In Quest of Pathognomonic/Endophenotypic Markers of Attention Deficit Hyperactivity Disorder (ADHD): Potential of EEG-Based Frequency Analysis and ERPs to Better Detect, Prevent and Manage ADHD

References

• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 1st ed. Washington, DC, USA: American Psychiatric Association; 1952.
   Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 2nd ed. Washington, DC, USA: American Psychiatric Association:; 1968.
   Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. Washington, DC, USA: American Psychiatric Association; 1980.
   Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd rev ed. Washington, DC, USA: American Psychiatric Association; 1987.
   Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Arlington, VA, USA: American Psychiatric Association; 1994. 20. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th text rev. ed.; American Psychiatric Association: Arlington, VA, USA, 2000.
   Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC, USA: American Psychiatric Association; 2013.
   Google Scholar
• Kooij JJ, Huss M, Asherson P, et al. Distinguishing comorbidity and successful management of adult ADHD. J Atten Disord. 2012;16(5 Suppl):3S–19S. doi:10.1177/1087054711435361
   PubMed Web of Science ®Google Scholar
• Gloss D, Varma JK, Pringsheim T, Nuwer MR. Practice advisory: the utility of EEG theta/beta power ratio in ADHD diagnosis: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology. 2016;87(22):2375–2379.
   Web of Science ®Google Scholar
• Lenartowicz A, Loo SK. Use of EEG to diagnose ADHD. Curr Psychiatry Rep. 2014;16(11):498. doi:10.1007/s11920-014-0498-0
   PubMed Web of Science ®Google Scholar
• McLoughlin G, Makeig S, Tsuang MT. In search of biomarkers in psychiatry: EEG-based measures of brain function. Am J Med Genet B Neuropsychiatr Genet. 2014;165:111–121. doi:10.1002/ajmg.b.32208
   Web of Science ®Google Scholar
• Markiewcz R. The use of EEG biofeedback/neurofeedback in psychiatric rehabilitation. Psychiatr Pol. 2017;51(6):1095–1106. doi:10.12740/PP/68919 Epub 2017 Dec 30.
   Web of Science ®Google Scholar
• Crichton A. An inquiry into the nature and origin of mental derangement: comprehending a concise system of the physiology and pathology of the human mind and a history of the passions and their effects. J Atten Disord. 1798;12:200–204. [ Cadell T Jr, Davies W, London [Reprint: Crichton A (2008) An inquiry into the nature and origin of mental derangement. On attention and its diseases. doi:10.1177/1087054708315137
   Web of Science ®Google Scholar
• Palmer E, Finger S. An early description of ADHD (Inattentive Subtype): dr Alexander Crichton and `Mental Restlessness’ (1798) Child Psychol Psychiatry Rev. 2001;6:66–73.
   Google Scholar
• Lange KW, Reichl S, Lange KM, Tucha L, Tucha O. The history of attention deficit hyperactivity disorder. Atten Defic Hyperact Disord. 2010;2(4):241–255. doi:10.1007/s12402-010-0045-8
   Google Scholar
• Carlew AR, Zartman AL. DSM nosology changes in neuropsychological diagnoses through the years: a look at ADHD and mild neurocognitive disorder. Behav Sci (Basel). 2016;7(1):1. doi:10.3390/bs7010001
   Google Scholar
• Barkley RA. Issues in the diagnosis of attention-deficit/hyperactivity disorder in children. Brain Dev. 2003;25:77–83. doi:10.1016/S0387-7604(02)00152-3
   PubMed Web of Science ®Google Scholar
• Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull. 1997;121:65–94. doi:10.1037/0033-2909.121.1.65
   PubMed Web of Science ®Google Scholar
• Barkley RA. Concentration deficit disorder (sluggish cognitive tempo). In: Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. New York, NY, USA: Guilford Press; 2015:267–313.
   Google Scholar
• American Academy of Pediatrics. Clinical Practice Guideline: diagnosis and evaluation of the child with attention-deficit/hyperactivity disorder. Pediatrics. 2000;105:1158–1170. doi:10.1542/peds.105.5.1158
   PubMed Web of Science ®Google Scholar
• Fayyad J, Sampson NA, Hwang I, et al. The descriptive epidemiology of DSM-IV adult ADHD in the World Health Organization World Mental Health Surveys. Atten Defic Hyperact Disord. 2017;9:47–65. doi:10.1007/s12402-016-0208-3
   PubMedGoogle Scholar
• Faraone SV, Biederman J, Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med. 2006;36:159–165.
   PubMed Web of Science ®Google Scholar
• Ebejer JL, Medland SE, van der Werf J, et al. Attention deficit hyperactivity disorder in Australian adults: prevalence, persistence, conduct problems and disadvantage. PLoS One. 2012;7:e47404. doi:10.1371/journal.pone.0047404
   PubMed Web of Science ®Google Scholar
• Torgersen T, Gjervan B, Rasmussen K. ADHD in adults: a study of clinical characteristics, impairment and comorbidity. Nord J Psychiatry. 2006;60(1):38–43. doi:10.1080/08039480500520665
   PubMed Web of Science ®Google Scholar
• Sobanski E, Brüggemann D, Alm B, et al. Psychiatric comorbidity and functional impairment in a clinically referred sample of adults with attention-deficit/hyperactivity disorder (ADHD). Eur Arch Psychiatry Clin Neurosci. 2007;257(7):371–377. doi:10.1007/s00406-007-0712-8
   PubMed Web of Science ®Google Scholar
• Anker E, Bendiksen B, Heir T. Comorbid psychiatric disorders in a clinical sample of adults with ADHD, and associations with education, work and social characteristics: a cross-sectional study. BMJ Open. 2018;8(3):e019700. doi:10.1136/bmjopen-2017-019700
   PubMed Web of Science ®Google Scholar
• Russell G, Rodgers LR, Ukoumunne OC, Ford T. Prevalence of parent-reported ASD and ADHD in the UK: findings from the millennium cohort study. J Autism Dev Disord. 2014;44:31–40. doi:10.1007/s10803-013-1849-0
   PubMed Web of Science ®Google Scholar
• van der Meer JMJ, Oerlemans AM, van Steijn DJ, et al. Are autism spectrum disorder and attention-deficit/hyperactivity disorder different manifestations of one overarching disorder? Cognitive and symptom evidence from a clinical and population-based sample. J Am Acad Child Adolesc Psychiatry. 2012;51:1160–1172.e3. doi:10.1016/j.jaac.2012.08.024
   PubMed Web of Science ®Google Scholar
• Katzman MA, Bilkey TS, Chokka PR, Fallu A, Klassen LJ. Adult ADHD and comorbid disorders: clinical implications of a dimensional approach. BMC Psychiatry. 2017;17(1):302. doi:10.1186/s12888-017-1463-3
   PubMed Web of Science ®Google Scholar
• Klassen LJ, Katzman MA, Chokka P. Adult ADHD and its comorbidities, with a focus on bipolar disorder. J Affect Disord. 2010;124(1–2):1–8. doi:10.1016/j.jad.2009.06.036
   PubMed Web of Science ®Google Scholar
• McIntosh D, Kutcher S, Binder C, Levitt A, Fallu A, Rosenbluth M. Adult ADHD and comorbid depression: a consensus-derived diagnostic algorithm for ADHD. Neuropsychiatr Dis Treat. 2009;5:137–150. doi:10.2147/ndt.s4720
   PubMed Web of Science ®Google Scholar
• Canadian Attention Deficit Hyperactivity Disorder Resource Alliance (CADDRA): Canadian ADHD Practice Guidelines. 3rd ed. Toronto ON: CADDRA; 2011
   Google Scholar
• Deberdt W, Thome J, Lebrec J, et al. Prevalence of ADHD in nonpsychotic adult psychiatric care (ADPSYC): A multinational cross-sectional study in Europe. BMC Psychiatry. 2015;15:242. doi:10.1186/s12888-015-0624-5
   PubMed Web of Science ®Google Scholar
• Reale L, Bartoli B, Cartabia M, et al.; Lombardy ADHD Group. Comorbidity prevalence and treatment outcome in children and adolescents with ADHD. Eur Child Adolesc Psychiatry. 2017;26(12):1443–1457. Epub 2017 May 19. doi:10.1007/s00787-017-1005-z
   PubMed Web of Science ®Google Scholar
• Chen W, Zhou K, Sham P, et al. DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1450–1460. doi:10.1002/ajmg.b.30672
   PubMed Web of Science ®Google Scholar
• Sherman D, Iacono W, McGue M. Attention deficit hyperactivity disorder dimensions: a twin study of inattention and impulsivity hyperactivity. J Am Acad Child Adolesc Psychiatry. 1997;36:745–753. doi:10.1097/00004583-199706000-00010
   PubMed Web of Science ®Google Scholar
• Langner I, Garbe E, Banaschewski T, Mikolajczyk RT. Twin and sibling studies using health insurance data: the example of attention deficit/hyperactivity disorder (ADHD). PLoS One. 2013;8:e62177. doi:10.1371/journal.pone.0062177
   Web of Science ®Google Scholar
• Gizer IR, Ficks C, Waldman ID. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet. 2009;126:51–90.
   PubMed Web of Science ®Google Scholar
• Bonvicini C, Faraone SV, Scassellati C. Attention-deficit hyperactivity disorder in adults: a systematic review and metaanalysis of genetic, pharmacogenetic and biochemical studies. Mol Psychiatry. 2016;21:1643. doi:10.1038/mp.2016.128
   PubMed Web of Science ®Google Scholar
• Faraone SV, Mick E. Molecular genetics of attention deficit hyperactivity disorder. Psychiatr Clin North Am. 2010;33(1):159–180. doi:10.1016/j.psc.2009.12.004
   PubMed Web of Science ®Google Scholar
• Schachar R. Genetics of Attention Deficit Hyperactivity Disorder (ADHD): recent updates and future prospects. Curr Dev Disord Rep. 2014;1:41. doi:10.1007/s40474-013-0004-0
   Google Scholar
• Lai CS, Gerrelli D, Monaco AP, Fisher SE, Copp AJ. FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. Brain. 2003;126(Pt 11):2455–2462. doi:10.1093/brain/awg247
   Web of Science ®Google Scholar
• Demontis D, Walters RK, Martin J, et al. Discovery of the first genome-wide significant risk loci for ADHD. Submitted for Publication, bioRxiv. 2017;14558:1–43.
   Google Scholar
• Valbonesi S, Magri C, Traversa M, et al. Copy number variants in attention-deficit hyperactive disorder: identification of the 15q13 deletion and its functional role. Psychiatr Genet. 2015;25:59–70. doi:10.1097/YPG.0000000000000056
   PubMed Web of Science ®Google Scholar
• Kollins SH, McClernon FJ, Fuemmeler BF. Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults. Arch Gen Psychiatry. 2005;62:1142–1147. doi:10.1001/archpsyc.62.10.1142
   PubMed Web of Science ®Google Scholar
• Levin ED, Conners CK, Silva D, et al. Transdermal nicotine effects on attention. Psychopharmacol (Berl). 1998;140:135–141. doi:10.1007/s002130050750
   PubMed Web of Science ®Google Scholar
• Anttila V, Bulik-Sullivan B, et al.; Brainstorm Consortium. Analysis of shared heritability in common disorders of the brain. Science. 2018;360(6395):eaap8757. doi:10.1126/science.aap8757.
   PubMed Web of Science ®Google Scholar
• Willcutt EG, Doyle AE, Nigg JT, Faraone SV, Pennington BF. Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry. 2005;57:1336–1346. doi:10.1016/j.biopsych.2005.02.006;pmid
   PubMed Web of Science ®Google Scholar
• Banaschewski T, Hollis C, Oosterlaan J, et al. Towards an understanding of unique and shared pathways in the psychopathophysiology of ADHD. Dev Sci. 2005;8(2):132–140. doi:10.1111/j.1467-7687.2005.00400.x
   PubMed Web of Science ®Google Scholar
• Gallo EF, Posner J. Moving towards causality in attention-deficit hyperactivity disorder: overview of neural and genetic mechanisms. Lancet Psychiatry. 2016;3(6):555–567. doi:10.1016/S2215-0366(16)00096-1
   PubMed Web of Science ®Google Scholar
• Shaw P, Eckstrand K, Sharp W, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A. 2007;104:19649–19654. doi:10.1073/pnas.0707741104
   PubMed Web of Science ®Google Scholar
• Ellison-Wright I, Ellison-Wright Z, Bullmore E. Structural brain change in attention deficit hyperactivity disorder identified by meta-analysis. BMC Psychiatry. 2008;8:51. doi:10.1186/1471-244X-8-51
   PubMed Web of Science ®Google Scholar
• Nakao T, Radua C, Rubia K, Mataix-Cols D. Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication. Am J Psychiatry. 2011;168:1154–1163. doi:10.1176/appi.ajp.2011.11020281
   PubMed Web of Science ®Google Scholar
• Frodl T, Skokauskas N. Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects. Acta Psychiatr Scand. 2012;125:114–126. doi:10.1111/j.1600-0447.2011.01786.x
   PubMed Web of Science ®Google Scholar
• Almeida LG, Ricardo-Garcell J, Prado H, et al. Reduced right frontal cortical thickness in children, adolescents and adults with ADHD and its correlation to clinical variables: a cross-sectional study. J Psychiatr Res. 2010;44:1214–1223. doi:10.1016/j.jpsychires.2010.04.026
   PubMed Web of Science ®Google Scholar
• Montes LGA, Alcántara HP, García RBM, De La Torre LB, Acosta DÁ, Duarte MG. Brain cortical thickness in ADHD: age, sex, and clinical correlations. J Atten Disord. 2012;17:641–654. doi:10.1177/1087054711434351
   Web of Science ®Google Scholar
• Rubia K. Neuro-anatomic evidence for the maturational delay hypothesis of ADHD. Proc Natl Acad Sci USA. 2007;104:19663–19664. doi:10.1073/pnas.0710329105
   PubMed Web of Science ®Google Scholar
• van Ewijk H, Heslenfeld DJ, Zwiers MP, Buitelaar JK, Oosterlaan J. Diffusion tensor imaging in attention deficit/hyperactivity disorder: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2012;36:1093–1106. doi:10.1016/j.neubiorev.2012.01.003
   PubMed Web of Science ®Google Scholar
• Nagel BJ, Bathula D, Herting M, et al. Altered white matter microstructure in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2011;50:283–292. doi:10.1016/j.jaac.2010.12.003
   PubMed Web of Science ®Google Scholar
• Cha J, Fekete T, Siciliano F, et al. Neural correlates of aggression in medication-naive children with ADHD: multivariate analysis of morphometry and tractography. Neuropsychopharmacology. 2015;40:1717–1725. doi:10.1038/npp.2015.18
   Web of Science ®Google Scholar
• Posner J, Park C, Wang Z. Connecting the dots: a review of resting connectivity MRI studies in attention-deficit/hyperactivity disorder. Neuropsychol Rev. 2014;24:3–15. doi:10.1007/s11065-014-9251-z
   PubMed Web of Science ®Google Scholar
• Fair DA, Posner J, Nagel BJ, et al. Atypical default network connectivity in youth with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;68:1084–1091. doi:10.1016/j.biopsych.2010.07.003
   PubMed Web of Science ®Google Scholar
• Castellanos FX, Margulies DS, Kelly C, et al. Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63:332–337. doi:10.1016/j.biopsych.2007.06.025
   PubMed Web of Science ®Google Scholar
• Sonuga-Barke EJ, Castellanos FX. Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neurosci Biobehav Rev. 2007;31:977–986. doi:10.1016/j.neubiorev.2007.02.005
   PubMed Web of Science ®Google Scholar
• Peterson BS, Potenza MN, Wang Z, et al. An FMRI study of the effects of psychostimulants on default-mode processing during Stroop task performance in youths with ADHD. Am J Psychiatry. 2009;166:1286–1294. doi:10.1176/appi.ajp.2009.08050724
   PubMed Web of Science ®Google Scholar
• Hart H, Radua J, Nakao T, Mataix-Cols D, Rubia K. Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effects. JAMA Psychiatry. 2013;70:185–198. doi:10.1001/jamapsychiatry.2013.277
   PubMed Web of Science ®Google Scholar
• Cortese S, Kelly C, Chabernaud C, et al. Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies. Am J Psychiatry. 2012;169:1038–1055. doi:10.1176/appi.ajp.2012.11101521
   PubMed Web of Science ®Google Scholar
• Makris N, Biederman J, Valera EM, et al. Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder. Cereb Cortex. 2007;17:1364–1375. doi:10.1093/cercor/bhl047
   PubMed Web of Science ®Google Scholar
• Purper-Ouakil D, Ramoz N, Lepagnol-Bestel AM, et al. Neurobiology of attention deficit/hyperactivity disorder. Pediatr Res. 2011;69:69R–76R. doi:10.1203/PDR.0b013e318212b40f
   PubMed Web of Science ®Google Scholar
• Morein-Zamir S, Dodds C, van Hartevelt TJ, et al. Hypoactivation in right inferior frontal cortex is specifically associated with motor response inhibition in adult ADHD. Hum Brain Mapp. 2014;35:5141–5152. doi:10.1002/hbm.22539
   PubMed Web of Science ®Google Scholar
• Karch S, Voelker JM, Thalmeier T, et al. Deficits during voluntary selection in adult patients with ADHD: new insights from single-trial coupling of simultaneous EEG/fMRI. Front Psychiatry. 2014;5:41. doi:10.3389/fpsyt.2014.00041
   Web of Science ®Google Scholar
• Dickstein SG, Bannon K, Castellanos FX, et al. The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis. J Child Psychol Psychiatry. 2006;47:1051–1062. doi:10.1111/j.1469-7610.2006.01671.x
   PubMed Web of Science ®Google Scholar
• Cubillo A, Halari R, Giampietro V, et al. Fronto-striatal underactivation during interference inhibition and attention allocation in grown up children with attention deficit/hyperactivity disorder and persistent symptoms. Psychiatry Res. 2011;193:17–27. doi:10.1016/j.pscychresns.2010.12.014
   PubMed Web of Science ®Google Scholar
• Volkow ND, Wang GJ, Newcorn J, et al. Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2007;64:932–940. doi:10.1001/archpsyc.64.8.932
   PubMed Web of Science ®Google Scholar
• Maltezos S, Horder J, Coghlan S, et al. Glutamate/glutamine and neuronal integrity in adults with ADHD: a proton MRS study. Transl Psychiatry. 2014;4:e373. doi:10.1038/tp.2014.11
   PubMed Web of Science ®Google Scholar
• Perlov E, Philipsen A, Hesslinger B, et al. Reduced cingulate glutamate/glutamine-to-creatine ratios in adult patients with attention deficit/hyperactivity disorder — a magnet resonance spectroscopy study. J Psychiatr Res. 2007;41:934–941. doi:10.1016/j.jpsychires.2006.12.007
   PubMed Web of Science ®Google Scholar
• Del Campo N, Fryer TD, Hong YT, et al. A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment. Brain. 2013;136:3252–3270. doi:10.1093/brain/awt263
   PubMed Web of Science ®Google Scholar
• Tomasi D, Volkow ND. Functional connectivity of substantia nigra and ventral tegmental area: maturation during adolescence and effects of ADHD. Cereb Cortex. 2014;24:935–944. doi:10.1093/cercor/bhs382
   Web of Science ®Google Scholar
• Lau-Zhu A, Fritz A, McLoughlin G. Overlaps and distinctions between attention deficit/hyperactivity disorder and autism spectrum disorder in young adulthood: systematic review and guiding framework for EEG-imaging research. Neurosci Biobehav Rev. 2019;96:93–115. doi:10.1016/j.neubiorev.2018.10.009
   PubMed Web of Science ®Google Scholar
• Thapar A, Cooper M, Rutter M. Neurodevelopmental disorders. Lancet Psychiatry. 2017;4:339–346. doi:10.1016/S2215-0366(16)30376-5
   PubMed Web of Science ®Google Scholar
• Beauchaine TP. The role of biomarkers and endophenotypes in prevention and treatment of psychopathological disorders. Biomark Med. 2009;3(1):1–3. doi:10.2217/17520363.3.1.1
   Web of Science ®Google Scholar
• Beauchaine TP, Constantino JN. Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity. Biomark Med. 2017;11(9):769–780. doi:10.2217/bmm-2017-0002
   PubMed Web of Science ®Google Scholar
• McKiernan KA, D’Angelo BR, Kaufman JN, Binder JR. Interrupting the ‘stream of consciousness’: an fMRI investigation. NeuroImage. 2006;29:1185–1191. doi:10.1016/j.neuroimage.2005.09.030
   PubMed Web of Science ®Google Scholar
• Uddin LQ, Kelly AMC, Biswal BB, Castellanos FX, Milham MP. Functional connectivity of default mode network components: correlation, anticorrelation and causality. Hum Brain Mapp. 2009;30:625–637. doi:10.1002/hbm.20531
   PubMed Web of Science ®Google Scholar
• Fox MD, Corbetta M, Snyder AZ, Vincent JL, Raichle ME. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proc Natl Acad Sci U S A. 2006b;103:10046–10051. doi:10.1073/pnas.0604187103
   PubMed Web of Science ®Google Scholar
• Fox MD, Snyder AZ, Vincent JL, et al. The human brain is intrinsically organised into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A. 2005;102:9673–9678. doi:10.1073/pnas.0504136102
   PubMed Web of Science ®Google Scholar
• Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A. 2003;100:253–258. doi:10.1073/pnas.0135058100
   PubMed Web of Science ®Google Scholar
• Raichle ME, MacLeod AM, Snyder AZ, et al. A default mode of brain function. Proc Natl Acad Sci U S A. 2001;98:676–682. doi:10.1073/pnas.98.2.676
   PubMed Web of Science ®Google Scholar
• Damoiseaux JS, Rombouts SARB, Barkhof F, et al. Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci U S A. 2006;103:13848–13853. doi:10.1073/pnas.0601417103
   PubMed Web of Science ®Google Scholar
• Beckmann CF, DeLuca M, Devlin JT, Smith SM. Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc B. 2005;360. doi:10.1098/rstb.2005.1634
   Web of Science ®Google Scholar
• Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci. 2002;3:215–229. doi:10.1038/nrn755
   Web of Science ®Google Scholar
• Buzsáki G, Draguhn A. Neuronal oscillations in cortical networks. Science. 2004;304:1926–1929. doi:10.1126/science.1099745
   PubMed Web of Science ®Google Scholar
• Weissman DH, Roberts KC, Visscher KM, Woldorff MG. The neural basis of momentary lapses in attention. Nat Neurosci. 2006;9:971–978. doi:10.1038/nn1727
   PubMed Web of Science ®Google Scholar
• Fassbender C, Zhang H, Buzy WM, et al. A lack of default network suppression is linked to increased distractibility in ADHD. Brain Res. 2009;1273:114–128. doi:10.1016/j.brainres.2009.02.070
   PubMed Web of Science ®Google Scholar
• Broyd SJ, Helps SK, Sonuga-Barke EJ. Attention-induced deactivations in very low frequency EEG oscillations: differential localisation according to ADHD symptom status. PLoS One. 2011;6(3):e17325. doi:10.1371/journal.pone.0017325
   Web of Science ®Google Scholar
• Chikara RK, Ko LW. Neural activities classification of human inhibitory control using hierarchical model. Sensors (Basel). 2019;19(17):E3791. doi:10.3390/s19173791
   Web of Science ®Google Scholar
• Faraone SV, Biederman J, Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med. 2006;36:159–165.
   PubMed Web of Science ®Google Scholar
• Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: A systematic review and metaregression analysis. American Journal of Psychiatry. 2007;164:942–948. doi:10.1176/ajp.2007.164.6.942
   PubMed Web of Science ®Google Scholar
• Simon V, Czobor P, Balint S, Meszaros A, Bitter I. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry. 2009;194:204–211. doi:10.1192/bjp.bp.107.048827
   PubMed Web of Science ®Google Scholar
• Cheung CHM, Rijsdijk F, McLoughlin G, et al. Cognitive and neurophysiological markers of ADHD persistence and remission. The British Journal of Psychiatry. J Ment Sci. 2016;208:548–555.
   Google Scholar
• Wood AC, Rijsdijk F, Johnson KA, et al. The relationship between ADHD and key cognitive phenotypes is not mediated by shared familial effects with IQ. Psychol Med. 2011;41:861–871. doi:10.1017/S003329171000108X
   PubMed Web of Science ®Google Scholar
• Cheung CH, Fazier-Wood AC, Asherson P, Rijsdijk F, Kuntsi J. Shared cognitive impairments and aetiology in ADHD symptoms and reading difficulties. PLoS One. 2014;9:e98590. doi:10.1371/journal.pone.0098590
   PubMed Web of Science ®Google Scholar
• Wood AC, Asherson P, Rijsdijk F, Kuntsi J. Is overactivity a core feature in ADHD? Familial and receiver operating characteristic curve analysis of mechanically assessed activity level. J Am Acad Child Adolesc Psychiatry. 2009;48:1023–1030. doi:10.1097/CHI.0b013e3181b54612
   PubMed Web of Science ®Google Scholar
• Kooij JJS, Francken MH. DIVA 2.0 Diagnostic Interview Voor ADHD in Adults Bij Volwassenen [DIVA 2.0 Diagnostic Interview for ADHD in Adults]. DIVA Foundation; 2010.
   Google Scholar
• Barkley RA, Murphy K. Attention Deficit Hyperactivity Disorder: A Clinical Workbook. 3rd ed. Guilford Press; 2006.
   Google Scholar
• Wechsler D. Wechsler Abbreviated Scale of Intelligence (WASI). Harcourt Assessment; 1999.
   Google Scholar
• Wechsler D. Wechsler Intelligence Scale for Children. 3rd ed. The Psychological Corporation; 1991.
   Google Scholar
• Wechsler D. Wechsler Adult Intelligence Scale. 3rd ed. The Psychological Corporation; 1997.
   Google Scholar
• Albrecht B, Brandeis D, Uebel H, et al. Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder. Psychol Med. 2013;43:1997–2011. doi:10.1017/S003329171200270X
   PubMed Web of Science ®Google Scholar
• Doehnert M, Brandeis D, Straub M, Steinhausen HC, Drechsler R. Slow cortical potential neurofeedback in attention deficit hyperactivity disorder: is there neurophysiological evidence for specific effects? J Neural Transm. 2008;115:1445–1456. doi:10.1007/s00702-008-0104-x
   PubMed Web of Science ®Google Scholar
• Kuntsi J, Wood AC, Rijsdijk F, et al. Separation of cognitive impairments in attention-deficit/hyperactivity disorder into 2 familial factors. Arch Gen Psychiatry. 2010;67:1159–1167. doi:10.1001/archgenpsychiatry.2010.139
   Web of Science ®Google Scholar
• Kuntsi J, Pinto R, Price TS, van der Meere JJ, Frazier-Wood AC, Asherson P. The separation of ADHD inattention and hyperactivity-impulsivity symptoms: pathways from genetic effects to cognitive impairments and symptoms. J Abnorm Child Psychol. 2014;42:127–136. doi:10.1007/s10802-013-9771-7
   PubMed Web of Science ®Google Scholar
• McLoughlin G, Asherson P, Albrecht B, et al. Cognitive-electrophysiological indices of attentional and inhibitory processing in adults with ADHD: familial effects. Behav Brain Funct. 2011;7:26. doi:10.1186/1744-9081-7-26
   Web of Science ®Google Scholar
• Andreou P, Neale BM, Chen W, et al. Reaction time performance in ADHD: improvement under fast-incentive condition and familial effects. Psychol Med. 2007;37:1703–1715. doi:10.1017/S0033291707000815
   PubMed Web of Science ®Google Scholar
• Uebel H, Albrecht B, Asherson P, et al. Performance variability, impulsivity errors and the impact of incentives as gender-independent endophenotypes for ADHD. J Child Psychol Psychiatry. 2010;51:210–218.
   Web of Science ®Google Scholar
• Valko L, Doehnert M, Muller UC, et al. Differences in neurophysiological markers of inhibitory and temporal processing deficits in children and adults with ADHD. J Psychophysiol. 2009;23:235–246. doi:10.1027/0269-8803.23.4.235
   Web of Science ®Google Scholar
• Biederman J, Petty CR, Ball SW, et al. Are cognitive deficits in attention deficit/hyperactivity disorder related to the course of the disorder? A prospective controlled follow-up study of grown up boys with persistent and remitting course. Psychiatry Res. 2009;170:177–182. doi:10.1016/j.psychres.2008.09.010
   PubMed Web of Science ®Google Scholar
• McAuley T, Crosbie J, Charach A, Schachar R. The persistence of cognitive deficits in remitted and unremitted ADHD: a case for the state-independence of response inhibition. J Child Psychol Psychiatry Allied Discipl. 2014;55:292–300. doi:10.1111/jcpp.12160
   PubMed Web of Science ®Google Scholar
• Pazvantoğlu O, Aker AA, Karabekiroğlu K, et al. Neuropsychological weaknesses in adult ADHD: cognitive functions as core deficit and roles of them in persistence to adulthood. JINS. 2012;18:819–826. doi:10.1017/S1355617712000574
   PubMed Web of Science ®Google Scholar
• van Lieshout M, Luman M, Buitelaar J, Rommelse NNJ, Oosterlaan J. Does neurocognitive functioning predict future or persistence of ADHD? A systematic review. Clin Psychol Rev. 2013;33:539–560. doi:10.1016/j.cpr.2013.02.003
   PubMed Web of Science ®Google Scholar
• Bédard A-CV, Trampush JW, Newcorn JH, Halperin JM. Perceptual and motor inhibition in adolescents/young adults with childhood-diagnosed ADHD. Neuropsychology. 2010;24:424–434. doi:10.1037/a0018752
   Web of Science ®Google Scholar
• Francx W, Oldehinkel M, Oosterlaan J, et al. The executive control network and symptomatic improvement in attention-deficit/hyperactivity disorder. Cortex. 2015;73:62–72. doi:10.1016/j.cortex.2015.08.012
   PubMed Web of Science ®Google Scholar
• Cheung CHM, McLoughlin G, Brandeis D, Banaschewski T, Asherson P, Kuntsi J. Neurophysiological correlates of attentional fluctuation in attention-deficit/hyperactivity disorder. Brain Topogr. 2017;30(3):320–332. doi:10.1007/s10548-017-0554-2
   Web of Science ®Google Scholar
• Cheung CH, Rijsdijk F, McLoughlin G, et al. Cognitive and neurophysiological markers of ADHD persistence and remission. Br J Psychiatry. 2016;208(6):548–555. doi:10.1192/bjp.bp.114.145185
   PubMed Web of Science ®Google Scholar
• Michelini G, Kitsune GL, Cheung CHM, et al. ADHD remission is linked to better neurophysiological error detection and attention-vigilance processes. Biol Psychiatry. 2016;15:923–932. doi:10.1016/j.biopsych.2016.06.021
   Web of Science ®Google Scholar
• James S-N, Cheung CHM, Rijsdijk F, Asherson P, Kuntsi J. Modifiable arousal in ADHD and its etiological association with fluctuating reaction times.. Biol Psychiatry Cogn Neurosci Neuroimag. 2016;1:539–547.
   Google Scholar
• Zahn TP, Abate F, Little BC, Wender PH. Minimal brain dysfunction, stimulant drugs, and autonomic nervous system activity. Arch Gen Psychiatry. 1975;32:381–387. doi:10.1001/archpsyc.1975.01760210115009
   PubMed Web of Science ®Google Scholar
• Conzelmann AB, Gerdes RF, Weyers MP, et al. hypoactivity in boys with attention-deficit/hyperactivity disorder and the influence of methylphenidate. World J Biol Psychiatry. 2014;15:56–65. doi:10.3109/15622975.2013.829584
   PubMed Web of Science ®Google Scholar
• Mayer K, Wyckoff SN. Strehl U. Underarousal in adult ADHD: how are peripheral and cortical arousal related? Clin EEG Neurosci. 2016; 47:171–179.
   PubMed Web of Science ®Google Scholar
• Du Rietz E, Cheung CH, McLoughlin G, et al. Self-report of ADHD shows limited agreement with objective markers of persistence and remittance. J Psychiatr Res. 2016;82:91–99. doi:10.1016/j.jpsychires.2016.07.020
   PubMed Web of Science ®Google Scholar
• Michelini G, Kitsune GL, Cheung CH, et al. Attention-deficit/hyperactivity disorder remission is linked to better neurophysiological error detection and attention-vigilance processes. Biol Psychiatry. 2016;80(12):923–932. doi:10.1016/j.biopsych.2016.06.021
   PubMed Web of Science ®Google Scholar
• Yeung N, Cohen JD. The impact of cognitive deficits on conflict monitoring: predictable dissociations between the error-related negativity and N2. Psychol Sci. 2006;17:164–171. doi:10.1111/j.1467-9280.2006.01680.x
   PubMed Web of Science ®Google Scholar
• Nieuwenhuis S, Yeung N, van den Wildenberg W, Ridderinkhof KR. Electrophysiological correlates of anterior cingulate function in a go/no-go task: effects of response conflict and trial type frequency. Cogn Affect Behav Neurosci. 2003;3:17–26. doi:10.3758/CABN.3.1.17
   PubMed Web of Science ®Google Scholar
• Falkenstein M, Hielscher H, Dziobek I, et al. Action monitoring, error detection, and the basal ganglia: an ERP study. Neuroreport. 2001;12:157–161. doi:10.1097/00001756-200101220-00039
   PubMed Web of Science ®Google Scholar
• Segalowitz SJ, Dywan J. Individual differences and developmental change in the ERN response: implications for models of ACC function. Psychol Res. 2009;73:857–870. doi:10.1007/s00426-008-0193-z
   PubMed Web of Science ®Google Scholar
• Endrass T, Reuter B, Kathmann N. ERP correlates of conscious error recognition: aware and unaware errors in an antisaccade task. Eur J Neurosci. 2007;26:1714–1720. doi:10.1111/j.1460-9568.2007.05785.x
   PubMed Web of Science ®Google Scholar
• Nieuwenhuis S, Ridderinkhof KR, Blom J, Band GP, Kok A. Error-related brain potentials are differentially related to awareness of response errors: evidence from an antisaccade task. Psychophysiology. 2001;38:752–760. doi:10.1111/1469-8986.3850752
   PubMed Web of Science ®Google Scholar
• Albrecht B, Brandeis D, Uebel H, Heinrich H, Mueller UC, Hasselhorn M. Action monitoring in boys with attention-deficit/hyperactivity disorder, their nonaffected siblings, and normal control subjects: evidence for an endophenotype. Biol Psychiatry. 2008;64:615–625. doi:10.1016/j.biopsych.2007.12.016
   PubMed Web of Science ®Google Scholar
• McLoughlin G, Albrecht B, Banaschewski T, et al. Performance monitoring is altered in adult ADHD: a familial event-related potential investigation. Neuropsychologia. 2009;47:3134–3142. doi:10.1016/j.neuropsychologia.2009.07.013
   Web of Science ®Google Scholar
• Wild-Wall N, Oades RD, Schmidt-Wessels M, Christiansen H, Falkenstein M. Neural activity associated with executive functions in adolescents with attention-deficit/hyperactivity disorder (ADHD). Int J Psychophysiol. 2009;74:19–27.
   PubMed Web of Science ®Google Scholar
• Geburek AJ, Rist F, Gediga G, Stroux D, Pedersen A. Electrophysiological indices of error monitoring in juvenile and adult attention deficit hyperactivity disorder (ADHD)—A meta-analytic appraisal. Int J Psychophysiol. 2013;87:349–362. doi:10.1016/j.ijpsycho.2012.08.006
   Web of Science ®Google Scholar
• Rodriguez PD, Baylis GC. Activation of brain attention systems in individuals with symptoms of ADHD. Behav Neurol. 2007;18(2):115–130. doi:10.1155/2007/865717
   Web of Science ®Google Scholar
• McLoughlin G, Palmer JA, Rijsdijk F, Makeig S. Genetic overlap between evoked frontocentral theta-band phase variability, reaction time variability, and attention-deficit/hyperactivity disorder symptoms in a twin study. Biol Psychiatry. 2014;75:238–247. doi:10.1016/j.biopsych.2013.07.020
   Web of Science ®Google Scholar
• Bender S, Weisbrod M, Bornfleth H, Resch F, Oelkers-Ax R. How do children prepare to react? Imaging maturation of motor preparation and stimulus anticipation by late contingent negative variation. Neuroimage. 2005;27:737–752. doi:10.1016/j.neuroimage.2005.05.020
   PubMed Web of Science ®Google Scholar
• Segalowitz SJ, Dywan J, Unsal A. Attentional factors in response time variability after traumatic brain injury: an ERP study. J Int Neuropsychol Soc. 1997;3:95–107. doi:10.1017/S1355617797000957
   PubMedGoogle Scholar
• Rommelse NN, Oosterlaan J, Buitelaar J, Faraone SV, Sergeant JA. Time reproduction in children with ADHD and their nonaffected siblings. J Am Acad Child Adolesc Psychiatry. 2007;46:582–590. doi:10.1097/CHI.0b013e3180335af7
   PubMed Web of Science ®Google Scholar
• Banaschewski T, Jennen-Steinmetz C, Brandeis D, et al. Neuropsychological correlates of emotional lability in children with ADHD. J Child Psychol Psychiatry. 2012;53:1139–1148. doi:10.1111/j.1469-7610.2012.02596.x
   PubMed Web of Science ®Google Scholar
• McLoughlin G, Albrecht B, Banaschewski T, et al. Electrophysiological evidence for abnormal preparatory states and inhibitory processing in adult ADHD. Behav Brain Funct. 2010;6:66. doi:10.1186/1744-9081-6-66
   Web of Science ®Google Scholar
• Overtoom CC, Bekker EM, van der Molen MW, et al. Methylphenidate restores link between stop-signal sensory impact and successful stopping in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2009;65:614–619. doi:10.1016/j.biopsych.2008.10.048
   PubMed Web of Science ®Google Scholar
• Pliszka SR. Pharmacologic treatment of attention-deficit/hyperactivity disorder: efficacy, safety and mechanisms of action. Neuropsychol Rev. 2007;17:61–72. doi:10.1007/s11065-006-9017-3
   PubMed Web of Science ®Google Scholar
• Kratz O, Studer P, Baack J, et al. Differential effects of methylphenidate and atomoxetine on attentional processes in children with ADHD: an event-related potential study using the Attention Network Test. Prog Neuropsychopharmacol Biol Psychiatry. 2012;37:81–89. doi:10.1016/j.pnpbp.2011.12.008
   Web of Science ®Google Scholar
• Linssen AM, Vuurman EF, Sambeth A, et al. Contingent negative variation as a dopaminergic biomarker: evidence from dose-related effects of methylphenidate. Psychopharmacology (Berl). 2011;218:533–542. doi:10.1007/s00213-011-2345-x
   PubMed Web of Science ®Google Scholar
• Wiersema R, van der Meere J, Antrop I, Roeyers H. State regulation in adult ADHD: an event-related potential study. J Clin Exp Neuropsychol. 2006;28:1113–1126. doi:10.1080/13803390500212896
   PubMed Web of Science ®Google Scholar
• Wiersema R, van der Meere J, Roeyers H, Van Coster R, Baeyens D. Event rate and event-related potentials in ADHD. J Child Psychol Psychiatry. 2006;47:560–567. doi:10.1111/j.1469-7610.2005.01592.x
   PubMed Web of Science ®Google Scholar
• Groom MJ, Scerif G, Liddle PF, et al. Effects of motivation and medication on electrophysiological markers of response inhibition in children with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;67:624–631. doi:10.1016/j.biopsych.2009.09.029
   PubMed Web of Science ®Google Scholar
• Heinrich H, Gevensleben H, Freisleder FJ, Moll GH, Rothenberger A. Training of slow cortical potentials in attention-deficit/hyperactivity disorder: evidence for positive behavioral and neurophysiological effects. Biol Psychiatry. 2004;55:772–775. doi:10.1016/j.biopsych.2003.11.013
   PubMed Web of Science ®Google Scholar
• Wangler S, Gevensleben H, Albrecht B, et al. Neurofeedback in children with ADHD: specific event-related potential findings of a randomized controlled trial. Clin Neurophysiol. 2011;122:942–950. doi:10.1016/j.clinph.2010.06.036
   PubMed Web of Science ®Google Scholar
• Doehnert M, Brandeis D, Schneider G, Drechsler R, Steinhausen HC. A neurophysiological marker of impaired preparation in an 11-year follow-up study of attention-deficit/hyperactivity disorder (ADHD). J Child Psychol Psychiatry. 2013;54:260–270. doi:10.1111/j.1469-7610.2012.02572.x
   PubMed Web of Science ®Google Scholar
• van den Berg B, Krebs RM, Lorist MM, Woldorff MG. Utilization of reward-prospect enhances preparatory attention and reduces stimulus conflict. Cogn Affect Behav Neurosci. 2014;14:561–577. doi:10.3758/s13415-014-0281-z
   PubMed Web of Science ®Google Scholar
• Ramchurn A, de Fockert JW, Mason L, Darling S, Bunce D. Intraindividual reaction time variability affects P300 amplitude rather than latency. Front Hum Neurosci. 2014;8:557. doi:10.3389/fnhum.2014.00557
   Web of Science ®Google Scholar
• Albaugh MD, Orr C, Chaarani B, et al. Inattention and reaction time variability are linked to ventromedial prefrontal volume in adolescents. Biol Psychiatry. 2017;82(9):660–668. doi:10.1016/j.biopsych.2017.01.003
   Web of Science ®Google Scholar
• Kofler MJ, Rapport MD, Sarver DE, et al. Reaction time variability in ADHD: a meta-analytic review of 319 studies. Clin Psychol Rev. 2013;33:795–811. doi:10.1016/j.cpr.2013.06.001
   PubMed Web of Science ®Google Scholar
• Stuss DT, Murphy KJ, Binns MA, Alexander MP. Staying on the job: the frontal lobes control individual performance variability. Brain. 2003;126:2363–2380. doi:10.1093/brain/awg237
   PubMed Web of Science ®Google Scholar
• Bellgrove MA, Hester R, Garavan H. The functional neuroanatomical correlates of response variability: evidence from a response inhibition task. Neuropsychologia. 2004;42:1910–1916. doi:10.1016/j.neuropsychologia.2004.05.007
   PubMed Web of Science ®Google Scholar
• Egeland J. Frequency of attention deficit in first-episode schizophrenia compared to ADHD. Appl Neuropsychol. 2010;17:125–134. doi:10.1080/09084280903297859
   PubMed Web of Science ®Google Scholar
• Thaler NS, Allen DN, Park BS, McMurray JC, Mayfield J. Attention processing abnormalities in children with traumatic brain injury and attention-deficit/hyperactivity disorder: differential impairment of component processes. J Clin Exp Neuropsychol. 2010;32:929–936. doi:10.1080/13803391003596488
   PubMed Web of Science ®Google Scholar
• Parasuraman R, Nestor P. Attention and driving. Assessment in Elderly Individuals with Dementia Clin Geriatr Med. 1993;9:377–387.
   PubMedGoogle Scholar
• Uebel H, Albrecht B, Asherson P, et al. Performance variability, impulsivity errors and the impact of incentives as gender-independent endophenotypes for ADHD. J Child Psychol Psychiatry. 2010;51:210–218.
   Web of Science ®Google Scholar
• Huang-Pollock CL, Mikami AY, Pfiffner L, McBurnett K. ADHD subtype differences in motivational responsivity but not inhibitory control: evidence from a reward-based variation of the stop signal paradigm. J Clin Child Adolesc Psychol. 2007;36:127–136. doi:10.1080/15374410701274124
   PubMed Web of Science ®Google Scholar
• Nigg JT. The ADHD response-inhibition deficit as measured by the stop task: replication with DSM-IV combined type, extension, and qualification. J Abnorm Child Psychol. 1999;27:393–402. doi:10.1023/A:1021980002473
   PubMed Web of Science ®Google Scholar
• Shanahan MA, Pennington BF, Willcutt EW. Do motivational incentives reduce the inhibition deficit in ADHD? Dev Neuropsychol. 2008;33:137–159. doi:10.1080/87565640701884238
   PubMed Web of Science ®Google Scholar
• Pasini A, Paloscia C, Alessandrelli R, Porfirio MC, Curatolo P. Attention and executive functions profile in drug naive ADHD subtypes. Brain Dev. 2007;29:400–408. doi:10.1016/j.braindev.2006.11.010
   PubMed Web of Science ®Google Scholar
• Solanto MV, Gilbert SN, Raj A, et al. Neurocognitive functioning in AD/HD, predominantly inattentive and combined subtypes. J Abnorm Child Psychol. 2007;35:729–744. doi:10.1007/s10802-007-9123-6
   PubMed Web of Science ®Google Scholar
• Walhovd KB, Fjell AM. White matter volume predicts reaction time instability. Neuropsychologia. 2007;45:2277–2284. doi:10.1016/j.neuropsychologia.2007.02.022
   PubMed Web of Science ®Google Scholar
• Bunce D, Anstey KJ, Christensen H, Dear K, Wen W, Sachdev P. White matter hyperintensities and within-person variability in community-dwelling adults aged 60–64 years. Neuropsychologia. 2007;45:2009–2015. doi:10.1016/j.neuropsychologia.2007.02.006
   PubMed Web of Science ®Google Scholar
• Castellanos FX, Sonuga-Barke EJ, Scheres A, Martino A, Hyde C, Walters JR. Varieties of attention-deficit/hyperactivity disorder-related intra-individual variability. Biol Psychiatry. 2005;57:1416–1423. doi:10.1016/j.biopsych.2004.12.005
   PubMed Web of Science ®Google Scholar
• Epstein JN, Brinkman WB, Froehlich T, et al. Effects of stimulant medication, incentives, and event rate on reaction time variability in children with ADHD. Neuropsychopharmacology. 2011;36:1060–1072. doi:10.1038/npp.2010.243
   PubMed Web of Science ®Google Scholar
• Spencer SV, Hawk LW, Richards JB, Shiels K, Pelham WE, Waxmonsky JG. Stimulant treatment reduces lapses in attention among children with ADHD: the effects of methylphenidate on intra-individual response time distributions. J Abnorm Child Psychol. 2009;37:805–816. doi:10.1007/s10802-009-9316-2
   Web of Science ®Google Scholar
• Boonstra AM, Kooij JJ, Oosterlaan J, Sergeant JA, Buitelaar JK. Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD? J Clin Exp Neuropsychol. 2005;27:278–298. doi:10.1080/13803390490515757
   PubMed Web of Science ®Google Scholar
• Rosa-Neto P, Lou HC, Cumming P, et al. Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder. Neuroimage. 2005;25:868–876. doi:10.1016/j.neuroimage.2004.11.031
   PubMed Web of Science ®Google Scholar
• Fitzpatrick PA, Klorman R, Brumaghim JT, Borgstedt AD. Effects of sustained-release and standard preparations of methylphenidate on attention deficit disorder. J Am Acad Child Adolesc Psychiatry. 1992;31:226–234. doi:10.1097/00004583-199203000-00008
   PubMed Web of Science ®Google Scholar
• Teicher MH, Lowen SB, Polcari A, Foley M, McGreenery CE. Novel strategy for the analysis of CPT data provides new insight into the effects of methylphenidate on attentional states in children with ADHD. J Child Adolesc Psychopharm. 2004;14:219–232. doi:10.1089/1044546041648995
   PubMed Web of Science ®Google Scholar
• Tannock R, Schachar R, Logan G. Methylphenidate and cognitive flexibility: dissociated dose effects in hyperactive children. J Abnorm Child Psychol. 1995;23:235–266. doi:10.1007/BF01447091
   PubMed Web of Science ®Google Scholar
• Epstein JN, Conners CK, Hervey AS, et al. Assessing medication effects in the MTA study using neuropsychological outcomes. J Child Psychol Psychiatry. 2006;47:446–456. doi:10.1111/j.1469-7610.2005.01469.x
   PubMed Web of Science ®Google Scholar
• Epstein JN, Tsal Y. Evidence for cognitive training as a treatment strategy for children with attention-deficit/hyperactivity disorder. J ADHD Relat Disord. 2010;1:49–64.
   Google Scholar
• Tamm L, McCandliss BD, Liang A, Wigal TL, Posner MI, Swanson JM. Can Attention Itself Be Trained? Attention Training for Children at Risk for ADHD. Attention Deficit/Hyperactivity Disorder: Concepts, Controversies, New Directions. New York: Informa Healthcare; 2007:399–411.
   Google Scholar
• Lutz A, Slagter HA, Rawlings NB, Francis AD, Greischar LL, Davidson RJ. Mental training enhances attentional stability: neural and behavioral evidence. Neurosci. 2009;29:13418–13427. doi:10.1523/JNEUROSCI.1614-09.2009
   Web of Science ®Google Scholar
• Scarpelli S, Gorgoni M, D’Atri A, Reda F, De Gennaro L. Advances in understanding the relationship between sleep and Attention Deficit-Hyperactivity Disorder (ADHD). J Clin Med. 2019;8(10):E1737. doi:10.3390/jcm8101737
   Web of Science ®Google Scholar
• Bussalb A, Congedo M, Barthélemy Q, et al. Clinical and experimental factors influencing the efficacy of neurofeedback in ADHD: a meta-analysis. Front Psychiatry. 2019;10:35. doi:10.3389/fpsyt.2019.00035
   Web of Science ®Google Scholar
• Van Doren J, Arns M, Heinrich H, Vollebregt MA, Strehl U, Loo K. Sustained effects of neurofeedback in ADHD: a systematic review and meta-analysis. Eur Child Adolesc Psychiatry. 2019;28(3):293–305. doi:10.1007/s00787-018-1121-4
   Web of Science ®Google Scholar
• Lau-Zhu A, Tye C, Rijsdijk F, McLoughlin G. No evidence of associations between ADHD and event-related brain potentials from a continuous performance task in a population-based sample of adolescent twins. PLoS One. 2019;14(10):e0223460. doi:10.1371/journal.pone.0223460
   Web of Science ®Google Scholar
• Ogrim G, Kropotov JD. Predicting clinical gains and side effects of stimulant medication in pediatric attention-deficit/hyperactivity disorder by combining measures from qEEG and ERPs in a Cued GO/NOGO task. Clin EEG Neurosci. 2019;50(1):34–43. doi:10.1177/1550059418782328
   Web of Science ®Google Scholar
• Song DH, Shin DW, Jon DI, Ha EH. Effects of methylphenidate on quantitative EEG of boys with attention-deficit hyperactivity disorder in continuous performance test. Yonsei Med J. 2005;46(1):34–41. doi:10.3349/ymj.2005.46.1.34
   Web of Science ®Google Scholar
• Rapport MD, Kelly KL. Psychostimulant effects on learning and cognitive function: findings and implication for children with attention deficit hyperactivity disorder. Clin Psychol Rev. 1991;11:61–92. doi:10.1016/0272-7358(91)90138-K
   Web of Science ®Google Scholar
• Coon HW, Klorman R, Borgstedt AD. Effects of methylphenidate on adolescents with a childhood history of attention deficit disorder: II. Information processing. J Am Acad Child Adolesc Psychiatry. 1987;26:368–374. doi:10.1097/00004583-198705000-00016
   Web of Science ®Google Scholar
• Garfinkel BD, Brown WA, Klee SH, Braden W, Beauchesne H, Shapiro SK. Neuroendocrine and cognitive responses to amphetamine in adolescents with a history of attention deficit disorder. J Am Acad Child Adolesc Psychiatry. 1986;25:503–508. doi:10.1016/S0002-7138(10)60009-X
   Web of Science ®Google Scholar
• Greenberg LM, Waldman ID. Developmental normative data on the Test of Variables of Attention (TOVA). J Child Psychol Psychiatry. 1993;34:1019–1030.
   PubMed Web of Science ®Google Scholar
• Moreno-García I, Delgado-Pardo G, Camacho-vara de Rey C, Meneres-Sancho S, Servera-Barceló M. Neurofeedback, pharmacological treatment and behavioral therapy in hyperactivity: multilevel analysis of treatment effects on electroencephalography. Int J Clin Health Psychol. 2015;15(3):217–225. doi:10.1016/j.ijchp.2015.04.003
   Web of Science ®Google Scholar
• Barkley RB. Defiant Children: A Clinician Manual for Parent Training. New York: Guilford Press; 1987.
   Google Scholar
• Woltering S, Jung J, Liu Z, Tannock R. Resting state EEG oscillatory power differences in ADHD college students and their peers. Behav Brain Funct. 2012;8:60. doi:10.1186/1744-9081-8-60
   PubMed Web of Science ®Google Scholar
• Jasper H, Solomon P, Bradley C. Electroencephalographic analyses of behavior problem children. Am J Psychiatry. 1938;95:641. doi:10.1176/ajp.95.3.641
   Google Scholar
• Satterfield JH, Lesser LI, Saul RE, Cantwell DP. EEG aspects in the diagnosis and treatment of minimal brain dysfunction. Ann NY Acad Sci. 1973;205:274–282. doi:10.1111/j.1749-6632.1973.tb43185.x
   PubMed Web of Science ®Google Scholar
• Monastra VJ, Lubar JF, Linden M. The development of a quantitative electroencephalographic scanning process for attention deficit-hyperactivity disorder: reliability and validity studies. Neuropsychology. 2001;15:136–144. doi:10.1037/0894-4105.15.1.136
   PubMed Web of Science ®Google Scholar
• Williams LM, Hermens DF, Thein T, et al. Using brain-based cognitive measures to support clinical decisions in ADHD. Pediatr Neurol. 2010;42:118–126. doi:10.1016/j.pediatrneurol.2009.08.010
   PubMed Web of Science ®Google Scholar
• Van Dongen-boomsma M, Lansbergen MM, Bekker EM, et al. Relation between resting EEG to cognitive performance and clinical symptoms in adults with attention-deficit/hyperactivity disorder. Neurosci Lett. 2010;469:102–106. doi:10.1016/j.neulet.2009.11.053
   PubMed Web of Science ®Google Scholar
• Ogrim G, Kropotov J, Hestad K. The quantitative EEG theta/beta ration in attention deficit/hyperactivity disorder and normal controls: sensitivity, specificity, and behavioral correlates. Psychiatry Res. 2012;198:482–488. doi:10.1016/j.psychres.2011.12.041
   PubMed Web of Science ®Google Scholar
• Buyck I, Wieserma JR. Resting electroencephalogram in attention deficit hyperactivity disorder: developmental course and diagnostic value. Psychiatry Res. 2014;216:391–397. doi:10.1016/j.psychres.2013.12.055
   PubMed Web of Science ®Google Scholar
• Arns M, Loo SK, Sterman MB, et al. Editorial Perspective: how should child psychologists and psychiatrists interpret FDA device approval? Caveat emptor. J Child Psychol Psychiatr. 2016;57:656–658. doi:10.1111/jcpp.12524
   Web of Science ®Google Scholar
• The Department of Health & Human Services, Food and Drug Administration. Letter to NEBA Health, LLC. Re: K112711 Neuropsychiatric EEG-based assessment aid for ADHD (NEBA) System. 2013. Available from: https://www.accessdata.fda.gov/cdrh_docs/pdf11/K112711.pdf.
   Google Scholar
• Verbaten MN, Overtoom CCE, Koelega HS, et al. Methylphenidate influences on both early and late ERP waves of ADHD children in a continuous performance test. J Abnorm Child Psychol. 1994;22:561–578. doi:10.1007/BF02168938
   PubMed Web of Science ®Google Scholar
• Winsberg BG, Javitt DC, Shanahan Silipo G. Electrophysiological indices of information processing in methylphenidate responders. Biol Psychiatry. 1997;42:434–445. doi:10.1016/S0006-3223(96)00429-5
   PubMed Web of Science ®Google Scholar
• US Department of Health and Human Services. FDA approval letter for NEBA System. Available from. fda.gov/cdrh_docs/pdf11/K112711.pdf. Accessed April 2, 2020.
   Google Scholar
• FDA. 2013. De Novo Classification Request for Neuropsychiatric EEG-Based Assessment Aid for ADHD (NEBA) System K112711, July 15; 2013.
   Google Scholar
• Gloss D, Varma JK, Pringsheim T, Nuwer MR. Practice advisory: the utility of EEG theta/beta power ratio in ADHD diagnosis: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology. 2016;87(22):2375–2379.
   Web of Science ®Google Scholar
• Lenartowicz A, Loo SK. Use of EEG to diagnose ADHD. Curr Psychiatry Rep. 2014;16(11):498. doi:10.1007/s11920-014-0498-0
   PubMed Web of Science ®Google Scholar
• Loo SK, Cho A, Hale TS, McGough J, McCracken J, Smalley SL. Characterization of the theta to beta ratio in ADHD: identifying potential sources of heterogeneity. J Atten Disord. 2013;17(5):384–392. doi:10.1177/1087054712468050 Epub 2012 Dec 20.
   PubMed Web of Science ®Google Scholar
• Liechti MD, Valko L, Müller UC, et al. Diagnostic value of resting electroencephalogram in attention-deficit/hyperactivity disorder across the lifespan. Brain Topogr. 2013;26(1):135–151. doi:10.1007/s10548-012-0258-6 Epub 2012 Oct 9.
   PubMed Web of Science ®Google Scholar
• Petersen IT, Hoyniak CP, Bates JE, Staples AD, Molfese DL. A longitudinal, within-person investigation of the association between the P3 ERP component and externalizing behavior problems in young children. J Child Psychol Psychiatry. 2018;59(10):1044–1051. doi:10.1111/jcpp.12975
   PubMed Web of Science ®Google Scholar
• Szuromi B, Czobor P, Komlosi S, Bitter I. P300 deficits in adults with attention deficit hyperactivity disorder: a meta-analysis. Psychol Med. 2011;41:1529–1538. doi:10.1017/S0033291710001996
   PubMed Web of Science ®Google Scholar
• Seidman LJ, Valera EM, Makris N. Structural brain imaging of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:1263–1272. doi:10.1016/j.biopsych.2004.11.019
   PubMed Web of Science ®Google Scholar
• Corbetta M, Patel G, Shulman GL. The reorienting system of the human brain: from environment to theory of mind. Neuron. 2008. doi:10.1016/j.neuron.2008.04.017
   Web of Science ®Google Scholar
• Casey BJ, Jones RM, Hare TA. The adolescent brain. Ann N Y Acad Sci. 2008;1124:111–126. doi:10.1196/annals.1440.010
   PubMed Web of Science ®Google Scholar
• Polich J. Updating P300: an integrative theory of P3a and P3b. Clin Neurophysiol. 2007;118:2128–2148. doi:10.1016/j.clinph.2007.04.019 PubMed: 17573239.
   PubMed Web of Science ®Google Scholar
• Hoyniak CP, Petersen IT, McQuillan ME, Staples AD, Bates JE. Less efficient neural processing related to irregular sleep and less sustained attention in toddlers. Dev Neuropsychol. 2015;40(3):155–166. doi:10.1080/87565641.2015.1016162 PubMed: 26151613.
   PubMed Web of Science ®Google Scholar
• Johnstone SJ, Barry RJ, Clarke AR. Ten years on: a follow-up review of ERP research in attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2013;124:644657. doi:10.1016/j.clinph.2012.09.006
   Web of Science ®Google Scholar
• van Dinteren R, Arns M, Jongsma MLA, Kessels RPC. P300 development across the lifespan: a systematic review and meta-analysis. PLoS One. 2014;9:e87347. doi:10.1371/journal.pone.0087347 PubMed: 24551055.
   PubMed Web of Science ®Google Scholar
• Friedman D, Cycowicz YM, Gaeta H. The novelty P3: an event-related brain potential (ERP) sign of the brain’s evaluation of novelty. Neurosci Biobehav Rev. 2001;25:355–373. doi:10.1016/S0149-7634(01)00019-7 PubMed: 11445140.
   PubMed Web of Science ®Google Scholar
• Hermens DF, Ward PB, MAR H, Kaur M, Naismith SL, Hickie IB. Impaired MMN/P3a complex in first-episode psychosis: cognitive and psychosocial associations. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:822–829. doi:10.1016/j.pnpbp.2010.03.019 PubMed: 20302901.
   Web of Science ®Google Scholar
• Dodge KA, Crick NR. Social information-processing bases of aggressive behavior in children. Pers Soc Psychol Bull. 1990;16:8–22. doi:10.1177/0146167290161002
   Web of Science ®Google Scholar
• Iacono WG, Malone SM. Developmental endophenotypes: indexing genetic risk for substance abuse with the P300 brain event-related potential. Child Dev Perspect. 2011;5:239–247. doi:10.1111/j.1750-8606.2011.00205.x
   PubMed Web of Science ®Google Scholar
• Gao Y, Raine A. P3 event-related potential impairments in antisocial and psychopathic individuals: A meta-analysis. Biol Psychol. 2009;82:199–210. doi:10.1016/j.biopsycho.2009.06.006
   PubMed Web of Science ®Google Scholar
• Pasion R, Fernandes C, Pereira MR, Barbosa F. Antisocial behaviour and psychopathy: uncovering the externalizing link in the P3 modulation. Neurosci Biobehav Rev. 2018;91:170–186. doi:10.1016/j.neubiorev.2017.03.012
   Web of Science ®Google Scholar
• van Beijsterveldt CEM, van Baal GCM. Twin and family studies of the human electroencephalogram: a review and a meta-analysis. Biol Psychol. 2002;61:111–138. doi:10.1016/S0301-0511(02)00055-8
   PubMed Web of Science ®Google Scholar
• Hicks BM, Bernat E, Malone SM, et al. Genes mediate the association between P3 amplitude and externalizing disorders. Psychophysiology. 2007;44:98–105. doi:10.1111/j.1469-8986.2006.00471.x
   PubMed Web of Science ®Google Scholar
• Pogarell O, Padberg F, Karch S, et al. Dopaminergic mechanisms of target detection — P300 event related potential and striatal dopamine. Psychiatry Res. 2011;194:212–218. doi:10.1016/j.pscychresns.2011.02.002
   PubMed Web of Science ®Google Scholar
• Soltani M, Knight RT. Neural origins of the P300. Crit Rev Neurobiol. 2000;14:199–224. doi:10.1615/CritRevNeurobiol.v14.i3-4.20
   PubMedGoogle Scholar
• Gatzke-Kopp LM, Beauchaine TP, Shannon KE, et al. Neurological correlates of reward responding in adolescents with and without externalizing behavior disorders. J Abnorm Psychol. 2009;118:203–213. doi:10.1037/a0014378 PubMed: 19222326.
   PubMed Web of Science ®Google Scholar
• Aasen IE, Øgrim G, Kropotov J, Brunner JF. Methylphenidate selectively modulates one sub-component of the no-go P3 in pediatric ADHD medication responders. Biol Psychol. 2018;134:30–38. doi:10.1016/j.biopsycho.2018.02.011 Epub 2018 Feb 21.
   Web of Science ®Google Scholar
• Heinrich H, Grunitz J, Stonawski V, et al. Attention, cognitive control and motivation in ADHD: linking event-related brain potentials and DNA methylation patterns in boys at early school age. Sci Rep. 2017;7(1):3823. doi:10.1038/s41598-017-03326-3
   PubMed Web of Science ®Google Scholar
• Baijot S, Cevallos C, Zarka D, et al. EEG dynamics of a go/nogo task in children with ADHD. Brain Sci. 2017;7(12):E167. doi:10.3390/brainsci7120167
   Web of Science ®Google Scholar
• Petersen IT, Hoyniak CP, Bates JE, Staples AD, Molfese DL. A longitudinal, within-person investigation of the association between the P3 ERP component and externalizing behavior problems in young children. J Child Psychol Psychiatry. 2018;59(10):1044–1051. doi:10.1111/jcpp.12975
   PubMed Web of Science ®Google Scholar
• Chronaki G, Soltesz F, Benikos N, Sonuga-Barke EJS. An electrophysiological investigation of reinforcement effects in attention deficit/hyperactivity disorder: dissociating cue sensitivity from down-stream effects on target engagement and performance. Dev Cogn Neurosci. 2017;28:12–20. doi:10.1016/j.dcn.2017.10.003
   Web of Science ®Google Scholar
• Arns M, Conners CK, Kraemer HC. A decade of EEG theta/Beta ratio research in ADHD: a meta-analysis. J Atten Disord. 2013;17:374–383. doi:10.1177/1087054712460087
   PubMed Web of Science ®Google Scholar
• Van der Heijden KB, Smits MG, Van Someren EJW, Gunning WB. Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: a circadian rhythm sleep disorder. Chronobiol Int. 2005;22:559–570. doi:10.1081/cbi-200062410
   PubMed Web of Science ®Google Scholar
• Van Dongen HPA, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep. 2003;26:117–126. doi:10.1093/sleep/26.2.117
   PubMed Web of Science ®Google Scholar
• Cortese S, Brown TE, Corkum P, et al. Assessment and management of sleep problems in youths with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2013;52:784–796. doi:10.1016/j.jaac.2013.06.001
   PubMed Web of Science ®Google Scholar
• Rybak YE, McNeely HE, Mackenzie BE, Jain UR, Levitan RD. Seasonality and circadian preference in adult attention-deficit/hyperactivity disorder: clinical and neuropsychological correlates. Compr Psychiatry. 2007;48:562–571. doi:10.1016/j.comppsych.2007.05.008
   PubMed Web of Science ®Google Scholar
• Hoedlmoser K, Pecherstorfer T, Gruber G, et al. Instrumental conditioning of human sensorimotor rhythm (12–15 hz) and its impact on sleep as well as declarative learning. Sleep. 2008;31:1401–1408.
   PubMed Web of Science ®Google Scholar
• Cortoos A, De Valck E, Arns M, Breteler MHM, Cluydts R. An exploratory study on the effects of tele-neurofeedback and tele-biofeedback on objective and subjective sleep in patients with primary insomnia. Appl Psychophysiol Biofeedback. 2010;35:125–134. doi:10.1007/s10484-009-9116-z
   PubMed Web of Science ®Google Scholar
• Dijk D-J, Roth C, Landolt H-P, et al. Melatonin effect on daytime sleep in men: suppression of EEG low frequency activity and enhancement of spindle frequency activity. Neuroscience Letters. 1995;201(1):13–16. doi:10.1016/0304-3940(95)12118-n
   Web of Science ®Google Scholar
• De Gennaro L, Ferrara M. Sleep spindles: an overview. Sleep Med Rev. 2003;7:423–440. doi:10.1053/smrv.2002.0252
   PubMed Web of Science ®Google Scholar
• Newson JJ, Thiagarajan TC. EEG frequency bands in psychiatric disorders: a review of resting state studies. Front Hum Neurosci. 2019;12:521. doi:10.3389/fnhum.2018.00521
   PubMed Web of Science ®Google Scholar
• Flint J, Munafò MR. The endophenotype concept in psychiatric genetics. Psychol Med. 2007;37(2):163–180. doi:10.1017/S0033291706008750
   PubMed Web of Science ®Google Scholar
• Boomsma DI, Saviouk V, Hottenga JJ, et al. Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults. PLoS One. 2010;5(5):e10621. doi:10.1371/journal.pone.0010621
   Web of Science ®Google Scholar