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REVIEW

Uncovering the Benefits of Povidone Iodine Compared to Other Therapeutic Agents in Wound Infection Prevention and Healing Outcomes: A Scoping Review

, , ORCID Icon, & ORCID Icon
Pages 3605-3616 | Received 15 Mar 2024, Accepted 10 Jul 2024, Published online: 24 Jul 2024

References

  • Singh S, Young A, McNaught CE. The physiology of wound healing. Surgery. 2017;35(9):473–477. doi:10.1016/j.mpsur.2017.06.004
  • Platini H, Adammayanti KA, Maulana S, et al. The potential of autologous platelet-rich plasma gel for diabetic foot ulcer care among older adults: a systematic review and meta-analysis. Ther Clin Risk Manag. 2024;20(null):21–37. doi:10.2147/TCRM.S433033
  • Sira J, Eyre L. Physiology of haemostasis. Anaesth Intensive Care Med. 2016;17(2):79–82. doi:10.1016/j.mpaic.2015.11.004
  • Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Adv Wound Care. 2015;4(9):560–582. doi:10.1089/wound.2015.0635
  • Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA. Povidone iodine in wound healing: a review of current concepts and practices. Int J Surg. 2017;44:260–268. doi:10.1016/j.ijsu.2017.06.073
  • Sauerbrei A. Bactericidal and virucidal activity of ethanol and povidone-iodine. Microbiologyopen. 2020;9(9):e1097. doi:10.1002/mbo3.1097
  • Babalska ZŁ, Korbecka-Paczkowska M, Karpiński TM. Wound antiseptics and European guidelines for antiseptic application in wound treatment. Pharmaceuticals. 2021;14(12). doi:10.3390/ph14121253
  • Jeong TS, Yee GT. Prospective multicenter surveillance study of surgical site infection after spinal surgery in Korea: a preliminary study. J Korean Neurosurg Soc. 2018;61(5):608–617. doi:10.3340/jkns.2018.0118
  • Berríos-Torres SI, Umscheid CA, Bratzler DW, et al. Centers for disease control and prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg. 2017;152(8):784–791. doi:10.1001/jamasurg.2017.0904
  • Wang P, Wang D, Zhang L. Effectiveness of chlorhexidine versus povidone-iodine for preventing surgical site wound infection: a meta-analysis. Int Wound J. 2024;21(2):e14394. doi:10.1111/iwj.14394
  • Jalalzadeh H, Groenen H, Buis DR, et al. Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis. Lancet Microbe. 2022;3(10):e762–e771. doi:10.1016/S2666-5247(22)00187-2
  • Shi L, Cai L, Wan F, Jiang Y, Choudhury R, Rastogi S. Does povidone-iodine application in surgical procedures help in the prevention of surgical site infections? An updated meta-analysis. Wideochir Inne Tech Maloinwazyjne. 2022;17(2):261–278. doi:10.5114/wiitm.2021.112479
  • Monstrey SJ, Govaers K, Lejuste P, Lepelletier D, Ribeiro de Oliveira P. Evaluation of the role of povidone-iodine in the prevention of surgical site infections. Surg Open Sci. 2023;13:9–17. doi:10.1016/j.sopen.2023.03.005
  • Tricco AC, Lillie E, Zarin W, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–473. doi:10.7326/M18-0850
  • Dior UP, Kathurusinghe S, Cheng C, et al. Effect of surgical skin antisepsis on surgical site infections in patients undergoing gynecological laparoscopic surgery: a double-blind randomized clinical trial. JAMA Surg. 2020;155(9):807–815. doi:10.1001/jamasurg.2020.1953
  • Lopezosa-Reca E, Martínez-Nova A, Sánchez-Rodríguez R, et al. Effectiveness of hyaluronic acid in post-surgical cures following partial matricectomies with the phenol/alcohol technique: a randomized clinical trial. J Tissue Viability. 2023;32(1):59–62. doi:10.1016/j.jtv.2023.01.010
  • Skeith AE, Morgan DM, Schmidt PC. Vaginal preparation with povidone-iodine or chlorhexidine before hysterectomy: a propensity score matched analysis. Am J Obstet Gynecol. 2021;225(5):560.e1–560.e9. doi:10.1016/j.ajog.2021.08.035
  • Slobogean GP, Sprague S, Wells JL, et al. Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial. Lancet. 2022;400(10360):1334–1344. doi:10.1016/S0140-6736(22)01652-X
  • Lakhi NA, Tricorico G, Osipova Y, Moretti ML. Vaginal cleansing with chlorhexidine gluconate or povidone-iodine prior to cesarean delivery: a randomized comparator-controlled trial. Am J Obstet Gynecol MFM. 2019;1(1):2–9. doi:10.1016/j.ajogmf.2019.03.004
  • Ritter B, Herlyn PKE, Mittlmeier T, Herlyn A. Preoperative skin antisepsis using chlorhexidine may reduce surgical wound infections in lower limb trauma surgery when compared to povidone-iodine - a prospective randomized trial. Am J Infect Control. 2020;48(2):167–172. doi:10.1016/j.ajic.2019.08.008
  • Pak CS, Park DH, Oh TS, et al. Comparison of the efficacy and safety of povidone-iodine foam dressing (Betafoam), hydrocellular foam dressing (Allevyn), and petrolatum gauze for split-thickness skin graft donor site dressing. Int Wound J. 2019;16(2):379–386. doi:10.1111/iwj.13043
  • Park KH, Baek K, Kim M, Ju MJ, Jung WH, Yoon YS. A prospective, randomized, non-inferiority trial to compare the efficacy of 3% povidone-iodine foam dressing and silver foam dressing in the treatment of pressure injuries. J Wound Manag Res. 2023;19(1):13–20. doi:10.22467/jwmr.2023.02376
  • Gözüküçük A, Çakıroğlu B. Comparison of hypochlorous acid and Povidone Iodine as a disinfectant in neonatal circumcision. J Pediatr Urol. 2022;18(3):341.e1–341.e5. doi:10.1016/j.jpurol.2022.03.011
  • Unver M, Kebapci E, Guner M, et al. Which method is better to provide wound healing in Fournier gangrene: dakin solution or conventional antiseptic dressings? A retrospective study. Int Surg. 2019;104(1–2):21–26. doi:10.9738/INTSURG-D-16-00029.1
  • Schmitz G, Rosenblatt L, Salerno N, et al. Treatment data using a topical povidone-iodine antiseptic in patients with superficial skin abscesses. Data Brief. 2019;23:103715. doi:10.1016/j.dib.2019.103715
  • Karuserci ÖK, Sucu S, Özcan HÇ, et al. Topical rifampicin versus povidone-iodine for the prevention of incisional surgical site infections following benign gynecologic surgery: a prospective, randomized, controlled trial. New Microbiol. 2019;42(4):205–209.
  • Di Stadio A, Gambacorta V, Cristi MC, et al. The use of povidone‐iodine and sugar solution in surgical wound dehiscence in the head and neck following radio‐chemotherapy. Int Wound J. 2019. doi:10.1111/iwj.13118
  • Roberto RF, Rowan FA, Nallur D, Durbin-Johnson B, Javidan Y, Klineberg EO. Povidone-iodine irrigation combined with vancomycin powder lowers infection rates in pediatric deformity surgery. Spine Deform. 2021;9(5):1315–1321. doi:10.1007/s43390-021-00333-3
  • Bocoum A, Riel Van SJJM, Traoré SO, et al. Medical-grade honey enhances the healing of caesarean section wounds and is similarly effective to antibiotics combined with povidone-iodine in the prevention of infections—a prospective cohort study. Antibiotics. 2023;12(1):92. doi:10.3390/antibiotics12010092
  • Roshdy H, Seaoud E, Elbelbesy R. Low‐budget, single‐session elimination of CIED pocket infection. Pacing Clin Electrophysiol. 2021;44(1):129–134. doi:10.1111/pace.14133
  • Gwak HC, Han SH, Lee J, et al. Efficacy of a povidone‐iodine foam dressing (betafoam) on diabetic foot ulcer. Int Wound J. 2020;17(1):91–99. doi:10.1111/iwj.13236
  • Prezzavento GE, Mas CR, Achaval Rodríguez J, et al. Comparison of efficacy of povidone-iodine, ethanol, and an aerosol formulation of silver sulfadiazine in controlling microbial burden on sutures from clean surgeries. J Burn Care Res. 2021;42(5):975–980. doi:10.1093/jbcr/irab022
  • Chen J, Zou Q, Hamblin MR, Wen X. A preliminary clinical trial comparing wet silver dressings versus wet-to-dry povidone-iodine dressings for wound healing in pemphigus vulgaris patients. Dermatol Ther. 2021;34(3). doi:10.1111/dth.14906
  • Kobayashi N, Kamono E, Maeda K, Misumi T, Yukizawa Y, Inaba Y. Effectiveness of diluted povidone-iodine lavage for preventing periprosthetic joint infection: an updated systematic review and meta-analysis. J Orthop Surg Res. 2021;16(1). doi:10.1186/s13018-021-02703-z
  • Karuserci ÖK, Balat Ö. Subcutaneous rifampicin versus povidone-iodine for the prevention of incisional surgical site infections following gynecologic oncology surgery - a prospective, randomized, controlled trial. Ginekol Pol. 2020;91(9):513–518. doi:10.5603/GP.a2020.0134
  • Fu C, Meng L, Ma M, Li N, Zhang J. Effect of wound irrigation on the prevention of surgical site infections: a meta-analysis. Int Wound J. 2022;19(7):1878–1886. doi:10.1111/iwj.13794
  • Martin VT, Zhang Y, Wang Z, Liu QL, Yu B. A systematic review and meta-analysis comparing intrawound vancomycin powder and povidone iodine lavage in the prevention of periprosthetic joint infection of Hip and knee arthroplasties. J Orthop Sci. 2022. doi:10.1016/j.jos.2022.11.013
  • Levine DP Vancomycin: a History. Available from: https://academic.oup.com/cid/article/42/Supplement_1/S5/275962. Accessed July 19, 2024.
  • Nunan R, Harding KG, Martin P. Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity. Dis Model Mech. 2014;7(11):1205–1213. doi:10.1242/dmm.016782
  • Hihara M, Fukui M, Mitsui T, Kakudo N, Kuro A. Osteolytic metatarsal osteomyelitis regenerated by combined treatment of artificial carbon dioxide foot bathing and povidone–iodine sugar ointment: a case report. J Med Case Rep. 2022;16(1):434. doi:10.1186/s13256-022-03654-7
  • Alves PJ, Gryson L, Hajjar J, et al. Role of antiseptics in the prevention and treatment of infections in nursing homes. J Hosp Infect. 2023;131:58–69. doi:10.1016/j.jhin.2022.09.021
  • Alves PJ, Barreto RT, Barrois BM, Gryson LG, Meaume S, Monstrey SJ. Update on the role of antiseptics in the management of chronic wounds with critical colonisation and/or biofilm. Int Wound J. 2021;18(3):342–358. doi:10.1111/iwj.13537