Matrix metalloproteinases in impaired wound healing

References

• Kanitakis J. Anatomy, histology and immunohistochemistry of normal human skin. Eur J Dermatol. 2002;12(4):390–399.
   PubMed Web of Science ®Google Scholar
• Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol. 2008;17(12):1063–1072.
   PubMed Web of Science ®Google Scholar
• Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008;453(7193):314–321.
   PubMed Web of Science ®Google Scholar
• Martin P. Wound healing – aiming for perfect skin regeneration. Science. 1997;276(5309):75–81.
   PubMed Web of Science ®Google Scholar
• Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341(10):738–746.
   PubMed Web of Science ®Google Scholar
• Schäfer M, Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol. 2008;9(8):628–638.
   PubMed Web of Science ®Google Scholar
• Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci. 2008;13:3532–3548.
   PubMed Web of Science ®Google Scholar
• Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007;127(3):514–525.
   PubMed Web of Science ®Google Scholar
• Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83(3):835–870.
   PubMed Web of Science ®Google Scholar
• Hinz B. Formation and function of the myofibroblast during tissue repair. J Invest Dermatol. 2007;127(3):526–537.
   PubMed Web of Science ®Google Scholar
• Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol. 2007;8(3):221–233.
   PubMed Web of Science ®Google Scholar
• Parks WC. Matrix metalloproteinases in repair. Wound Repair Regen. 1999;7(6):423–432.
   PubMed Web of Science ®Google Scholar
• Edwards DR, Handsley MM, Pennington CJ. The ADAM metalloproteinases. Mol Aspects Med. 2008;29(5):258–289.
   PubMed Web of Science ®Google Scholar
• Gross J, Lapiere CM. Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci U S A. 1962;48:1014–1022.
   PubMed Web of Science ®Google Scholar
• Rodríguez D, Morrison CJ, Overall CM. Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics. Biochim Biophys Acta. 2010;1803(1):39–54.
   PubMed Web of Science ®Google Scholar
• Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001;17:463–516.
   PubMed Web of Science ®Google Scholar
• Overall CM, López-Otín C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2002;2(9):657–672.
   PubMed Web of Science ®Google Scholar
• Martins VL, Caley M, O’Toole EA. Matrix metalloproteinases and epidermal wound repair. Cell Tissue Res. 2013;351(2):255–268.
   PubMed Web of Science ®Google Scholar
• Malemud CJ. Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci. 2006;11:1696–1701.
   PubMed Web of Science ®Google Scholar
• Khokha R, Murthy A, Weiss A. Metalloproteinases and their natural inhibitors in inflammation and immunity. Nat Rev Immunol. 2013;13(9):649–665.
   PubMed Web of Science ®Google Scholar
• McCarty SM, Cochrane CA, Clegg PD, Percival SL. The role of endogenous and exogenous enzymes in chronic wounds: a focus on the implications of aberrant levels of both host and bacterial proteases in wound healing. Wound Repair Regen. 2012;20(2):125–136.
   PubMed Web of Science ®Google Scholar
• Madlener M, Parks WC, Werner S. Matrix metalloproteinases (MMPs) and their physiological inhibitors (TIMPs) are differentially expressed during excisional skin wound repair. Exp Cell Res. 1998;242(1):201–210.
   PubMed Web of Science ®Google Scholar
• Gill SE, Parks WC. Metalloproteinases and their inhibitors: regulators of wound healing. Int J Biochem Cell Biol. 2008;40(6–7):1334–1347.
   PubMed Web of Science ®Google Scholar
• Stadelmann WK, Digenis AG, Tobin GR. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg. 1998;176(2A Suppl):26S–38S.
   PubMed Web of Science ®Google Scholar
• O’Toole EA. Extracellular matrix and keratinocyte migration. Clin Exp Dermatol. 2001;26(6):525–530.
   Web of Science ®Google Scholar
• Chen P, Parks WC. Role of matrix metalloproteinases in epithelial migration. J Cell Biochem. 2009;108(6):1233–1243.
   Web of Science ®Google Scholar
• Parks WC, Wilson CL, López-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol. 2004;4(8):617–629.
   PubMed Web of Science ®Google Scholar
• McCarty SM, Percival SL. Proteases and delayed wound healing. Adv Wound Care (New Rochelle). 2013;2(8):438–447.
   PubMedGoogle Scholar
• Ren Y, Gu G, Yao M, Driver VR. Role of matrix metalloproteinases in chronic wound healing: diagnostic and therapeutic implications. Chin. Med J (Engl). 2014;127(8):1572–1581.
   Web of Science ®Google Scholar
• Sen CK, Gordillo GM, Roy S, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 2009;17(6):763–771.
   PubMed Web of Science ®Google Scholar
• Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clin Dermatol. 2007;25(1):9–18.
   PubMed Web of Science ®Google Scholar
• Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF. Impaired wound healing. Clin Dermatol. 2007;25(1):19–25.
   PubMed Web of Science ®Google Scholar
• Armstrong DG, Jude EB. The role of matrix metalloproteinases in wound healing. J Am Podiatr Med Assoc. 2002;92(1):12–18.
   PubMed Web of Science ®Google Scholar
• Falanga V. The chronic wound: impaired healing and solutions in the context of wound bed preparation. Blood Cells Mol Dis. 2004;32(1):88–94.
   Web of Science ®Google Scholar
• Menke MN, Menke NB, Boardman CH, Diegelmann RF. Biologic therapeutics and molecular profiling to optimize wound healing. Gynecol Oncol. 2008;111(2 Suppl):S87–S91.
   PubMed Web of Science ®Google Scholar
• Widgerow AD. Chronic wound fluid – thinking outside the box. Wound Repair Regen. 2011;19(3):287–291.
   PubMed Web of Science ®Google Scholar
• Gibson DJ, Schultz GS. Molecular wound assessments: matrix metalloproteinases. Adv Wound Care (New Rochelle). 2013;2(1):18–23.
   Google Scholar
• Fleck CA, Simman R. Modern collagen wound dressings: function and purpose. J Am Col Certif Wound Spec. 2010;2(3):50–54.
   PubMedGoogle Scholar
• Lenselink EA. Role of fibronectin in normal wound healing. Int Wound J. 2013;9999(9999).
   Google Scholar
• Nelson ML, Levy SB. The history of the tetracyclines. Ann N Y Acad Sci. 2011;1241:17–32.
   PubMed Web of Science ®Google Scholar
• Garrido-Mesa N, Zarzuelo A, Gálvez J. What is behind the non-antibiotic properties of minocycline? Pharmacol Res. 2013;67(1):18–30.
   PubMed Web of Science ®Google Scholar
• Acharya MR, Venitz J, Figg WD, Sparreboom A. Chemically modified tetracyclines as inhibitors of matrix metalloproteinases. Drug Resist Updat. 2004;7(3):195–208.
   PubMed Web of Science ®Google Scholar
• Monk E, Shalita A, Siegel DM. Clinical applications of non-antimicrobial tetracyclines in dermatology. Pharmacol Res. 2011;63(2):130–145.
   Web of Science ®Google Scholar
• Tilakaratne A, Soory M. Anti-inflammatory actions of adjunctive tetracyclines and other agents in periodontitis and associated comorbidities. Open Dent J. 2014;8:109–124.
   PubMedGoogle Scholar
• Serra R, Gallelli L, Buffone G, et al. Doxycycline speeds up healing of chronic venous ulcers. Int. Wound J. Epub April 5, 2013.
   Google Scholar
• Redin GS. Antibacterial activity in mice of minocycline, a new tetracycline. Antimicrob Agents Chemother (Bethesda). 1966;6:371–376.
   Google Scholar
• Serra R, Grande R, Buffone G, Gallelli L, De Franciscis S. The effects of minocycline on extracellular matrix in patients with chronic venous leg ulcers. Acta Phlebol. 2013;14:99–107.
   Google Scholar
• Suomalainen K, Halinen S, Ingman T, et al. Tetracycline inhibition identifies the cellular sources of collagenase in gingival crevicular fluid in different forms of periodontal diseases. Drugs Exp Clin Res. 1992;18(3):99–104.
   Google Scholar
• Cazalis J, Tanabe S, Gagnon G, Sorsa T, Grenier D. Tetracyclines and chemically modified tetracycline-3 (CMT-3) modulate cytokine secretion by lipopolysaccharide-stimulated whole blood. Inflammation. 2009;32(2):130–137.
   Web of Science ®Google Scholar
• Ramamurthy NS, Kucine AJ, McClain SA, McNamara TF, Golub LM. Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin. Adv Dent Res. 1998;12(2):144–148.
   Google Scholar
• Yager DR, Zhang LY, Liang HX, Diegelmann RF, Cohen IK. Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids. J Invest Dermatol. 1996;107(5):743–748.
   PubMed Web of Science ®Google Scholar
• Leaper DJ. Silver dressings: their role in wound management. Int Wound J. 2006;3(4):282–294.
   PubMedGoogle Scholar
• Politano AD, Campbell KT, Rosenberger LH, Sawyer RG. Use of silver in the prevention and treatment of infections: silver review. Surg Infect (Larchmt). 2013;14(1):8–20.
   PubMed Web of Science ®Google Scholar
• Hiro ME, Pierpont YN, Ko F, Wright TE, Robson MC, Payne WG. Comparative evaluation of silver-containing antimicrobial dressings on in vitro and in vivo processes of wound healing. Eplasty. 2012;12:e48.
   PubMedGoogle Scholar
• Widgerow AD. Nanocrystalline silver, gelatinases and the clinical implications. Burns. 2010;36(7):965–974.
   Web of Science ®Google Scholar
• Wright JB, Lam K, Buret AG, Olson ME, Burrell RE. Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound Repair Regen. 2002;10(3):141–151.
   PubMed Web of Science ®Google Scholar
• Metzmacher I, Ruth P, Abel M, Friess W. In vitro binding of matrix metalloproteinase-2 (MMP-2), MMP-9, and bacterial collagenase on collagenous wound dressings. Wound Repair Regen. 2007;15(4):549–555.
   Web of Science ®Google Scholar
• Vasconcelos A, Cavaco-Paulo A. Wound dressings for a proteolytic-rich environment. Appl Microbiol Biotechnol. 2011;90(2):445–460.
   Web of Science ®Google Scholar
• Weber L, Kirsch E, Müller P, Krieg T. Collagen type distribution and macromolecular organization of connective tissue in different layers of human skin. J Invest Dermatol. 1984;82(2):156–160.
   PubMed Web of Science ®Google Scholar
• Ruszczak Z. Effect of collagen matrices on dermal wound healing. Adv Drug Deliv Rev. 2003;55(12):1595–1611.
   PubMed Web of Science ®Google Scholar
• Elgharably H, Roy S, Khanna S, et al. A modified collagen gel enhances healing outcome in a preclinical swine model of excisional wounds. Wound Repair Regen. 2013;21(3):473–481.
   PubMed Web of Science ®Google Scholar
• Elgharably H, Ganesh K, Dickerson J, et al. A modified collagen gel dressing promotes angiogenesis in a pre-clinical swine model of chronic ischemic wounds. Wound Repair Regen. Epub September 15, 2014.
   Google Scholar
• Liu Y, Griffith M, Watsky MA, et al. Properties of porcine and recombinant human collagen matrices for optically clear tissue engineering applications. Biomacromolecules. 2006;7(6):1819–1828.
   Web of Science ®Google Scholar
• Adhirajan N, Shanmugasundaram N, Shanmuganathan S, Babu M. Collagen-based wound dressing for doxycycline delivery: in-vivo evaluation in an infected excisional wound model in rats. J Pharm Pharmacol. 2009;61(12):1617–1623.
   PubMed Web of Science ®Google Scholar
• Gottrup F, Cullen BM, Karlsmark T, Bischoff-Mikkelsen M, Nisbet L, Gibson MC. Randomized controlled trial on collagen/oxidized regenerated cellulose/silver treatment. Wound Repair Regen. 2013;21(2):216–225.
   Web of Science ®Google Scholar
• Dalla Paola L. Diabetic foot wounds: the value of negative pressure wound therapy with instillation. Int Wound J. 2013;10(Suppl 1):25–31.
   Google Scholar
• Orgill DP, Bayer LR. Negative pressure wound therapy: past, present and future. Int Wound J. 2013;10(Suppl 1):15–19.
   PubMed Web of Science ®Google Scholar
• Huang C, Leavitt T, Bayer LR, Orgill DP. Effect of negative pressure wound therapy on wound healing. Curr Probl Surg. 2014;51(7):301–331.
   PubMed Web of Science ®Google Scholar
• Mouës CM, van Toorenenbergen AW, Heule F, Hop WC, Hovius SE. The role of topical negative pressure in wound repair: expression of biochemical markers in wound fluid during wound healing. Wound Repair Regen. 2008;16(4):488–494.
   PubMed Web of Science ®Google Scholar
• Wiegand C, Hipler UC. A superabsorbent polymer-containing wound dressing efficiently sequesters MMPs and inhibits collagenase activity in vitro. J Mater Sci Mater Med. 2013;24(10):2473–2478.
   Web of Science ®Google Scholar
• Eming S, Smola H, Hartmann B, et al. The inhibition of matrix metalloproteinase activity in chronic wounds by a polyacrylate superabsorber. Biomaterials. 2008;29(19):2932–2940.
   Web of Science ®Google Scholar
• Humbert P, Faivre B, Véran Y, et al. Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers – a randomized controlled trial. J Eur Acad Dermatol Venereol. 2014;28(12):1742–1750.
   Web of Science ®Google Scholar
• Golub LM. Introduction and background. Pharmacol Res. 2011;63(2):99–101.
   Google Scholar
• Erfurt-Berge C, Renner R. Recent developments in topical wound therapy: impact of antimicrobiological changes and rebalancing the wound milieu. Biomed Res Int. 2014;2014:819525.
   Web of Science ®Google Scholar