20
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Luobitong Potentiates MTX’s Anti-Rheumatoid Arthritis Activity via Targeting Multiple Inflammatory Pathways

ORCID Icon, , , , , , , , & ORCID Icon show all
Pages 4389-4403 | Received 12 Apr 2024, Accepted 18 Jun 2024, Published online: 05 Jul 2024

References

  • Tobón GJ, Youinou P, Saraux A. The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis. J Autoimmun. 2010;35(1):10–14. doi:10.1016/j.jaut.2009.12.009
  • Balanescu AR, Citera G, Pascual-Ramos V, et al. Infections in patients with rheumatoid arthritis receiving tofacitinib versus tumour necrosis factor inhibitors: results from the open-label, randomised controlled ORAL Surveillance trial. Ann Rheum Dis. 2022;81(11):1491–1503. doi:10.1136/ard-2022-222405
  • Tang Y, Zhang Y, Li L, Xie Z, Wen C, Huang L. Kunxian Capsule for Rheumatoid Arthritis: inhibition of Inflammatory Network and Reducing Adverse Reactions Through Drug Matching. Front Pharmacol. 2020;11:485. doi:10.3389/fphar.2020.00485
  • Zhu L, Wang J, Wei T, et al. Effects of Naringenin on inflammation in complete freund’s adjuvant-induced arthritis by regulating Bax/Bcl-2 balance. Inflammation. 2015;38(1):245–251. doi:10.1007/s10753-014-0027-7
  • Hu C, Qian L, Miao Y, et al. Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis. Cell Mol Immunol. 2012;9(3):245–254. doi:10.1038/cmi.2011.50
  • Liu W, Zhang Y, Zhu W, et al. Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets. Front Immunol. 2018;9:2228. doi:10.3389/fimmu.2018.02228
  • Abtahi S, Driessen J, Burden AM, et al. Low-dose oral glucocorticoid therapy and risk of osteoporotic fractures in patients with rheumatoid arthritis: a cohort study using the Clinical Practice Research Datalink. Rheumatology (Oxford). 2022;61(4):1448–1458. doi:10.1093/rheumatology/keab548
  • Morris G, Berk M, Walder K, Maes M. Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses. BMC Med. 2015;13:28. doi:10.1186/s12916-014-0259-2
  • Roubille C, Richer V, Starnino T, et al. The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis. Ann Rheum Dis. 2015;74(3):480–489. doi:10.1136/annrheumdis-2014-206624
  • Lee DM, Weinblatt ME. Rheumatoid arthritis. Lancet. 2001;358(9285):903–911. doi:10.1016/S0140-6736(01)06075-5
  • Dougados M, Soubrier M, Antunez A, et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis. 2014;73(1):62–68. doi:10.1136/annrheumdis-2013-204223
  • Peng X, Wang Q, Li W, et al. Comprehensive overview of microRNA function in rheumatoid arthritis. Bone Res. 2023;11(1):8. doi:10.1038/s41413-023-00244-1
  • Roberts CA, Dickinson AK, Taams LS. The Interplay Between Monocytes/Macrophages and CD4(+) T Cell Subsets in Rheumatoid Arthritis. Front Immunol. 2015;6:571. doi:10.3389/fimmu.2015.00571
  • Shi X, Song P, Tao S, Zhang X, Chu CQ. Silencing RORγt in Human CD4(+) T cells with CD30 aptamer-RORγt shRNA Chimera. Sci Rep. 2019;9(1):10375. doi:10.1038/s41598-019-46855-9
  • Tu J, Huang W, Zhang W, Mei J, Zhu C. A Tale of Two Immune Cells in Rheumatoid Arthritis: the Crosstalk Between Macrophages and T Cells in the Synovium. Front Immunol. 2021;12:655477. doi:10.3389/fimmu.2021.655477
  • Yoon SS, Moon EY. B Cell Adhesion to Fibroblast-Like Synoviocytes Is Up-Regulated by Tumor Necrosis Factor-Alpha via Expression of Human Vascular Cell Adhesion Molecule-1 Mediated by B Cell-Activating Factor. Int J Mol Sci. 2021;22(13):7166. doi:10.3390/ijms22137166
  • Fu Y, Chryssafidis AL, Browne JA, O’Sullivan J, McGettigan PA, Mulcahy G. Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection. PLoS Negl Trop Dis. 2016;10(9):e0005015. doi:10.1371/journal.pntd.0005015
  • Li X, Lei Y, Gao Z, et al. Effect of IL-34 on T helper 17 cell proliferation and IL-17 secretion by peripheral blood mononuclear cells from rheumatoid arthritis patients. Sci Rep. 2020;10(1):22239. doi:10.1038/s41598-020-79312-z
  • Joseph RM, Ray DW, Keevil B, van Staa TP, Dixon WG. Low salivary cortisol levels in patients with rheumatoid arthritis exposed to oral glucocorticoids: a cross-sectional study set within UK electronic health records. RMD Open. 2018;4(2):e000700. doi:10.1136/rmdopen-2018-000700
  • Li J, Bao J, Zeng J, Yan A, Zhao C, Shu Q. Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology. Bone Res. 2019;7:27. doi:10.1038/s41413-019-0067-6
  • Singh JA, Hossain A, Mudano AS, et al. Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2017;5(5):CD012657. doi:10.1002/14651858.CD012657
  • Arbab D, König DP. Atraumatic Femoral Head Necrosis in Adults. Dtsch Arztebl Int. 2016;113(3):31–38. doi:10.3238/arztebl.2016.0031
  • Bellinger DL, Wood C, Wergedal JE, Lorton D. Driving β2- While Suppressing α-Adrenergic Receptor Activity Suppresses Joint Pathology in Inflammatory Arthritis. Front Immunol. 2021;12:628065. doi:10.3389/fimmu.2021.628065
  • Pham DT, Thao N, Thuy B, Tran V, Nguyen T, Nguyen N. Silk fibroin hydrogel containing Sesbania sesban L. extract for rheumatoid arthritis treatment. Drug Deliv. 2022;29(1):882–888. doi:10.1080/10717544.2022.2050848
  • Davies H, Olson L, Gibson P. Methotrexate as a steroid sparing agent for asthma in adults. Cochrane Database Syst Rev. 2000;1998(2):CD000391. doi:10.1002/14651858.CD000391
  • Vanni K, Lyu H, Solomon DH. Cytopenias among patients with rheumatic diseases using methotrexate: a meta-analysis of randomized controlled clinical trials. Rheumatology (Oxford). 2020;59(4):709–717. doi:10.1093/rheumatology/kez343
  • Emery P, Burmester GR, Bykerk VP, et al. Evaluating drug-free remission with Abatacept in early rheumatoid arthritis: results from the phase 3b, multicentre, randomised, active-controlled AVERT study of 24 months, with a 12-month, double-blind treatment period. Ann Rheum Dis. 2015;74(1):19–26. doi:10.1136/annrheumdis-2014-206106
  • Schaff LR, Lobbous M, Carlow D, et al. Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center Phase I study. BMC Cancer. 2022;22(1):60. doi:10.1186/s12885-021-09164-x
  • Zhai KF, Duan H, Chen Y, et al. Apoptosis effects of imperatorin on synoviocytes in rheumatoid arthritis through mitochondrial/caspase-mediated pathways. Food Funct. 2018;9(4):2070–2079. doi:10.1039/c7fo01748k
  • Zhai KF, Duan H, Khan GJ, et al. Salicin from Alangium chinense Ameliorates Rheumatoid Arthritis by Modulating the Nrf2-HO-1-ROS Pathways. J Agric Food Chem. 2018;66(24):6073–6082. doi:10.1021/acs.jafc.8b02241
  • Ma Z, Fan Y, Wu Y, et al. Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment. Int J Nanomed. 2019;14:2029–2053. doi:10.2147/IJN.S197889
  • Luo Y, Hou X, Xi A, Luo M, Wang K, Xu Z. Tripterygium wilfordii Hook F combination therapy with methotrexate for rheumatoid arthritis: an updated meta-analysis. J Ethnopharmacol. 2023;307:116211. doi:10.1016/j.jep.2023.116211
  • Zhou YZ, Zhao LD, Chen H, et al. Comparison of the impact of Tripterygium wilfordii Hook F and Methotrexate treatment on radiological progression in active rheumatoid arthritis: 2-year follow up of a randomized, non-blinded, controlled study. Arthritis Res Ther. 2018;20(1):70. doi:10.1186/s13075-018-1563-6
  • Li M, Luo Q, Chen X, et al. Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns. BMC Complement Med Ther. 2023;23(1):9. doi:10.1186/s12906-023-03836-w
  • Wei X, Zhou R, Chen Y, et al. Systemic pharmacological verification of Baixianfeng decoction regulating TNF-PI3K-Akt-NF-κB pathway in treating rheumatoid arthritis. Bioorg Chem. 2022;119:105519. doi:10.1016/j.bioorg.2021.105519
  • Yuan H, Ma Q, Cui H, et al. How Can Synergism of Traditional Medicines Benefit from Network Pharmacology. Molecules. 2017;22(7):1135. doi:10.3390/molecules22071135
  • Piñero J, Ramírez-Anguita JM, Saüch-Pitarch J, et al. The DisGeNET knowledge platform for disease genomics: 2019 update. Nucleic Acids Res. 2020;48(D1):D845–D855. doi:10.1093/nar/gkz1021
  • Carvalho-Silva D, Pierleoni A, Pignatelli M, et al. Open Targets Platform: new developments and updates two years on. Nucleic Acids Res. 2019;47(D1):D1056–D1065. doi:10.1093/nar/gky1133
  • Rappaport N, Twik M, Plaschkes I, et al. MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search. Nucleic Acids Res. 2017;45(D1):D877–D887. doi:10.1093/nar/gkw1012
  • Davis AP, Grondin CJ, Johnson RJ, et al. The Comparative Toxicogenomics Database: update 2019. Nucleic Acids Res. 2019;47(D1):D948–D954. doi:10.1093/nar/gky868
  • Safran M, Dalah I, Alexander J, et al. GeneCards Version 3: the human gene integrator. Database (Oxford). 2010;2010:baq020. doi:10.1093/database/baq020
  • Dennis G, Sherman BT, Hosack DA, et al. DAVID: database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 2003;4(5).
  • Szklarczyk D, Morris JH, Cook H, et al. The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 2017;45(D1):D362–D368. doi:10.1093/nar/gkw937
  • Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–2504. doi:10.1101/gr.1239303
  • Wishart DS, Feunang YD, Guo AC, et al. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018;46(D1):D1074–D1082. doi:10.1093/nar/gkx1037
  • Wang Y, Zhang S, Li F, et al. Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. Nucleic Acids Res. 2020;48(D1):D1031–D1041. doi:10.1093/nar/gkz981
  • Gaulton A, Hersey A, Nowotka M, et al. The ChEMBL database in 2017. Nucleic Acids Res. 2017;45(D1):D945–D954. doi:10.1093/nar/gkw1074
  • UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019;47(D1):D506–D515. doi:10.1093/nar/gky1049
  • Davis AP, Wiegers TC, Johnson RJ, Sciaky D, Wiegers J, Mattingly CJ. Comparative Toxicogenomics Database (CTD): update 2023. Nucleic Acids Res. 2023;51(D1):D1257–D1262. doi:10.1093/nar/gkac833
  • Kim S, Thiessen PA, Bolton EE, et al. PubChem Substance and Compound databases. Nucleic Acids Res. 2016;44(D1):D1202–1213. doi:10.1093/nar/gkv951
  • Bindea G, Mlecnik B, Hackl H, et al. ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics. 2009;25(8):1091–1093. doi:10.1093/bioinformatics/btp101
  • Kotake S, Udagawa N, Takahashi N, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 1999;103(9):1345–1352. doi:10.1172/JCI5703
  • Taams LS. Interleukin-17 in rheumatoid arthritis: trials and tribulations. J Exp Med. 2020;217(3):e20192048. doi:10.1084/jem.20192048
  • van den Berg WB, Miossec P. IL-17 as a future therapeutic target for rheumatoid arthritis. Nat Rev Rheumatol. 2009;5(10):549–553. doi:10.1038/nrrheum.2009.179
  • Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol. 2010;10(7):479–489. doi:10.1038/nri2800
  • McGeachy MJ, Cua DJ, Gaffen SL. The IL-17 Family of Cytokines in Health and Disease. Immunity. 2019;50(4):892–906. doi:10.1016/j.immuni.2019.03.021
  • Lin J, Tang J, Lin J, et al. YY1 regulation by miR-124-3p promotes Th17 cell pathogenicity through interaction with T-bet in rheumatoid arthritis. JCI Insight. 2021;6(22):e149985. doi:10.1172/jci.insight.149985
  • Roeleveld DM, van Nieuwenhuijze AE, van den Berg WB, Koenders MI. The Th17 pathway as a therapeutic target in rheumatoid arthritis and other autoimmune and inflammatory disorders. BioDrugs. 2013;27(5):439–452. doi:10.1007/s40259-013-0035-4
  • Kumar LD, Karthik R, Gayathri N, Sivasudha T. Advancement in contemporary diagnostic and therapeutic approaches for rheumatoid arthritis. Biomed Pharmacother. 2016;79:52–61. doi:10.1016/j.biopha.2016.02.001
  • Jiang H, Li M, Du K, et al. Traditional Chinese Medicine for adjuvant treatment of breast cancer: taohong Siwu Decoction. Chin Med. 2021;16(1):129. doi:10.1186/s13020-021-00539-7
  • Hou J, Chen W, Lu H, et al. Exploring the Therapeutic Mechanism of Desmodium styracifolium on Oxalate Crystal-Induced Kidney Injuries Using Comprehensive Approaches Based on Proteomics and Network Pharmacology. Front Pharmacol. 2018;9:620. doi:10.3389/fphar.2018.00620
  • Kong X, Liu C, Lu P, et al. Combination of UPLC-Q-TOF/MS and Network Pharmacology to Reveal the Mechanism of Qizhen Decoction in the Treatment of Colon Cancer. ACS Omega. 2021;6(22):14341–14360. doi:10.1021/acsomega.1c01183
  • Guo B, Zhao C, Zhang C, et al. Elucidation of the anti-inflammatory mechanism of Er Miao San by integrative approach of network pharmacology and experimental verification. Pharmacol Res. 2022;175:106000. doi:10.1016/j.phrs.2021.106000
  • Han C, Yang Y, Sheng Y, et al. Glaucocalyxin B inhibits cartilage inflammatory injury in rheumatoid arthritis by regulating M1 polarization of synovial macrophages through NF-κB pathway. Aging (Albany NY). 2021;13(18):22544–22555. doi:10.18632/aging.203567
  • Kanagawa H, Masuyama R, Morita M, et al. Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors. J Bone Miner Metab. 2016;34(5):526–531. doi:10.1007/s00774-015-0702-2
  • Nistala K, Adams S, Cambrook H, et al. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc Natl Acad Sci U S A. 2010;107(33):14751–14756. doi:10.1073/pnas.1003852107
  • Tardito S, Martinelli G, Soldano S, et al. Macrophage M1/M2 polarization and rheumatoid arthritis: a systematic review. Autoimmun Rev. 2019;18(11):102397. doi:10.1016/j.autrev.2019.102397
  • Fang Q, Zhou C, Nandakumar KS. Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis. Mediators Inflamm. 2020;2020:3830212. doi:10.1155/2020/3830212
  • Saxena Y, Routh S, Mukhopadhaya A. Immunoporosis: role of Innate Immune Cells in Osteoporosis. Front Immunol. 2021;12:687037. doi:10.3389/fimmu.2021.687037
  • Qiuping L, Pan P, Zhenzhen L, Zhen Z, Xuezhu Z, Shuting L. Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia. Heliyon. 2023;9(2):e13346. doi:10.1016/j.heliyon.2023.e13346
  • Hashimoto M. Th17 in Animal Models of Rheumatoid Arthritis. J Clin Med. 2017;6(7):73. doi:10.3390/jcm6070073
  • Park H, Li Z, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6(11):1133–1141. doi:10.1038/ni1261
  • Wu W, Huang J, Duan B, et al. Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med. 2012;186(5):420–427. doi:10.1164/rccm.201202-0182OC
  • Deligne C, Casulli S, Pigenet A, et al. Differential expression of interleukin-17 and interleukin-22 in inflamed and non-inflamed synovium from osteoarthritis patients. Osteoarthritis Cartilage. 2015;23(11):1843–1852. doi:10.1016/j.joca.2014.12.007
  • Pan F, Xiang H, Yan J, et al. Dendritic Cells from Rheumatoid Arthritis Patient Peripheral Blood Induce Th17 Cell Differentiation via miR-363/Integrin αv/TGF-β Axis. Scand J Immunol. 2017;85(6):441–449. doi:10.1111/sji.12550