Neural correlates of fear: insights from neuroimaging

References

• Damasio A, Carvalho GB. The nature of feelings: evolutionary and neurobiological origins. Nat Rev Neurosci. 2013;14:143–152.
   PubMed Web of Science ®Google Scholar
• Darwin C. The Expression of the Emotions in Man and Animals. London: John Murray; 1872.
   Google Scholar
• Ekman P. Darwin and Facial Expression: A Century of Research in Review. New York: Academic; 1973.
   Google Scholar
• Panksepp J. The basic emotional circuits of mammalian brains: do animals have affective lives? Neurosci Biobehav R. 2011;35:1791–1804.
   PubMed Web of Science ®Google Scholar
• Adolphs R, Gosselin F, Buchanan TW, Tranel D, Schyns P, Damasio AR. A mechanism for impaired fear recognition after amygdala damage. Nature. 2005;433:68–72.
   PubMed Web of Science ®Google Scholar
• Altenmuller E, Schmidt S, Zimmermann E, editors. Evolution of Emotional Communication: From Sounds in Nonhuman Mammals to Speech and Music in Man. Oxford: Oxford University Press; 2013.
   Google Scholar
• Barrett LF. Solving the emotion paradox: categorization and the experience of emotion. Pers Soc Psychol Rev. 2006;10:20–46.
   PubMed Web of Science ®Google Scholar
• Barrett LF. Psychological construction: the Darwinian approach to the science of emotion. Emot Rev. 2013;5:379–389.
   Web of Science ®Google Scholar
• Gendron M, Barrett LF. Reconstructing the past: a century of ideas about emotion in psychology. Emot Rev. 2009;1:316–339.
   PubMed Web of Science ®Google Scholar
• James W. The physical basis of emotion [reprint]. Psychol Rev. 1994;101:205–210.
   PubMed Web of Science ®Google Scholar
• Harrison NA, Kreibig S, Critchley HD. Physiology of emotion responses in the brain. In: Vuilleumier P, Armony JL, editors. Handbook of Human Affective Neuroscience. Cambridge: Cambridge University Press; 2013.
   Google Scholar
• Kreibig SD. Autonomic nervous system activity in emotion: a review. Biol Psychol. 2010;84:394–421.
   PubMed Web of Science ®Google Scholar
• Stemmler G, Heldmann M, Pauls CA, Scherer T. Constraints for emotion specificity in fear and anger: the context counts. Psychophysiology. 2001;38:275–291.
   PubMed Web of Science ®Google Scholar
• Rainville P, Bechara A, Naqvi N, Damasio AR. Basic emotions are associated with distinct patterns of cardiorespiratory activity. Int J Psychophysiol. 2006;61:5–18.
   PubMed Web of Science ®Google Scholar
• Fredrickson BL, Levenson RW. Positive emotions speed recovery from the cardiovascular sequelae of negative emotions. Cogn Emot. 1998;12:191–220.
   PubMed Web of Science ®Google Scholar
• Ohman A, Hamm A, Hugdahl K. Cognition and the autonomic nervous system: orienting, anticipation and conditioning. In: Cacioppo JT, Tassinary LG, Berntson GG, editors. Handbook of Psychophysiology. New York: Cambridge University Press; 2000:533–575.
   Google Scholar
• Etzel JA, Johnsen EL, Dickerson J, Tranel D, Adolphs R. Cardiovascular and respiratory responses during musical mood induction. Int J Psychophysiol. 2006;61:57–69.
   PubMed Web of Science ®Google Scholar
• Pruessner JC, Declovic K, Khalili-Mahani N, et al. Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance Imaging studies. Biol Psychiatry. 2008;63:234–240.
   PubMed Web of Science ®Google Scholar
• LaBar KS, Gatenby JC, Gore JC, LeDoux JE, Phelps EA. Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron. 1998;20:937–945.
   PubMed Web of Science ®Google Scholar
• Morris JS, Dolan RJ. Dissociable amygdala and orbitofrontal responses during reversal fear conditioning. Neuroimage. 2004;22:372–380.
   PubMed Web of Science ®Google Scholar
• Morris JS, Ohman A, Dolan RJ. A subcortical pathway to the right amygdala mediating “unseen” fear. Proc Natl Acad Sci U S A. 1999;96:1680–1685.
   PubMed Web of Science ®Google Scholar
• Williams LM, Phillips ML, Brammer MJ, et al. Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording. Neuroimage. 2001;14:1070–1079.
   PubMed Web of Science ®Google Scholar
• Phelps EA, O’Connor KJ, Gatenby JC, Gore JC, Grillon C, Davis M. Activation of the left amygdala to a cognitive representation of fear. Nat Neurosci. 2001;4:437–441.
   PubMed Web of Science ®Google Scholar
• Williams LM, Liddell BJ, Kemp AH, et al. Amygdala-prefrontal dissociation of subliminal and supraliminal fear. Hum Brain Mapp. 2006;27:652–661.
   PubMed Web of Science ®Google Scholar
• Critchley HD, Elliott R, Mathias CJ, Dolan RJ. Neural activity relating to generation and representation of galvanic skin conductance responses: a functional magnetic resonance imaging study. J Neurosci. 2000;20:3033–3040.
   PubMed Web of Science ®Google Scholar
• Dimberg U. Facial reactions to fear-relevant stimuli for subjects high and low in specific fear. Scand J Psychol. 1990;31:65–69.
   PubMed Web of Science ®Google Scholar
• Schmidt NB, Richey JA, Zvolensky MJ, Maner JK. Exploring human freeze responses to a threat stressor. J Behav Ther Exp Psychiatry. 2008;39:292–304.
   PubMed Web of Science ®Google Scholar
• Lang PJ, Bradley MM, Cuthbert BN. Emotion, attention, and the startle reflex. Psychol Rev. 1990;97:377–395.
   PubMed Web of Science ®Google Scholar
• Pissiota A, Frans O, Michelgard A, et al. Amygdala and anterior cingulate cortex activation during affective startle modulation: a PET study of fear. Eur J Neurosci. 2003;18:1325–1331.
   PubMed Web of Science ®Google Scholar
• Mujica-Parodi LR, Strey HH, Frederick B, et al. Chemosensory cues to conspecific emotional stress activate amygdala in humans. Plos One. 2009;4:e6415.
   PubMed Web of Science ®Google Scholar
• Brannan S, Liotti M, Egan G, et al. Neuroimaging of cerebral activations and deactivations associated with hypercapnia and hunger for air. Proc Natl Acad Sci U S A. 2001;98:2029–2034.
   PubMed Web of Science ®Google Scholar
• Corfield DR, Fink GR, Ramsay SC, et al. Evidence for limbic system activation during CO2-stimulated breathing in man. J Physiol. 1995;488:77–84.
   PubMed Web of Science ®Google Scholar
• Evans KC, Banzett RB, Adams L, McKay L, Frackowiak RS, Corfield DR. BOLD fMRI identifies limbic, paralimbic, and cerebellar activation during air hunger. J Neurophysiol. 2002;88:1500–1511.
   PubMed Web of Science ®Google Scholar
• Feinstein JS, Buzza C, Hurlemann R, et al. Fear and panic in humans with bilateral amygdala damage. Nat Neurosci. 2013;16:270–272.
   PubMed Web of Science ®Google Scholar
• Eser D, Leicht G, Lutz J, et al. Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers. Hum Brain Mapp. 2009;30:511–522.
   PubMed Web of Science ®Google Scholar
• Schunck T, Erb G, Mathis A, et al. Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety. Neuroimage. 2006;31:1197–1208.
   PubMed Web of Science ®Google Scholar
• Schunck T, Mathis A, Erb G, Namer IJ, Demazieres A, Luthringer R. Effects of lorazepam on brain activity pattern during an anxiety symptom provocation challenge. J Psychopharmacol. 2010;24:701–708.
   PubMed Web of Science ®Google Scholar
• Dedovic K, Rexroth M, Wolff E, et al. Neural correlates of processing stressful information: an event-related fMRI study. Brain Res. 2009;1293:49–60.
   PubMed Web of Science ®Google Scholar
• Wager TD, Waugh CE, Lindquist M, Noll DC, Fredrickson BL, Taylor SF. Brain mediators of cardiovascular responses to social threat: part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity. Neuroimage. 2009;47:821–835.
   PubMed Web of Science ®Google Scholar
• Wager TD, van Ast VA, Hughes BL, Davidson ML, Lindquist MA, Ochsner KN. Brain mediators of cardiovascular responses to social threat: part II: Prefrontal-subcortical pathways and relationship with anxiety. Neuroimage. 2009;47:836–851.
   PubMed Web of Science ®Google Scholar
• Critchley HD, Corfield DR, Chandler MP, Mathias CJ, Dolan RJ. Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans. J Physiol. 2000;523:259–270.
   PubMed Web of Science ®Google Scholar
• Frankenstein UN, Richter W, McIntyre MC, Remy F. Distraction modulates anterior cingulate gyrus activations during the cold pressor test. Neuroimage. 2001;14:827–836.
   PubMed Web of Science ®Google Scholar
• Harrison NA, Brydon L, Walker C, et al. Neural origins of human sickness in interoceptive responses to inflammation. Biol Psychiatry. 2009;66:415–422.
   PubMed Web of Science ®Google Scholar
• Tracey I, Becerra L, Chang I, et al. Noxious hot and cold stimulation produce common patterns of brain activation in humans: a functional magnetic resonance imaging study. Neurosci Lett. 2000;288:159–162.
   PubMed Web of Science ®Google Scholar
• Gianaros PJ, Sheu LK, Matthews KA, Jennings JR, Manuck SB, Hariri AR. Individual differences in stressor-evoked blood pressure reactivity vary with activation, volume, and functional connectivity of the amygdala. J Neurosci. 2008;28:990–999.
   PubMed Web of Science ®Google Scholar
• Eisenberger NI, Gable SL, Lieberman MD. Functional magnetic resonance imaging responses relate to differences in real-world social experience. Emotion. 2007;7:745–754.
   PubMed Web of Science ®Google Scholar
• Singer T, Seymour B, O’Doherty J, Kaube H, Dolan RJ, Frith CD. Empathy for pain involves the affective but not sensory components of pain. Science. 2004;303:1157–1162.
   PubMed Web of Science ®Google Scholar
• Critchley HD. Psychophysiology of neural, cognitive and affective integration: fMRI and autonomic indicants. Int J Psychophysiol. 2009;73:88–94.
   PubMed Web of Science ®Google Scholar
• Critchley HD, Nagai Y, Gray MA, Mathias CJ. Dissecting axes of autonomic control in humans: insights from neuroimaging. Auton Neurosci. 2011;161:34–42.
   PubMed Web of Science ®Google Scholar
• Seeley WW, Menon V, Schatzberg AF, et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci. 2007;27:2349–2356.
   PubMed Web of Science ®Google Scholar
• Phan KL, Wager T, Taylor SF, Liberzon I. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage. 2002;16:331–348.
   PubMed Web of Science ®Google Scholar
• Gianaros PJ, Onyewuenyi IC, Sheu LK, Christie IC, Critchley HD. Brain systems for baroreflex suppression during stress in humans. Hum Brain Mapp. 2012;33:1700–1716.
   PubMed Web of Science ®Google Scholar
• Winston JS, O’Doherty J, Dolan RJ. Common and distinct neural responses during direct and incidental processing of multiple facial emotions. Neuroimage. 2003;20:84–97.
   PubMed Web of Science ®Google Scholar
• Quirk GJ. Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery. Learn Mem. 2002;9:402–407.
   PubMed Web of Science ®Google Scholar
• LeDoux JE. The Emotional Brain: The Mysterious Underpinnings of Emotional Life. New York: Simon and Schuster; 1998.
   Google Scholar
• Buchel C, Dolan RJ. Classical fear conditioning in functional neuroimaging. Curr Opin Neurobiol. 2000;10:219–223.
   PubMed Web of Science ®Google Scholar
• Sehlmeyer C, Schöning S, Zwitserlood P, et al. Human fear conditioning and extinction in neuroimaging: a systematic review. Plos One. 2009;4:e5865.
   PubMed Web of Science ®Google Scholar
• Breiter HC, Etcoff NL, Whalen PJ, et al. Response and habituation of the human amygdala during visual processing of facial expression. Neuron. 1996;17:875–887.
   PubMed Web of Science ®Google Scholar
• Knutson B, Cooper JC. The lure of the unknown. Neuron. 2006;51:280–282.
   PubMed Web of Science ®Google Scholar
• Critchley HD, Mathias CJ, Dolan RJ. Fear conditioning in humans: the influence of awareness and autonomic arousal on functional neuroanatomy. Neuron. 2002;33:653–663.
   PubMed Web of Science ®Google Scholar
• Schachter S, Singer JE. Cognitive, social, and physiological determinants of emotional state. Psychol Rev. 1962;69:379–399.
   PubMed Web of Science ®Google Scholar
• Milad MR, Quirk GJ. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature. 2002;420:70–74.
   PubMed Web of Science ®Google Scholar
• Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry. 2007;62:446–454.
   PubMed Web of Science ®Google Scholar
• Nagai Y, Critchley HD, Featherstone E, Trimble MR, Dolan RJ. Activity in ventromedial prefrontal cortex covaries with sympathetic skin conductance level: a physiological account of a “default mode” of brain function. Neuroimage. 2004;22:243–251.
   PubMed Web of Science ®Google Scholar
• Maren S, Phan KL, Liberzon I. The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci. 2013;14:417–428.
   PubMed Web of Science ®Google Scholar
• Bouton ME, Westbrook RF, Corcoran KA, Maren S. Contextual and temporal modulation of extinction: behavioral and biological mechanisms. Biol Psychiatry. 2006;60:352–360.
   PubMed Web of Science ®Google Scholar
• Melzig CA, Michalowski JM, Holtz K, Hamm AO. Anticipation of interoceptive threat in highly anxiety sensitive persons. Behav Res Ther. 2008;46:1126–1134.
   PubMed Web of Science ®Google Scholar
• Drabant EM, Kuo JR, Ramel W, et al. Experiential, autonomic, and neural responses during threat anticipation vary as a function of threat intensity and neuroticism. Neuroimage. 2011;55:401–410.
   PubMed Web of Science ®Google Scholar
• Mee S, Bunney BG, Reist C, Potkin SG, Bunney WE. Psychological pain: a review of evidence. J Psychiatr Res. 2006;40:680–690.
   PubMed Web of Science ®Google Scholar
• Morris JS, Frith CD, Perrett DI, et al. A differential neural response in the human amygdala to fearful and happy facial expressions. Nature. 1996;383:812–815.
   PubMed Web of Science ®Google Scholar
• Baron-Cohen S, Ring HA, Wheelwright S, et al. Social intelligence in the normal and autistic brain: an fMRI study. Eur J Neurosci. 1999;11:1891–1898.
   PubMed Web of Science ®Google Scholar
• Corden B, Critchley HD, Skuse D, Dolan RJ. Fear recognition ability predicts differences in social cognitive and neural functioning in men. J Cogn Neurosci. 2006;18:889–897.
   PubMed Web of Science ®Google Scholar
• Morris JS, deBonis M, Dolan RJ. Human amygdala responses to fearful eyes. Neuroimage. 2002;17:214–222.
   PubMed Web of Science ®Google Scholar
• Whalen PJ, Kagan J, Cook RG, et al. Human amygdala responsivity to masked fearful eye whites. Science. 2004;306:2061.
   PubMed Web of Science ®Google Scholar
• Garfinkel SN, Minati L, Gray MA, Seth AK, Dolan RJ, Critchley HD. Fear from the heart: sensitivity to fear stimuli depends on individual heartbeats. J Neurosci. 2014;34:6573–6582.
   PubMed Web of Science ®Google Scholar
• Gray MA, Harrison NA, Wiens S, Critchley HD. Modulation of emotional appraisal by false physiological feedback during fMRI. Plos One. 2007;2:e546.
   PubMed Web of Science ®Google Scholar
• Kret ME, Pichon S, Grèzes J, de Gelder B. Similarities and differences in perceiving threat from dynamic faces and bodies. An fMRI study. Neuroimage. 2011;54:1755–1762.
   PubMed Web of Science ®Google Scholar
• Pichon S, de Gelder B, Grèzes J. Two different faces of threat. Comparing the neural systems for recognizing fear and anger in dynamic body expressions. Neuroimage. 2009;47:1873–1883.
   PubMed Web of Science ®Google Scholar
• Baumgartner T, Lutz K, Schmidt CF, JÄncke L. The emotional power of music: how music enhances the feeling of affective pictures. Brain Res. 2006;1075:151–164.
   PubMed Web of Science ®Google Scholar
• Koelsch S, Skouras S, Fritz T, et al. The roles of superficial amygdala and auditory cortex in music-evoked fear and joy. Neuroimage. 2013;81:49–60.
   PubMed Web of Science ®Google Scholar
• Juslin PN, Laukka P. Communication of emotions in vocal expression and music performance: different channels, same code? Psychol Bull. 2003;129:770–814.
   PubMed Web of Science ®Google Scholar
• Fritz T, Jentschke S, Gosselin N, et al. Universal recognition of three basic emotions in music. Curr Biol. 2009;19:573–576.
   PubMed Web of Science ®Google Scholar
• Vuilleumier P. How brains beware: neural mechanisms of emotional attention. Trends Cogn Sci. 2005;9:585–594.
   PubMed Web of Science ®Google Scholar
• De Martino B, Kalisch R, Rees G, Dolan RJ. Enhanced processing of threat stimuli under limited attentional resources. Cereb Cortex. 2009;19:127–133.
   PubMed Web of Science ®Google Scholar
• Schwabe L, Merz CJ, Walter B, Vaitl D, Wolf OT, Stark R. Emotional modulation of the attentional blink: the neural structures involved in capturing and holding attention. Neuropsychologia. 2011;49:416–425.
   PubMed Web of Science ®Google Scholar
• Armony JL, Dolan RJ. Modulation of spatial attention by fear-conditioned stimuli: an event-related fMRI study. Neuropsychologia. 2002;40:817–826.
   PubMed Web of Science ®Google Scholar
• Pourtois G, Grandjean D, Sander D, Vuilleumier P. Electrophysiological correlates of rapid spatial orienting towards fearful faces. Cereb Cortex. 2004;14:619–633.
   PubMed Web of Science ®Google Scholar
• Weymar M, Keil A, Hamm AO. Timing the fearful brain: unspecific hypervigilance and spatial attention in early visual perception. Soc Cogn Affect Neurosci. 2014;9:723–729.
   PubMed Web of Science ®Google Scholar
• Pourtois G, Schwartz S, Seghier ML, Lazeyras F, Vuilleumier P. Neural systems for orienting attention to the location of threat signals: an event-related fMRI study. Neuroimage. 2006;31:920–933.
   PubMed Web of Science ®Google Scholar
• LeDoux JE. Coming to terms with fear. Proc Natl Acad Sci U S A. 2014;111:2871–2878.
   PubMed Web of Science ®Google Scholar
• Blanchard RJ, Blanchard DC. Anti-predator defence as models of fear and anxiety. In: Brain PF, Parmigiani S, Blanchard RJ, Mainardi D, editors. Fear and Defence. Amsterdam: Harwood Academic; 1990:89–108.
   Google Scholar
• Mobbs D, Petrovic P, Marchant JL, et al. When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans. Science. 2007;317:1079–1083.
   PubMed Web of Science ®Google Scholar
• Fanselow MS. Neural organization of the defensive behavior system responsible for fear. Psychon Bull Rev. 1994;1:429–438.
   PubMed Web of Science ®Google Scholar
• Aviezer H, Trope Y, Todorov A. Body cues, not facial expressions, discriminate between intense positive and negative emotions. Science. 2012;338:1225–1229.
   PubMed Web of Science ®Google Scholar
• de Gelder B. Towards the neurobiology of emotional body language. Nat Rev Neurosci. 2006;7:242–249.
   PubMed Web of Science ®Google Scholar
• Lee TW, Dolan RJ, Critchley HD. Controlling emotional expression: behavioral and neural correlates of nonimitative emotional responses. Cereb Cortex. 2008;18:104–113.
   PubMed Web of Science ®Google Scholar
• Price TF, Dieckman LW, Harmon-Jones E. Embodying approach motivation: body posture influences startle eyeblink and event-related potential responses to appetitive stimuli. Biol Psychol. 2012;90:211–217.
   PubMed Web of Science ®Google Scholar
• Gray MA, Beacher FD, Minati L, et al. Emotional appraisal is influenced by cardiac afferent information. Emotion. 2012;12:180–191.
   PubMed Web of Science ®Google Scholar
• Del-Ben CM, Ferreira CA, Sanchez TA, et al. Effects of diazepam on BOLD activation during the processing of aversive faces. J Psychopharmacol. 2012;26:443–451.
   PubMed Web of Science ®Google Scholar
• Domes G, Heinrichs M, Glascher J, Buchel C, Braus DF, Herpertz SC. Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol Psychiatry. 2007;62:1187–1190.
   PubMed Web of Science ®Google Scholar
• Kirsch P, Esslinger C, Chen Q, et al. Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci. 2005;25:11489–11493.
   PubMed Web of Science ®Google Scholar
• Domes G, Lischke A, Berger C, et al. Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology. 2010;35:83–93.
   PubMed Web of Science ®Google Scholar
• Lischke A, Gamer M, Berger C, et al. Oxytocin increases amygdala reactivity to threatening scenes in females. Psychoneuroendocrinology. 2012;37:1431–1438.
   PubMed Web of Science ®Google Scholar
• Koch SBJ, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M. Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: salience processing and fear inhibition processes. Psychoneuroendocrinology. 2014;40:242–256.
   PubMed Web of Science ®Google Scholar
• Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–389.
   PubMed Web of Science ®Google Scholar
• Heils A, Mossner R, Lesch KP. The human serotonin transporter gene polymorphism – basic research and clinical implications. J Neural Transm. 1997;104:1005–1014.
   PubMed Web of Science ®Google Scholar
• Lonsdorf TB, Golkar A, Lindstöm KM, et al. 5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation. Biol Psychol. 2011;87:106–112.
   PubMed Web of Science ®Google Scholar
• Domschke K, Baune BT, Havlik L, et al. Catechol-O-methyltransferase gene variation: impact on amygdala response to aversive stimuli. Neuroimage. 2012;60:2222–2229.
   PubMed Web of Science ®Google Scholar
• Dannlowski U, Kugel H, Franke F, et al. Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli. Neuropsychopharmacology. 2011;36:1879–1885.
   PubMed Web of Science ®Google Scholar
• Stevens JS, Almli LM, Fani N, et al. PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus. Proc Natl Acad Sci U S A. 2014;111:3158–3163.
   PubMed Web of Science ®Google Scholar
• Frielingsdorf H, Bath KG, Soliman F, DiFede J, Casey BJ, Lee FS. Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder. Ann N Y Acad Sci. 2010;1208:150–157.
   PubMed Web of Science ®Google Scholar
• Lonsdorf TB, Weike AI, Golkar A, Schalling M, Hamm AO, Ohman A. Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism. Behav Neurosci. 2010;124:9–15.
   PubMed Web of Science ®Google Scholar
• Eccles JA, Beacher FD, Gray MA, et al. Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms. Br J Psychiatry. 2012;200:508–509.
   PubMed Web of Science ®Google Scholar
• Smoller JW, Gardner-Schuster E, Covino J. The genetic basis of panic and phobic anxiety disorders. Am J Med Genet C Semin Med Genet. 2008;148C:118–126.
   PubMed Web of Science ®Google Scholar
• Fanselow MS, Dong HW. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron. 2010;65:7–19.
   PubMed Web of Science ®Google Scholar
• Koelsch S. Brain correlates of music-evoked emotions. Nat Rev Neurosci. 2014;15:170–180.
   PubMed Web of Science ®Google Scholar
• Beacher FD, Gray MA, Mathias CJ, Critchley HD. Vulnerability to simple faints is predicted by regional differences in brain anatomy. Neuroimage. 2009;47:937–945.
   PubMed Web of Science ®Google Scholar
• Birbaumer N, Grodd W, Diedrich O, et al. fMRI reveals amygdala activation to human faces in social phobics. Neuroreport. 1998;9:1223–1226.
   PubMed Web of Science ®Google Scholar
• Ipser JC, Singh L, Stein DJ. Meta-analysis of functional brain imaging in specific phobia. Psychiatry Clin Neurosci. 2013;67:311–322.
   PubMed Web of Science ®Google Scholar
• Etkin A, Wager TD. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry. 2007;164:1476–1488.
   PubMed Web of Science ®Google Scholar
• Lommen MJ, Engelhard IM, Sijbrandij M, van den Hout MA, Hermans D. Pre-trauma individual differences in extinction learning predict posttraumatic stress. Behav Res Ther. 2013;51:63–67.
   PubMed Web of Science ®Google Scholar
• Orr SP, Roth WT. Psychophysiological assessment: clinical applications for PTSD. J Affect Disord. 2000;61:225–240.
   PubMed Web of Science ®Google Scholar
• Sijbrandij M, Engelhard IM, Lommen MJ, Leer A, Baas JM. Impaired fear inhibition learning predicts the persistence of symptoms of posttraumatic stress disorder (PTSD). J Psychiatr Res. 2013;47:1991–1997.
   PubMed Web of Science ®Google Scholar
• Milad MR, Pitman RK, Ellis CB, et al. Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder. Biol Psychiatry. 2009;66:1075–1082.
   PubMed Web of Science ®Google Scholar
• Sripada RK, Sarah NG, Liberzon I. Avoidant symptoms in PTSD predict fear circuit activation during multimodal fear extinction. Front Hum Neurosci. 2013;7:672.
   PubMed Web of Science ®Google Scholar
• Rougemont-Bücking A, Linnman C, Zeffiro TA, et al. Altered processing of contextual information during fear extinction in PTSD: an fMRI study. CNS Neurosci Ther. 2011;17:227–236.
   PubMed Web of Science ®Google Scholar
• Rauch SL, Whalen PJ, Shin LM, et al. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biol Psychiatry. 2000;47:769–776.
   PubMed Web of Science ®Google Scholar
• Liberzon I, Martis B. Neuroimaging studies of emotional responses in PTSD. Ann N Y Acad Sci. 2006;1071:87–109.
   PubMed Web of Science ®Google Scholar
• Ochsner KN, Bunge SA, Gross JJ, Gabrieli JD. Rethinking feelings: an fMRI study of the cognitive regulation of emotion. J Cogn Neurosci. 2002;14:1215–1229.
   PubMed Web of Science ®Google Scholar
• Quirk GJ, Russo GK, Barron JL, Lebron K. The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J Neurosci. 2000;20:6225–6231.
   PubMed Web of Science ®Google Scholar
• St Jacques PL, Botzung A, Miles A, Rubin DC. Functional neuroimaging of emotionally intense autobiographical memories in post-traumatic stress disorder. J Psychiatr Res. 2011;45:630–637.
   PubMed Web of Science ®Google Scholar
• Brown S, Freeman T, Kimbrell T, Cardwell D, Komoroski R. In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of former prisoners of war with and without posttraumatic stress disorder. J Neuropsychiatry Clin Neurosci. 2003;15:367–370.
   PubMed Web of Science ®Google Scholar
• De Bellis MD, Keshavan MS, Shifflett H, et al. Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study. Biol Psychiatry. 2002;52:1066–1078.
   PubMed Web of Science ®Google Scholar
• Orsini CA, Kim JH, Knapska E, Maren S. Hippocampal and prefrontal projections to the basal amygdala mediate contextual regulation of fear after extinction. J Neurosci. 2011;31:17269–17277.
   PubMed Web of Science ®Google Scholar
• Jovanovic T, Kazama A, Bachevalier J, Davis M. Impaired safety signal learning may be a biomarker of PTSD. Neuropharmacology. 2012;62:695–704.
   PubMed Web of Science ®Google Scholar
• Deliramich AN, Gray MJ. Changes in women’s sexual behavior following sexual assault. Behav Modif. 2008;32:611–621.
   PubMed Web of Science ®Google Scholar
• Killgore WD, Cotting DI, Thomas JL, et al. Post-combat invincibility: violent combat experiences are associated with increased risk-taking propensity following deployment. J Psychiatr Res. 2008;42:1112–1121.
   PubMed Web of Science ®Google Scholar
• Foa EB, Feske U, Murdock TB, Kozak MJ, Mccarthy PR. Processing of threat-related information in rape victims. J Abnorm Psychol. 1991;100:156–162.
   PubMed Web of Science ®Google Scholar
• Pole N. The psychophysiology of posttraumatic stress disorder: a meta-analysis. Psychol Bull. 2007;133:725–746.
   PubMed Web of Science ®Google Scholar
• Shin LM, Liberzon I. The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology. 2010;35:169–191.
   PubMed Web of Science ®Google Scholar
• El Khoury-Malhame M, Reynaud E, Soriano A, et al. Amygdala activity correlates with attentional bias in PTSD. Neuropsychologia. 2011;49:1969–1973.
   PubMed Web of Science ®Google Scholar
• Fani N, Jovanovic T, Ely TD, et al. Neural correlates of attention bias to threat in post-traumatic stress disorder. Biol Psychol. 2012;90:134–142.
   PubMed Web of Science ®Google Scholar
• Kimble M, Kaloupek D, Kaufman M, Deldin P. Stimulus novelty differentially affects attentional allocation in PTSD. Biol Psychiatry. 2000;47:880–890.
   PubMed Web of Science ®Google Scholar
• Mcfarlane AC, Weber DL, Clark CR. Abnormal stimulus processing in posttraumatic stress disorder. Biol Psychiatry. 1993;34:311–320.
   PubMed Web of Science ®Google Scholar
• Christianson JP, Fernando AB, Kazama AM, Jovanovic T, Ostroff LE, Sangha S. Inhibition of fear by learned safety signals: a mini-symposium review. J Neurosci. 2012;32:14118–14124.
   PubMed Web of Science ®Google Scholar
• Garfinkel SN, Abelson JL, King A, et al. Impaired contextual modulation of memories in PTSD: An fMRI and psychophysiological study of extinction retention and fear renewal. Journal of Neuroscience. 2014;40:13435–13443.
   Google Scholar