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Original Research

Tramadol/paracetamol fixed-dose combination in the treatment of moderate to severe pain

, , , , , , , & show all
Pages 327-346 | Published online: 29 Aug 2012

References

  • World Health Organization (WHO)WHO’s pain ladder [web page on the Internet]GenevaWHO2012 Available from: http://www.who.int/cancer/palliative/painladder/en/Accessed May 12, 2011
  • WHOAchieving Balance in National Opioids Control Policy: Guidelines for AssessmentGenevaWHO2000 Available from: whqlibdoc.who.int/hq/2000/who_edm_qsm_20004.pdfAccessed May 13, 2011
  • WHONational Cancer Control Programmes: Policies and Managerial Guidelines2nd edGenevaWHO2002 Available from: http://www.who.int/cancer/media/en/408.pdfAccessed May 13, 2010
  • WHOCancer Pain Relief with a Guide to Opioid Availability2nd edGenevaWHO1996 Available from: whqlibdoc.who.int/publications/9241544821.pdfAccessed May 12, 2011
  • BrennanFCarrDBCousinsMPain management: a fundamental human rightAnesth Analg2007105120522117578977
  • HallJKBoswellMVEthics, law, and pain management as a patient rightPain Physician200912349950619461819
  • GwytherLBrennanFHardingRAdvancing palliative care as a human rightJ Pain Symptom Manage200938576777419783399
  • FishmanSMRecognizing pain management as a human right: a first stepAnesth Analg200710518917578943
  • The Societal Impact of PainEuropean positioning statement: chronic pain fundamental for European healthInternational multi-stakeholder platform acknowledges chronic pain as disease in its own-European policy-makers challenged to respond2012 Accessed from http://www.sip-platform.eu/sip-2012.htmlAccessed on June 27, 2012
  • VarrassiGMüller-SchwefeGPergolizziJPharmacological treatment of chronic pain – the need for CHANGECurr Med Res Opin20102651231124520337502
  • ClaxtonRNBlackhallLWeisbordSDHolleyJLUndertreatment of symptoms in patients on maintenance hemodialysisJ Pain Symptom Manage201039221121819963337
  • OttBBProgress in ethical decision making in the care of the dyingDimens Crit Care Nurs2010292738020160544
  • FontanaJSThe social and political forces affecting prescribing practices for chronic painJ Prof Nurs2008241303518206840
  • NathanJIChronic pain treatment: a high moral imperative with offsetting personal risks for the physician – a medical student’s perspectivePain Pract20109215516319140905
  • RejehNVaismoradiMPerspectives and experiences of elective surgery patients regarding pain managementNurs Health Sci2010121677320487328
  • BenyaminRMDattaSFalcoFJA perfect storm in interventional pain management: regulated, but unbalancedPain Physician201013210911620309377
  • FerrellBEthical perspectives on pain and sufferingPain Manage Nur20056338390
  • RejehNAhmadiFMohamadiEAnooshehMKazemnejadAEthical challenges in pain management post-surgeryNurs Ethics200916216117119237470
  • MacphersonCUndertreating pain violates ethical principlesJ Med Ethics2009351060360619793939
  • FerrellBRThe role of ethics committees in responding to the moral outrage of unrelieved painBioethics Forum1997133111611655234
  • KönigHHeiderDLehnertTESEMeD/MHEDEA 2000 investigatorsHealth status of the advanced elderly in six European countries: results from a representative survey using EQ-5D and SF-12Health Qual Life Outcomes2010814321114833
  • BreivikHCollettBVentafriddaVCohenRGallacherDSurvey of chronic pain in Europe: prevalence, impact on daily life, and treatmentEur J Pain200610428733316095934
  • GerbershagenKGerbershagenHLutzJPain prevalence and risk distribution among inpatients in a German teaching hospitalClin J Pain200925543143719454878
  • VlajkovicGSindjelicRStefanovicIKetorolac as a pre-emptive analgesic in retinal detachment surgery: a prospective, randomized clinical trialInt J Clin Pharmacol Ther5200745525926317542347
  • WeinerKPain Issues: Pain is an EpidemicSonora, CAAmerican Academy of Pain Management2001 Available from: http://www.aapainmanage.org/literature/Articles/PainAnEpidemic.pdfAccessed May 13, 2011
  • ChristoPJLiSGibsonSJFinePHameedHEffective treatments for pain in the older patientCurr Pain Headache Rep2011151223421128021
  • American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older PersonsPharmacological management of persistent pain in older personsJ Am Geriatr Soc200957813311346 http://www.cdc.gov/nchs/data/hus/hus06.pdfAccessed December 6, 201019573219
  • National Center for Health StatisticsHealth, United States, 2006: with Chartbook on Trends in the Health of AmericansHyattsville, MDNational Center for Health Statistics2006 Available from: http://www.cdc.gov/nchs/data/hus/hus06.pdfAccessed December 6, 2010
  • AntmanEMBennettJSDaughertyAFurbergCRobertsHTaubertKAAmerican Heart AssociationUse of nonsteroidal anti-inflammatory drugs: an update for clinicians: a scientific statement from the American Heart AssociationCirculation2007115121634164217325246
  • RaffaRBFriderichsEReimannWShankRPCoddEEVaughtJLOpioid and nonopioid components independently contribute to the mechanism of action of tramadol, an ‘atypical’ opioid analgesicJ Pharmacol Exp Ther199226012752851309873
  • TallaridaRJRaffaRBTesting for synergism over a range of fixed ratio drug combinations: replacing the isobologramLife Sci1996582PL 23PL 28
  • DesmeulesJAPiguetVCollartLDayerPContribution of mono-aminergic modulation to the analgesic effect of tramadolBr J Clin Pharmacol19964117128824687
  • FilitzJIhmsenHGüntherWSupra-additive effects of tramadol and acetaminophen in a human pain modelPain2008136326227017709207
  • BaronRBinderAWasnerGNeuropathic pain: diagnosis, pathophysiological mechanisms, and treatmentLancet Neurol20109880781920650402
  • LoeserJDTreedeRDThe Kyoto protocol of IASP basic pain terminologyPain2008137347347718583048
  • International Association for the Study of Pain (IASP)IASP taxonomy [web page on the Internet]Seattle, WAIASPnd [updated May 22, 2012]. http://www.iasp-pain.org/Content/NavigationMenu/GeneralResourceLinks/PainDefinitions/default.htmAccessed June 10, 2012
  • WoolfCJAmerican College of Physicians; American Physiological SocietyPain: moving from symptom control toward mechanism-specific pharmacologic managementAnn Intern Med2004140644145115023710
  • ScholzJWoolfCJCan we conquer pain?Nat Neurosci20025Suppl1062106712403987
  • RainvillePDuncanGHPriceDDCarrierBBushnellMCPain affect encoded in human anterior cingulate but not somatosensory cortexScience199727753289689719252330
  • WoolfCJSalterMWNeuronal plasticity: increasing the gain in painScience200028854721765176910846153
  • MogilJSYuLBasbaumAIPain genes?: natural variation and transgenic mutantsAnnu Rev Neurosci20002377781110845081
  • GoldMSGebhartGFNociceptor sensitisation in pain pathogenesisNat Med201016111248125720948530
  • BruehlSAn update on the pathophysiology of complex regional pain syndromeAnesthesiology2010113371372520693883
  • RenKDubnerRInteractions between the immune and nervous systems in painNat Med201016111267127620948535
  • Graven-NielsenTArednt-NielsenLAssessment of mechanisms in localized and widespread musculoskeletal painNat Rev Rheumatol201061059960620664523
  • HolmesAWilliamsonOHoggMPredictors of pain severity 3 months after serious injuryPain Med2010117990100020642728
  • BuvanendranAAliAStoubTRKroinJSTumanKJBrain activity associated with chronic cancer painPain Phys2010135E337E342
  • PerrotSJavierRMMartyMLe JeunneCLarocheFCEDR (Cercle d’Etude de la Douleur en Rhumatologie France), French Rheumatological Society, Pain Study Section Is there any evidence to support the use of anti-depressants in painful rheumatological conditions? Systematic review of pharmacological and clinical studiesRheumatology (Oxford)20084781117112318445628
  • ChappellASOssannaMJLiu-SeifertHDuloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trialPain2009146325326019625125
  • JungACStaiglerTSullivanMThe efficacy of selective serotonin reuptake inhibitors for the management of chronic painJ Gen Intern Med19971263843899192257
  • MeasePJFurther strategies for treating fibromyalgia: the role of serotonin and norepinephrine reuptake inhibitorsAm J Med200912212 SupplS44S5519962496
  • PerrotSAllaertFAConcasVLarocheF“When will I recover?” A national survey on patients’ and physicians’ expectations concerning the recovery time for acute back painEur Spine J200918341942919132411
  • JavierRMPerrotSDo men and women experience pain differently? What are the implications for the rheumatologist?Joint Bone Spine201077319820020444634
  • BoothMOpium: A HistoryNew York, NYSimon and Schuster1996
  • MoulinDEClarkAJGilronICanadian Pain SocietyPharmacological management of chronic neuropathic pain – consensus statement and guidelines from the Canadian Pain SocietyPain Res Manag2007121132117372630
  • AttalNCruccuGHaanpääMEFNS Task ForceEFNS guidelines on pharmacological treatment of neuropathic painEur J Neurol200613111153116917038030
  • FinnerupNBOttoMMcQuayHJJensenTSSindrupSHAlgorithm for neuropathic pain treatment: an evidence based proposalPain2005118328930516213659
  • DworkinRHO’ConnorABBackonjaMPharmacologic management of neuropathic pain: evidence-based recommendationsPain2007132323725117920770
  • Vargas-SchafferGIs the WHO analgesic ladder still valid?Can Fam Physician201056651451720547511
  • SmithHSPotential analgesic mechanisms of acetaminophenPain Physician200912126928019165309
  • American Academy of Pediatrics. Committee on DrugsAcetaminophen toxicity in childrenPediatrics200110841020102411581462
  • JamesLPLetzigLSimpsonPMPharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failureDrug Metab Dispos20093781779178419439490
  • RyderSDBeckinghamIJABC of diseases of liver, pancreas and biliary system. Other causes of parenchymal liver diseaseBMJ2001322728129029211157536
  • BronsteinACSpykerDACantilenaLRJrGreenJLRumackBHGriffinSL2008 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 26th Annual ReportClin Toxicol200947109111084
  • BowerWAJohnsMMargolisHSWilliamsITBellBPPopulation-based surveillance for acute liver failureAm J Gastroenterol2007102112459246317608778
  • WilsonSLPoulterNRThe effect of non-steroidal anti-inflammatory drugs and other commonly used non-narcotic analgesics on blood pressure level in adultsJ Hypertens20062481457146916877945
  • FormanJPRimmEBCurhanGCFrequency of analgesic use and risk of hypertension among menArch Intern Med2007167439439917325302
  • SudanoIFlammerAJPériatDAcetaminophen increases blood pressure in patients with coronary artery diseaseCirculation2010122181789179620956208
  • MontgomeryBDoes paracetamol cause hypertension?BMJ200833676541190119118497418
  • MontgomeryBDAnalgesic use and risk of hypertension: concern about biasArch Intern Med2007167212368236918039998
  • WhiteWBCampbellPBlood pressure destabilization on nonsteroidal anti-inflammatory agents: acetaminophen exposed?Circulation2010122181779178120956214
  • RaoPKnausEEEvolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyondJ Pharm Pharm Sci200811281s110s19203472
  • VaneJRBottingRMThe mechanism of action of aspirinThromb Res20031105–625525814592543
  • LeuppiJDSchnyderPHartmannKReinhartWHKuhnMDrug-induced bronchospasm: analysis of 187 spontaneously reported casesRespiration200168434535111464079
  • van der LindenMWvan der BijSWelsingPKupiersEJHeringsRMThe balance between severe cardiovascular and gastrointestinal events among users of selective and non-selective non-steroidal anti-inflammatory drugsAnn Rheum Dis200968566867318495734
  • NgSCChanFKNSAID-induced gastrointestinal and cardiovascular injuryCurr Opin Gastroenterol201026661161720948372
  • LanasAPerez-AisaMAFeuFInvestigators of the Asociación Española de Gastroenterología (AEG)A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal anti-inflammatory drug useAm J Gastroenterol200510081685169316086703
  • Schjerning OlsenAMFosbølELLindhardsenJDuration of treatment with nonsteroidal anti-inflammatory drugs and impact on risk of death and recurrent myocardial infarction in patients with prior myocardial infarction: a nationwide cohort studyCirculation20111232226223521555710
  • ZhangWMoskowitzRWNukiGOARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelinesOsteoarthritis Cartilage200816213716218279766
  • American College of Rheumatology Ad Hoc Group on Use of Selective and Nonselective Nonsteroidal Anti-inflammatory DrugsRecommendations for use of selective and nonselective nonsteroidal anti-inflammatory drugs: an American College of Rheumatology white paperArthritis Rheum20085981058107318668613
  • National Institute for Health and Excellence (NICE)Osteoarthritis: The Care and Management of Osteoarthritis in AdultsNICE clinical guideline 59LondonNICE2008 Available from: http://www.nice.org.uk/nicemedia/pdf/CG59NICEguideline.pdfAccessed December 15, 2010
  • LanzaFLChanFKQuigleyEMPractice Parameters Committee of the American College of GastroenterologyGuidelines for prevention of NSAID-related ulcer complicationsAm J Gastroenterol2009104372873819240698
  • BhattDLScheimanJAbrahamNSACCF Task Force ACCF/ACG/AHA2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus DocumentsJ Am Coll Cardiol200852181502151719017521
  • TrelleSReichenbachSWandelSCardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysisBMJ2011342c708621224324
  • DesaiJCSanyalSMGooTPrimary prevention of adverse gastroduodenal effects from short-term use of non-steroidal anti-inflammatory drugs by omeprazole 20 mg in healthy subjects: a randomized, double-blind, placebo-controlled studyDig Dis Sci20085382059206518224442
  • RaffaRBPharmacology of oral combination analgesics: rational therapy for painJ Clin Pharm Ther200126425726411493367
  • RaffaRBPergolizziJVSegarnickDJTallaridaRJOxycodone combinations for pain reliefDrugs Today (Barc)201046637939820571607
  • TallaridaRJCowanARaffaRBAntinociceptive synergy, additivity, and subaddivity with combinations of oral glucosamine plus nonopioid analgesics in miceJ Pharmacol Exp Ther2003307269970412966152
  • TallaridaRJDrug synergism: its detection and applicationsJ Pharmacol Exp Ther2001298386587211504778
  • TallaridaRJStoneDJJrRaffaRBEfficient designs for studying synergistic drug combinationsLife Sci19976126PL 417PL 425
  • TallaridaRJInteractions between drugs and occupied receptorsPharmacol Ther2007113119720917079019
  • TallaridaRJAn overview of drug combination analysis with isobolograms. Perspectives in pharmacologyJ Pharmacol Exp Ther200631911716670349
  • LoeweLAntagonisms and antagonistsPharmacol Rev19579223724213465303
  • LoeweSThe problem of synergism and antagonism of combined drugsArzneimittelforschung19533628529013081480
  • TallaridaRJDrug Synergism and Dose-Effect Data AnalysisBoca Raton, FLCRC/Chapman-Hall2000
  • GrabovskyYTallardiaRJIsobologrphic analysis for combinations of full and partial agonists: curved isobolesJ Pharmacol Exp Ther2004310398198615175417
  • BravermanASTallaridaRJRuggieriMRSrThe use of occupation isoboles for analysis of a response mediated by two receptors: M2 and M3 muscarinic receptor subtype-induced mouse stomach contractionJ Pharmacol Exp Ther2008325395496018339971
  • IdeSMinamiMIshiharaKUhlGRSoraIIkedaKMu opioid receptor-dependent and independent components in effects of tramadolNeuropharmacology200651365165816793069
  • ChristophTKögelBStrassburgerWSchugSATramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain modelsDrugs R D200781515717249849
  • Zaldiar® product monographAachenGruenenthal GmbH2002 Available from: http://www.zaldiar.com/zal/en_EN/pdf/zaldiar_product_monograph.pdfAccessed June 27, 2012
  • BonnefontJCouradeJPAllouiAEschalierAAntinociceptive mechanism of action of paracetamolDrugs200363Spec No 214 French14758785
  • HawtonKWareCMistryHParacetamol self-poisoning: characteristics, prevention and harm reductionBr J Psychiatry1996168143488770427
  • KuffnerEKDartRCBogdanGMHillRECasperEDartonLEffect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trialArch Intern Med2001161182247225211575982
  • GregoireNHovsepianLGualanoVEveneEDufourGGendronASafety and pharmacokinetics of paracetamol following intravenous administration of 5 g during the first 24 h with a 2-g starting doseClin Pharmacol Ther200781340140517339870
  • McClellanKScottLJTramadol/paracetamolDrugs200363111079108612749738
  • DhillonSTramadol/paracetamol fixed-dose combination: a review of its use in the management of moderate to severe painClin Drug Investig20103010711738
  • ScheimanJMBalancing risks and benefits of cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugsGastroenterol Clin N Am2009382305314
  • van der LindenMWGaugrisSKuipersEJCOX-2 inhibitors: complex association with lower risk of hospitalization for gastrointestinal events compared to traditional NSAIDs plus proton pump inhibitorsPharmacoepidemiol Drug Saf2009181088089019593747
  • RahmeEBarkunANTouboutiYScaleraARochonSLelorierJDo proton-pump inhibitors confer additional gastrointesntinal protection in patients given celecoxib?Arthritis Rheum200757574875517530673
  • LaineLProton pump inhibitor co-therapy with nonsteroidal anti-inflammatory drugs – nice or necessary?Rev Gastroenterol Disord20044Suppl 4S33S4115580145
  • ChanFKWongVWSuenBYCombination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trialLancet200736995731621162617499604
  • VonkemanHEFernandesRWvan der PalenJvan RoonENvan de LaarMAProton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control studyArthritis Res Ther200793R5217521422
  • US Food and Drug Administration (FDA)Safe Use Initiative: collaborating to reduce preventable harm from medications [web page on the Internet]Silver Spring, MDFDAnd [updated April 26, 2012]. Available from: http://www.fda.gov/Drugs/DrugSafety/SafeUseInitiative/default.htmAccessed May 13, 2011
  • WongVWChanFKCycolooxygenase-2 inhibitors in patients with high gastrointestinal risk: are we there yet?J Gastroenterol200944Suppl 19535619148794
  • WoolfADZeidlerHHaglundUMusculoskeletal pain in Europe: its impact and a comparison of population and medical perceptions of treatment in eight European countriesAnn Rheum Dis200463434234715020325
  • SchnitzerTJUpdate on guidelines for the treatment of chronic musculoskeletal painClin Rheumatol200625Suppl 1S22S2916741783
  • AltmanRDPractical considerations for the pharmacologic management of osteoarthritisAm J Manag Care2009158 SupplS236S24319817510
  • AltmanRDEarly management of osteoarthritisAm J Manag Care201016Suppl ManagementS414720297876
  • NICERheumatoid Arthritis: The Management of Rheumatoid Arthritis in AdultsNICE clinical guideline 79LondonNICE2009 Available from: http://www.nice.org.uk/nicemedia/live/12131/43327/43327.pdfAccessed December 18, 2010
  • LuqmaniRHennellSEstrachCBritish Society for Rheumatology; British Health Professionals in Rheumatology Standards, Guidelines and Audit Working GroupBritish Society for Rheumatology and british health professionals in Rheumatology guideline for the management of rheumatoid arthritis (the first two years)Rheumatology (Oxford)20064591167116916844700
  • LuqmaniRHennellSEstrachCBritish Society for Rheumatology; British Health Professionals in Rheumatology Standards, Guidelines and Audit Working GroupBritish Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of rheumatoid arthritis (after the first 2 years)Rheumatology (Oxford)200948443643919174570
  • CombeBLandeweRLukasCEULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)Ann Rheum Dis2007661344516396980
  • CarvilleSFArendt-NielsenSBliddalHEULAREULAR evidence-based recommendations for the management of fibromyalgia syndromeAnn Rheum Dis200867453654117644548
  • BurckhardtCGoldenbergDCroffordLGuideline for the Management of Fibromyalgia Syndrome Pain in Adults and ChildrenClinical practice guideline 42005 Available from: http://www.ampainsoc.org/library/pt_fibromyalgia.htmAccessed December 18, 2010
  • AiraksinenOBroxJICedraschiCCOST B13 Working Group on Guidelines for Chronic Low Back PainChapter 4. European guidelines for the management of chronic nonspecific low back painEur Spine J200615Suppl 2S19230016550448
  • ChouRHoyt-HuffmanLAmerican Pain Society; American College of PhysiciansMedications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guidelineAnn Intern Med2007147750551417909211
  • NICELow Back Pain: Early Management of Persistent Non-Specific Low Back PainNICE clinical guideline 88LondonNICE2009 Available from: http://www.nice.org.uk/nicemedia/live/11887/44343/44343.pdfAccessed December 18, 2010
  • FDAProposed NSAID package insert labeling template 1Silver Spring, MDFDAnd Available from: http://www.fda.gov/downloads/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm106230.pdfAccessed December 18, 2010
  • KoSHKwonHSYuJMComparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathyDiabet Med20102791033104020722677
  • FreemanRRaskinPHewittDJCAPSS-237 Study GroupRandomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathyCurr Med Res Opin200723114716117257476
  • MullicanWSLacyJRTRAMAP-ANAG-006 Study GroupTramadol/acetaminophen combination tablets and codeine/ acetaminophen combination capsules for the management of chronic pain: a comparative trialClin Ther20012391429144511589258
  • SmithABRavikumarTSKaminMJordanDXiangJRosenthalNCAPSS-115 Study GroupCombination tramadol plus acetaminophen for postsurgical painAm J Surg2004187452152715041504
  • PickeringGEstradeMDubrayCComparative trial of tramadol/ paracetamol and codeine/paracetamol combination tablets on the vigilance of healthy volunteersFundam Clin Pharmacol200519670771116313283
  • RichmondJHunterDIrrgangJAmerican Academy of Orthopaedic SurgeonsAmerican Academy of Orthopaedic Surgeons clinical practice guideline on the treatment of osteoarthritis (OA) of the kneeJ Bone Joint Surg Am201092499099320360527
  • CibulkaMTWhiteDMWoehrleJHip pain and mobility deficits – hip osteoarthritis: clinical practice guidelines linked to the international classification of functioning, disability, and health from the orthopaedic section of the American Physical Therapy AssociationJ Orthop Sports Phys Ther42009394A1A2519352008
  • SchnitzerTJAmerican College of Rheumatology Update of ACR guidelines for osteoarthritis: role of the coxibsJ Pain Symptom Manage2002234 SupplS2430 discussion S31–3411992747
  • ConaghanPGDicksonJGrantRLCare and management of osteoarthritis in adults: summary of NICE guidanceBMJ2008336764250250318310005
  • ZhangWDohertyMArdenNEULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)Ann Rheum Dis200564566968115471891
  • FrickeJRJrKarimRJordanDRosenthalNA double-blind, single-dose comparison of the analgesic efficacy of tramadol/acetaminophen combination tablets, hydrocodone/acetaminophen combination tablets, and placebo after oral surgeryClin Ther200224695396812117085
  • MacleodAGAshfordBVoltzMParacetamol versus paracetamol-codeine in the treatment of post-operative dental pain: a randomized, double-blind, prospective trialAust Den J2002472147151
  • EdwardsJEMcQuayHJMooreRACombination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative painJ Pain Symptom Manage200223212113011844632
  • JungYSKimDKKimMKKimHJChaIHLeeEWOnset of analgesia and analgesic efficacy of tramadol/acetaminophen and codeine/acetaminophen/ibuprofen in acute postoperative pain: a single-center, single-dose, randomized, active-controlled, parallel-group study in a dental surgery pain modelClin Ther20042671037104515336468
  • LitkowskiLJChristensenSEAdamsonDNVan DykeTHanSHNewmanKBAnalgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg compared with those of oxycodone 5 mg/ acetaminophen 325 mg and hydrocodone 7.5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: a randomized, double-blind, placebo-controlled, single-dose, parallel-group study in a dental pain modelClin Ther200527441842915922815
  • DanielsSEGoulderMAAspleySReaderSA randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental painPain2011152363264221257263
  • WhitePFJoshiGPCarpenterRLFragenRJA comparison of oral ketorolac and hydrocodone-acetaminophen for analgesia after ambulatory surgery: arhroscopy versus laparoscopic tubal ligationAnesth Analg199785137439212119
  • PalangioMDamaskMJMorrisECombination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic painClin Ther200022787989210945514
  • SniezekPJBrodlandDGZitelliJAA randomized controlled trial comparing acetaminophen, acetaminophen and ibuprofen, and acetaminophen and codeine for postoperative pain relief after Mohs surgery and cutaneous reconstructionDermatol Surg20113771007101321561527
  • RawalNMacquaireVCataláEBertiMCostaRWietlisbachMTramadol/paracetamol combination tablet for postoperative pain following ambulatory hand surgery: a double-blind, double-dummy, randomized, parallel-group trialJ Pain Res2011410311021559356
  • SerrieAGanryHCreuzéASchatzBEpidemiological data, efficacy and safety on a fixed combination of paracetamol (325 mg) and tramadol (37.5 mg) in the treatment of moderate to severe pain, in general practice (ELZA survey: Efficacité et ToLerance de ZAldier®)Journal of Applied Therapeutic Research20118135
  • MejjadOSerrieAGanryHEpidemiological data, efficacy and safety of a paracetamol–tramadol fixed combination in the treatment of moderate-to-severe pain. SALZA: a post-marketing study in general practiceCurr Med Res Opin20112751013102021401445
  • EmkeyRRosenthalNWuSCJordanDKaminMCAPSS-114 Study GroupEfficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal anti-inflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trialJ Rheumatol200431115015614705234
  • CorsinoviLMartinelliEFonteGEfficacy of oxycodone/ acetaminophen and codeine/acetaminophen vs conventional therapy in elderly women with persistent, moderate to severe osteoarthritis-related painArch Gerontol Geriatr2009493387382
  • PareekAChandurkarNSharmaVDDesaiMKiniSBartakkeGA randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-upExpert Opin Pharmacother200910572773519351223
  • PareekAChandurkarNAmbadeRChandanwaleABartakkeGEfficacy and safety of etodolac-paracetamol fixed dose combination in patients with knee osteoarthritis flare-up: a randomized, double-blind comparative evaluationClin J Pain201026756156620639739
  • DohertyMHawkeyCGoulderMA randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/ paracetamol in community-derived people with knee painAnn Rheum Dis20117091534154121804100
  • ConaghanPGO’BrienCMWilsonMSchofieldJPTransdermal buprenorphine plus oral paracetamol vs an oral codeine-paracetamol combination for osteoarthritis of hip and/or knee: a randomised trialOsteoarthritis Cartilage201119893093821477658
  • PalangioMMorrisEDoyleRTJrDornseifBEValenteTJCombination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back painClin Ther2002241879911833838
  • RuoffGERosenthalNJordanDKarimRKaminMProtocol CAPSS-112 Study GroupTramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multicenter, randomized, double-blind, placebo-controlled outpatient studyClin Ther20032541123114112809961
  • PerrotSKrauseDCrozesPNaïmCGRTF-ZAL-1 Study GroupEfficacy and tolerability of paracetamol/tramadol (325 mg/37.5 mg) monotherapy in patients with subacute low back pain: a multicenter, randomized, double-blind, parallel-group, 10-day treatment studyClin Ther200628101592160617157115
  • BennettRMKaminMKarimRRosenthalNTramadol and acetaminophen combination tablets in the treatment of fiobromyalgia pain: a double-blind, randomized, placebo-controlled studyAm J Med2003114753754512753877
  • LeeEYLeeEBParkBJTramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trialClin Ther200628122052206017296461
  • RaffaeliWPariCCorvettaAOxycodone/acetaminophen at low dosage: an alternative pain treatment for patients with rheumatoid arthritisJ Opioid Manag201061404620297613
  • GrahamGGGrahamRIDayROComparative analgesia, cardiovascular, and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol)Curr Pharm Des20028121063107511945151
  • HershEVPintoAMoorePAAdverse drug interactions involving common prescription and over-the-counter analgesic agentsClin Ther200729Suppl2477249718164916
  • HochbergMCAltmanRDToupin AprilKAmerican College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and kneeArthritis Care and Research201264446547422563589
  • DworkinRHO’ConnorABAudetteJRecommendations for the pharmacological management of neuropathic pain: an overview and literature updateMayo Clin Proc2010853 SupplS3S1420194146
  • HaanpääMBackonjaMMBennettMAssessment of neuropathic pain in primary careAm J Med200912210 SupplS13S2119801048
  • FDA Executive summary [web page on the Internet; McNeil background package to the Nonprescription Drug Advisory Committee]Silver Spring, MDFDA2002 Available from: http://www.fda.gov/ohrms/dockets/ac/02/briefing/3882B1_13_McNeil-Acetaminophen.htm#_Toc18717551Accessed May 13, 2011