106
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

N-Ethyl-N-Nitrosourea Induced Leukaemia in a Mouse Model: Protective Effect of Icaritin via Inhibition of IL-6/JAK2/STAT3 Pathway Causes Apoptosis

, , , & ORCID Icon
Pages 777-790 | Received 23 Sep 2023, Accepted 20 Jan 2024, Published online: 06 Feb 2024

References

  • Prakash G, Bhattacharjee U, Ck D. Chronic myeloid leukemia blast crisis: an emergency. Onco-Critical Care. 2022;74:271–277.
  • Haferlach C, Rieder H, Lillington DM, et al. Proposals for standardized protocols for cytogenetic analyses of acute leukemias. Chronic Lymphocytic Leukemia. 2007;46(5):494–499.
  • Rausch CR, DiPippo AJ, Jiang Y, et al. Comparison of mold active triazoles as primary antifungal prophylaxis in patients with newly diagnosed acute myeloid leukemia in the era of molecularly targeted therapies; 2022.;
  • Nath P, Modak S, Akter T, Maiti DJIJOP, Sciences A. Effects of N Ethyl N′ nitrosourea in mice brain in time fashion: effect of ENU in brain. Indian J Physiol. 2022;74:1.
  • Vohra N, Chavez T, Troncoso JR, et al. Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer. J Med Im. 2021;8(2):023504. doi:10.1117/1.JMI.8.2.023504
  • Martinez A, Merchan J, Sala M, et al. Carcinogénesis y nitrosoamidas. Patolog. 1974; 7:225–230.
  • Slikker III W, Mei N, Chen TJTS. N-ethyl-N-nitrosourea (ENU) increased brain mutations in prenatal and neonatal mice but not in the adults. Toxicol Sci. 2004;81(1):112–120.
  • Bulnes S, Bermúdez G, Lafuente JVJO. Association of Notch-1. Steo Stem-Like Cells ENU-Glioma Malig Proc. 2018;9(59):31330.
  • Kumar CC. Genetic abnormalities and challenges in the treatment of acute myeloid leukemia. Genes Cancer. 2011;2(2):95–107. doi:10.1177/1947601911408076
  • Huang B, Lang X, Li X. The role of IL-6/JAK2/STAT3 signaling pathway in cancers. Front Oncol. 2022;12:1023177. doi:10.3389/fonc.2022.1023177
  • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9(11):798–809. doi:10.1038/nrc2734
  • Wang Y, Zheng N, Sun T, Zhao H, Chen Y, Liu CJMMR. Role of TGM2 in T‑cell lymphoblastic lymphoma via regulation of IL‑6/JAK/STAT3 signalling. Mol Med Rep. 2022;25(3):1–9.
  • Xu L, Yao Y, Lu T, LJJom J. interactions n. miR-451a targeting IL-6R activates JAK2/STAT3 pathway, thus regulates proliferation and apoptosis of multiple myeloma cells. Journal of Musculoskeletal & Neuronal Interactions. 2022;22(2):251–260.
  • Wu X-Y, Tian F, Su M-H, et al. BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway. Int Immunopharmacol. 2018; 64(24–32):1.
  • Sheikh IN, Ragoonanan D, Franklin A, et al. Cardiac relapse of acute lymphoblastic leukemia following hematopoietic stem cell transplantation: a case report and review of literature. Cancers. 2021;13(22):5814. doi:10.3390/cancers13225814
  • Allodji RS, Tucker MA, Hawkins MM, et al. Role of radiotherapy and chemotherapy in the risk of leukemia after childhood cancer: an international pooled analysis. International Journal of Cancer. 2021;148(9):2079–2089. doi:10.1002/ijc.33361
  • Piktel D, Nair RR, Rellick SL, et al. Pitavastatin is anti-leukemic in a bone marrow microenvironment model of b-lineage acute lymphoblastic Leukemia. Cancers. 2022;14(11):2681. doi:10.3390/cancers14112681
  • Bukhari S, Siddique MH, Naeem A, et al. Combined efficacy of Cinnamomum zeylanicum and doxorubicin against leukemia through regulation of TRAIL and NF-kappa B pathways in rat model. Mol Biol Rep. 2022; 49:1–13.
  • Maher T, Ahmad Raus R, Daddiouaissa D, et al. Medicinal Plants with anti-leukemic effects: a review. Molecules. 2021;26(9):2741. doi:10.3390/molecules26092741
  • Gao L, Zhang SQ, Effects A. Pharmacokinetics, and drug delivery systems of icaritin: advances and prospects. Pharmaceuticals. 2022;154: 1. doi:10.3390/ph15040397
  • Liu S, Liu C, Xiong L, et al. Icaritin alleviates glutamate-induced neuronal damage by inactivating GluN2B-containing NMDARs through the ERK/DAPK1 pathway. Front Neurosci. 2021;15:525615. doi:10.3389/fnins.2021.525615
  • Wo Y, Zhu D, Hu Y, Wang ZQ, Liu J, Lou Y. Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells. J Cellular Bioche. 2008;103(5):1536–1550. doi:10.1002/jcb.21541
  • Liu S, Guo Y, Wang J, et al. A novel anticancer agent SNG1153 inhibits growth of lung cancer stem/progenitor cells. Oncotarget. 2016;7(29):45158. doi:10.18632/oncotarget.9783
  • Zhu J, Li Z, Zhang G, et al. Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3/AKT signalings. PLoS One. 2011;6(8): e23720. doi:10.1371/journal.pone.0023720
  • Aliyu A, Shaari MR, Ahmad Sayuti NS, et al. N-Ethyl-n-Nitrosourea induced Leukaemia in a mouse model through upregulation of vascular endothelial growth factor and evading apoptosis. Cancers. 2020;12(3):678. doi:10.3390/cancers12030678
  • Li S, Priceman SJ, Xin H, et al. Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma. PLoS One. 2013;8(12): e81657. doi:10.1371/journal.pone.0081657
  • Kayser S, Levis M. Updates on targeted therapies for acute myeloid leukaemia. British J Haematol. 2022;196(2):316–328. doi:10.1111/bjh.17746
  • Shallis RM, Wang R, Davidoff A, Ma X, Zeidan A. Epidemiology of acute myeloid leukemia: recent progress and enduring challenges. Blood Reviews. 2019;36:70–87. doi:10.1016/j.blre.2019.04.005
  • Bhatia S. Therapy-Related Myelodysplasia and Acute Myeloid Leukemia. Elsevier; 2013:666–675.
  • Aliyu A, Shaari MR, Mustapha NM, et al. Some chemical carcinogens for leukaemia induction and their animal models. Annual Res. 2019; 2019:1–7.
  • Nath P, DJJoB M. A review of the mutagenic potential of N‐ethyl‐N‐nitrosourea (ENU) to induce hematological malignancies. J Biochem Molecu Toxicol. 2022;36(7): e23067. doi:10.1002/jbt.23067
  • Kennedy CL, MKJHru O. N-ethyl-N-nitrosourea (ENU) mutagenesis and male fertility research. Human Reprod Update. 2006;12(3):293–301. doi:10.1093/humupd/dmk004
  • Wang J, Liu X, Heflich RH, Tjts C. Time course of cII gene mutant manifestation in the liver, spleen, and bone marrow of N-ethyl-N-nitrosourea-treated big blue transgenic mice. Toxicol Sci. 2004;82(1):124–128. doi:10.1093/toxsci/kfh234
  • Rathkolb B, Klempt M, Sabrautzki S, et al. Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels. Biometals. 2015;28(2):293–306. doi:10.1007/s10534-015-9824-1
  • Abou Elazab MF, Elbaiomy AE, Ahmed MS, et al. Ameliorative effects of bovine lactoferrin on benzene-induced hematotoxicity in albino rats. Veteri Sci. 2022; 9(5): doi:10.3390/vetsci9050240
  • Van Etten RA. Aberrant cytokine signaling in leukemia. Oncogene. 2007;26(47):6738–6749. doi:10.1038/sj.onc.1210758
  • Kartikasari AE, Huertas CS, Mitchell A, Plebanski MJFi O. Tumor-induced inflammatory cytokines and the emerging diagnostic devices for cancer detection and prognosis. Front Oncol. 2021; 11.
  • Zhang CC, Lodish HF. Cytokines regulating hematopoietic stem cell function. Current Opinion Hematol. 2008;15(4):307–311. doi:10.1097/MOH.0b013e3283007db5
  • Parajuli B, Sonobe Y, Kawanokuchi J, et al. GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia J Neuroinflam. 2012;9(1):1–12.
  • Reynaud D, Pietras E, Barry-Holson K, et al. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell. 2011;20(5):661–673. doi:10.1016/j.ccr.2011.10.012
  • Hu J, Yang T, Xu H, Hu M, Wen H, Jiang H. A novel anticancer agent icaritin inhibited proinflammatory cytokines in TRAMP mice. Int Urol Nephrol. 2016;48(10):1649–1655. doi:10.1007/s11255-016-1341-9
  • Zhou J, Ching YQ, Chng WJ. Aberrant nuclear factor-kappa B activity in acute myeloid leukemia: from molecular pathogenesis to therapeutic target. Oncotarget. 2015;6(8):5490–5500. doi:10.18632/oncotarget.3545
  • Zhang T, Ma C, Zhang Z, Zhang H, Hu H. NF-κB signaling in inflammation and cancer. Med Comm. 2021;2(4):618–653. doi:10.1002/mco2.104
  • Liu L, Zhao Z, Lu L, et al. Icariin and icaritin ameliorated hippocampus neuroinflammation via inhibiting HMGB1-related pro-inflammatory signals in lipopolysaccharide-induced inflammation model in C57BL/6 J mice. Int Immunol. 2019;68:95–105. doi:10.1016/j.intimp.2018.12.055
  • Johnson DE, Ra O, Grandis JR. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15(4):234–248. doi:10.1038/nrclinonc.2018.8
  • Yang J-G, Lu R, X-J Y, Zhang J, Tan Y-Q, Zhou G. Icaritin reduces oral squamous cell carcinoma progression via the inhibition of STAT3 signaling. Int J Mol Sci. 2017;18(1):132. doi:10.3390/ijms18010132
  • Park C, Moon D-O, Rhu C-H, et al. Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio. Bio Phar Bulle. 2007;30(7):1317–1323. doi:10.1248/bpb.30.1317
  • Tong J-S, Zhang Q-H, Huang X, et al. Icaritin causes sustained ERK1/2 activation and induces apoptosis in human endometrial cancer cells. PLoS One. 2011;6(3): e16781. doi:10.1371/journal.pone.0016781
  • Guo Y, Zhang X, Meng J, Wang Z-Y. An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells. Eur J Pharmacol. 2011;658(2–3):114–122. doi:10.1016/j.ejphar.2011.02.005