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Original Research

Subacute toxicity study in Wistar rats fed with StemEnhanceTM, an extract from Aphanizomenon flos-aquae

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Pages 125-135 | Published online: 06 Dec 2010

References

  • Schaeffer DJ, Krylov VS. Anti-HIV activity of extracts and compounds from algae and cyanobacteria. Ecotoxicol Environ Saf. 2000;45(3): 208–227.
  • Singh S, Kate BN, Banerjee UC. Bioactive compounds from cyanobacteria and microalgae: an overview. Crit Rev Biotechnol. 2005; 25(3):73–95.
  • Kushak RI, Drapeau C, van Cott EM, Winter HH. Favorable effects of blue-green algae Aphanizomenon flos-aquae on rat plasma lipids. J Am Nutraceut Assoc. 2000;2(3):59–65.
  • Jensen GS, Ginsberg DI, Huerta P, Citton M, Drapeau C. Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation of and function of immune cells in humans. J Am Nutraceut Assoc. 2000; 2(3):50–58.
  • Lahitová N, Doupovcová M, Zvonár J, Chandoga J, Hocman G. Anti- mutagenic properties of fresh-water blue-green algae. Folia Microbiol (Praha). 1994;39(4):301–303.
  • Benedetti S, Benvenuti F, Pagliarani S, Francogli S, Scoglio S, Canestrari F. Antioxidant properties of a novel phycocyanin extract from the blue-green alga Aphanizomenon flos-aquae. Life Sci. 2004;75(19): 2353–2362.
  • Benedetti S, Rinalducci S, Benvenuti F, et al. Purification and characterization of phycocyanin from the blue-green alga Aphanizomenon flos-aquae. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;833(1): 12–18.
  • Kay RA. Microalgae as food and supplement. Crit Rev Food Sci Nutr. 1991;30(6):555–573.
  • Hertzberg S, Jensen SL. The carotenoids of Aphanizomenonflos-aquae. Phytochemistry. 1966;5(4):565–570.
  • Schaeffer DJ, Malpas PB, Barton LL. Risk assessment of microcystin in dietary Aphanizomenon flos-aquae. Ecotoxicol Environ Saf. 1999; 44(1):73–80.
  • Gilroy DJ, Kauffman KW, Hall RA, Huang X, Chu FS. Assessing potential health risks from microcystin toxins in blue-green algae dietary supplements. Environ Health Perspect. 2000;108(5):435–439.
  • Dietrich D, Hoeger S. Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements): a reasonable or misguided approach? Toxicol Appl Pharmacol. 2005;203(3):273–289.
  • Jensen GS, Hart AN, Zaske LA, et al. Mobilization of human CD34+ CD133+ and CD34+ CD133(-) stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae-related to modulation of CXCR4 expression by an L-selectin ligand? Cardiovasc Revasc Med. 2007;8(3):189–202.
  • Organization for Economic Cooperation and Development. Guidelines for the Testing of Chemical Substances, No. 401 Acute Oral Toxicity. Paris, France: OECD; 1987. Available from: http://oberon.sourceoecd.org/vl=4838556/cl=17/nw=1/rpsv/ij/oecdjournals/1607310x/v1n4/s2/p1. Accessed Jan 15 2008.
  • Organization for Economic Cooperation and Development. Draft Updated Test Guideline 407 Repeated Dose 28-Day Oral Toxicity Study in Rodents; Updated with Parameters for Endocrine Effect. Paris: OECD; 2007. Available from: http://www.oecd.org/dataoecd/24/34/38557476.pdf. Accessed Jan 15 2008.
  • Charles River Laboratories. Baseline Hematology and Clinical Chemistry Values for Charles River Wistar Rats – (CRL:(WI)BR) as a Function of Sex and Age. Technical Bulletin. Wilmington, MA: CRL; 1998. Available from: http://www.criver.com/sitecollection documents/rm_rm_r_hematology_crl_wi_br_sex_age.pdf. Accessed 2010 Jul.
  • Boehm O, Zur B, Koch A, et al. Clinical chemistry reference database for Wistar rats and C57/BL6 mice. Bio Chem. 2007;388(5): 547–554.
  • Brown DC, Gatter KC. Ki67 protein: the immaculate deception? Histopathology. 2002;40(1):2–11.
  • Kato M, Fukunishi K, Ikegawa S, et al. Overview of studies on rat sperm motion analysis using a Hamilton-Thorne Sperm Analyzercollaborative working study. J Toxicol Sci. 2001;26(5):285–297.
  • Lewi PJ, Marsboom RP. Toxicology Reference Data-Wistar Rat. Amsterdam, The Netherlands: Elsevier/North-Holland Biomedical Press; 1981.
  • Stutler SA, Johnson EW, Still KR, Schaeffer DJ, Hess RA, Arfsten DP. Effect of method of euthanasia on sperm motility of mature Sprague- Dawley rats. J Am Assoc Lab Anim Sci. 2007;46(2):13–20.
  • Kok DJ. Intratubular crystallization events. World J Urol. 1997;15(4): 219–228.
  • Janardan SK, Olson CS, Schaeffer DJ. Quantitative comparisons of acute toxicity of organic chemicals to rat and fish. Ecotoxicol Environ Saf. 1984;8(6):531–539.
  • Venman BC, Flaga C. Development of an acceptable factor to estimate chronic end points from acute toxicity data. Toxicol Ind Health. 1985; 1(4):261–269.
  • Giesy JP, Graney RL. Recent developments in and intercomparisons of acute and chronic bioassays and bioindicators. Hydrobiologia. 1989;188–189(1):21–60.
  • Duboudin C, Ciffroy P, Magaud H. Acute-to-chronic species sensitivity distribution extrapolation. Environ Toxicol Chem. 2004;23(7): 1774–1785.
  • González-Doncel M, Ortiz J, Izquierdo JJ, Martín B, Sánchez P Tarazona JV Statistical evaluation of chronic toxicity data on aquatic organisms for the hazard identification: the chemicals toxicity distribution approach. Chemosphere. 2006;63(5):835–844.
  • Toman R, Hluchý S, Massányi P, et al. Computer-assisted semen analysis of rat spermatozoa after an intraperitoneal administration of insecticide diazinon. Lucrǎri Stiintifice Zootehnie Biotehnologii. 2008;41(l):802–806.
  • Moore HD, Akhondi MA. Fertilizing capacity of rat spermatozoa is correlated with decline in straight-line velocity measured by continuous computer-aided sperm analysis: epididymal rat spermatozoa from the proximal cauda have a greater fertilizing capacity in vitro than those from the distal cauda or vas deferens. J Androl. 1996;17(1): 50–60.
  • Cancel AM, Lobdell D, Mendola P, Perreault SD. Objective evaluation of hyperactivated motility in rat spermatozoa using computer-assisted sperm analysis. Hum Reprod. 2000;15(6):1322–1328.
  • Hilscher B, Hilscher W, Maurer W. Autoradiographische untersuchungen iiber den modus der proliferation und regeneration des samenepithels der Wistarratte. Z Zellforsch. 1960;94(4):593–604.
  • Huckins C. Duration of spermatogenesis in pre- and postpubertal Wistar rats. Anat Rec. 1965;151(3):364.