Neutrophil-to-Lymphocyte Ratio as an Indicator of Opioid-Induced Immunosuppression After Thoracoscopic Surgery: A Randomized Controlled Trial

References

• Kinoshita T, Goto T. Links between inflammation and postoperative cancer recurrence. J Clin Med. 2021;10(2):228. doi:10.3390/jcm10020228
   PubMed Web of Science ®Google Scholar
• García-López L, Adrados I, Ferres-Marco D, et al. A blueprint for cancer-related inflammation and host innate immunity. Cells. 2021;10(11):3211. doi:10.3390/cells10113211
   PubMed Web of Science ®Google Scholar
• Muncey AR, Patel SY, Whelan CJ, et al. The intersection of regional anesthesia and cancer progression: a theoretical framework. Cancer Control. 2020;27(1):1073274820965575. doi:10.1177/1073274820965575
   Web of Science ®Google Scholar
• Byrne K, Levins KJ, Buggy DJ. Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis? Can J Anaesth. 2016;63(2):184–192. doi:10.1177/1073274820965575
   PubMed Web of Science ®Google Scholar
• Hayama T, Ozawa T, Asako K, et al. Impact of colon cancer location on the prognostic significance of nutritional indexes and inflammatory markers. Vivo. 2021;35(2):1261–1269. doi:10.21873/invivo.12377
   PubMed Web of Science ®Google Scholar
• Dolan RD, McSorley ST, Park JH, et al. The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores. Br J Cancer. 2018;119(1):40–51.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Xu D, Song H, et al. Inflammation and nutrition-based biomarkers in the prognosis of oesophageal cancer: a systematic review and meta-analysis. BMJ Open. 2021;11(9):e048324. doi:10.1136/bmjopen-2020-048324
   PubMed Web of Science ®Google Scholar
• Kim R. Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence. J Transl Med. 2018;16(1):8. doi:10.1186/s12967-018-1389-7
   PubMed Web of Science ®Google Scholar
• Wen S, Jiang Y, Liang S, et al. Opioids regulate the immune system: focusing on macrophages and their organelles. Front Pharmacol. 2022;12:814241. doi:10.3389/fphar.2021.814241
   PubMed Web of Science ®Google Scholar
• Cho U, Park HS, Im SY, et al. Prognostic value of systemic inflammatory markers and development of a nomogram in breast cancer. PLoS One. 2018;13(7):e0200936. doi:10.1371/journal.pone.0200936
   PubMed Web of Science ®Google Scholar
• Chen JH, Zhai ET, Yuan YJ, et al. Systemic immune-inflammation index for predicting prognosis of colorectal cancer. World J Gastroenterol. 2017;23(34):6261–6272. doi:10.3748/wjg.v23.i34.6261
   PubMed Web of Science ®Google Scholar
• Eisenstein TK. The role of opioid receptors in immune system function. Front Immunol. 2019;12:2904. doi:10.3389/fimmu.2019.02904
   Web of Science ®Google Scholar
• Gao Z, Xiao Y, Wang Q, et al. Comparison of dexmedetomidine and dexamethasone as adjuvant for ropivacaine in ultrasound-guided erector spinae plane block for video-assisted thoracoscopic lobectomy surgery: a randomized, double-blind, placebo-controlled trial. Ann Transl Med. 2019;7(22):668. doi:10.21037/atm.2019.10.74
   PubMed Web of Science ®Google Scholar
• Kwanten LE, O’Brien B, Anwar S. Opioid-based anesthesia and analgesia for adult cardiac surgery: history and narrative review of the literature. J Cardiothorac Vasc Anesth. 2019;33(3):808–816. doi:10.1053/j.jvca.2018.05.053
   PubMed Web of Science ®Google Scholar
• Malafoglia V, Ilari S, Vitiello L, et al. The interplay between chronic pain, opioids, and the immune system. Neuroscientist. 2021;16:10738584211030493. doi:10.1177/10738584211030493
   Web of Science ®Google Scholar
• Soffin EM, Lee BH, Kumar KK, et al. The prescription opioid crisis: role of the anaesthesiologist in reducing opioid use and misuse. Br J Anaesth. 2019;122(6):e198–e208. doi:10.1016/j.bja.2018.11.019
   PubMed Web of Science ®Google Scholar
• Machelska H, Celik MÖ. Opioid receptors in immune and glial cells-implications for pain control. Front Immunol. 2020;4; 11:300. doi:10.3389/fimmu.2020.00300
   Web of Science ®Google Scholar
• Zhang P, Yang M, Chen C, et al. Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility. Front Immunol. 2020;11(8):1455. doi:10.3389/fimmu.2020.01455
   PubMed Web of Science ®Google Scholar
• Cascella M, Cuomo A, Bifulco F, et al. Could the perioperative use of opioids influence cancer outcomes after surgery? A scoping review protocol. BMJ Open. 2022;12(3):e054520. doi:10.1136/bmjopen-2021-054520
   PubMed Web of Science ®Google Scholar
• Wodehouse T, Demopoulos M, Petty R, et al. A randomized pilot study to investigate the effect of opioids on immunomarkers using gene expression profiling during surgery. Pain. 2019;160(12):2691–2698. doi:10.1097/j.pain.0000000000001677
   PubMed Web of Science ®Google Scholar
• Maher DP, Walia D, Heller NM. Suppression of human natural killer cells by different classes of opioids. Anesth Analg. 2019;128(5):1013–1021. doi:10.1213/ANE.0000000000004058
   PubMed Web of Science ®Google Scholar
• Zhu X, Zhu J. CD4 T helper cell subsets and related human immunological disorders. Int J Mol Sci. 2020;21(21):8011. doi:10.3390/ijms21218011
   PubMed Web of Science ®Google Scholar
• Mahapatro M, Erkert L, Becker C. Cytokine-mediated crosstalk between immune cells and epithelial cells in the gut. Cells. 2021;10(1):111. doi:10.3390/cells10010111
   PubMed Web of Science ®Google Scholar
• Elias-Oliveira J, Leite JA, Pereira ÍS, et al. NLR and intestinal dysbiosis-associated inflammatory illness: drivers or dampers? Front Immunol. 2020;11(11):1810. doi:10.3389/fimmu.2020.01810
   PubMed Web of Science ®Google Scholar
• Yao C, Liu X, Tang Z. Prognostic role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for hospital mortality in patients with AECOPD. Int J Chron Obstruct Pulmon Dis. 2017;3(12):2285–2290. doi:10.2147/COPD.S141760
   Web of Science ®Google Scholar