383
Views
4
CrossRef citations to date
0
Altmetric
Original Research

Inhaled Methoxyflurane versus Intravenous Morphine for Severe Trauma Pain in the Emergency Setting: Subgroup Analysis of MEDITA, a Multicenter, Randomized, Controlled, Open-Label Trial

ORCID Icon, , , ORCID Icon, , , , , ORCID Icon, ORCID Icon, ORCID Icon & show all
Pages 491-502 | Published online: 06 Mar 2020

References

  • Cordell WH, Keene KK, Giles BK, Jones JB, Jones JH, Brizendine EJ. The high prevalence of pain in emergency medical care. Am J Emerg Med. 2002;20:165–169. doi:10.1053/ajem.2002.32643
  • Berben SA, Meijs TH, van Dongen RT, et al. Pain prevalence and pain relief in trauma patients in the Accident and Emergency Department. Injury. 2008;39:578–585. doi:10.1016/j.injury.2007.04.013
  • Mura P, Serra E, Marinangeli F, et al. Prospective study on prevalence, intensity, type, and therapy of acute pain in a second-level urban emergency department. J Pain Res. 2017;10:2781–2788. doi:10.2147/JPR
  • Marinangeli F, Narducci C, Ursini ML, et al. Acute pain and availability of analgesia in the prehospital emergency setting in Italy: a problem to be solved. Pain Pract. 2009;9:282–288. doi:10.1111/ppr.2009.9.issue-4
  • World Health Organization. WHO’s cancer pain ladder for adults 1986. Available from: http://www.who.int/cancer/palliative/painladder/en/. Accessed January 24, 2020.
  • Diβmann PD, Maignan M, Cloves PD, Gutierrez Parres B, Dickerson S, Eberhardt A. A review of the burden of trauma pain in emergency settings in Europe. Pain Ther. 2018;7:179–192. doi:10.1007/s40122-018-0101-1
  • Berben SA, Meijs TH, van Grunsven PM, Schoonhoven L, van Achterberg T. Facilitators and barriers in pain management for trauma patients in the chain of emergency care. Injury. 2012;43:1397–1402. doi:10.1016/j.injury.2011.01.029
  • Pierik JG, IJzerman MJ, Gaakeer MI, et al. Pain management in the emergency chain: the use and effectiveness of pain management in patients with acute musculoskeletal pain. Pain Med. 2015;16:970–984. doi:10.1111/pme.12668
  • Casamayor M, DiDonato K, Hennebert M, Brazzi L, Prosen G. Administration of intravenous morphine for acute pain in the emergency department inflicts an economic burden in Europe. Drugs Context. 2018;7:212524. doi:10.7573/dic.212524
  • Hansen MS, Dahl JB. Limited evidence for intranasal fentanyl in the emergency department and the prehospital setting: a systematic review. Dan Med J. 2013;60:A4563.
  • Porter KM, Dayan AD, Dickerson S, Middleton PM. The role of inhaled methoxyflurane in acute pain management. Open Access Emerg Med. 2018;10:149–164. doi:10.2147/OAEM.S181222
  • Jephcott C, Grummet J, Nguyen N, Spruyt O. A review of the safety and efficacy of inhaled methoxyflurane as an analgesic for outpatient procedures. Br J Anaesth. 2018;120:1040–1048. doi:10.1016/j.bja.2018.01.011
  • Blair HA, Frampton JE. Methoxyflurane: a review in trauma pain. Clin Drug Investig. 2016;36:1067–1073. doi:10.1007/s40261-016-0473-0
  • Penthrox® summary of product characteristics. Available from: https://www.medicines.org.uk/emc/medicine/31391. Accessed January 24, 2020.
  • Oxer HF. Effects of Penthrox® (methoxyflurane) as an analgesic on cardiovascular and respiratory functions in the pre-hospital setting. J Mil Veterans Health. 2016;24:14–20.
  • Blair HA, Frampton JE. Methoxyflurane inhalation vapour in trauma pain: a profile of its use in the EU. Drugs Ther Perspect. 2017;33:403–408. doi:10.1007/s40267-017-0433-7
  • Coffey F, Wright J, Hartshorn S, et al. STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain. Emerg Med J. 2014;31:613–618. doi:10.1136/emermed-2013-202909
  • Medical Developments International. Penthrox: European Update, 07 February 2017. Available from: https://www.medicaldev.com/wp-content/uploads/2017/02/ASX-Announcement-Penthrox-European-Update-7-Feb-2017.pdf. Accessed January 24, 2020.
  • Medical Developments International. Penthrox is approved in Canada, 10 April 2018. Available from: https://www.medicaldev.com/wp-content/uploads/2018/04/ASX-Announcement-Penthrox-is-approved-in-Canada-100418.pdf. Accessed January 24, 2020.
  • Borobia AM, García Collado S, Carballo Cardona C et al; On behalf of the InMEDIATE investigators group. Inhaled methoxyflurane provides greater analgesia and faster onset of action versus standard analgesia in patients with trauma pain. InMEDIATE: a randomized controlled trial in Emergency Departments. Ann Emerg Med. 2019. doi:10.1016/j.annemergmed.2019.07.028
  • Mercadante S, Voza A, Serra S, et al; MEDITA Study Group. Analgesic efficacy, practicality and safety of inhaled methoxyflurane versus standard analgesic treatment for acute trauma pain in the emergency setting: a randomised, open-label, active-controlled, multicentre trial in Italy (MEDITA). Adv Ther. 36;2019:3030–3046. doi:10.1007/s12325-019-01055-9
  • Marinangeli F, Reggiardo G, Sblendido A, Soldi A, Farina A; On behalf of The METEORA Group. Prospective, multicentre trial of methoxyflurane for acute trauma-related pain in helicopter emergency medical systems and hostile environments: METEORA protocol. Adv Ther. 2018;35:2081–2092. doi:10.1007/s12325-018-0816-8
  • Hartshorn S, Barrett MJ, Lyttle MD, et al; in collaboration with Paediatric Emergency Research in the UK and Ireland (PERUKI). Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children-the MAGPIE trial (MEOF-002): study protocol for a randomised controlled trial. Trials. 2019;20:393. doi:10.1186/s13063-019-3511-4
  • Raccomandazioni Intersocietarie Italiane (SIAARTI, SIMEU, SIS 118, AISD, SIARED, SICUT, IRC) sulla gestione del dolore in emergenza. Available from: http://www.aisd.it/e107_files/downloads/raccintersocietarie_it_complete31052014.pdf. Accessed January 24, 2020.
  • Fabbri A, Carpinteri G, Ruggiano G, et al. Methoxyflurane versus standard of care for acute trauma-related pain in the emergency setting: protocol for a randomised, controlled study in italy (MEDITA). Adv Ther. 2019;36:244–256. doi:10.1007/s12325-018-0830-x
  • Savoi G, Coluzzi F, Di Maria C, et al. Italian Intersociety Recommendations on pain management in the emergency setting (SIAARTI, SIMEU, SIS 118, AISD, SIARED, SICUT, IRC). Minerva Anestesiol. 2015;81:205–225.
  • Middleton PM, Simpson PM, Sinclair G, Dobbins TA, Math B, Bendall JC. Effectiveness of morphine, fentanyl, and methoxyflurane in the prehospital setting. Prehosp Emerg Care. 2010;14:439–447. doi:10.3109/10903127.2010.497896
  • Bendall JC, Simpson PM, Middleton PM. Effectiveness of prehospital morphine, fentanyl, and methoxyflurane in pediatric patients. Prehosp Emerg Care. 2011;15:158–165. doi:10.3109/10903127.2010.541980
  • Coffey F, Dissmann P, Mirza K, Lomax M. Methoxyflurane analgesia in adult patients in the emergency department: a subgroup analysis of a randomized, double-blind, placebo-controlled study (STOP!). Adv Ther. 2016;33:2012–2031. doi:10.1007/s12325-016-0405-7