The Role of NLRP3 Inflammasome Signaling on Arrhythmias in Diabetes

References

• Ceriello A, Prattichizzo F, Phillip M, et al. Glycaemic management in diabetes: old and new approaches. Lancet Diabetes Endocrinol. 2022;10(1):75–84. doi:10.1016/S2213-8587(21)00245-X
   PubMed Web of Science ®Google Scholar
• Sun H, Saeedi P, Karuranga S, et al. IDF diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2021;183:109119. doi:10.1016/j.diabres.2021.109119
   PubMed Web of Science ®Google Scholar
• Echouffo-Tcheugui JB, Shrader P, Thomas L, et al. Care patterns and outcomes in atrial fibrillation patients with and without diabetes: ORBIT-AF Registry. J Am Coll Cardiol. 2017;70(11):1325–1335. doi:10.1016/j.jacc.2017.07.755
   PubMed Web of Science ®Google Scholar
• Weidner K, Behnes M, Schupp T, et al. Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias. Cardiovasc Diabetol. 2018;17(1):125. doi:10.1186/s12933-018-0768-y
   PubMed Web of Science ®Google Scholar
• Lynge TH, Svane J, Pedersen-Bjergaard U, et al. Sudden cardiac death among persons with diabetes aged 1–49 years: a 10-year nationwide study of 14 294 deaths in Denmark. Eur Heart J. 2020;41(28):2699–2706. doi:10.1093/eurheartj/ehz891
   PubMed Web of Science ®Google Scholar
• Powers MA, Bardsley J, Cypress M, et al. Diabetes self-management education and support in type 2 diabetes: a joint position statement of the American diabetes association, the American association of diabetes educators, and the academy of nutrition and dietetics. Diabetes Care. 2015;38(7):1372–1382. doi:10.2337/dc15-0730
   PubMed Web of Science ®Google Scholar
• Karam BS, Chavez-Moreno A, Koh W, et al. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovasc Diabetol. 2017;16(1):120. doi:10.1186/s12933-017-0604-9
   PubMed Web of Science ®Google Scholar
• Grune J, Yamazoe M, Nahrendorf M. Electroimmunology and cardiac arrhythmia. Nat Rev Cardiol. 2021;18(8):547–564. doi:10.1038/s41569-021-00520-9
   PubMed Web of Science ®Google Scholar
• Varghese B, Feldman DI, Chew C, et al. Inflammation, atrial fibrillation, and the potential role for colchicine therapy. Heart Rhythm O2. 2021;2(3):298–303. doi:10.1016/j.hroo.2021.03.011
   PubMedGoogle Scholar
• Bai Y, Mu Q, Bao X, et al. Targeting NLRP3 inflammasome in the treatment Of diabetes and diabetic complications: role of natural compounds from herbal medicine. Aging Dis. 2021;12(7):1587–1604. doi:10.14336/AD.2021.0318
   PubMed Web of Science ®Google Scholar
• Sharma A, Tate M, Mathew G, et al. Oxidative stress and NLRP3-inflammasome activity as significant drivers of diabetic cardiovascular complications: therapeutic implications. Front Physiol. 2018;9:114. doi:10.3389/fphys.2018.00114
   PubMed Web of Science ®Google Scholar
• Menini S, Iacobini C, Vitale M, et al. The Inflammasome in chronic complications of diabetes and related metabolic disorders. Cells. 2020;9(8):1812. doi:10.3390/cells9081812
   PubMed Web of Science ®Google Scholar
• Sokolova M, Ranheim T, Louwe MC, et al. NLRP3 inflammasome: a novel player in metabolically induced inflammation-potential influence on the myocardium. J Cardiovasc Pharmacol. 2019;74(4):276–284. doi:10.1097/FJC.0000000000000704
   PubMed Web of Science ®Google Scholar
• Monnerat G, Alarcon ML, Vasconcellos LR, et al. Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice. Nat Commun. 2016;7:13344. doi:10.1038/ncomms13344
   PubMed Web of Science ®Google Scholar
• Li Y, Huang H, Liu B, et al. Inflammasomes as therapeutic targets in human diseases. Signal Transduct Target Ther. 2021;6(1):247. doi:10.1038/s41392-021-00650-z
   PubMed Web of Science ®Google Scholar
• Rathinam VA, Vanaja SK, Fitzgerald KA. Regulation of inflammasome signaling. Nat Immunol. 2012;13(4):333–342. doi:10.1038/ni.2237
   PubMed Web of Science ®Google Scholar
• Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of pro-IL-beta. Mol Cell. 2002;10(2):417–426. doi:10.1016/s1097-2765(02)00599-3
   PubMed Web of Science ®Google Scholar
• Kanneganti TD. The inflammasome: firing up innate immunity. Immunol Rev. 2015;265(1):1–5. doi:10.1111/imr.12297
   PubMed Web of Science ®Google Scholar
• Ratsimandresy RA, Dorfleutner A, Stehlik C. An update on PYRIN domain-containing pattern recognition receptors: from immunity to pathology. Front Immunol. 2013;4:440. doi:10.3389/fimmu.2013.00440
   PubMed Web of Science ®Google Scholar
• Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19(8):477–489. doi:10.1038/s41577-019-0165-0
   PubMed Web of Science ®Google Scholar
• Monteleone M, Stow JL, Schroder K. Mechanisms of unconventional secretion of IL-1 family cytokines. Cytokine. 2015;74(2):213–218. doi:10.1016/j.cyto.2015.03.022
   PubMed Web of Science ®Google Scholar
• Grebe A, Hoss F, Latz E. NLRP3 Inflammasome and the IL-1 pathway in atherosclerosis. Circ Res. 2018;122(12):1722–1740. doi:10.1161/CIRCRESAHA.118.311362
   PubMed Web of Science ®Google Scholar
• Xiao H, Li H, Wang JJ, et al. IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult. Eur Heart J. 2018;39(1):60–69. doi:10.1093/eurheartj/ehx261
   PubMed Web of Science ®Google Scholar
• Enni JBA, Ninh V, Miyamoto S, et al. NLRP3 inflammasome products IL-1beta and IL-18 have a direct effect on cardiomyocytes. FASEB J. 2020;34(Suppl 1):1. doi:10.1096/fasebj.2020.34.s1.06628
   Web of Science ®Google Scholar
• Sun Y, Ding S. NLRP3 inflammasome in diabetic cardiomyopathy and exercise intervention. Int J Mol Sci. 2021;22(24):13228. doi:10.3390/ijms222413228
   PubMed Web of Science ®Google Scholar
• Frati G, Schirone L, Chimenti I, et al. An overview of the inflammatory signaling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy. Cardiovasc Res. 2017;113(4):378–388. doi:10.1093/cvr/cvx011
   PubMed Web of Science ®Google Scholar
• Qiu Z, Lei S, Zhao B, et al. NLRP3 inflammasome activation-mediated pyroptosis aggravates myocardial ischemia/reperfusion injury in diabetic rats. Oxid Med Cell Longev. 2017;2017:9743280. doi:10.1155/2017/9743280
   PubMed Web of Science ®Google Scholar
• Zhang D, He Y, Ye X, et al. Activation of autophagy inhibits nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation and attenuates myocardial ischemia-reperfusion injury in diabetic rats. J Diabetes Investig. 2020;11(5):1126–1136. doi:10.1111/jdi.13235
   PubMed Web of Science ®Google Scholar
• Zaharieva E, Kamenov Z, Velikova T, et al. Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes. Endocr Connect. 2018;7(1):179–185. doi:10.1530/EC-17-0273
   PubMed Web of Science ®Google Scholar
• Niu J, Gilliland MG, Jin Z, et al. MCP-1and IL-1β expression in the myocardia of two young patients with Type 1 diabetes mellitus and fatal diabetic ketoacidosis. Exp Mol Pathol. 2014;96(1):71–79. doi:10.1016/j.yexmp.2013.11.001
   PubMed Web of Science ®Google Scholar
• Zhang X, Fu Y, Li H, et al. H3 relaxin inhibits the collagen synthesis via ROS- and P2X7R-mediated NLRP3 inflammasome activation in cardiac fibroblasts under high glucose. J Cell Mol Med. 2018;22(3):1816–1825. doi:10.1111/jcmm.13464
   PubMed Web of Science ®Google Scholar
• Luo B, Li B, Wang W, et al. NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model. PLoS One. 2014;9(8):e104771. doi:10.1371/journal.pone.0104771
   PubMed Web of Science ®Google Scholar
• Ernault AC, Meijborg VMF, Coronel R. Modulation of cardiac arrhythmogenesis by epicardial adipose tissue: JACC state-of-The-art review. J Am Coll Cardiol. 2021;78(17):1730–1745. doi:10.1016/j.jacc.2021.08.037
   PubMed Web of Science ®Google Scholar
• Yan SF, Ramasamy R, Naka Y, et al. Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ Res. 2003;93(12):1159–1169. doi:10.1161/01.RES.0000103862.26506.3D
   PubMed Web of Science ®Google Scholar
• Sciarretta S, Paneni F, Palano F, et al. Role of the renin-angiotensin-aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction. Clin Sci. 2009;116(6):467–477. doi:10.1161/01.RES.0000103862.26506.3D
   PubMed Web of Science ®Google Scholar
• Che H, Wang Y, Li H, et al. Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy. FASEB J. 2020;34(4):5282–5298. doi:10.1096/fj.201902692R
   PubMed Web of Science ®Google Scholar
• Wang A, Green JB, Halperin JL, Piccini JP Sr. Atrial fibrillation and diabetes mellitus: JACC review topic of the week. J Am Coll Cardiol. 2019;74(8):1107–1115. doi:10.1016/j.jacc.2019.07.020
   PubMed Web of Science ®Google Scholar
• Yao C, Veleva T, Scott L Jr, et al. Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation. Circulation. 2018;138(20):2227–2242. doi:10.1161/CIRCULATIONAHA.118.035202
   PubMed Web of Science ®Google Scholar
• Scott Jr L Jr, Fender AC, Saljic A, et al. NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias. Cardiovasc Res. 2021;117(7):1746–1759. doi:10.1093/cvr/cvab024
   PubMed Web of Science ®Google Scholar
• Wu X, Liu Y, Tu D, et al. Role of NLRP3-inflammasome/caspase-1/galectin-3 pathway on atrial remodeling in diabetic rabbits. J Cardiovasc Transl Res. 2020;13(5):731–740. doi:10.1007/s12265-020-09965-8
   PubMed Web of Science ®Google Scholar
• Heijman J, Muna AP, Veleva T, et al. Atrial myocyte NLRP3/CaMKII nexus forms a substrate for postoperative atrial fibrillation. Circ Res. 2020;127(8):1036–1055. doi:10.1161/CIRCRESAHA.120.316710
   PubMed Web of Science ®Google Scholar
• Li N, Brundel B. Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation. Circ Res. 2020;127(1):73–90. doi:10.1161/CIRCRESAHA.119.316364
   PubMed Web of Science ®Google Scholar
• Chen M, Li X, Wang S, et al. The role of cardiac macrophage and cytokines on ventricular arrhythmias. Front Physiol. 2020;11:1113. doi:10.3389/fphys.2020.01113
   PubMed Web of Science ®Google Scholar
• Liu H, Zhao Y, Xie A, et al. Interleukin-1beta, Oxidative stress, and abnormal calcium handling mediate diabetic arrhythmic risk. JACC Basic Transl Sci. 2021;6(1):42–52. doi:10.1016/j.jacbts.2020.11.002
   PubMedGoogle Scholar
• Tian CJ, Zhang JH, Liu J, et al. Ryanodine receptor and immune-related molecules in diabetic cardiomyopathy. ESC Heart Fail. 2021;8(4):2637–2646. doi:10.1002/ehf2.13431
   PubMed Web of Science ®Google Scholar