Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor

References

• MackayFBrowningJLBAFF: a fundamental survival factor for B cellsNat Rev Immunol20022746547512094221
   PubMed Web of Science ®Google Scholar
• SchneiderPMacKayFSteinerVBAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growthJ Exp Med1999189111747175610359578
   PubMed Web of Science ®Google Scholar
• NardelliBBelvedereORoschkeVSynthesis and release of B-lymphocyte stimulator from myeloid cellsBlood200197119820411133761
   PubMed Web of Science ®Google Scholar
• MackayFSchneiderPCracking the BAFF codeNat Rev Immunol20099749150219521398
   PubMed Web of Science ®Google Scholar
• NgLGSutherlandAPNewtonRB cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cellsJ Immunol2004173280781715240667
   PubMed Web of Science ®Google Scholar
• GoenkaRMatthewsAHZhangBLocal BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturationJ Exp Med20142111455624367004
   PubMed Web of Science ®Google Scholar
• MoreauxJLegouffeEJourdanEBAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasoneBlood200410383148315715070697
   PubMed Web of Science ®Google Scholar
• HaiatSBillardCQuineyCAjchenbaum-CymbalistaFKolbJPRole of BAFF and APRIL in human B-cell chronic lymphocytic leukaemiaImmunology2006118328129216827889
   PubMed Web of Science ®Google Scholar
• CheemaGSRoschkeVHilbertDMStohlWElevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseasesArthritis Rheum20014461313131911407690
   PubMed Web of Science ®Google Scholar
• NeriPKumarSFulcinitiMTNeutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma modelClin Cancer Res200713195903590917908986
   PubMed Web of Science ®Google Scholar
• ThienMPhanTGGardamSExcess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone nichesImmunity200420678579815189742
   PubMed Web of Science ®Google Scholar
• LesleyRXuYKalledSLReduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFFImmunity200420444145315084273
   PubMed Web of Science ®Google Scholar
• StohlWMetyasSTanSMB lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observationsArthritis Rheum200348123475348614673998
   PubMed Web of Science ®Google Scholar
• PetriMStohlWChathamWAssociation of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosusArthritis Rheum20085882453245918668552
   PubMed Web of Science ®Google Scholar
• HarigaiMKawamotoMHaraMKubotaTKamataniNMiyasakaNExcessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13BJ Immunol200818132211221918641361
   PubMed Web of Science ®Google Scholar
• TanSMXuDRoschkeVLocal production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritisArthritis Rheum200348498299212687540
   PubMed Web of Science ®Google Scholar
• NavarraSVGuzmanRMGallacherAEEfficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trialLancet2011377976772173121296403
   PubMed Web of Science ®Google Scholar
• FurieRPetriMZamaniOA phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosusArthritis Rheum201163123918393022127708
   PubMed Web of Science ®Google Scholar
• BakerKPEdwardsBMMainSHGeneration and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulatorArthritis Rheum200348113253326514613291
   PubMed Web of Science ®Google Scholar
• ZolaHMonoclonal Antibodies: A Manual of TechniquesBoca Raton (FL)CRC Press1987
   Google Scholar
• TosatoGSeamonKBGoldmanNDMonocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)Science198823948395025042829354
   PubMed Web of Science ®Google Scholar
• FoxNSolterDExpression and regulation of the pituitary- and placenta-specific human glycoprotein hormone alpha-subunit gene is restricted to the pituitary in transgenic miceMol Cell Biol1988812547054762468998
   PubMed Web of Science ®Google Scholar
• LabrijnAFBuijsseAOvan den BremerETTherapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivoNat Biotechnol200927876777119620983
   PubMed Web of Science ®Google Scholar
• MoorePABelvedereOOrrABLyS: member of the tumor necrosis factor family and B lymphocyte stimulatorScience1999285542526026310398604
   PubMed Web of Science ®Google Scholar
• ClaudioEBrownKParkSWangHSiebenlistUBAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cellsNat Immunol200231095896512352969
   PubMed Web of Science ®Google Scholar
• GrellMDouniEWajantHThe transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptorCell19958357938028521496
   PubMed Web of Science ®Google Scholar
• HoriuchiTMitomaHHarashimaSTsukamotoHShimodaTTransmembrane TNF-alpha: structure, function and interaction with anti-TNF agentsRheumatology (Oxford)20104971215122820194223
   PubMed Web of Science ®Google Scholar
• BossenCCacheroTGTardivelATACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablastsBlood200811131004101217942754
   PubMed Web of Science ®Google Scholar
• GorelikLGilbrideKDoblesMKalledSLZandmanDScottMLNormal B cell homeostasis requires B cell activation factor production by radiation-resistant cellsJ Exp Med2003198693794512975458
   PubMed Web of Science ®Google Scholar
• BossenCTardivelAWillenLMutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responsesEur J Immunol201141378779721287546
   PubMed Web of Science ®Google Scholar
• RochasCHillionSSarauxATransmembrane BAFF from rheumatoid synoviocytes requires interleukin-6 to induce the expression of recombination-activating gene in B lymphocytesArthritis Rheum20096051261127119404965
   PubMed Web of Science ®Google Scholar
• ChuVTEnghardPRiemekastenGBerekCIn vitro and in vivo activation induces BAFF and APRIL expression in B cellsJ Immunol200717995947595717947668
   PubMed Web of Science ®Google Scholar
• Abu-RishEYAmraniYBrowningMJToll-like receptor 9 activation induces expression of membrane-bound B-cell activating factor (BAFF) on human B cells and leads to increased proliferation in response to both soluble and membrane-bound BAFFRheumatology (Oxford)20135271190120123436580
   PubMed Web of Science ®Google Scholar
• KiklyKManettaJSmithHWierdaDWitcherDCharacterization of LY2127399, A neutralizing antibody for BAFFArthritis Rheum200960S10
   Google Scholar
• GenoveseMCBojinSBiaginiIMTabalumab in rheumatoid arthritis patients with an inadequate response to methotrexate and naive to biologic therapy: a phase II, randomized, placebo-controlled trialArthritis Rheum201365488088923359344
   PubMed Web of Science ®Google Scholar
• BadrGBorhisGLefevreEABAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cellsBlood200811152744275418172003
   PubMed Web of Science ®Google Scholar
• WallaceDJStohlWFurieRAA phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosusArthritis Rheum20096191168117819714604
   PubMed Web of Science ®Google Scholar
• van VollenhovenRFKinnmanNVincentEWaxSBathonJAtacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlld trialArthritis Rheum20116371782179221452294
   PubMed Web of Science ®Google Scholar