Electrocardiogram Features in Non-Cardiac Diseases: From Mechanisms to Practical Aspects

References

• Gore M, Bansal K, Khan Suheb MZ. Asuncion RMD: Lacunar Stroke. Treasure Island (FL): StatPearls Publishing; 2023.
   Google Scholar
• Ustrell X, Pellisé A. Cardiac workup of ischemic stroke. Curr Cardiol Rev. 2010;6(3):175–183.
   PubMedGoogle Scholar
• Omisore AD, Ayoola OO, Ibitoye BO, Fawale MB, Adetiloye VA. Sonographic Evaluation of Endothelial Function in Brachial Arteries of Adult Stroke Patients. J of Ultrasound Medicine. 2017;36(2):345–351.
   PubMed Web of Science ®Google Scholar
• Sacco RL, Kasner SE, Broderick JP, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064–2089.
   PubMed Web of Science ®Google Scholar
• Kuriakose D, Xiao Z. Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci. 2020;21(20):7609.
   PubMed Web of Science ®Google Scholar
• Owolabi M, Ogbole G, Akinyemi R, et al. Development and reliability of a user-friendly multicenter phenotyping application for hemorrhagic and ischemic stroke. J Stroke Cerebrovasc Dis. 2017;26(11):2662–2670.
   PubMed Web of Science ®Google Scholar
• Katsanos AH, Korantzopoulos P, Tsivgoulis G, Kyritsis AP, Kosmidou M, Giannopoulos S. Electrocardiographic abnormalities and cardiac arrhythmias in structural brain lesions. Int J Cardiol. 2013;167(2):328–334.
   PubMed Web of Science ®Google Scholar
• Christensen H, Boysen G, Christensen A, Johannesen H. Insular lesions, ECG abnormalities, and outcome in acute stroke. J Neurol Neurosurg Psychiatry. 2005;76(2):269–271.
   PubMed Web of Science ®Google Scholar
• Sethuraman M, Hrishi AP, Prathapadas U, et al. Electrocardiographic changes in patients with raised intracranial pressure from supratentorial brain tumors. JNRP. 2023;14(1):55.
   Google Scholar
• Balta A, Ceasovschih A, Șorodoc V, et al. Broad Electrocardiogram Syndromes Spectrum: from Common Emergencies to Particular Electrical Heart Disorders. J Pers Med. 2022;12(11):1754. doi:10.3390/jpm12111754
   PubMed Web of Science ®Google Scholar
• Chen Z, Venkat P, Seyfried D, Chopp M, Yan T, Chen J. Brain–heart interaction: cardiac complications after stroke. Circ Res. 2017;121(4):451–468. doi:10.1161/CIRCRESAHA.117.311170
   PubMed Web of Science ®Google Scholar
• Scheitz JF, Nolte CH, Doehner W, Hachinski V, Endres M. Stroke–heart syndrome: clinical presentation and underlying mechanisms. Lancet Neurol. 2018;17(12):1109–1120.
   PubMed Web of Science ®Google Scholar
• Mitro P, Šimurda M, Lazúrová Z, Jakubová M. Etiology of syncope in patients with preexisting atrioventricular conduction disorders. Pacing Clin Electrophysiol. 2020;43(11):1268–1272.
   PubMed Web of Science ®Google Scholar
• Khechinashvili G, Asplund K. Electrocardiographic changes in patients with acute stroke: a systematic review. Cerebrovasc Dis. 2002;14(2):67–76.
   PubMed Web of Science ®Google Scholar
• Pescador Ruschel MA, De Jesus O. Migraine Headache. Treasure Island (FL): StatPearls Publishing; 2023.
   Google Scholar
• Akerman S, Holland PR, Goadsby PJ. Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci. 2011;12(10):570–584.
   PubMed Web of Science ®Google Scholar
• Miglis MG. Migraine and autonomic dysfunction: which is the horse and which is the jockey? Curr Pain Headache Rep. 2018;22:1–7.
   PubMed Web of Science ®Google Scholar
• Aygun D, Altintop L, Doganay Z, Guven H, Baydin A. Electrocardiographic changes during migraine attacks. J Headache Pain. 2003;43(8):861–866.
   Google Scholar
• Wayne V. A possible relationship between migraine and coronary artery spasm. Aust N Z J Med. 1986;16(5):708–710.
   PubMedGoogle Scholar
• Clark E. Serum carditis: the morphologic cardiac alterations in man associated with serum disease. JAMA. 1938;110(14):1098–1100.
   Google Scholar
• Kounis N, Zavras G. Histamine-induced coronary artery spasm: the concept of allergic angina. Br J Clin Pract. 1991;45(2):121–128.
   PubMedGoogle Scholar
• Sueda S, Sasaki Y, Habara H, Kohno H. Kounis syndrome (allergic angina and allergic myocardial infarction) for cardiologists. J Cardiol Cases. 2015;12(4):110–112.
   PubMedGoogle Scholar
• Biteker M. A new classification of Kounis syndrome. Int J Cardiol. 2010;145(3):553.
   PubMed Web of Science ®Google Scholar
• Gázquez V, Dalmau G, Gaig P, Gómez C, Navarro S, Mercé J. Kounis syndrome: report of 5 cases. J Investig Allergol Clin Immunol. 2010;20(2):162–165.
   PubMed Web of Science ®Google Scholar
• Lionte C. An unusual cause of hypotension and abnormal electrocardiogram (ECG)—scombroid poisoning. Cent Eur J Med. 2010;5:292–297.
   Google Scholar
• Forzese E, Pitrone C, Cianci V, et al. An Insight into Kounis Syndrome: bridging Clinical Knowledge with Forensic Perspectives. Life. 2024;14(1):91.
   PubMedGoogle Scholar
• Kogias JS, Papadakis EX, Tsatiris CG, et al. Kounis syndrome: a manifestation of drug-eluting stent thrombosis associated with allergic reaction to contrast material. Int J Cardiol. 2010;139(2):206–209.
   PubMed Web of Science ®Google Scholar
• González-de-Olano D, Alvarez-Twose I, Matito A, Sanchez-Munoz L, Kounis N, Escribano L. Mast cell activation disorders presenting with cerebral vasospasm-related symptoms: a “Kounis-like” syndrome? Int J Cardiol. 2011;150(2):210–211.
   PubMed Web of Science ®Google Scholar
• Schwartz H, Yunginger J, Schwartz L. Is unrecognized anaphylaxis a cause of sudden unexpected death? Clin Exp Allergy. 1995;25(9):866–870.
   PubMed Web of Science ®Google Scholar
• Salari H, Chan-Yeung M. Mast cell mediators stimulate synthesis of arachidonic acid metabolites in macrophages. J Immunol. 1989;142(8):2821–2827.
   PubMed Web of Science ®Google Scholar
• Şaylan B, Cevik A, Firat C. Kounis syndrome, a cause of chest pain to keep in mind, may be associated with E148Q mutation. J Emerg Crit Care Med. 2012;19(4):278–282.
   Google Scholar
• Gilfillan AM, Tkaczyk C. Integrated signalling pathways for mast-cell activation. Nat Rev Immunol. 2006;6(3):218–230.
   PubMed Web of Science ®Google Scholar
• Coppola G, Caccamo G, Bacarella D, et al. Vasospastic angina and scombroid syndrome: a case report. Acta Clin Belg. 2012;67(3):222–225.
   PubMed Web of Science ®Google Scholar
• Johnson JL, Jackson CL, Angelini GD, George SJ. Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 1998;18(11):1707–1715.
   PubMed Web of Science ®Google Scholar
• Allen S, Dashwood M, Chester A, et al. Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leukotriene C4. Cardioscience. 1993;4(1):47–54.
   PubMedGoogle Scholar
• Poggiali E, Benedetti I, Vertemati V, et al. Kounis syndrome: from an unexpected case in the Emergency Room to a review of the literature. Acta Biomed. 2022;93(1):567.
   Google Scholar
• Fisher MM. Clinical observations on the pathophysiology and treatment of anaphylactic cardiovascular collapse. Anaesth Intensive Care. 1986;14(1):17–21.
   PubMed Web of Science ®Google Scholar
• Lippi G, Buonocore R, Schirosa F, Cervellin G. Cardiac troponin I is increased in patients admitted to the emergency department with severe allergic reactions. A case–control study. Int J Cardiol. 2015;194:68–69.
   PubMed Web of Science ®Google Scholar
• Muraro A, Roberts G, Worm M, et al. Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology. Allergy. 2014;69(8):1026–1045.
   PubMed Web of Science ®Google Scholar
• Abdelghany M, Subedi R, Shah S, Kozman H. Kounis syndrome: a review article on epidemiology, diagnostic findings, management and complications of allergic acute coronary syndrome. Int J Cardiol. 2017;232:1–4.
   PubMed Web of Science ®Google Scholar
• Kounis GN, Kouni SA, Hahalis G, Kounis NG. Mesalamine hypersensitivity and Kounis syndrome in a pediatric ulcerative colitis patient. World J Gastroenterol. 2008;14(46):7141.
   PubMed Web of Science ®Google Scholar
• Matta A, Elenizi K, Bouisset F, Roncalli J. Utility of enhanced cardiac magnetic resonance imaging in Kounis syndrome: a case report. Eur Heart J Case Rep. 2020;4(4):1–5.
   Google Scholar
• Kounis NG. Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management. Clin Chem Lab Med. 2016;54(10):1545–1559.
   PubMed Web of Science ®Google Scholar
• Kounis NG, Koniari I, Soufras GD, et al. The humble relation of kounis syndrome, MINOCA (myocardial infarction with nonobstructive coronary arteries) and MACE (major adverse cardiac events). Can J Cardiol. 2018;34(8):1089. e7.
   PubMed Web of Science ®Google Scholar
• Kounis NG, Mazarakis A, Tsigkas G, Giannopoulos S, Goudevenos J. Kounis syndrome: a new twist on an old disease. Future Cardiol. 2011;7(6):805–824.
   PubMedGoogle Scholar
• Cevik C, Nugent K, Shome GP, Kounis NG. Treatment of Kounis syndrome. Int J Cardiol. 2010;143(3):223–226.
   PubMed Web of Science ®Google Scholar
• Salouage I, El Aidli S, Kastalli S, Daghfous R, Lakhal M. Fatal Kounis syndrome with stent thrombosis secondary to amoxicillin/clavulanic acid use: a case report and literature review. Therapies. 2016;71(6):535–539.
   PubMed Web of Science ®Google Scholar
• Kitulwatte I, Gangahawatte S, Perera U, Edirisinghe P. Death following ceftazidime-induced Kounis syndrome. Med Leg J. 2017;85(4):215–218.
   PubMedGoogle Scholar
• Moreno Diaz R. New Fatal Case of Kounis Syndrome Triggered by Metamizole: a Case Report. J Aesthet Reconstr Surg. 2018;4(2):12.
   Google Scholar
• Buğdacı MS, Tüzün A, Koca H, Çavusoğlu T, Akyüz Ü, Şentürk H. QT interval changes and reversibility of QT dispersion in patients with acute pancreatitis. Turk J Gastroenterol. 2014;25(1):59–62.
   PubMedGoogle Scholar
• Yegneswaran B, Kostis JB, Pitchumoni C. Cardiovascular manifestations of acute pancreatitis. J Crit Care. 2011;26(2):225. e11–225. e18.
   PubMed Web of Science ®Google Scholar
• Pădureanu V, Boldeanu MV, Streaţă I, et al. Determination of VEGFR-2 (KDR) 604A> G polymorphism in pancreatic disorders. Int J Mol Sci. 2017;18(2):439.
   PubMed Web of Science ®Google Scholar
• Bulava A, Skvarilová M, Marek O, Lukl J. Electrocardiographic changes in patients with acute pancreatitis. Case report and review of the literature. Vnitrni Lekarstvi. 2001;47(6):407–410.
   PubMedGoogle Scholar
• Khan U, Petrechko O, Sagheer S, et al. Acute pancreatitis and myocardial infarction: a narrative review. Cardiology. 2023;148(1):1–11.
   PubMed Web of Science ®Google Scholar
• Sethi P, Murtaza G, Sharma A, Paul T. ST segment elevation with normal coronaries. Case Rep Med. 2016;2016:657.
   Google Scholar
• Khairy P, Marsolais P. Pancreatitis with electrocardiographic changes mimicking acute myocardial infarction. Can J Gastroenterol Hepatol. 2001;15:522–526.
   Google Scholar
• Rubio-Tapia A, García-Leiva J, Asensio-Lafuente E, Robles-Díaz G, Vargas-Vorácková F. Electrocardiographic abnormalities in patients with acute pancreatitis. J Clin Gastroenterol. 2005;39(9):815–818.
   PubMed Web of Science ®Google Scholar
• Long Y, Tang M, Wang J, et al. Case report: abnormal ECG in a patient with acute pancreatitis. Front Cardiovasc med. 2021;8:741253.
   PubMed Web of Science ®Google Scholar
• Lionte C, Sorodoc V, Bologa C, Tuchilus C, Jaba E. Usefulness of transthoracic echocardiography parameters and brain natriuretic peptide as mortality predictors in hospitalized acutely poisoned patients: a prospective observational study. Basic Clin Pharmacol Toxicol. 2017;120(5):498–504.
   PubMed Web of Science ®Google Scholar
• Costache II, Miron A, Hăncianu M, et al. Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products. Cardiovasc Ther. 2019;2019:9402781.
   PubMed Web of Science ®Google Scholar
• Lionte C, Bologa C, Sorodoc V, et al. Biomarkers of inflammation and inflammation-related indexes upon emergency department admission are predictive for the risk of intensive care unit hospitalization and mortality in acute poisoning: a 6-year prospective observational study. Dis Markers. 2021;2021.
   PubMed Web of Science ®Google Scholar
• Farzam K, Jan A. Beta Blockers. Treasure Island (FL): StatPearls Publishing; 2023.
   Google Scholar
• Oliver E, Mayor F, D’Ocon P. Beta-blockers: historical perspective and mechanisms of action. Rev Esp Cardiol. 2019;72(10):853–862.
   PubMed Web of Science ®Google Scholar
• Tucker WD, Sankar P, Theetha Kariyanna P. Selective Beta-1 Blockers. Treasure Island (FL): StatPearls Publishing; 2023.
   Google Scholar
• Marcu DTM, Adam CA, Dorobanțu DM, et al. Beta-Blocker-Related Atrioventricular Conduction Disorders-A Single Tertiary Referral Center Experience. Medicina (Kaunas). 2022;58(2):320.
   PubMed Web of Science ®Google Scholar
• Love JN, Enlow B, Howell JM, Klein-Schwartz W, Litovitz TL. Electrocardiographic changes associated with β-blocker toxicity. Ann Emerg Med. 2002;40(6):603–610.
   PubMed Web of Science ®Google Scholar
• Lionte C, Sorodoc V, Tuchilus C, Cimpoiesu D, Jaba E. Biomarkers, lactate, and clinical scores as outcome predictors in systemic poisons exposures. Hum Exp Toxicol. 2017;36(7):651–662.
   PubMed Web of Science ®Google Scholar
• McKeever RG, Hamilton RJ. Calcium Channel Blockers. 2022 Aug 5. Treasure Island (FL): StatPearls Publishing; 2023.
   Google Scholar
• Costache II, Miftode E, Mitu O, Aursulesei V. Sex Differences in Cardiovascular Risk Factors in a Rural Community from North Romania Region. Rev Cercet Interv Soc. 2016;55:204–214.
   Web of Science ®Google Scholar
• Handler J. Dihydropyridine/nondihydropyridine calcium channel blocker combination therapy. J Clin Hypertens. 2005;7(1):50.
   Google Scholar
• Elliott WJ, Ram CVS. Calcium channel blockers. J Clin Hypertens. 2011;13(9):687.
   PubMed Web of Science ®Google Scholar
• Bologa C, Lionte C, Coman A, Sorodoc L. Lipid emulsion therapy in cardiodepressive syndrome after diltiazem overdose--case report. Am J Emerg Med. 2013;31(7):1154. e3–4.
   PubMed Web of Science ®Google Scholar
• Chakraborty RK, Hamilton RJ. Calcium Channel Blocker Toxicity. Treasure Island (FL): StatPearls Publishing; 2023.
   Google Scholar
• David MNV, Shetty M. Digoxin. Treasure Island (FL): StatPearls Publishing; 2023.
   Google Scholar
• Djohan AH, Sia C-H, Singh D, Lin W, Kong WK-F, Poh -K-K. A myriad of electrocardiographic findings associated with digoxin use. Singapore Med J. 2020;61(1):9.
   PubMed Web of Science ®Google Scholar
• Negroni MS, Marengo A, Caruso D, et al. A case report of accidental intoxication following ingestion of foxglove confused with borage: high digoxinemia without major complications. Case Rep Cardiol. 2019;2019:567.
   Web of Science ®Google Scholar
• Anderson BJ. Paracetamol (Acetaminophen): mechanisms of action. Paediatr Anaesth. 2008;18(10):915–921.
   PubMed Web of Science ®Google Scholar
• Mahadeva S, Parekh N, Bosomworth M, Millson C, Berkin K, Bellamy M. Cardiac troponin I as a marker of myocardial injury in paracetamol induced acute liver failure. Crit Care. 2001;5(Suppl 1).
   Google Scholar
• Sorodoc L, Lionte C, Laba V. A rare cause of non-Q myocardial infarction--acute carbon monoxide poisoning. Rev Med Chir Soc Med Nat Iasi. 2004;108(4):782–785.
   PubMedGoogle Scholar
• Khabazianzadeh F, Kazemi T, Nakhaee S, Ng PC, Mehrpour O. Acetaminophen poisoning-induced heart injury: a case-based review. Daru. 2019;27:839–851.
   PubMed Web of Science ®Google Scholar
• Erglu M, Omer U, Zafer I, Yalcin M, Yildrim A, Kardesglu E. Carbon monoxide poisoning increase Tpeak-Tend dispersion and QTc dispersion. Cardiovasc J Afr. 2014;25:106–109.
   PubMed Web of Science ®Google Scholar
• Maready E, Holstege C, Brady W, Baer A. Electrocardiographic abnormality in carbon monoxide–poisoned patients. Ann Emerg Med. 2004;44(4).
   Web of Science ®Google Scholar
• Palaniswamy C, Aronow W, Sugunaraj JP, Kang JJ, Kar K, Kalra A. Brugada electrocardiographic pattern in carbon monoxide poisoning. Arch Med Sci. 2013;9(2):377–380.
   PubMed Web of Science ®Google Scholar
• Akdemir HU, Güngörer B, Çalışkan F, Colak S, Güzel M. Atrial fibrillation related to carbon monoxide poisoning in a female patient. Am J Emerg Med. 2014;32(9):1154. e3–5.
   PubMed Web of Science ®Google Scholar
• LaHood AJ, Kok SJ. Ethanol Toxicity. Treasure Island (FL): StatPearls Publishing; 2023.
   Google Scholar
• Voskoboinik A, Prabhu S, L-h L, Kalman JM, Kistler PM. Alcohol and atrial fibrillation: a sobering review. J Am Coll Cardiol. 2016;68(23):2567–2576.
   PubMed Web of Science ®Google Scholar
• Ihekire NL, Okobi OE, Adedoye EA, et al. Heartache in a Bottle: understanding Alcoholic Cardiomyopathy. Cureus. 2023;15(8):547.
   Web of Science ®Google Scholar
• Sereny G. Effects of alcohol on the electrocardiogram. Circulation. 1971;44(4):558–564.
   PubMed Web of Science ®Google Scholar
• Raheja H, Namana V, Chopra K, et al. Electrocardiogram changes with acute alcohol intoxication: a systematic review. Open Cardiovasc Med J. 2018;12:1.
   PubMedGoogle Scholar
• Aasebø W, Aasebø W, Erikssen J, Jonsbu J, Stavem K. ECG changes in patients with acute ethanol intoxication. Scand Cardiovasc J. 2007;41(2):79–84.
   PubMed Web of Science ®Google Scholar
• Nagesh I, Koley K, Sen S, Mohan S, Sahu S. Ethylene glycol poisoning. Med J Armed Forces India. 2015;71:S36–S38.
   PubMedGoogle Scholar
• Leth PM, Gregersen M. Ethylene glycol poisoning. Forensic Sci Int. 2005;155(2–3):5677.
   Web of Science ®Google Scholar
• Bologa C, Ciuhodaru L, Coman A, et al. Unusual cause of spontaneous unilateral intracerebral hematoma-acute methanol poisoning: case report. Am J Emerg Med. 2014;32(9):1154.e1–2.
   PubMed Web of Science ®Google Scholar
• Suit PF, Estes ML. Methanol intoxication: clinical features and differential diagnosis. Cleve Clin J Med. 1990;57(5):464–471.
   PubMed Web of Science ®Google Scholar
• Dibajnia P, Sivilotti ML, Juurlink D, Shurrab M. ST-elevation in ethylene glycol toxicity mimicking myocardial infarction. J Electrocardiol. 2020;58:128–131.
   PubMed Web of Science ®Google Scholar
• Iqbal A, Glagola JJ, Nappe TM. Ethylene glycol toxicity. Am J Clin Pathol. 2019;45:46.
   Google Scholar
• Denning D, Berendt A, Chia Y, Morgan S. Myocarditis complicating ethylene glycol poisoning in the absence of neurological features. Postgrad Med J. 1988;64(757):867–870.
   PubMed Web of Science ®Google Scholar
• Jaff Z, McIntyre WF, Yazdan-Ashoori P, Baranchuk A. Impact of methanol intoxication on the human electrocardiogram. Cardiol J. 2014;21(2):170–175.
   PubMed Web of Science ®Google Scholar
• Marrs TC, Maynard RL, Sidell FR, eds. Chemical Warfare Agents: Toxicology and Treatment. 1st ed. Wiley; 2007.
   Google Scholar
• Ludomirsky A, Klein HO, Sarelli P, et al. Q-T prolongation and polymorphous (“torsade de pointes”) ventricular arrhythmias associated with organophosphorus insecticide poisoning. Am J Cardiol. 1982;49(7):1654–1658. doi:10.1016/0002-9149(82)90242-9
   PubMed Web of Science ®Google Scholar
• Ahishali E, Boynuegri B, Ozpolat E, et al. Approach to mushroom intoxication and treatment: can we decrease mortality? Clin Res Hepatol Gastroenterol. 2012;36(2):139–145. doi:10.1016/j.clinre.2011.11.004
   PubMed Web of Science ®Google Scholar
• Unverir P, Soner BC, Dedeoglu E, Karcioglu O, Boztok K, Tuncok Y. Renal and hepatic injury with elevated cardiac enzymes in Amanita phalloides poisoning: a case report. Hum Exp Toxicol. 2007;26(9):757–761. doi:10.1177/0960327107083972
   PubMed Web of Science ®Google Scholar
• Qin Z, Luo L, Ge L. Electrocardiogram of a patient with mushroom poisoning-induced myocarditis. Ann Noninvasive Electrocardiol. 2023;28(2):e13011. doi:10.1111/anec.13011
   PubMed Web of Science ®Google Scholar
• Erenler AK, Doğan T, Koçak C, Ece Y. Investigation of toxic effects of mushroom poisoning on the cardiovascular system. Basic Clin Pharmacol Toxicol. 2016;119(3):317–321. doi:10.1111/bcpt.12569
   PubMed Web of Science ®Google Scholar
• Thomsen JH, Hassager C, Bro-Jeppesen J, et al. Sinus bradycardia during hypothermia in comatose survivors of out-of-hospital cardiac arrest – a new early marker of favorable outcome? Resuscitation. 2015;89:36–42. doi:10.1016/j.resuscitation.2014.12.031
   PubMed Web of Science ®Google Scholar
• Cheng D. The EKG of hypothermia1. J Emerg Med. 2002;22(1):87–91. doi:10.1016/S0736-4679(01)00441-3
   PubMed Web of Science ®Google Scholar
• Feldman A, Freedberg NA, Antonelli D, Rozner E, Turgeman Y. Prognostic Value of J (Osborn) Waves on Surface Electrocardiogram Tracing during Therapeutic Hypothermia in Out-of-Hospital Cardiac Arrest Survivors (JOW trial). Isr Med Assoc J. 2021;23(5):291–296.
   PubMed Web of Science ®Google Scholar
• de Souza D, Riera ARP, Bombig MT, et al. Electrocardiographic changes by accidental hypothermia in an urban and a tropical region. journal of Electrocardiology. 2007;40(1):47–52. doi:10.1016/j.jelectrocard.2006.08.094
   PubMed Web of Science ®Google Scholar
• Doshi HH, Giudici MC. The EKG in hypothermia and hyperthermia. journal of Electrocardiology. 2015;48(2):203–209. doi:10.1016/j.jelectrocard.2014.12.001
   PubMed Web of Science ®Google Scholar
• Marques A, Caldeira D, Briosa A, João I, Pereira H. Alterações Eletrocardiográficas Induzidas pela Hipotermia. Arq Bras Cardiol. 2020;114(6):1076–1077. doi:10.36660/abc.20200081
   PubMedGoogle Scholar
• Rolfast CL, Lust EJ, de Cock CC. Electrocardiographic changes in therapeutic hypothermia. Crit Care. 2012;16(3):1–7. doi:10.1186/cc11369
   Web of Science ®Google Scholar
• Menezes MA, Herbella FAM. Pathophysiology of gastroesophageal reflux disease. World J Surg. 2017;41(7):1666–1671. doi:10.1007/s00268-017-3952-4
   PubMed Web of Science ®Google Scholar
• Milovanovic B, Filipovic B, Mutavdzin S, et al. Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease. World J Gastroenterol. 2015;21(22):6982. doi:10.3748/wjg.v21.i22.6982
   PubMed Web of Science ®Google Scholar
• Kaya H, Barutçu S. Gastroesophageal reflux disease is associated with abnormal ventricular repolarization indices. Turk J Gastroenterol. 2020;30(12):1021. doi:10.5152/tjg.2019.181008
   Web of Science ®Google Scholar
• Ciobanu A, Tse G, Liu T, et al. Electrocardiographic measures of repolarization dispersion and their relationships with echocardiographic indices of ventricular remodeling and premature ventricular beats in hypertension. J. Geriatr Cardiol. 2017;14(12):717.
   PubMedGoogle Scholar
• Nichols KB, Littmann L. Electrical alternans as a manifestation of pulmonary embolism. Am J Emerg Med. 2011;9(29):1236. e5–1236. e7.
   Google Scholar
• Hubloue I, Schoors D, Wilde C, Diltoer M, Van Tussenbroek F. Early electrocardiographic signs in acute massive pulmonary embolism. Eur J Emerg Med. 1996;3(3):199–204. doi:10.1097/00063110-199609000-00012
   PubMedGoogle Scholar
• Marchick MR, Courtney DM, Kabrhel C, et al. 12-lead ECG findings of pulmonary hypertension occur more frequently in emergency department patients with pulmonary embolism than in patients without pulmonary embolism. Ann Emerg Med. 2010;55(4):331–335. doi:10.1016/j.annemergmed.2009.07.025
   PubMed Web of Science ®Google Scholar
• Shopp JD, Stewart LK, Emmett TW, Kline JA. Findings from 12‐lead electrocardiography that predict circulatory shock from pulmonary embolism: systematic review and meta‐analysis. Acad Emerg Med. 2015;22(10):1127–1137.
   PubMed Web of Science ®Google Scholar
• Geibel A, Zehender M, Kasper W, Olschewski M, Klima C, Konstantinides SV. Prognostic value of the ECG on admission in patients with acute major pulmonary embolism. Eur Respir J. 2005;25(5):843–848.
   PubMed Web of Science ®Google Scholar
• Larssen MS, Hodnesdal C, Skjorten I, et al. Mechanisms of ECG changes in chronic obstructive pulmonary disease. Eur Respir Soc. 2016.
   Google Scholar
• Gupta P, Jain H, Gill M, et al. Electrocardiographic changes in Emphysema. World J Cardiol. 2021;13(10):533.
   PubMed Web of Science ®Google Scholar
• Kotlyarov S, Kotlyarova A. Bioinformatic Analysis of ABCA1 Gene Expression in Smoking and Chronic Obstructive Pulmonary Disease. Membranes. 2021;11(9):674.
   PubMed Web of Science ®Google Scholar
• Calaras D, Mathioudakis AG, Lazar Z, Corlateanu A. Combined Pulmonary Fibrosis and Emphysema: comparative Evidence on a Complex Condition. Biomedicines. 2023;11(6):1636.
   PubMed Web of Science ®Google Scholar
• Corlateanu A, Montanari G, Mathioudakis A. Management of stable COPD: an update. Curr Respir Med Rev. 2013;9(6):352–359.
   Google Scholar
• Corlateanu A, Plahotniuc A, Corlateanu O, et al. Multidimensional indices in the assessment of chronic obstructive pulmonary disease. Respir Med. 2021;185:106519.
   PubMed Web of Science ®Google Scholar
• Incalzi RA, Fuso L, De Rosa M, et al. Electrocardiographic signs of chronic cor pulmonale: a negative prognostic finding in chronic obstructive pulmonary disease. Circulation. 1999;99(12):1600–1605.
   PubMed Web of Science ®Google Scholar
• Lazović B, Jovičić N, Radlović V, et al. Electrocardiographic predictors of five-years mortality in chronic obstructive pulmonary disease patients. Srp Arh Celok Lek. 2021;149(3–4).
   Web of Science ®Google Scholar
• Arsenescu Georgescu C, Anghel L. The significance of new left bundle branch block complicating acute myocardial infarction. Rev Chim. 2018;69(1):144–147.
   Web of Science ®Google Scholar
• Siegler D. Reversible electrocardiographic changes in severe acute asthma. Thorax. 1977;32(3):328–332.
   PubMed Web of Science ®Google Scholar
• Abdulmanaf AM, Hijran KSK. A Study of Electrocardiographic Changes in Asthmatic Patients Attending Kirkuk General Hospital. Kirkuk J Med Sci. 2021;6(1):18–25.
   Google Scholar
• Corlateanu A, Siafakas N, Botnaru V. Defining COPD: from simplistic approach to multilateral assessment of COPD. Curr Respir Care Rep. 2012;1:177–182.
   Google Scholar
• Kotlyarov S. Involvement of the innate immune system in the pathogenesis of chronic obstructive pulmonary disease. Int J Mol Sci. 2022;23(2):985.
   PubMed Web of Science ®Google Scholar
• Levis JT. ECG diagnosis: hyperkalemia. Perm J. 2013;17(1):69.
   PubMedGoogle Scholar
• Weiss J, Qu Z, Shivkumar K. Electrophysiology of hypokalemia and hyperkalemia. Circ Arrhythmia Electrophysiol. 2017;10(3).
   Web of Science ®Google Scholar
• Acker CG, Johnson JP, Palevsky PM, Greenberg A. Hyperkalemia in hospitalized patients: causes, adequacy of treatment, and results of an attempt to improve physician compliance with published therapy guidelines. Arch Intern Med. 1998;158(8):917–924.
   PubMedGoogle Scholar
• Rafique Z, Aceves J, Espina I, et al. Can physicians detect hyperkalemia based on the electrocardiogram? Am J Emerg Med. 2020;38(1):105–108.
   PubMed Web of Science ®Google Scholar
• Teymouri N, Mesbah S, Navabian SMH, et al. ECG frequency changes in potassium disorders: a narrative review. Am J Cardiovasc. 2022;12(3):112.
   Google Scholar
• Krijthe BP, Heeringa J, Kors JA, et al. Serum potassium levels and the risk of atrial fibrillation: the Rotterdam Study. Int J Cardiol. 2013;168(6):5411–5415.
   PubMed Web of Science ®Google Scholar
• Phillips CT, Wang J, Celi LA, Zhang Z, Feng M. Association of hypokalemia with an increased risk for medically treated arrhythmias. PLoS One. 2019;14(6):e0217432.
   PubMed Web of Science ®Google Scholar
• Diercks DB, Shumaik GM, Harrigan RA, Brady WJ, Chan TC. Electrocardiographic manifestations: electrolyte abnormalities. J Emerg Med. 2004;27(2):153–160.
   PubMed Web of Science ®Google Scholar
• El-Sherif N, Turitto G. Electrolyte disorders and arrhythmogenesis. Cardiol J. 2011;18(3):233–245.
   PubMed Web of Science ®Google Scholar
• Webster A, Brady W, Morris F. Recognising signs of danger: ECG changes resulting from an abnormal serum potassium concentration. Emerg Med J. 2002;19(1):74–77.
   PubMed Web of Science ®Google Scholar
• Slovis C, Jenkins R. Conditions not primarily affecting the heart. BMJ. 2002;324(7349):1320–1323.
   PubMedGoogle Scholar
• Carlstedt F, Lind L. Hypocalcemic syndromes. CriCare Clin. 2001;17(1):139–153.
   PubMed Web of Science ®Google Scholar
• Ziegler R. Hypercalcemic Crisis. J Am Soc Nephrol. 2001;12(suppl_1).
   PubMedGoogle Scholar
• Chorin E, Rosso R, Viskin S. Electrocardiographic Manifestations of Calcium Abnormalities. Ann Noninvasive Electrocardiol. 2016;21(1):7–9.
   PubMed Web of Science ®Google Scholar
• Negru AG, Pastorcici A, Crisan S, Cismaru G, Popescu FG, Luca CT. The role of hypomagnesemia in cardiac arrhythmias: a clinical perspective. Biomedicines. 2022;10(10):2356.
   PubMed Web of Science ®Google Scholar
• Rosanoff A, West C, Elin RJ, et al. Recommendation on an updated standardization of serum magnesium reference ranges. Eur J Nutr. 2022;61(7):3697–3706.
   PubMed Web of Science ®Google Scholar
• Markovits N, Kurnik D, Halkin H, et al. Database evaluation of the association between serum magnesium levels and the risk of atrial fibrillation in the community. Int J Cardiol. 2016;205:142–146.
   PubMed Web of Science ®Google Scholar
• Yang Y, Chen C, Duan P, et al. The ECG characteristics of patients with isolated hypomagnesemia. Front Physiol. 2021;11:617374.
   PubMed Web of Science ®Google Scholar
• Kim M-Y, Jee SH, Yun JE, Baek SJ, Lee D-C. Hemoglobin concentration and risk of cardiovascular disease in Korean men and women-the Korean heart study. J Korean Med Sci. 2013;28(9):1316–1322.
   PubMed Web of Science ®Google Scholar
• Anderson J, Glynn LG, Newell J, Iglesias AA, Reddan D, Murphy AW. The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study. BMC Cardiovasc Disord. 2009;9:1–8.
   PubMed Web of Science ®Google Scholar
• Kwon JM, Cho Y, Jeon K-H, et al. A deep learning algorithm to detect anaemia with ECGs: a retrospective, multicentre study. Lancet Digit Health. 2020;2(7):e358–e367.
   PubMedGoogle Scholar
• Stanojević M, Stankov S. Electrocardiographic changes in patients with chronic anemia. Srp Arh Celok Lek. 1998;126(11–12).
   Google Scholar
• Khatri M, Deokar V, Patel J, Jaju G. Study of electrocardiographic changes in mild, moderate and severe anaemia in a tertiary care hospital. Int J Contemp Med Res. 2018;5(12):9–13.
   Google Scholar
• Pereira AA, Sarnak MJ. Anemia as a risk factor for cardiovascular disease: management of comorbidities in kidney disease in the 21st century: anemia and bone disease. Kidney Int. 2003;64:S32–S39.
   Google Scholar
• Kumari R, Bharti RK, Singh K, et al. Prevalence of iron deficiency and iron deficiency anaemia in adolescent girls in a tertiary care hospital. J Clin Diagn Res. 2017;11(8):7.
   Google Scholar
• Scheller B, Pipa G, Kertscho H, et al. Low hemoglobin levels during normovolemia are associated with electrocardiographic changes in pigs. Shock. 2011;35(4):375–381.
   PubMed Web of Science ®Google Scholar
• Biradar SM, Holiyachi R, Shannawaz M, Teja VR. Electrocardiographic abnormalities in severe anaemia and its reversibility after correction of anaemia in North Karnataka, India. IJAM. 2020;7(10):1566–1569.
   Google Scholar
• Khode VH, Kammar K. QTc Changes in Non-pregnant Females with Severe iron Deficiency Anaemia. J Clin Diagn Res. 2012;6(5).
   Google Scholar
• Bindra K, Berry C, Rogers J, et al. Abnormal haemoglobin levels in acute coronary syndromes. J Assoc Physicians. 2006;99(12):851–862.
   Google Scholar
• Patil A, Munavalli VP, Morappanavar K. Study of Electrocardiographic Findings in Severe Anaemia. Jebmh. 2020;7(49):2964–2967.
   Google Scholar
• Sumalatha B, Jyotsna M, Indrani G. Electrocardiographic Changes during Normal Pregnancy. Indian J Cardiovasc Dis Women. 2017;02:035–038.
   Google Scholar
• Traian MG, Coman AE, Popa E, Traian L, Petrovanu R. Stress: from symptom to disease. Rev Med Chir Soc Med Nat Iasi. 2013;117(1):72–77.
   PubMedGoogle Scholar
• Boyle DM, Lloyd‐Jones R. The electrocardiographs st segment in pregnancy. BJOG. 1966;73(6):986–987.
   Google Scholar
• Sunitha M, Chandrasekharappa S, Electrocardiographic QRS Axis BS. Q wave and T-wave changes in 2nd and 3rd trimester of normal pregnancy. J Clin Diagn Res. 2014;8(9).
   Google Scholar
• Oram S, Holt M. Innocent depression of the s‐t segment and flattening of the t‐wave during pregnancy. BJOG. 1961;68(5):765–770.
   Google Scholar
• Drenthen W, Boersma E, Balci A, et al. Predictors of pregnancy complications in women with congenital heart disease. Eur Heart J. 2010;31(17):2124–2132.
   PubMed Web of Science ®Google Scholar
• Wang Y, Joyner RW, Wagner MB, Cheng J, Lai D, Crawford BH. Stretch-activated channel activation promotes early afterdepolarizations in rat ventricular myocytes under oxidative stress. Am J Physiol Heart Circ Physiol. 2009;296(5).
   Web of Science ®Google Scholar
• Ramlakhan KP, Kauling RM, Schenkelaars N, et al. Supraventricular arrhythmia in pregnancy. Heart. 2022;108(21):1674–1681.
   PubMed Web of Science ®Google Scholar
• Gowda RM, Punukollu G, Khan IA, et al. Lone atrial fibrillation during pregnancy. Int J Cardiol. 2003;88(1):123–124.
   PubMed Web of Science ®Google Scholar
• Kuczkowski KM. New onset transient lone atrial fibrillation in a healthy parturient: déjà vu. Int J Cardiol. 2004;97(2):339.
   PubMed Web of Science ®Google Scholar
• Wichter T, Milberg P, Wichter HD, Dechering DG. Pregnancy in arrhythmogenic cardiomyopathy. Herzschrittmacherther Elektrophysiol. 2021;32(2):186–198.
   PubMedGoogle Scholar
• Ng KS, Lauer MR, Young C, Liem LB, Sung RJ. Correlation of P-wave polarity with underlying electrophysiologic mechanisms of long RP’ tachycardia. Am J Cardiol. 1996;77(12):1129–1132.
   PubMed Web of Science ®Google Scholar
• Riva SI, Della Bella P, Fassini G, Carbucicchio C, Tondo C. Value of analysis of ST segment changes during tachycardia in determining type of narrow QRS complex tachycardia. J Am Coll Cardiol. 1996;27(6):1480–1485.
   PubMed Web of Science ®Google Scholar
• Seth R, Moss AJ, McNitt S, et al. Long QT Syndrome and Pregnancy. JACC. 2007;49(10):1092–1098.
   Google Scholar
• Kusumoto FM, Schoenfeld MH, Barrett C, et al. 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2019;74(7):e51–e156.
   PubMed Web of Science ®Google Scholar
• Matta B, Magee P. Wenckebach type heart block following spinal anaesthesia for caesarean section. Can J Anaesth. 1992;39:1067–1068.
   PubMed Web of Science ®Google Scholar
• Thaman R, Curtis S, Faganello G, et al. Cardiac outcome of pregnancy in women with a pacemaker and women with untreated atrioventricular conduction block. Europace. 2011;13(6):859–863.
   PubMed Web of Science ®Google Scholar
• Young D, Turaga NSS, Amisha F, Hayes K, Paydak H, Devabhaktuni SR. Recurrence of complete heart block in pregnancy. HeartRhythm Case Rep. 2021;7(10):679–682.
   PubMedGoogle Scholar
• Mahmoudi E, Mollazadeh R, Mansouri P, et al. Ventricular repolarization heterogeneity in patients with COVID‐19: original data, systematic review, and meta‐analysis. Clin Cardiol. 2022;45(1):110–118.
   PubMed Web of Science ®Google Scholar
• Ulinici M, Covantev S, Wingfield-Digby J, Beloukas A, Mathioudakis AG, Corlateanu A. Screening, diagnostic and prognostic tests for COVID-19: a comprehensive review. Life. 2021;11(6):561.
   PubMedGoogle Scholar
• Timpau A-S, Miftode R-S, Leca D, et al. A real Pandora’s box in pandemic times: a narrative review on the acute cardiac injury due to COVID-19. Life. 2022;12(7):1085.
   PubMedGoogle Scholar
• Yenerçağ M, Arslan U, Doğduş M, et al. Evaluation of electrocardiographic ventricular repolarization variables in patients with newly diagnosed COVID-19. J Electrocardiol. 2020;62:5–9.
   PubMed Web of Science ®Google Scholar
• Lampert J, Miller M, Halperin JL, et al. Prognostic value of electrocardiographic QRS diminution in patients hospitalized with COVID-19 or influenza. Am J Cardiol. 2021;159:129–137.
   PubMed Web of Science ®Google Scholar
• Asoglu R, Tibilli H, Asoglu E, Aladag N, Ozdemir M, Suner A. Evaluation of index of cardiac electrophysiological balance in COVID-19 patients. Bratisl Lek Listy. 2021;122(8):598–604.
   PubMed Web of Science ®Google Scholar
• Anghel L, Tudurachi B-S, Leonte A, et al. The Challenge of High Coronary Thrombotic Events in Patients with ST-Segment Elevation Myocardial Infarction and COVID-19. J Clin Med. 2022;11(21):6542.
   PubMed Web of Science ®Google Scholar
• Nordin C, Kohli A, Beca S, et al. Importance of hepatitis C coinfection in the development of QT prolongation in HIV-infected patients. J Electrocardiol. 2006;39(2):199–205.
   PubMed Web of Science ®Google Scholar
• Abrams MP, Wan EY, Waase MP, et al. Clinical and Cardiac Characteristics of COVID‐19 Mortalities in a Diverse New York City Cohort. J Cardiovasc Electrophysiol. 2020;31(12):3086–3096.
   PubMed Web of Science ®Google Scholar
• Nathala P, Salunkhe V, Samanapally H, et al. Electrocardiographic Features and Outcome: correlations in 124 Hospitalized Patients With COVID-19 and Cardiovascular Events. J Cardiothorac Vasc Anesth. 2022;36(8):2927–2934.
   PubMed Web of Science ®Google Scholar
• Rubin GA, Desai AD, Chai Z, et al. Cardiac corrected QT interval changes among patients treated for COVID-19 infection during the early phase of the pandemic. JAMA Network Open. 2021;4(4):e216842–e216842.
   PubMed Web of Science ®Google Scholar
• Centurion OA. Wide QRS complex and left ventricular lateral repolarization abnormality: the importance of ECG markers on outcome prediction in patients with COVID-19. Am J Med Sci. 2021;362(1):1–2.
   PubMed Web of Science ®Google Scholar
• Angeli F, Spanevello A, De Ponti R, et al. Electrocardiographic features of patients with COVID-19 pneumonia. Eur J Intern Med. 2020;78:101–106.
   PubMed Web of Science ®Google Scholar
• Barman HA, Atici A, Alici G, et al. The effect of the severity COVID-19 infection on electrocardiography. Am J Emerg Med. 2021;46:317–322.
   PubMed Web of Science ®Google Scholar
• Verdecchia P, Cavallini C, Spanevello A, Angeli F. The pivotal link between ACE2 deficiency and SARS-CoV-2 infection. Eur J Intern Med. 2020;76:14–20.
   PubMed Web of Science ®Google Scholar
• Thanassoulis G, Massaro JM, O’Donnell CJ, et al. Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study. Circ Arrhythm Electrophysiol. 2010;3(4):345–350.
   PubMed Web of Science ®Google Scholar
• Anghel L, Prisacariu C, Arsenescu Georgescu C. Is there a sex difference of cardiovascular risk factors in patients with acute myocardial infarction? Rev Chim. 2018;69(1):255–258.
   Web of Science ®Google Scholar
• Grigorescu ED, Lăcătușu CM, Floria M, et al. Association of Inflammatory and Metabolic Biomarkers with Mitral Annular Calcification in Type 2 Diabetes Patients. J Pers Med. 2022;12(9):1484.
   PubMed Web of Science ®Google Scholar
• Garcia‐Zamora S, Lee S, Haseeb S, et al. Arrhythmias and electrocardiographic findings in Coronavirus disease 2019: a systematic review and meta‐analysis. Pacing Clin Electrophysiol. 2021;44(6):1062–1074.
   PubMed Web of Science ®Google Scholar