Acoustic Waves in Axonal Membrane and Caveolins are the New Targets for Pain Treatment with High Frequency Ultrasound

References

• Blackmore J, Shrivastava S, Sallet J, Butler CR, Cleveland RO. Ultrasound neuromodulation: a review of results, mechanisms and safety. Ultrasound Med Biol. 2019;45(7):1509–1536. doi:10.1016/j.ultrasmedbio.2018.12.015
   Web of Science ®Google Scholar
• Tasaki I, Carnay L, Watanabe A. Transient changes in extrinsic fluorescence of nerve produced by electric stimulation. Proc Natl Acad Sci USA. 1969;64(4):1362–1368. doi:10.1073/pnas.64.4.1362
   Web of Science ®Google Scholar
• Terakawa S. Potential‐dependent variations of the intracellular pressure in the intracellularly perfused squid giant axon. J Physiol. 1985;369(1):229–248. doi:10.1113/jphysiol.1985.sp015898
   Web of Science ®Google Scholar
• Heimburg T, Jackson AD. On the action potential as a propagating density pulse and the role of anesthetics. Biophys Rev Lett. 2007;2(1):57–78. doi:10.1142/S179304800700043X
   Google Scholar
• Yang Y, Liu XW, Wang H, et al. Imaging action potential in single mammalian neurons by tracking the accompanying sub-nanometer mechanical motion. ACS Nano. 2018;12(5):4186–4193. doi:10.1021/acsnano.8b00867
   Web of Science ®Google Scholar
• Rvachev MM. On axoplasmic pressure waves and their possible role in nerve impulse propagation. Biophys Rev Lett. 2010;5(2):73–88. doi:10.1142/S1793048010001147
   Google Scholar
• El Hady A, Machta BB. Mechanical surface waves accompany action potential propagation. Nat Commun. 2015;6(1):1–7. doi:10.1038/ncomms7697
   Web of Science ®Google Scholar
• Engelbrecht J, Peets T, Tamm K. Electromechanical coupling of waves in nerve fibres. Biomech Model Mechanobiol. 2018;17(6):1771–1783. doi:10.1007/s10237-018-1055-2
   Web of Science ®Google Scholar
• Shrivastava S, Kang KH, Schneider MF. Collision and annihilation of nonlinear sound waves and action potentials in interfaces. J R Soc Interface. 2018;15(143):20170803. doi:10.1098/rsif.2017.0803
   Web of Science ®Google Scholar
• Fichtl B, Shrivastava S, Schneider MF. Protons at the speed of sound: predicting specific biological signaling from physics. Sci Rep. 2016;6(1):22874. doi:10.1038/srep22874
   Web of Science ®Google Scholar
• Prieto ML, Oralkan Ö, Khuri-Yakub BT, Maduke MC, Phillips W. Dynamic response of model lipid membranes to ultrasonic radiation force. PLoS One. 2013;8(10):e77115. doi:10.1371/journal.pone.0077115
   Web of Science ®Google Scholar
• Menz MD, Ye P, Firouzi K, et al. Radiation force as a physical mechanism for ultrasonic neurostimulation of the ex vivo retina. J Neurosci. 2019;39(32):6251–6264. doi:10.1523/JNEUROSCI.2394-18.2019
   Web of Science ®Google Scholar
• Wei W, Thiessen DB, Marston PL. Acoustic radiation force on a compressible cylinder in a standing wave. J Acoust Soc Am. 2004;116(1):201–208. doi:10.1121/1.1753291
   Web of Science ®Google Scholar
• Shrivastava S, Cleveland RO, Schneider MF. On measuring the acoustic state changes in lipid membranes using fluorescent probes. Soft Matter. 2018;14(47):9702–9712. doi:10.1039/c8sm01635f
   Web of Science ®Google Scholar
• Kruglikov IL. Modeling of the spatiotemporal distribution of temperature fields in skin and subcutaneous adipose tissue after exposure to ultrasound waves of different frequencies. AIP Adv. 2017;7(10):105317. doi:10.1063/1.4997833
   Web of Science ®Google Scholar
• Suchaoin W, Chanvorachote P. Caveolin-1 attenuates hydrogen peroxide-induced oxidative damage to lung carcinoma cells. Anticancer Res. 2012;32(2):483–490.
   Web of Science ®Google Scholar
• Zou H, Stoppani E, Volonte D, Galbiati F. Caveolin-1, cellular senescence and age-related diseases. Mech Ageing Dev. 2011;132(11–12):533–542. doi:10.1016/j.mad.2011.11.001
   PubMed Web of Science ®Google Scholar
• Mougeolle A, Poussard S, Decossas M, et al. Oxidative stress induces caveolin 1 degradation and impairs caveolae functions in skeletal muscle cells. PLoS One. 2015;10(3):e0122654. doi:10.1371/journal.pone.0122654
   PubMed Web of Science ®Google Scholar
• Chen Y-H, Lin -W-W, Liu C-S, Su S-L. H2O2 induces caveolin-1 degradation and impaired mitochondrial function in E11 podocytes. Mol Med Rep. 2017;16(5):7841–7847. doi:10.3892/mmr.2017.7497
   Web of Science ®Google Scholar
• Khalil Z, Liu T, Helme RD. Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury. Pain. 1999;79(1):31–37. doi:10.1016/s0304-3959(98)00143-2
   Web of Science ®Google Scholar
• Stern CM, Mermelstein PG. Caveolin regulation of neuronal intracellular signaling. Cell Mol Life Sci. 2010;67(22):3785–3795. doi:10.1007/s00018-010-0447-y
   Web of Science ®Google Scholar
• Mikol DD, Scherer SS, Duckett SJ, Hong HL, Feldman EL. Schwann cell caveolin‐1 expression increases during myelination and decreases after axotomy. Glia. 2002;38(3):191–199. doi:10.1002/glia.10063
   Web of Science ®Google Scholar
• Luo X, Tao L, Lin P, Mo X, Chen H. Extracellular heat shock protein 72 protects schwann cells from hydrogen peroxide‐induced apoptosis. J Neurosci Res. 2012;90(6):1261–1269. doi:10.1002/jnr.22810
   Web of Science ®Google Scholar
• Guzhova I, Kislyakova K, Moskaliova O, et al. In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res. 2001;914(1–2):66–73. doi:10.1016/s0006-8993(01)02774-3
   Web of Science ®Google Scholar
• Black AT, Hayden PJ, Casillas RP, et al. Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol. 2011;253(2):112–120. doi:10.1016/j.taap.2011.03.015
   PubMed Web of Science ®Google Scholar
• Kawabata A. Prostaglandin E2 and pain—an update. Biol Pharm Bull. 2011;34(8):1170–1173. doi:10.1248/bpb.34.1170
   Web of Science ®Google Scholar
• Liou JY, Deng WG, Gilroy DW, Shyue SK, Wu KK. Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts. J Biol Chem. 2001;276(37):34975–34982. doi:10.1074/jbc.M105946200
   Web of Science ®Google Scholar
• Rodriguez DA, Tapia JC, Fernandez JG, et al. Caveolin-1–mediated suppression of cyclooxygenase-2 via a β-catenin-Tcf/Lef–dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. Mol Biol Cell. 2009;20(8):2297–2310. doi:10.1091/mbc.e08-09-0939
   Web of Science ®Google Scholar
• Mickle AD, Shepherd AJ, Mohapatra DP. Nociceptive TRP channels: sensory detectors and transducers in multiple pain pathologies. Pharmaceuticals. 2016;9(4):72. doi:10.3390/ph9040072
   Google Scholar
• Khan A, Khan S, Kim YS. Insight into pain modulation: nociceptors sensitization and therapeutic targets. Curr Drug Target. 2019;20(7):775–788. doi:10.2174/1389450120666190131114244
   PubMed Web of Science ®Google Scholar
• Startek JB, Talavera K. Lipid raft destabilization impairs mouse TRPA1 responses to cold and bacterial lipopolysaccharides. Int J Mol Sci. 2020;21(11):3826. doi:10.3390/ijms21113826
   Web of Science ®Google Scholar
• Koivisto A, Jalava N, Bratty R, Pertovaara A. TRPA1 antagonists for pain relief. Pharmaceuticals. 2018;11(4):117. doi:10.3390/ph11040117
   Web of Science ®Google Scholar
• De Logu F, Nassini R, Materazzi S, et al. Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice. Nat Commun. 2017;8(1):1–16. doi:10.1038/s41467-017-01739-2
   Web of Science ®Google Scholar
• Razani B, Engelman JA, Wang XB, et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem. 2001;276(41):38121–38138. doi:10.1074/jbc.M105408200
   PubMed Web of Science ®Google Scholar
• Schubert W, Frank PG, Woodman SE, et al. Microvascular hyper-permeability in caveolin-1 (-/-) knock-out mice: treatment with a specific NOS inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice. J Biol Chem. 2002;277(42):40091–40098. doi:10.1074/jbc.M205948200
   PubMed Web of Science ®Google Scholar
• Maniatis NA, Kardara M, Hecimovich D, et al. Role of caveolin-1 expression in the pathogenesis of pulmonary edema in ventilator-induced lung injury. Pulm Circ. 2012;2(4):452–460. doi:10.4103/2045-8932.105033
   PubMedGoogle Scholar
• Choi KH, Kim HS, Park MS, et al. Overexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation. Oncotarget. 2016;7(42):67857. doi:10.18632/oncotarget.12346
   Google Scholar
• McGuire JF, Rouen S, Siegfreid E, Wright DE, Dobrowsky RT. Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy. Diabetes. 2009;58(11):2677–2686. doi:10.2337/db09-0594
   Web of Science ®Google Scholar
• Yu C, Rouen S, Dobrowsky RT. Hyperglycemia and downregulation of caveolin‐1 enhance neuregulin‐induced demyelination. Glia. 2008;56(8):877–887. doi:10.1002/glia.20662
   Web of Science ®Google Scholar
• Fahmi H, Martel-Pelletier J, Pelletier JP, Kapoor M. Peroxisome proliferator-activated receptor gamma in osteoarthritis. Mod Rheumatol. 2011;21(1):1–9. doi:10.1007/s10165-010-0347-x
   PubMed Web of Science ®Google Scholar
• Llaverias G, Vázquez-Carrera M, Sánchez RM, et al. Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. J Lipid Res. 2004;45(11):2015–2024. doi:10.1194/jlr.M400049-JLR200
   PubMed Web of Science ®Google Scholar
• Werion A, Joris V, Hepp M, et al. Pioglitazone, a PPARγ agonist, upregulates the expression of caveolin-1 and catalase, essential for thyroid cell homeostasis: a clue to the pathogenesis of hashimoto’s thyroiditis. Thyroid. 2016;26(9):1320–1331. doi:10.1089/thy.2015.0625
   Web of Science ®Google Scholar
• Kruglikov IL, Scherer PE. Caveolin as a universal target in dermatology. Int J Mol Sci. 2020;21(1):80. doi:10.3390/ijms21010080
   Web of Science ®Google Scholar
• Volonte D, Liu Y, Galbiati F. The modulation of caveolin‐1 expression controls satellite cell activation during muscle repair. FASEB J. 2005;19(2):237–239. doi:10.1096/fj.04-2215fje
   PubMed Web of Science ®Google Scholar
• Echarri A, Del Pozo MA. Caveolae–mechanosensitive membrane invaginations linked to actin filaments. J Cell Sci. 2015;128(15):2747–2758. doi:10.1242/jcs.153940
   Web of Science ®Google Scholar
• Kruglikov IL, Scherer PE. Caveolin-1 as a pathophysiological factor and target in psoriasis. NPJ Aging Mech Dis. 2019;5(1):1–7. doi:10.1038/s41514-019-0034-x
   Web of Science ®Google Scholar
• Kruglikov IL, Scherer PE. Caveolin-1 as a target in prevention and treatment of hypertrophic scarring. NPJ Regen Med. 2019;4(1):1–7. doi:10.1038/s41536-019-0071-x
   Web of Science ®Google Scholar
• Mizrahi N, Zhou EH, Lenormand G, et al. Low intensity ultrasound perturbs cytoskeleton dynamics. Soft Matter. 2012;8(8):2438–2443. doi:10.1039/C2SM07246G
   PubMed Web of Science ®Google Scholar
• Samandari M, Abrinia K, Mokhtari-Dizaji M, Tamayol A. Ultrasound induced strain cytoskeleton rearrangement: an experimental and simulation study. J Biomech. 2017;60:39–47. doi:10.1016/j.jbiomech.2017.06.003
   PubMed Web of Science ®Google Scholar
• Sontag W, Kruglikov IL. Expression of heat shock proteins after ultrasound exposure in HL-60 cells. Ultrasound Med Biol. 2009;35(6):1032–1041. doi:10.1016/j.ultrasmedbio.2008.12.011
   Web of Science ®Google Scholar
• Yang Q, Nanayakkara GK, Drummer C, et al. Low-intensity ultrasound-induced anti-inflammatory effects are mediated by several new mechanisms including gene induction, immunosuppressor cell promotion, and enhancement of exosome biogenesis and docking. Front Physiol. 2017;8:818. doi:10.3389/fphys.2017.00818
   PubMed Web of Science ®Google Scholar
• Sinha B, Köster D, Ruez R, et al. Cells respond to mechanical stress by rapid disassembly of caveolae. Cell. 2011;144(3):402–413. doi:10.1016/j.cell.2010.12.031
   Web of Science ®Google Scholar
• Kubanek J, Shukla P, Das A, Baccus SA, Goodman MB. Ultrasound elicits behavioral responses through mechanical effects on neurons and ion channels in a simple nervous system. J Neurosci. 2018;38(12):3081–3091. doi:10.1523/JNEUROSCI.1458-17.2018
   Web of Science ®Google Scholar
• Kruglikov IL. Very high frequency ultrasound. Hautarzt. 2015;66(11):829–833. doi:10.1007/s00105-015-3676-z
   Web of Science ®Google Scholar
• Kruglikov IL. Sehr hochfrequenter Ultraschall in der ästhetischen Medizin und Chirurgie. J Ästh Chir. 2018;11(3):124–129. doi:10.1007/s12631-018-0140-9
   Web of Science ®Google Scholar
• Kruglikov IL, Zhang Z, Scherer PE. Caveolin-1 in skin aging. From innocent bystander to major contributor. Ageing Res Rev. 2019;55:100959. doi:10.1016/j.arr.2019.100959
   Web of Science ®Google Scholar
• Kruglikov IL, Scherer PE. Caveolin‐1 as a possible target in the treatment for acne. Exp Dermatol. 2020;29(2):177–183. doi:10.1111/exd.14063
   Web of Science ®Google Scholar
• Kruglikov IL, Kruglikova E. Dual treatment strategy by venous ulcers: pilot study to dual-frequency ultrasound application. J Cos Dermatol Sci Appl. 2011;1(4):157–163.
   Google Scholar
• Tausch I, Kruglikov I. The benefit of dual-frequency ultrasound in patients treated by injection lipolysis. J Clin Aesthet Dermatol. 2015;8(8):42–46.
   Google Scholar
• Ahn KH, Lee SJ, Park ES, Park YG. Satisfaction with the effect of local dynamical micro-massage therapy on the pain and discomfort after breast reconstruction surgery. Med Laser. 2020;9(1):39–43. doi:10.25289/ML.2020.9.1.39
   Google Scholar
• Choi YS, Park ES. Application of dual-frequency ultrasound to radiation-induced fibrosis in a breast cancer patient. Med Laser. 2017;6(2):86–89. doi:10.25289/ML.2017.6.2.86
   Google Scholar