A Case-Control Study of the MTHFR C665T Gene Polymorphism on Macrocytic Anemia Among HIV-Infected Patients Receiving Zidovudine

References

• Ministry of Health Republic of Indonesia. Regulation of Indonesian ministry of health No. 87 of 2014 on antiretroviral treatment guidelines. Indonesian Ministry of Health; 2015:2004–2006.
   Google Scholar
• Parkes-Ratanshi R, Katende D, Levin J, et al. Development of severe anemia and changes in hemoglobin in a cohort of HIV-infected Ugandan adults receiving zidovudine-, stavudine-, and tenofovir-containing antiretroviral regimens. J Int Assoc Provid AIDS Care. 2015;14(5):455–462. doi:10.1177/2325957414557264
   PubMedGoogle Scholar
• Kufel WD, Hale CM, Sidman EF, Orellana CE, Miller CD. Nucleoside Reverse Transcriptase Inhibitor (NRTI) associated macrocytosis. Int J Virol AIDS. 2016;3:18. doi:10.23937/2469-567X/1510018
   Google Scholar
• Barik S. Megaloblastic anemia: a drug-induced disorder. J Blood Dis Transfus. 2016;7:1–3.
   Google Scholar
• Deavall DG, Martin EA, Horner JM, Roberts R. Drug-induced oxidative stress and toxicity. J Toxicol. 2012;2012:1–13. doi:10.1155/2012/645460
   Google Scholar
• Cheng Y, Ren X, Gowda ASP, et al. Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. Cell Death Dis. 2013;4(7):e731. doi:10.1038/cddis.2013.254
   PubMed Web of Science ®Google Scholar
• Mahajan S, Aundhakar S. A study of the prevalence of serum vitamin B12 and folic acid deficiency in Western Maharashtra. J Fam Med Prim Care. 2015;4(1):64. doi:10.4103/2249-4863.152255
   PubMedGoogle Scholar
• Haloi A, Das D. Vitamin B12 gene polymorphisms and chronic diseases. J Nutr Disord Ther. 2014;4:2.
   Google Scholar
• Rajagopalan P, Jahanshad N, Stein JL, et al. Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment. NeuroImage Clin. 2012;1(1):179–187. doi:10.1016/j.nicl.2012.09.012
   PubMed Web of Science ®Google Scholar
• Micheal S, Qamar R, Akhtar F, Khan MI, Khan WA, Ahmed A. MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma. Mol Vis. 2009;15:2268–2278.
   PubMed Web of Science ®Google Scholar
• Pramukarso DT, Faradz SM, Sari SH, Hadisaputro S. AB068. Association between MTHFR C677T and carotid intima medial thickness progression in post-ischemic stroke patient. Ann Transl Med. 2015;3(Suppl 2). doi:10.3978/j.issn.2305-5839.2015.AB068
   PubMedGoogle Scholar
• Carmel R. Megaloblastic anemias: disorders of impaired DNA synthesis. In: Wintrobe’s Clinical Hematology. Lippincott Williams and Wilkins; 2014:2140–2183.
   Google Scholar
• Veda P. Evaluation of macrocytosis in routine hemograms. Indian J Hematol Blood Transfus. 2013;29:26–30. doi:10.1007/s12288-011-0142-7
   PubMed Web of Science ®Google Scholar
• Kiragga AN, Castelnuovo B, Nakanjako D, Manabe YC. Baseline severe anaemia should not preclude use of zidovudine in antiretroviral-eligible patients in resource-limited settings. J Int AIDS Soc. 2010;13(1):42. doi:10.1186/1758-2652-13-42
   PubMed Web of Science ®Google Scholar
• World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. World Health Organization; 2011.
   Google Scholar
• Obirikorang C, Issahaku RG, Osakunor DNM, Osei-Yeboah J. Anaemia and iron homeostasis in a cohort of HIV-infected patients: a cross-sectional study in Ghana. AIDS Res Treat. 2016;2016:1–8. doi:10.1155/2016/1623094
   Web of Science ®Google Scholar
• Fenech M. Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity. Mutat Res–Fundam Mol Mech Mutagen. 2012;733(1–2):21–33. doi:10.1016/j.mrfmmm.2011.11.003
   PubMed Web of Science ®Google Scholar
• Guo S, Pang H, Guo H, et al. Ethnic differences in the prevalence of high homocysteine levels among low-income rural Kazakh and Uyghur adults in far western China and its implications for preventive public health. Int J Environ Res Public Health. 2015;12(5):5373–5385. doi:10.3390/ijerph120505373
   PubMed Web of Science ®Google Scholar
• Jeruszka-Bielak M, Isman C, Schroder TH, Li W, Green TJ, Lamers Y. South asian ethnicity is related to the highest risk of vitamin b12 deficiency in pregnant Canadian women. Nutrients. 2017;9(4):1–13. doi:10.3390/nu9040317
   Web of Science ®Google Scholar
• Goyal V, Vaish P, Deshmukh A, Mishra J, Deshmukh G. Hematological study (Blood and bone marrow) in HIV patients. Int J Contemp Med. 2016;4:94–99. doi:10.5958/2321-1032.2016.00020.6
   Google Scholar
• Tadele A. Prevalence of Zidovudine induced megaloblastic anemia among HIV/AIDS patients attending University of Gondar Hospital, Northwest Ethiopia. In: International Conference on Hematology & Blood Disorders. Journal of Blood Disorders & Transfusion. Hilton Baltimore-BWI Airport, USA; 2014.
   Google Scholar
• Ejeliogu EU, Oguche S, Ebonyi AO, et al. Zidovudine-induced anaemia in human immunodeficiency virus infected children on highly active anti-retroviral therapy in Jos, Nigeria. J Adv Med Pharm Sci. 2014;1:1–10. doi:10.9734/JAMPS/2014/11241
   Google Scholar
• Assefa M, Abegaz WE, Shewamare A, Medhin G, Belay M. Prevalence and correlates of anemia among HIV infected patients on highly active anti-retroviral therapy at Zewditu Memorial Hospital, Ethiopia. BMC Hematol. 2015;15(1):1–8. doi:10.1186/s12878-015-0024-6
   PubMedGoogle Scholar
• Agarwal V, Kochhar A, Sachdeva R. Sensory and nutritional evaluation of sweet milk products prepared using stevia powder for diabetics. Stud Ethno-Med. 2010;4(1):9–13. doi:10.1080/09735070.2010.11886357
   Google Scholar
• Adediran A, Osunkalu V, Wakama T, et al. Impact of HIV infection and zidovudine therapy on RBC parameters and urine methylmalonic acid levels. Interdiscip Perspect Infect Dis. 2016;2016:1–5. doi:10.1155/2016/5210963
   Google Scholar
• TL Pedersen, WR Keyes, Shahab-Ferdows S, LH Allen, JW Newman. Methylmalonic acid quantification in low serum volumes by UPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879(19):1502–1506. doi:10.1016/J.JCHROMB.2011.03.039
   PubMed Web of Science ®Google Scholar
• Sukriti S, Tauseef M, Yazbeck P, Mehta D. Mechanisms regulating endothelial permeability. Pulm Circ. 2014;4(4):535–551. doi:10.1086/677356
   PubMed Web of Science ®Google Scholar
• Das D. Vitamin B12 gene polymorphisms and chronic diseases. J Nutr Disord The. 2014;4(2):1–5. doi:10.4172/2161-0509.1000149
   Google Scholar
• Mihiretie H, Taye B, Tsegaye A. Magnitude of anemia and associated factors among pediatric HIV/aids patients attending Zewditu Memorial Hospital art clinic, Addis Ababa, Ethiopia. Anemia. 2015;2015:1–6. doi:10.1155/2015/479329
   Google Scholar
• Zhou B, Lu Y, Hajifathalian K, et al. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants. Lancet. 2016;387(10027):1513–1530. doi:10.1016/S0140-6736(16)00618-8
   PubMed Web of Science ®Google Scholar
• Nair M, Choudhury MK, Choudhury SS, et al. Association between maternal anaemia and pregnancy outcomes: a cohort study in Assam, India. BMJ Global Health. 2016;1(1):e000026. doi:10.1136/bmjgh-2015-000026
   PubMed Web of Science ®Google Scholar
• Leclerc D, Sibani S, Rozen R. Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and overview of mutations/polymorphisms. In: Madame Curie Bioscience Database. 2013;1–18.
   Google Scholar
• Al-Batayneh KM, Zoubi MSA, Shehab M, et al. Association between MTHFR 677C>T polymorphism and vitamin B12 deficiency: a case control study. J Med Biochem. 2018;7:1–7.
   Google Scholar
• Rahimi Z, Bozorgi M, Rahimi Z, et al. MTHFR C677T polymorphism is associated with the risk of breast cancer among Kurdish population from western Iran. Int J Cancer Manag. 2019;12(3). doi:10.5812/ijcm.67895
   Web of Science ®Google Scholar
• Mitchell ES, Conus N, Kaput J. B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neurosci Biobehav Rev. 2014;47:307–320. doi:10.1016/j.neubiorev.2014.08.006
   PubMed Web of Science ®Google Scholar
• Ueland P, Rozen R. MTHFR Polymorphisms and Disease. Eurekah Landes Bioscience; 2005.
   Google Scholar
• Sukla KK, Nagar R, Raman R. Vitamin-B12 and folate deficiency, major contributing factors for anemia: a population based study. e-SPEN J. 2014;9(1):e45–e48. doi:10.1016/j.clnme.2013.11.003
   Google Scholar
• Ni J, Zhang L, Zhou T, et al. Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China. J Chin Med Assoc. 2017;80:147–153. doi:10.1016/j.jcma.2016.07.005
   PubMed Web of Science ®Google Scholar
• Li W-X, Dai S-X, Zheng -J-J, Liu J-Q, Huang J-F. Homocysteine metabolism gene polymorphisms (MTHFR C677T, MTHFR A1298C, MTHFR A2756G and MTHFR A66G) jointly elevate the risk of folate deficiency. Nutrients. 2015;7:6670–6687. doi:10.3390/nu7085303
   PubMed Web of Science ®Google Scholar
• Rai V. Evaluation of the MTHFR C677T polymorphism as a risk factor for colorectal cancer in Asian populations. Asian Pac J Cancer Prev. 2016;16(18):8093–8100. doi:10.7314/APJCP.2015.16.18.8093
   Google Scholar
• Hoffbrand AV, Moss PAH. Essential Haematology. 7th ed. Willey Blackwell; 2016.
   Google Scholar
• Owiredu W, Quaye L, Amidu N, Addai-Mensah O. Prevalence of anaemia and immunological markers among Ghanaian HAART-naïve HIV-patients and those on HAART. Afr Health Sci. 2011;11(1):1–14.
   Web of Science ®Google Scholar