Role of Inhaled Methoxyflurane in the Management of Acute Trauma Pain

References

• Brennan F, Lohman D, Gwyther L. Access to pain management as a human right. Am J Public Health. 2019;109:61–65. doi:10.2105/AJPH.2018.304743
   PubMed Web of Science ®Google Scholar
• Grichnik KP, Ferrante FM. The difference between acute and chronic pain. Mt Sinai J Med. 1991;58(3):217–220.
   PubMedGoogle Scholar
• Berben SA, Schoonhoven L, Meijs TH, van Vugt AB, van Grunsven PM. Prevalence and relief of pain in trauma patients in emergency medical services. Clin J Pain. 2011;27:587–592. doi:10.1097/AJP.0b013e3182169036
   PubMed Web of Science ®Google Scholar
• Galinski M, Ruscev M, Gonzalez G, et al. Prevalence and management of acute pain in prehospital emergency medicine. Prehosp Emerg Care. 2010;14:334–339. doi:10.3109/10903121003760218
   PubMed Web of Science ®Google Scholar
• Berben SA, Meijs TH, van Dongen RT, et al. Pain prevalence and pain relief in trauma patients in the accident & emergency department. Injury. 2008;39:578–585. doi:10.1016/j.injury.2007.04.013
   PubMed Web of Science ®Google Scholar
• Cordell WH, Keene KK, Giles BK, Jones JB, Jones JH, Brizendine EJ. The high prevalence of pain in emergency medical care. Am J Emerg Med. 2002;20(3):165–169. doi:10.1053/ajem.2002.32643
   PubMed Web of Science ®Google Scholar
• Gueant S, Taleb A, Borel-Kuhner J, et al. Quality of pain management in the emergency department: results of a multicentre prospective study. Eur J Anaesthesiol. 2011;28(2):97–105. doi:10.1097/EJA.0b013e3283418fb0
   PubMed Web of Science ®Google Scholar
• International Association for the Study of Pain. Pain terms: a current list with definitions and notes on usage. Available from: www.iasp-pain.org/files/Content/ContentFolders/Publications2/ClassificationofChronicPain/Part_III-PainTerms.pdf. Accessed September, 2019.
   Google Scholar
• Ministero della Salute. Relazione sullo Stato Sanitario del Paese: 2009–2010. 2010. Available from: http://www.salute.gov.it/portale/documentazione/p6_2_2_1.jsp?lingua=italiano&id=1655. Accessed January, 2020.
   Google Scholar
• Parker M, Rodgers A. Management of pain in pre-hospital settings. Emerg Nurse. 2015;23:16–21; quiz 3. doi:10.7748/en.23.3.16.e1445
   Google Scholar
• Marinangeli F, Narducci C, Ursini ML, et al. Acute pain and availability of analgesia in the prehospital emergency setting in Italy: a problem to be solved. Pain Pract. 2009;9(4):282–288. doi:10.1111/j.1533-2500.2009.00277.x
   PubMed Web of Science ®Google Scholar
• Simpson PM, Bendall JC, Tiedemann A, Lord SR, Close JCT, Callaway CW. Provision of out-of-hospital analgesia to older fallers with suspected fractures: above par, but opportunities for improvement exist. Acad Emerg Med. 2013;20(8):761–768. doi:10.1111/acem.12190
   Web of Science ®Google Scholar
• Walsh B, Cone DC, Meyer EM, Larkin GL. Paramedic attitudes regarding prehospital analgesia. Prehosp Emerg Care. 2013;17:78–87. doi:10.3109/10903127.2012.717167
   PubMed Web of Science ®Google Scholar
• Siriwardena AN, Shaw D, Bouliotis G. Exploratory cross-sectional study of factors associated with pre-hospital management of pain. J Eval Clin Pract. 2010;16:1269–1275. doi:10.1111/j.1365-2753.2009.01312.x
   PubMed Web of Science ®Google Scholar
• Bakkelund KE, Sundland E, Moen S, Vangberg G, Mellesmo S, Klepstad P. Undertreatment of pain in the prehospital setting: a comparison between trauma patients and patients with chest pain. Eur J Emerg Med. 2013;20(6):428–430. doi:10.1097/MEJ.0b013e32835c9fa3
   PubMed Web of Science ®Google Scholar
• Motov SM, Khan AN. Problems and barriers of pain management in the emergency department: are we ever going to get better? J Pain Res. 2009;2:5–11.
   Google Scholar
• De Berardinis B, Magrini L, Calcinaro S, et al. Emergency department pain management and its impact on patients’ short term outcome. Open J Emerg Med. 2013;5:1–7. doi:10.2174/1876542420130729001
   Google Scholar
• Mills AM, Shofer FS, Chen EH, Hollander JE, Pines JM. The association between emergency department crowding and analgesia administration in acute abdominal pain patients. Acad Emerg Med. 2009;16(7):603–608. doi:10.1111/j.1553-2712.2009.00441.x
   PubMed Web of Science ®Google Scholar
• Karwowski-Soulie F, Lessenot-Tcherny S, Lamarche-Vadel A, et al. Pain in an emergency department: an audit. Eur J Emerg Med. 2006;13:218–224. doi:10.1097/01.mej.0000217975.31342.13
   PubMed Web of Science ®Google Scholar
• Kumar N. WHO normative guidelines on pain management. 2007. Available from: http://www.who.int/medicines/areas/quality_safety/delphi_study_pain_guidelines.pdf. Accessed January, 2020.
   Google Scholar
• Thomas SH Management of pain in the emergency department. ISRN Emergency Medicine 2013. Article ID 583132.
   Google Scholar
• Sills MR, Fairclough DL, Ranade D, Mitchell MS, Kahn MG. Emergency department crowding is associated with decreased quality of analgesia delivery for children with pain related to acute, isolated, long-bone fractures. Acad Emerg Med. 2011;18(12):1330–1338. doi:10.1111/j.1553-2712.2011.01136.x
   PubMed Web of Science ®Google Scholar
• EUSEM guidelines for the management of acute pain in emergency situations 2019. Available from: https://eusem.org/images/EUSEM_EPI_GUIDELINES_MARCH_2020.pdf.
   Google Scholar
• Penthrox 99.9% 3mL inhalation vapour, liquid. Summary of product characteristics. Available from: https://www.medicines.org.uk/emc/product/1939/smpc. Accessed January 10, 2020.
   Google Scholar
• Tomlin PJ. Methoxyflurane. Br J Anaesth. 1965;37(9):706–709. doi:10.1093/bja/37.9.706
   PubMed Web of Science ®Google Scholar
• Crandell WB, Pappas SG, Macdonald A. Nephrotoxicity associated with methoxyflurane anaesthesia. Anesthesiology. 1966;27:591–607. doi:10.1097/00000542-196609000-00010
   PubMed Web of Science ®Google Scholar
• Mazze RI, Shue GL, Jackson SH. Renal dysfunction associated with methoxyflurane anaesthesia: a randomised, prospective clinical evaluation. JAMA. 1971;216:278–288. doi:10.1001/jama.1971.03180280032006
   PubMed Web of Science ®Google Scholar
• Coffey F, Wright J, Hartshorn S, et al. STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain. Emerg Med J. 2014;31(8):613–618. doi:10.1136/emermed-2013-202909
   PubMed Web of Science ®Google Scholar
• Borobia AM, Collado SG, Cardona CC, et al. Inhaled methoxyflurane provides greater analgesia and faster onset of action versus standard analgesia in patients with trauma pain: inMEDIATE: a randomized controlled trial in emergency departments. Ann Emerg Med. 2020;75(3):315–328.
   Web of Science ®Google Scholar
• Mercadante S, Voza A, Serra S, et al. Analgesic efficacy, practicality and safety of inhaled methoxyflurane versus standard analgesic treatment for acute trauma pain in the emergency setting: a randomised, open-label, active-controlled, multicentre trial in Italy (MEDITA). Adv Ther. 2019;36(11):3030–3046. doi:10.1007/s12325-019-01055-9
   PubMed Web of Science ®Google Scholar
• Ricard-Hibon A, Lecoules N, Jacquin L, et al. Inhaled methoxyflurane for the management of trauma related pain in patients admitted to hospital emergency departments: a randomised, double-blind placebo-controlled trial (PenASAP study). Brit Med J. 2020.
   Google Scholar
• Marinangeli F, Reggiardo G, Sblendido A, Soldi A, Farina A; METEORA Group. Prospective, multicentre trial of methoxyflurane for acute trauma-related pain in helicopter emergency medical systems and hostile environments: METEORA protocol. Adv Ther. 2018;35(11):2081–2092. doi:10.1007/s12325-018-0816-8
   Web of Science ®Google Scholar