Early Blockade of EphA4 Pathway Reduces Trigeminal Neuropathic Pain

References

• Klein R. Bidirectional modulation of synaptic functions by Eph/ephrin signaling. Nat Neurosci. 2009;12(1):15–20. doi:10.1038/nn.2231
   PubMed Web of Science ®Google Scholar
• Murai KK, Pasquale EB. Eph receptors and ephrins in neuron-astrocyte communication at synapses. Glia. 2011;59(11):1567–1578. doi:10.1002/glia.21226
   PubMed Web of Science ®Google Scholar
• Pasquale EB. Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol. 2005;6(6):462–475. doi:10.1038/nrm1662
   PubMed Web of Science ®Google Scholar
• Du J, Fu C, Sretavan DW. Eph/ephrin signaling as a potential therapeutic target after central nervous system injury. Curr Pharm Des. 2007;13(24):2507–2518. doi:10.2174/138161207781368594
   PubMed Web of Science ®Google Scholar
• Coulthard MG, Morgan M, Woodruff TM, et al. Eph/Ephrin signaling in injury and inflammation. Am J Pathol. 2012;181(5):1493–1503. doi:10.1016/j.ajpath.2012.06.043
   PubMed Web of Science ®Google Scholar
• Goldshmit Y, Galea MP, Wise G, Bartlett PF, Turnley AM. Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. J Neurosci. 2004;24(45):10064–10073. doi:10.1523/JNEUROSCI.2981-04.2004
   PubMed Web of Science ®Google Scholar
• Frugier T, Conquest A, McLean C, Currie P, Moses D, Goldshmit Y. Expression and activation of EphA4 in the human brain after traumatic injury. J Neuropathol Exp Neurol. 2012;71(3):242–250. doi:10.1097/NEN.0b013e3182496149
   PubMed Web of Science ®Google Scholar
• Fabes J, Anderson P, Brennan C, Bolsover S. Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord. Eur J Neurosci. 2007;26(9):2496–2505. doi:10.1111/j.1460-9568.2007.05859.x
   PubMed Web of Science ®Google Scholar
• Goldshmit Y, Spanevello MD, Tajouri S, et al. EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice. PLoS One. 2011;6(9):e24636. doi:10.1371/journal.pone.0024636
   PubMed Web of Science ®Google Scholar
• Dong Y, Mao-Ying QL, Chen JW, Yang CJ, Wang YQ, Tan ZM. Involvement of EphB1 receptor/ephrinB1 ligand in bone cancer pain. Neurosci Lett. 2011;496(3):163–167. doi:10.1016/j.neulet.2011.04.008
   PubMed Web of Science ®Google Scholar
• Song XJ, Zheng JH, Cao JL, Liu WT, Song XS, Huang ZJ. EphrinB-EphB receptor signaling contributes to neuropathic pain by regulating neural excitability and spinal synaptic plasticity in rats. Pain. 2008;139(1):168–180. doi:10.1016/j.pain.2008.03.019
   PubMed Web of Science ®Google Scholar
• Ruan JP, Zhang HX, Lu XF, Liu YP, Cao JL. EphrinBs/EphBs signaling is involved in modulation of spinal nociceptive processing through a mitogen-activated protein kinases-dependent mechanism. Anesthesiology. 2010;112(5):1234–1249. doi:10.1097/ALN.0b013e3181d3e0df
   PubMed Web of Science ®Google Scholar
• Cao JL, Ruan JP, Ling DY, et al. Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice. Pain. 2008;139(3):617–631. doi:10.1016/j.pain.2008.06.023
   PubMed Web of Science ®Google Scholar
• Han SR, Yeo SP, Lee MK, Bae YC, Ahn DK. Early dexamethasone relieves trigeminal neuropathic pain. J Dent Res. 2010;89(9):915–920. doi:10.1177/0022034510374056
   Web of Science ®Google Scholar
• Won KA, Kim MJ, Yang KY, et al. The glial-neuronal GRK2 pathway participates in the development of trigeminal neuropathic pain in rats. J Pain. 2014;15(3):250–261. doi:10.1016/j.jpain.2013.10.013
   PubMed Web of Science ®Google Scholar
• Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav. 1976;17(6):1031–1036. doi:10.1016/0031-9384(76)90029-9
   Web of Science ®Google Scholar
• Kim HJ, Lee GW, Kim MJ, et al. Antinociceptive effects of transcytosed botulinum neurotoxin type A on trigeminal nociception in rats. Korean J Physiol Pharmacol. 2015;19(4):349–355. doi:10.4196/kjpp.2015.19.4.349
   Web of Science ®Google Scholar
• Yang GY, Lee MK, Bae YC, Ahn DK. Intracisternal administration of COX inhibitors attenuates mechanical allodynia following compression of the trigeminal ganglion in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(4):589–595. doi:10.1016/j.pnpbp.2009.02.010
   PubMed Web of Science ®Google Scholar
• Yang KY, Mun JH, Park KD, et al. Blockade of spinal glutamate recycling produces paradoxical antinociception in rats with orofacial inflammatory pain. Prog Neuropsychopharmacol Biol Psychiatry. 2015;57:100–109. doi:10.1016/j.pnpbp.2014
   Web of Science ®Google Scholar
• Jeon HJ, Han SR, Lim KH, Won KA, Bae YC, Ahn DK. Intracisternal administration of NR2 subunit antagonists attenuates the nociceptive behavior and p-p38 MAPK expression produced by compression of the trigeminal nerve root. Mol Pain. 2011;7:46. doi:10.1186/1744-8069-7-46
   PubMed Web of Science ®Google Scholar
• Lee MK, Han SR, Park MK, et al. Behavioral evidence for the differential regulation of p-p38 MAPK and p-NF-κB in rats with trigeminal neuropathic pain. Mol Pain. 2011;7:57. doi:10.1186/1744-8069-7-57
   PubMed Web of Science ®Google Scholar
• Ahn DK, Lee SY, Han SR, et al. Intratrigeminal ganglionic injection of LPA causes neuropathic pain-like behavior and demyelination in rats. Pain. 2009;146(1–2):114–120. doi:10.1016/j.pain.2009.07.012
   PubMed Web of Science ®Google Scholar
• Ahn DK, Lim EJ, Kim BC, et al. Compression of the trigeminal ganglion produces prolonged nociceptive behavior in rats. Eur J Pain. 2009;13(6):568–575. doi:10.1016/j.ejpain.2008.07.008
   Web of Science ®Google Scholar
• Yang KY, Kim MJ, Ju JS, et al. Antinociceptive effects of botulinum toxin type A on trigeminal neuropathic pain. J Dent Res. 2016;95(10):1183–1190. doi:10.1177/0022034516659278
   PubMed Web of Science ®Google Scholar
• Lee GW, Son JY, Lee AR, Ju JS, Bae YC, Ahn DK. Central VEGF-A pathway plays a key role in the development of trigeminal neuropathic pain in rats. Mol Pain. 2019;15:1–14. doi:10.1177/1744806919872602
   Web of Science ®Google Scholar
• Han SR, Yang GY, Ahn MH, et al. Blockade of microglial activation reduces mechanical allodynia in rats with compression of the trigeminal ganglion. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36(1):52–59. doi:10.1016/j.pnpbp.2011.10.007
   PubMed Web of Science ®Google Scholar
• Jeon HJ, Han SR, Park MK, Yang KY, Bae YC, Ahn DK. A novel trigeminal neuropathic pain model: compression of the trigeminal nerve root produces prolonged nociception in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2012;38(2):149–158. doi:10.1016/j.pnpbp.2012.03.002
   PubMed Web of Science ®Google Scholar
• Kim MJ, Shin HJ, Won KA, et al. Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve root. Mol Pain. 2012;8:16. doi:10.1186/1744-8069-8-16
   Web of Science ®Google Scholar
• Sessle BJ, Hu JW, Amano N, Zhong G. Convergence of cutaneous, tooth pulp, visceral, neck and muscle afferents onto nociceptive and non-nociceptive neurones in trigeminal subnucleus caudalis (medullary dorsal horn) and its implications for referred pain. Pain. 1986;27(2):219–235. doi:10.1016/0304-3959(86)90213-7
   PubMed Web of Science ®Google Scholar
• Brantley DM, Cheng N, Thompson EJ, et al. Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene. 2002;21(46):7011–7026. doi:10.1038/sj.onc.1205679
   PubMed Web of Science ®Google Scholar
• Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Giani C, Zbinden AM, Radanov BP. Central hypersensitivity in chronic pain after whiplash injury. Clin J Pain. 2001;17(4):306–315. doi:10.1097/00002508-200112000-00004
   PubMed Web of Science ®Google Scholar
• Eph Nomenclature Committee. Unified nomenclature for Eph family receptors and their ligands the ephrins. Cell. 1997;90(3):403–404. doi:10.1016/S0092-8674(00)80500-0
   Web of Science ®Google Scholar
• Pasquale EB. Eph-ephrin promiscuity is now crystal clear. Nat Neurosci. 2004;7(5):417–418. doi:10.1038/nn0504-417
   PubMed Web of Science ®Google Scholar
• Goldshmit Y, McLenachan S, Turnley A. Roles of Eph receptors and ephrins in the normal and damaged adult CNS. Brain Res Rev. 2006;52(2):327–345. doi:10.1016/j.brainresrev.2006.04.006
   PubMedGoogle Scholar
• Filosa A, Paixão S, Honsek SD, et al. Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat Neurosci. 2009;12(10):1285–1292. doi:10.1038/nn.2394
   PubMed Web of Science ®Google Scholar
• Murai KK, Nguyen LN, Irie F, Yamaguchi Y, Pasquale EB. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci. 2003;6(2):153–160. doi:10.1038/nn994
   PubMed Web of Science ®Google Scholar
• Lai KO, Ip FC, Cheung J, Fu AK, Ip NY. Expression of Eph receptors in skeletal muscle and their localization at the neuromuscular junction. Mol Cell Neurosci. 2001;17(6):1034–1047. doi:10.1006/mcne.2001.0997
   Web of Science ®Google Scholar
• Munro KM, Dixon KJ, Gresle MM, et al. EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE). PLoS One. 2013;8(2):e55948. doi:10.1371/journal.pone.0055948
   PubMed Web of Science ®Google Scholar
• Li J, Liu N, Wang Y, Wang R, Guo D, Zhang C. Inhibition of EphA4 signaling after ischemia-reperfusion reduces apoptosis of CA1 pyramidal neurons. Neurosci Lett. 2012;518(2):92–95. doi:10.1016/j.neulet.2012.04.060
   PubMed Web of Science ®Google Scholar
• Cruz-Orengo L, Figueroa JD, Velázquez I, et al. Blocking EphA4 upregulation after spinal cord injury results in enhanced chronic pain. Exp Neurol. 2006;202(2):421–433. doi:10.1016/j.expneurol.2006.07.005
   PubMed Web of Science ®Google Scholar
• Hefferan MP, O’Rielly DD, Loomis CW. Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat. Anesthesiology. 2003;99(5):1180–1188. doi:10.1097/00000542-200311000-00027
   Web of Science ®Google Scholar
• Verdi J, Jafari-Sabet M, Mokhtari R, Mesdaghinia A, Banafshe HR. The effect of progesterone on expression and development of neuropathic pain in a rat model of peripheral neuropathy. Eur J Pharmacol. 2013;699(1–3):207–212. doi:10.1016/j.ejphar.2012.11.052
   Web of Science ®Google Scholar
• Pegg CL, Cooper LT, Zhao J, et al. Glycoengineering of EphA4 Fc leads to a unique, long-acting and broad spectrum, Eph receptor therapeutic antagonist. Sci Rep. 2017;7(1):6519. doi:10.1038/s41598-017-06685-z
   PubMed Web of Science ®Google Scholar
• Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell. 2008;133(1):38–52. doi:10.1016/j.cell.2008.03.011
   PubMed Web of Science ®Google Scholar