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Review

Neuropsychiatric effects of tenofovir in comparison with other antiretroviral drugs

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Pages 1-10 | Published online: 22 Jan 2013

References

  • Palella FL Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338(13):853–860.
  • Berrey MM, Schacker T, Collier AC, et al. Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to AIDS. J Infect Dis. 2001;183(10):1466–1475.
  • Gallant JE, Staszewski S, Pozniak AL, et al. Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naïve patients: a 3-year randomized trial. JAMA. 2004;292(2):191–201.
  • Negredo E, Moltó J, Muñoz-Moreno JA, et al. Safety and efficacy of once-daily didanosine, tenofovir and nevirapine as a simplification antiretroviral approach. Antivir Ther. 2004;9(3):335–342.
  • Louie M, Hogan C, Hurley A, et al. Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naïve chronically HIV-1-infected individuals. AIDS. 2003;17(8):1151–1156.
  • Kearney BP, Abadi J, Rosenberg M, et al. Pharmacokinetics (PK) of tenofovir DF (TDF) oral suspension in HIV-1 infected children between 2 and 8 years of age. Paper presented at the 11th Conference on Retroviruses and Opportunistic Infections; February 8–11, 2004; San Francisco, CA, USA.
  • Ramos JT, Gonzalez Tome MI, Rojo P, Fernandez Ibieta M, Vargas K, Garcia-Pinal L. Experience with tenofovir disoproxil fumarate (TDF) in heavily pretreated HIV-infected children Paper presented at the 15th International AIDS Conference; July 11–16, 2004; Bangkok, Thailand.
  • Hazra R, Gani RI, Maldarelli F, et al. Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy for pediatric HIV infection. Pediatrics. 2005;116(6):e846–e854.
  • Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Updated January 12, 2012. Available from: http://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Accessed December 25, 2012.
  • World Health Organization. Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a Public Health Approach. Revised. Geneva: WHO; 2010. Available from: http://www.who.int/hiv/pub/arv/adult2010/en/index.html. Accessed October 15, 2012.
  • Panel on Antiretroviral Therapy and Medical Management of HIVInfected Children. Guidelines for the use of antiretroviral agents in pediatric HIV infection. Updated August 11, 2011. Available from http://aidsinfo.nih.gov/Contentfiles/PediatricGuidelines.pdf. Accessed October 15, 2012.
  • Cohen MS, McCauley M, Gamble TR. HIV treatment as prevention and HPTN 052. Curr Opin HIV AIDS. 2012;7(2):99–105.
  • Balzarini J, Holy A, Jindrich J, et al. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo, antiretrovirus activities of (R)-9- (2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrob Agents Chemother. 1993;37(2):332–338.
  • Robbins BL, Srinivas RV, Kim C, Bischofberger N, Fridland A. Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(isopropyloxymethylcarbonyl) PMPA. Antimicrob Agents Chemother. 1998;42(3):612–617.
  • Mulato AS, Cherrington JM. Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses. Antiviral Res. 1997;36(2):91–97.
  • Centers for Disease Control and Prevention (CDC). Interim guidance: pre-exposure prophylxais for the prevention of HIV in men who have sex with men. MMWR Morb Mortal Wkly Rep. 2011;60(3):65–68.
  • Centers for Disease Control and Prevention (CDC). Updated US public health service guidelines for the management of occupational exposures to HIV and recommendations for postexposure prophylaxis. MMWR Morb Mortal Wkly Rep. 2005;54(RR-9):1–17.
  • Smith DK, Grohskopf LA, Black RJ, et al. Antiretroviral postexposure prohylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV in the United States: recommendations from the US Department of Health and Human Services. MMWR Recomm Rep. 2005;54(RR-2):1–20.
  • Siberry G, Williams P, Mendez H, et al. Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants. AIDS. 2012;26(9):1151–1159.
  • van der Straten A, Van Damme L, Haberer J, Bangsberg D. Unraveling the divergent results of PrEP trials for HIV prevention. AIDS. 2012;26(7):F13–F19.
  • Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329(5996):1168–1174.
  • Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363(27):2587–2599.
  • Thigpen M, Debabetswe P, Smith D, et al. Daily oral antiretroviral use for the prevention of HIV infection in heterosexually active young adults in Botswana: results from the TDF2 study. Paper presented at the 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 17–20, 2011; Rome, Italy.
  • Baeten J, Celum C. Antiretroviral pre-exposure prophylaxis for HIV-1 prevention among heterosexual African men and women: the partners PrEP Study. Paper presented at the 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 17–20, 2011; Rome, Italy.
  • Family Health International. FHI statement on the FEM-PrEP HIV prevention study: FHI to initiate orderly closure of FEM-PrEP. 2011. Available from: http://www.mtnstopshiv.org/sites/default/files/attachments/FEM-PrEP%20Statement%20FINAL1.pdf. Accessed September 1, 2012.
  • Family Health International. VOICE HIV prevention trial continues, but researchers suspend oral tenofovir arm because of futility. Available from: http://www.fhi360.org/en/AboutFHI/Media/Releases/res_VOICE.htm. Accessed September 1, 2012.
  • Grim SA, Romanelli F. Tenofovir disoproxil fumarate. Ann Pharmacother. 2003;37(6):849–859.
  • Gallant JE, Deresinski S. Tenofovir disoproxil fumarate. Clin Infect Dis. 2003;37(7):944–950.zzzz
  • Viread [package insert]. 2012. Gilead Sciences, Foster City, CA, USA. Available from: http://www.gilead.com/pdf/viread_pi.pdf. Accessed September 5, 2012.
  • Barrios A, García-Benayas T, González-Lahoz J, et al. Tenofovir-related nephrotoxicity in HIV-infected patients. AIDS. 2004;18(6):960–963.
  • James CW, Steinhaus MC, Szabo S, et al. Tenofovir-related nephrotoxicity: case report and review of the literature. Pharmacotherapy. 2004;24(3):415–418.
  • Murphy MD, O’Hearn M, Chou S. Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine. Clin Infect Dis. 2003;36(8):1082–1085.
  • Schaaf B, Aries SP, Kramme E, et al. Acute renal failure associated with tenofovir treatment in a patient with acquired immunodeficiency syndrome. Clin Infect Dis. 2003;37(3):c41–c43.
  • Sax PE, Gallant JE, Klotman PE. Renal safety of tenofovir disoproxil fumarate. AIDS Read. 2007;17(2):90–92, 99–104, C3.
  • Scott JD, Wolfe PR, Bolan RK, Guyer W. Serious renal impairment occurs rarely with use of tenofovir DF. HIV Clin Trials. 2006;7(2): 55–58.
  • Rodríguez-Nóvoa S, Labarga P, Soriano V, et al. Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study. Clin Infect Dis. 2009;48(11):e108–e116.
  • Woodward CLN, Hall AM, Williams IG, et al. Tenofovir-associated renal and bone toxicity. HIV Med. 2009;10(8):482–487.
  • Cassetti I, Madruga JV, Suleiman JM, et al. The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through 6 years in antiretroviral-naïve HIV-1-infected patients. HIV Clin Trials. 2007;8(3):164–172.
  • Gafni RI, Hazra R, Reynolds JC, et al. Tenofovir disproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: impact on bone mineral density in HIV-infected children. Pediatrics. 2006;118:e711–e718.
  • Birkus G, Hitchcock MJM, Cihlar T. Assessment of mitochondrial toxicity in human cells treated with tenofovir. Antimicrob Agents Chemother. 2002;46:716–723.
  • McArthur JC, Sacktor N, Selnes OA. Human immunodeficiency virus-associated dementia. Semin Neurol. 1999;19(2):129–150.
  • Antinori A, Arendt G, Becker JT, et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology. 2007;69(18): 1789–1799.
  • Dennis BC, Houff SA, Han DY, Schmitt FA. Development of neurocognitive disorders in HIV/AIDS. Neurobehav HIV Med. 2011;2011(3):9–18.
  • Varatharajan L, Thomas SA. The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res. 2009;82(2):A99–A109.
  • Sacktor N, Nakasujja, Skolasky R, et al. HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda. Clin Infect Dis. 2009;49(5):780–786.
  • Letendre S, Ellis R, Ances B, McCutchan J. Neurologic complications of HIV disease and their treatment. Top HIV Med. 2010;18(2):45–55.
  • Cespedes M, Aberg J. Neuropsychiatric complications of antiretroviral therapy. Drug Saf. 2006;29(10):865–874.
  • Brew BJ, Pemberton L, Cunningham P, Law MG. Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage. J Infect Dis. 1997;175(4):963–966.
  • McArthur JC, McClemon DR, Cronin MF, et al. Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann Neurol. 1997;42(5):689–698.
  • Ellis RJ, Hsia K, Spector SA, et al. Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome. Ann Neurol. 1997;42:679–688.
  • Ellis RJ, Moore DJ, Childers ME, et al. Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA. Arch Neurol. 2002;59(6):923–928.
  • Wang H, Sun J, Goldstein H. Human immunodeficiency virus type 1 infection increases the in vivo capacity of peripheral monocytes to cross the blood-brain barrier into the brain and the in vivo sensitivity of the blood-brain barrier to disruption by lipopolysaccharide. J Virol. 2008;82(15):7591–7600.
  • Heaton RK, Clifford DB, Franklin DR Jr. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology. 2010;75(23):2087–2096.
  • Smith R, Chernoff M, Rutstein R, et al. The long-term impact of HIV disease severity on cognitive and adaptive functioning during childhood and adolescence. Paper presented at the 16th Conference on Retroviruses and Opportunistic Infections; February 8–11, 2009; Montreal, Canada.
  • Simioni S, Cavassini M, Annoni JM, et al. Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS. 2010;24(9):1243–1250.
  • Ellis R, Heaton R, Letendre S, et al. Higher CD4 nadir is associated with reduced rates of HIV-associated neurocognitive disorders in the CHARTER study: potential implications for early treatment initiation. Paper presented at the 16th Conference on Retroviruses and Opportunistic Infections; February 8–11, 2009; Montreal, Canada.
  • Tozzi V, Balestra P, Bellagamba R, et al. Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment: prevalence and risk factors. J Acquir Immune Defic Syndr. 2007;45(2):174–182.
  • Dawes S, Suarez P, Casey CY, et al. Variable patterns of neuropsychological performance in HIV-1 infection. J Clin Exp Neuropsychol. 2008;30(6):613–626.
  • Blankson JN, Persaud D, Siliciano RF. The challenge of viral reservoirs in HIV-1 infection. Annu Rev Med. 2002;53(1):557–593.
  • Price RW, Spudich S. Antiretroviral therapy and central nervous system HIV type 1 infection. J Infect Dis. 2008;197(Suppl 3):S294–S306.
  • Letendre S, Marquie-Beck J, Capparelli E, et al. Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol. 2008;65(1):65–70.
  • Smurzynski M, Wu K, Letendre S, et al. Effects of central nervous system antiretroviral penetration on cognitive functioning in the ALLRT cohort. AIDS. 2011;25:357–365.
  • Marra CM, Zhao Y, Clifford DB, et al. Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance. AIDS. 2009;23(11):1359–1366.
  • Robertson K, Jiang H, Kumwenda J, et al. Improved neuropsychological and neurological functioning across three antiretroviral regimens in diverse resource-limited settings: AIDS Clinical Trials Group study A5199, the International Neurological Study. Clin Infect Dis. 2012;55(6):868–876.
  • Blanch J, Martinez E, Rousaud A, et al. Preliminary data of a prospective study on neuropsychiatric side effects after initiation of efavirenz. J Acquir Immune Defic Syndr. 2001;27(4):336–343.
  • Cysique LA, Maruff P, Brew BJ. Antiretroviral therapy in HIV infection: are neurologically active drugs important? Arch Neurol. 2004;61(11):1699–1704.
  • O’Brien ME, Clark RA, Besch CL, Myers L, Kissinger P. Patterns and correlates of discontinuation of the initial HAART regimen in an urban outpatient cohort. J Acquir Immune Defic Syndr. 2003;34(4): 407–414.
  • Gazzard B, Balkin A, Hill A. Analysis of neuropsychiatric adverse events during clinical trials of efavirenz in antiretroviral-naïve patients: a systematic review. AIDS Rev. 2010;12(2):67–75.
  • Cavalcante GIT, Capistrano VL, Cavalcante FS, et al. Implications of efavirenz for neuropsychiatry: a review. Int J Neurosci. 2010;120(12): 739–745.
  • Tashima KT, Caliendo AM, Ahmad M, et al. Cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) suppression and efavirenz drug concentrations in HIV-1-infected patients receiving combination therapy. J Infect Dis. 1999;180(3):862–864.
  • Jena A, Sachdeva RK, Sharma A, Wanchu A. Adverse drug reactions to nonnucleoside reverse transcriptase inhibitor-based antiretroviral regimen: a 24-week prospective study. J Int Assoc Physicians AIDS Care. 2009;8(5):318–322.
  • Adkins JC, Noble S. Efavirenz. Drugs. 1998;56(6):1055–1064.
  • Bickel M, Stephan C, Rottmann C, et al. Severe CNS side-effect and persistent high efavirenz plasma levels in a patient with HIV/HCV coinfection and liver cirrhosis. Scand J Infect Dis. 2005;37:520–522.
  • Gutiérrez F, Navarro A, Padilla S, et al. Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring. Clin Infect Dis. 2005;41(11):1648–1653.
  • Treisman GJ, Kaplin AI. Neurologic and psychiatric complications of antiretroviral agents. AIDS. 2002;16(9):1201–1215.
  • Blanch J, Corbella B, García F, Parellada E, Gatell JM. Manic syndrome associated with efavirenz overdose. Clin Infect Dis. 2001;33(2): 270–271.
  • Lochet P, Peyriere H, Lotthé A, Mauboussins JM, Delmas B, Reynes J. Long-term assessment of neuropsychiatric adverse reactions associated with efavirenz. HIV Med. 2003;4(1):62–66.
  • Marzolini C, Telenti A, Decosterd LA, Greub G, Biollaz J, Buclin T. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS. 2001;15(1): 71–75.
  • Hasse B, Günthard F, Bleiber G, Krause M. Efavirenz intoxication due to slow hepatic metabolism. Clin Infect Dis. 2005;40(3):e22–e23.
  • Cohen CJ, Molina JM, Cahn P, et al. Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naïve HIV-1-infected patients: pooled results from the phase 3 double-blind randomized ECHO and THRIVE trials. J Acquir Immune Defic Syndr. 2012;60(1):33–42.
  • Anthonypillai C, Gibbs JE, Thomas SA. The distribution of the anti-HIV drug, tenofovir (PMPA), into the brain, CSF and choroid plexuses. Cerebrospinal Fluid Res. 2006;3(1):1.
  • Best B, Letendre S, Koopmans P, et al. Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir. J Acquir Immune Defic Syndr. 2012;59(4):376–381.
  • Gallant JE, DeJesus E, Arribas J, et al. Tenofovir DF, emtricitabine, and efavirenz vs zidovudine, lamivudine, and efavirenz for HIV. N Engl J Med. 2006;354(3):251–260.
  • Allavena C, Le Moal G, Michau C, Chiffoleau A, Raffi F. Neuropsychiatric adverse events after switching from an antiretroviral regimen containing efavirenz without tenofovir to an efavirenz regimen containing tenofovir: a report of nine cases. Antivir Ther. 2006;11(2): 263–265.
  • Rotger M, Colombo S, Furrer H, Décosterd L, Buclin T, Telenti A. Does tenofovir influence efavirenz pharmacokinetics? Antivir Ther. 2007;12(1):115–118.
  • HIV-druginteractions.org. Tenofovir efavirenz interaction report. Available from: http://www.hiv-druginteractions.org/interactions.aspx. Accessed September 1, 2012.