References
- MullemanDMammouSGriffoulIWatierHGoupillePPathophysiology of disk-related sciatica. I. – Evidence supporting a chemical componentJoint Bone Spine200673215115816046173
- ZuoYPerkinsNMTraceyDJGeczyCLInflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cellsPain2003105346747914527707
- WeiMMoSLNabarNRModification of Rat Model of Sciatica Induced by Lumber Disc Herniation and the Anti-Inflammatory Effect of Osthole Given by Epidural CatheterizationPharmacology2012905–625126323018204
- LiouJTSumDCLiuFCMaoCCLaiYSDayYJSpatial and temporal analysis of nociception-related spinal cord matrix metalloproteinase expression in a murine neuropathic pain modelJ Chin Med Assoc201376420121023557887
- NitzAJDobnerJJMatulionisDHStructural assessment of rat sciatic nerve following tourniquet compression and vascular manipulationAnat Rec1989225167762774214
- SaikaFKiguchiNKobayashiYFukazawaYKishiokaSCC-chemokine ligand 4/macrophage inflammatory protein-1β participates in the induction of neuropathic pain after peripheral nerve injuryEur J Pain20121691271128022528550
- XuLHuangYYuXYueJYangNZuoPThe influence of p38 mitogen-activated protein kinase inhibitor on synthesis of inflammatory cytokine tumor necrosis factor alpha in spinal cord of rats with chronic constriction injuryAnesth Analg200710561838184418042890
- TufekAKayaSTokgozOThe protective effect of dexmedetomidine on bupivacaine-induced sciatic nerve inflammation is mediated by mast cellsClin Invest Med2013362E95E10223544611
- PeleshokJCRibeiro-da-SilvaANeurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerveMol Pain20128122233577
- FuchsDBirkleinFReehPWSauerSKSensitized peripheral nociception in experimental diabetes of the ratPain2010151249650520832942
- Keppel HesselinkJMNew targets in pain, non-neuronal cells, and the role of palmitoylethanolamideOPJ201251223
- KuehlFAJacobTAGanleyOHOrmondREMeisingerMAPThe identification of N-(2-hydroxyethyl)-palmitamide as a naturally occurring anti-inflammatory agentJ Am Chem Soc1957792055775578
- MasekKPerlikFLetter: Slow encephalopathies, inflammatory responses, and arachis oilLancet19752793455851386
- CalignanoALa RanaGGiuffridaAPiomelliDControl of pain initiation by endogenous cannabinoidsNature199839466902772819685157
- DarmaniNAIzzoAADegenhardtBInvolvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studiesNeuropharmacology20054881154116315910891
- FranklinAParmentier-BatteurSWalterLGreenbergDAStellaNPalmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motilityJ Neurosci200323217767777512944505
- BulanovaEBulfone-PausSP2 receptor-mediated signaling in mast cell biologyPurinergic Signal20096131719921464
- OharaPTVitJPBhargavaAGliopathic pain: when satellite glial cells go badNeuroscientist200915545046319826169
- EspositoEPaternitiIMazzonEEffects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injuryBrain Behav Immun20112561099111221354467
- ScuderiCSteardoLNeuroglial Roots of Neurodegenerative Diseases: Therapeutic Potential of Palmitoylethanolamide in Models of Alzheimer’s DiseaseCNS Neurol Disord Drug Targets2013121626923394526
- LuongoLGuidaFBoccellaSPalmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in miceCNS Neurol Disord Drug Targets2013121455423394524
- BenitoCTolónRMCastilloAIβ−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptorsBr J Pharmacol201216641474148922321194
- SkaperSDFacciLMast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamidePhilos Trans R Soc Lond B Biol Sci201236716073312332523108549
- CostaBContiSGiagnoniGColleoniMTherapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo-oxygenase systemsBr J Pharmacol2002137441342012359622
- GodlewskiGOffertálerLWagnerJAKunosGReceptors for acylethanolamides-GPR55 and GPR119Prostaglandins Other Lipid Mediat2009893–410511119615459
- SmartDJonssonKOVandevoordeSLambertDMFowlerCJ‘Entourage’ effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolismBr J Pharmacol2002136345245812023948
- D’AgostinoGLa RanaGRussoRCentral administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root gangliaEur J Pharmacol20096131–3545919386271
- LoVermeJRussoRLa RanaGRapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alphaJ Pharmacol and Exp Ther200631931051106116997973
- TsuboiKTakezakiNUedaNThe N-acylethanolamine-hydrolyzing acid amidase (NAAA)Chem Biodivers2007481914192517712833
- SassoOMoreno-SanzGMartucciCAntinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain modelsPain2013154335036023218523
- BettoniIComelliFColomboABonfantiPCostaBNon-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamideCNS Neurol Disord Drug Targets2013121344423394519
- HelyesZNemethJThanMBolcskeiKPinterESzolcsanyiJInhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the ratLife Sci200373182345235312941436
- PetrosinoSPalazzoEde NovellisVChanges in spinal and supraspinal endocannabinoid levels in neuropathic ratsNeuropharmacology200752241542217011598
- Di Cesare MannelliLD’AgostinoGPaciniAPalmitoylethanolamide Is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism. mediators of inflammationMediators Inflamm2013201332879723533304
- StarowiczKMakuchWKorostynskiMFull inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolismPLoS One201384e6004023573230
- WallaceVCSegerdahlARLambertDMThe effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathyBr J Pharmacol200715171117112817558434
- EspositoECuzzocreaSPalmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with traumaMini Rev Med Chem201313223725522697514
- GuidaGde MartinoMde FabianiALa palmitoiletanolamida (Normast) en el dolor neuropatico cronico por lumbociatalgia de tipo compresivo: estudio clinico multicentrico [A multicenter clinical study of palmitoylethanolamide in chronic neuropathic pain: compression lumboischialgia]Dolor20102513542 Spanish
- Keppel HesselinkJMNon-neuronal cells new therapeutic targets for neuropathic painX Congresso Nazionale ACD SIAARTINovember 23–25; 2011Perugia
- CanteriLPetrosinoSGuidaGReducción del consumo de antiinflamatorios y analgésicos en el tratamiento del dolor neuropático crónico en pacientes afectados por lumbociatialgia de tipo compresivo y en tratamiento con Normast 300 mg [Reduction in consumption of anti-inflammatory and analgesic medication in the treatment of chronic neuropathic pain in patients affected by compression lumbocischialgia due to the treatment with Normast 300 mg]Dolor2010254227234 Spanish
- GattiALazzariMGianfeliceVDi PaoloASabatoESabatoAFPalmitoylethanolamide in the treatment of chronic pain caused by different etiopathogenesisPain Med20121391121113022845893
- DesioPCombination of oxycodone and palmitoylethanolamide for low back pain treatmentAMC2011126271
- PalombaRAAdilettaSCandielloAPenimpedeMBonacciaPDe MartinoCJAnalgesia multimodale per il dolore cronico: directive future e razionale. [Multimodal analgesia for chronic pain: rationale and future directions]33rd National Congress of the Italian Association for the Study of PainFlorence, Italy2010 Spanish
- DomínguezCMIbáñez PuertasMAPalmitoiletanolamida (PEA) en lumbociatica en asociacion al tratamiento habitual. [Palmitoylethanolamide in lumbosciatic pain in association with standard therapy]Rev Soc Esp Dolor20101735 Spanish
- AssiniALaricchiaDPizzoRP1577: The carpal tunnel syndrome in diabetes: clinical and electrophysiological improvement after treatment with palmitoylethanolamideEur J Neurol201017S329519863647
- ConigliaroRDragoVFosterPSSchievanoCDi MarzoVUse of palmitoylethanolamide in the entrapment neuropathy of the median in the wristMinerva Med2011102214114721483401