Dis. 2019;25(10):1681–1691. doi:10.1093/ibd/izz053
   PubMed Web of Science ®Google Scholar
• Harvey RF, Bradshaw JM. A simple index of Crohn’s-disease activity. Lancet. 1980;1(8167):514. doi:10.1016/S0140-6736(80)92767-1
   PubMed Web of Science ®Google Scholar
• Bjorkesten CG, Nieminen U, Turunen U, Arkkila PE, Sipponen T, Farkkila MA. Endoscopic monitoring of infliximab therapy in Crohn’s disease. Inflamm Bowel Dis. 2011;17(4):947–953. doi:10.1002/ibd.21439
   PubMed Web of Science ®Google Scholar
• Park Y, Cheon JH, Park YL, et al. Development of a novel predictive model for the clinical course of Crohn’s disease: results from the CONNECT study. Inflamm Bowel Dis. 2017;23(7):1071–1079. doi:10.1097/MIB.0000000000001106
   PubMed Web of Science ®Google Scholar
• Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55(6):749–753. doi:10.1136/gut.2005.082909
   PubMed Web of Science ®Google Scholar
• Hoekman DR, Stibbe JA, Baert FJ, et al. Long-term outcome of early combined immunosuppression versus conventional management in newly diagnosed Crohn’s disease. J Crohns Colitis. 2018;12(5):517–524. doi:10.1093/ecco-jcc/jjy014
   PubMed Web of Science ®Google Scholar
• Lichtenstein GR, Loftus EV, Isaacs KL, Regueiro MD, Gerson LB, Sands BE. ACG Clinical Guideline: management of Crohn’s disease in adults. Am J Gastroenterol. 2018;113(4):481–517. doi:10.1038/ajg.2018.27
   PubMed Web of Science ®Google Scholar
• Hanzel J. A novel endoscopic score for postoperative recurrence of Crohn’s disease: more information needed. Am J Gastroenterol. 2021;116(1):217–218. doi:10.14309/ajg.0000000000000918
   PubMed Web of Science ®Google Scholar
• Buisson A, Hordonneau C, Goutorbe F, et al. Bowel wall healing assessed using magnetic resonance imaging predicts sustained clinical remission and decreased risk of surgery in Crohn’s disease. J Gastroenterol. 2019;54(4):312–320. doi:10.1007/s00535-018-1505-8
   PubMed Web of Science ®Google Scholar
• Laterza L, Piscaglia AC, Minordi LM, et al. Multiparametric evaluation predicts different mid-term outcomes in Crohn’s disease. Dig Dis. 2018;36(3):184–193. doi:10.1159/000487589
   PubMed Web of Science ®Google Scholar
• Feagan B, Sandborn WJ, Rutgeerts P, et al. Performance of Crohn’s disease clinical trial endpoints based upon different cutoffs for patient reported outcomes or endoscopic activity: analysis of EXTEND data. Inflamm Bowel Dis. 2018;24(5):932–942. doi:10.1093/ibd/izx082
   PubMed Web of Science ®Google Scholar
• Bouguen G, Levesque BG, Pola S, Evans E, Sandborn WJ. Endoscopic assessment and treating to target increase the likelihood of mucosal healing in patients with Crohn’s disease. Clin Gastroenterol Hepatol. 2014;12(6):978–985. doi:10.1016/j.cgh.2013.11.005
   PubMed Web of Science ®Google Scholar
• Wu Y, Lin B, Thilakanathan C, et al. Therapeutic drug monitoring in inflammatory bowel disease reduces unnecessary use of infliximab with substantial associated cost-savings. Intern Med J. 2021;51(5):739–745. doi:10.1111/imj.14644
   PubMed Web of Science ®Google Scholar
• Lee JS, Kim ES, Moon W. Chronological review of endoscopic indices in inflammatory bowel disease. Clin Endosc. 2019;52(2):129–136. doi:10.5946/ce.2018.042
   PubMed Web of Science ®Google Scholar
• Levesque BG, Sandborn WJ, Ruel J, Feagan BG, Sands BE, Colombel JF. Converging goals of treatment of inflammatory bowel disease from clinical trials and practice. Gastroenterology. 2015;148(1):37–51. doi:10.1053/j.gastro.2014.08.003
   PubMed Web of Science ®Google Scholar
• Bemelman WA, Warusavitarne J, Sampietro GM, et al. ECCO-ESCP consensus on surgery for Crohn’s disease. J Crohns Colitis. 2018;12(1):1–16. doi:10.1093/ecco-jcc/jjx061
   PubMed Web of Science ®Google Scholar