Neutrophil to High-Density Lipoprotein Ratio is Associated with Hemorrhagic Transformation in Patients with Acute Ischemic Stroke

References

• Castro P, Azevedo E, Serrador J, Rocha I, Sorond F. Hemorrhagic transformation and cerebral edema in acute ischemic stroke: link to cerebral autoregulation. J Neurol Sci. 2017;372:256–261. doi:10.1016/j.jns.2016.11.065
   PubMed Web of Science ®Google Scholar
• Jickling GC, Liu D, Stamova B, et al. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab. 2014;34(2):185–199. doi:10.1038/jcbfm.2013.203
   PubMed Web of Science ®Google Scholar
• Rao NM, Levine SR, Gornbein JA, Saver JL. Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the National Institute of Neurological Disorders and Stroke tissue-type plasminogen activator trials. Stroke. 2014;45(9):2728–2733. doi:10.1161/STROKEAHA.114.005135
   PubMed Web of Science ®Google Scholar
• Nagaraja N, Tasneem N, Shaban A, et al. Cerebral microbleeds are an independent predictor of hemorrhagic transformation following intravenous alteplase administration in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2018;27(5):1403–1411. doi:10.1016/j.jstrokecerebrovasdis.2017.12.044
   PubMed Web of Science ®Google Scholar
• Fiorelli M, Bastianello S, von Kummer R, et al. Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort. Stroke. 1999;30(11):2280–2284. doi:10.1161/01.STR.30.11.2280
   PubMed Web of Science ®Google Scholar
• Ng FC, Churilov L, Yassi N, et al. Microvascular dysfunction in blood-brain barrier disruption and hypoperfusion within the infarct posttreatment are associated with cerebral edema. Stroke. 2021;53(5):1597–1605.
   PubMed Web of Science ®Google Scholar
• Rosell A, Foerch C, Murata Y, Lo EH. Mechanisms and markers for hemorrhagic transformation after stroke. Acta Neurochir Suppl. 2008;105:173–178.
   PubMedGoogle Scholar
• Turner RJ, Sharp FR. Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke. Front Cell Neurosci. 2016;10:56. doi:10.3389/fncel.2016.00056
   PubMed Web of Science ®Google Scholar
• Sarvari S, Moakedi F, Hone E, Simpkins JW, Ren X. Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke. Metab Brain Dis. 2020;35(6):851–868. doi:10.1007/s11011-020-00573-8
   PubMed Web of Science ®Google Scholar
• Guo Z, Yu S, Xiao L, et al. Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke. J Neuroinflammation. 2016;13(1):199. doi:10.1186/s12974-016-0680-x
   PubMed Web of Science ®Google Scholar
• Song Q, Li Y, Wang Y, Wei C, Liu J, Liu M. Increased neutrophil-to-lymphocyte ratios are associated with greater risk of hemorrhagic transformation in patients with acute ischemic stroke. Curr Neurovasc Res. 2018;15(4):326–335. doi:10.2174/1567202616666181204122457
   PubMed Web of Science ®Google Scholar
• Semerano A, Strambo D, Martino G, et al. Leukocyte counts and ratios are predictive of stroke outcome and hemorrhagic complications independently of infections. Front Neurol. 2020;11:201. doi:10.3389/fneur.2020.00201
   PubMed Web of Science ®Google Scholar
• Malekmohammad K, Bezsonov EE, Rafieian-Kopaei M. Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms. Front Cardiovasc Med. 2021;8:707529. doi:10.3389/fcvm.2021.707529
   PubMed Web of Science ®Google Scholar
• Wang HH, Garruti G, Liu M, Portincasa P, Wang DQ. Cholesterol and lipoprotein metabolism and atherosclerosis: recent advances in reverse cholesterol transport. Ann Hepatol. 2017;16(Suppl 1):S27–S42. doi:10.5604/01.3001.0010.5495
   PubMed Web of Science ®Google Scholar
• Yu C, Wan Y, Xu W, et al. Increased circulating cathepsin L in patients with coronary artery disease. Int Heart J. 2021;62(1):9–15. doi:10.1536/ihj.20-182
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li J, Liu C, et al. High-density lipoprotein cholesterol and the risk of first ischemic stroke in a Chinese hypertensive population. Clin Interv Aging. 2021;16:801–810. doi:10.2147/CIA.S295252
   PubMed Web of Science ®Google Scholar
• Yuan S, Tang B, Zheng J, Larsson SC. Circulating lipoprotein lipids, apolipoproteins and ischemic stroke. Ann Neurol. 2020;88(6):1229–1236. doi:10.1002/ana.25916
   PubMed Web of Science ®Google Scholar
• Lin SF, Chao AC, Hu HH, et al. Low cholesterol levels increase symptomatic intracranial hemorrhage rates after intravenous thrombolysis: a multicenter cohort validation study. J Atheroscler Thromb. 2019;26(6):513–527. doi:10.5551/jat.46151
   PubMed Web of Science ®Google Scholar
• Messe SR, Pervez MA, Smith EE, et al. Lipid profile, lipid-lowering medications, and intracerebral hemorrhage after tPA in get with the guidelines-stroke. Stroke. 2013;44(5):1354–1359. doi:10.1161/STROKEAHA.111.671966
   PubMed Web of Science ®Google Scholar
• Rocco A, Sykora M, Ringleb P, Diedler J. Impact of statin use and lipid profile on symptomatic intracerebral haemorrhage, outcome and mortality after intravenous thrombolysis in acute stroke. Cerebrovasc Dis. 2012;33(4):362–368. doi:10.1159/000335840
   PubMed Web of Science ®Google Scholar
• Lin TC, Lin YK, Chen CI, et al. Serum lipid level is not associated with symptomatic intracerebral hemorrhage after intravenous thrombolysis for acute ischemic stroke. PeerJ. 2018;6:e6021. doi:10.7717/peerj.6021
   PubMed Web of Science ®Google Scholar
• Curcic S, Holzer M, Frei R, et al. Neutrophil effector responses are suppressed by secretory phospholipase A2 modified HDL. Biochim Biophys Acta. 2015;1851(2):184–193. doi:10.1016/j.bbalip.2014.11.010
   PubMed Web of Science ®Google Scholar
• Cogny A, Atger V, Paul JL, Soni T, Moatti N. High-density lipoprotein 3 physicochemical modifications induced by interaction with human polymorphonuclear leucocytes affect their ability to remove cholesterol from cells. Biochem J. 1996;314(Pt 1)):285–292. doi:10.1042/bj3140285
   PubMed Web of Science ®Google Scholar
• Huang JB, Chen YS, Ji HY, et al. Neutrophil to high-density lipoprotein ratio has a superior prognostic value in elderly patients with acute myocardial infarction: a comparison study. Lipids Health Dis. 2020;19(1):59. doi:10.1186/s12944-020-01238-2
   PubMed Web of Science ®Google Scholar
• Kou T, Luo H, Yin L. Relationship between neutrophils to HDL-C ratio and severity of coronary stenosis. BMC Cardiovasc Disord. 2021;21(1):127. doi:10.1186/s12872-020-01771-z
   PubMed Web of Science ®Google Scholar
• Aho K, Harmsen P, Hatano S, Marquardsen J, Smirnov VE, Strasser T. Cerebrovascular disease in the community: results of a WHO collaborative study. Bull World Health Organ. 1980;58(1):113–130.
   PubMed Web of Science ®Google Scholar
• Adams HP, Del Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke. 2007;38(5):1655–1711. doi:10.1161/STROKEAHA.107.181486
   PubMed Web of Science ®Google Scholar
• Sacco RL, Kasner SE, Broderick JP, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064–2089. doi:10.1161/STR.0b013e318296aeca
   PubMed Web of Science ®Google Scholar
• Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35–41. doi:10.1161/01.STR.24.1.35
   PubMed Web of Science ®Google Scholar
• Li JJ, Gu HQ, Peng YJ, et al. The association of lipid profile and bleeding in patients with minor stroke or transient ischemic attack on antiplatelet therapy: subgroup analysis of CHANCE. Zhonghua Nei Ke Za Zhi. 2018;57(10):723–730. Chinese. doi:10.3760/cma.j.issn.0578-1426.2018.10.006
   PubMedGoogle Scholar
• Nakamura A, Otani K, Shichita T. Lipid mediators and sterile inflammation in ischemic stroke. Int Immunol. 2020;32(11):719–725. doi:10.1093/intimm/dxaa027
   PubMed Web of Science ®Google Scholar
• Wang MQ, Sun YY, Wang Y, et al. Platelet-to-neutrophil ratio after intravenous thrombolysis predicts unfavorable outcomes in acute ischemic stroke. Curr Neurovasc Res. 2020;17(4):411–419. doi:10.2174/1567202617666200517111802
   PubMed Web of Science ®Google Scholar
• Jiang M, Sun J, Zou H, et al. Prognostic role of neutrophil to high-density lipoprotein cholesterol ratio for all-cause and cardiovascular mortality in the general population. Front Cardiovasc Med. 2022;9:807339. doi:10.3389/fcvm.2022.807339
   PubMed Web of Science ®Google Scholar
• Segel GB, Halterman MW, Lichtman MA. The paradox of the neutrophil’s role in tissue injury. J Leukoc Biol. 2011;89(3):359–372. doi:10.1189/jlb.0910538
   PubMed Web of Science ®Google Scholar
• Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR. Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab. 2015;35(6):888–901. doi:10.1038/jcbfm.2015.45
   PubMed Web of Science ®Google Scholar
• Sorvillo N, Cherpokova D, Martinod K, Wagner DD. Extracellular DNA NET-works with dire consequences for health. Circ Res. 2019;125(4):470–488. doi:10.1161/CIRCRESAHA.119.314581
   PubMed Web of Science ®Google Scholar
• Brill A, Fuchs TA, Savchenko AS, et al. Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost. 2012;10(1):136–144. doi:10.1111/j.1538-7836.2011.04544.x
   PubMed Web of Science ®Google Scholar
• Puy L, Corseaux D, Perbet R, Deramecourt V, Cordonnier C, Berezowski V. Neutrophil extracellular traps (NETs) infiltrate haematoma and surrounding brain tissue after intracerebral haemorrhage: a post-mortem study. Neuropathol Appl Neurobiol. 2021;47(6):867–877. doi:10.1111/nan.12733
   PubMed Web of Science ®Google Scholar
• Denorme F, Portier I, Rustad JL, et al. Neutrophil extracellular traps regulate ischemic stroke brain injury. J Clin Invest. 2022;132(10). doi:10.1172/JCI154225
   Web of Science ®Google Scholar
• Rohatgi A. High-density lipoprotein function measurement in human studies: focus on cholesterol efflux capacity. Prog Cardiovasc Dis. 2015;58(1):32–40. doi:10.1016/j.pcad.2015.05.004
   PubMed Web of Science ®Google Scholar
• Wang Y, Cheng Y, Song Q, et al. The association between monocyte to high-density lipoprotein ratio and hemorrhagic transformation in patients with acute ischemic stroke. Aging. 2020;12(3):2498–2506. doi:10.18632/aging.102757
   PubMedGoogle Scholar
• Chen G, Yang N, Ren J, et al. Neutrophil counts to high-density lipoprotein cholesterol ratio: a potential predictor of prognosis in acute ischemic stroke patients after intravenous thrombolysis. Neurotox Res. 2020;38(4):1001–1009. doi:10.1007/s12640-020-00274-1
   PubMed Web of Science ®Google Scholar