Whey protein supplementation and muscle mass: current perspectives

References

• Battermann W. Whey protein for athletes. Dtsch Milchwirtschaft. 1986;37(33):1010–1012.
   Google Scholar
• Naclerio F, Larumbe-Zabala E. Effects of whey protein alone or as part of a multi-ingredient formulation on strength, fat-free mass, or lean body mass in resistance-trained individuals: a meta-analysis. Sport Med. 2016;46(1):125–137. doi:10.1007/s40279-015-0403-y
   PubMed Web of Science ®Google Scholar
• Phillips SM. The impact of protein quality on the promotion of resistance exercise-induced changes in muscle mass. Nutr Metab. 2016;13:64. doi:10.1186/s12986-016-0124-8
   Google Scholar
• Cermak NM, Res PT, de Groot LC, Saris WH, van Loon LJ. Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr. 2012;96(6):1454–1464. doi:10.3945/ajcn.112.037556
   PubMed Web of Science ®Google Scholar
• Miller PE, Alexander DD, Perez V. Effects of whey protein and resistance exercise on body composition: a meta-analysis of randomized controlled trials. J Am Coll Nutr. 2014;33(2):163–175. doi:10.1080/07315724.2013.875365
   PubMed Web of Science ®Google Scholar
• Morton RW, Murphy KT, McKellar SR, et al. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sport Med. 2018;52(6):376–384. doi:10.1136/bjsports-2017-097608
   PubMed Web of Science ®Google Scholar
• Reidy PT, Rasmussen BB. Role of ingested amino acids and protein in the promotion of resistance exercise-induced muscle protein anabolism. J Nutr. 2016;146(2):155–183. doi:10.3945/jn.114.203208
   PubMed Web of Science ®Google Scholar
• Reidy PT, Fry CS, Igbinigie S, et al. Protein supplementation does not affect myogenic adaptations to resistance training. Med Sci Sport Exerc. 2017;49(6):1197–1208. doi:10.1249/MSS.0000000000001224
   PubMed Web of Science ®Google Scholar
• Hector AJ, Phillips SM. Protein recommendations for weight loss in elite athletes: a focus on body composition and performance. Int J Sport Nutr Exerc Metab. 2018;28:170–177. doi:10.1123/ijsnem.2017-0273
   PubMed Web of Science ®Google Scholar
• Witard OC, Wardle SL, Macnaughton LS, Hodgson AB, Tipton KD. Protein considerations for optimising skeletal muscle mass in healthy young and older adults. Nutrients. 2016;8:181. doi:10.3390/nu8040181
   PubMed Web of Science ®Google Scholar
• Hoffman JR, Falvo MJ. Protein- which is the best? J Sport Sci Med. 2004;13:118–130.
   Google Scholar
• Marshall K. Therapeutic applications of whey protein. Altern Med Rev. 2004;9(2):136–156.
   PubMedGoogle Scholar
• Etzel MR. Manufacture and use of dairy protein fractions. J Nutr. 2004;134:996S–1002S. doi:10.1093/jn/134.4.996S
   PubMed Web of Science ®Google Scholar
• McGregor RA, Poppitt SD. Milk protein for improved metabolic health: a review of the evidence. Nutr Metab. 2013;10(1):46. doi:10.1186/1743-7075-10-46
   Google Scholar
• Morr CV, Ha EYW. Whey protein concentrates and isolates: processing and functional properties. Crit Rev Food Sci Nutr. 1993;33:431–476. doi:10.1080/10408399309527643
   PubMed Web of Science ®Google Scholar
• Calbet JA, MacLean DA. Plasma glucagon and insulin responses depend on the rate of appearance of amino acids after ingestion of different protein solutions in humans. J Nutr. 2002;132(8):2174–2182. doi:10.1093/jn/132.8.2174
   PubMed Web of Science ®Google Scholar
• West DW, Burd NA, Coffey VG, et al. Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. Am J Clin Nutr. 2011;94(3):795–803. doi:10.3945/ajcn.111.013722
   Web of Science ®Google Scholar
• Holmer-Jensen J, Mortensen LS, Astrup A, et al. Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects. Nutr Res. 2013;33(1):34–40. doi:10.1016/j.nutres.2012.11.004
   PubMed Web of Science ®Google Scholar
• Hamarsland H, Laahne JAL, Paulsen G, Cotter M, Børsheim E, Raastad T. Native whey induces higher and faster leucinemia than other whey protein supplements and milk: a randomized controlled trial. BMC Nutr. 2017;3:10. doi:10.1186/s40795-017-0131-9
   Google Scholar
• Hamarsland H, Nordengen AL, Nyvik Aas S, et al. Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: A randomized controlled trial. J Int Soc Sports Nutr. 2017;14:43. doi:10.1186/s12970-017-0202-y
   PubMed Web of Science ®Google Scholar
• Mitchell CJ, D’Souza RF, Fanning AC, Poppitt SD, Cameron-Smith D. Short communication: muscle protein synthetic response to microparticulated whey protein in middle-aged men. J Dairy Sci. 2017;100(6):4230–4234. doi:10.3168/jds.2016-12287
   PubMed Web of Science ®Google Scholar
• Renard D, Lavenant L, Sanchez C, Hemar Y, Horne D. Heat-induced flocculation of microparticulated whey proteins (MWP); consequences for mixed gels made of MWP and β-lactoglobulin. Colloids Surfaces B Biointerfaces. 2002;24:73–85. doi:10.1016/S0927-7765(01)00246-6
   Web of Science ®Google Scholar
• Dissanayake M, Liyanaarachchi S, Vasiljevic T. Functional properties of whey proteins microparticulated at low pH. J Dairy Sci. 2012;95:1667–1679. doi:10.3168/jds.2011-4823
   PubMed Web of Science ®Google Scholar
• Wu G. Amino acids: metabolism, functions, and nutrition. Amino Acids. 2009;37:1–17. doi:10.1007/s00726-009-0269-0
   PubMed Web of Science ®Google Scholar
• Wu G. Functional amino acids in nutrition and health. Amino Acids. 2013;45:407–411. doi:10.1007/s00726-013-1500-6
   PubMed Web of Science ®Google Scholar
• FAO Expert Consultation. Dietary Protein Quality Evaluation in Human Nutrition; Report of an FAO Expert Consultation Rome Italy 2013. Available from: http://www.fao.org/ag/humannutrition/35978-02317b979a686a57aa4593304ffc17f06.pdf. Accessed July 24, 2019.
   Google Scholar
• Wolfe RR. Update on protein intake: importance of milk proteins for health status of the elderly. Nutr Rev. 2015;73(Suppl 1):41–47. doi:10.1093/nutrit/nuv021
   Google Scholar
• Joy JM, Lowery RP, Wilson JM, et al. The effects of 8 weeks of whey or rice protein supplementation on body composition and exercise performance. Nutr J. 2013;12(1):86. doi:10.1186/1475-2891-12-86
   PubMedGoogle Scholar
• Babault N, Paizis C, Deley G, et al. Pea proteins oral supplementation promotes muscle thickness gains during resistance training: a double-blind, randomized, placebo-controlled clinical trial vs. Whey protein. J Int Soc Sport Nutr. 2015;12(1):3. doi:10.1186/s12970-014-0064-5
   PubMedGoogle Scholar
• Rutherfurd SM, Fanning AC, Miller BJ, Moughan PJ. protein digestibility-corrected amino acid scores and digestible indispensable amino acid scores differentially describe protein quality in growing male rats. J Nutr. 2015;145:372–379. doi:10.3945/jn.114.195438
   PubMed Web of Science ®Google Scholar
• Millward DJ. Knowledge gained from studies of leucine consumption in animals and humans. J Nutr. 2012;142:2212S–2219S. doi:10.3945/jn.111.157370
   Web of Science ®Google Scholar
• Millward DJ. Amino acid scoring patterns for protein quality assessment. Br J Nutr. 2012;108:S3–S21. doi:10.1017/S0007114512002462
   Web of Science ®Google Scholar
• Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr. 2001;131(3):856S–8560S. doi:10.1093/jn/131.3.856S
   PubMed Web of Science ®Google Scholar
• Phillips SM. Dietary protein requirements and adaptive advantages in athletes. Br J Nutr. 2012;108(Suppl):S158–67. doi:10.1017/S0007114512002516
   Google Scholar
• Devries MC, McGlory C, Bolster DR, et al. Protein leucine content is a determinant of shorter-and longer-term muscle protein synthetic responses at rest and following resistance exercise in healthy older women: A randomized, controlled trial. Am J Clin Nutr. 2018;107(2):217–226. doi:10.1093/ajcn/nqx028
   Web of Science ®Google Scholar
• Burke DG, Chilibeck PD, Davidson KS, Candow DG, Farthing J, Smith-Palmer T. The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength. Int J Sport Nutr Exerc Metab. 2001;11(3):349–364.
   Web of Science ®Google Scholar
• Phillips SM, Tipton KD, Aarsland AA, Wolf SE, Wolfe RR. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol. 1997;273:E99–E107.
   PubMed Web of Science ®Google Scholar
• Biolo G, Tipton KD, Klein S, Wolfe RR. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol Metab. 1997;273:E122–E129. doi:10.1152/ajpendo.1997.273.1.E122
   PubMed Web of Science ®Google Scholar
• Stokes T, Hector AJ, Morton RW, McGlory C, Phillips SM. Recent perspectives regarding the role of dietary protein for the promotion of muscle hypertrophy with resistance exercise training. Nutrients. 2018;10–18. doi:10.3390/nu10020180
   Web of Science ®Google Scholar
• Witard OC, Jackman SR, Breen L, Smith K, Selby A, Tipton KD. Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise. Am J Clin Nutr. 2014;99(1):86–95. doi:10.3945/ajcn.112.055517
   PubMed Web of Science ®Google Scholar
• Moore DR, Churchward-Venne TA, Witard O, et al. Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men. J Gerontol A Biol Sci Med Sci. 2015;70(1):57–62. doi:10.1093/gerona/glu103
   PubMed Web of Science ®Google Scholar
• Devries MC, Phillips SM. Supplemental protein in support of muscle mass and health: advantage whey. J Food Sci. 2015;80(Suppl 1):A8–A15. doi:10.1111/1750-3841.12802
   PubMed Web of Science ®Google Scholar
• Morton RW, McGlory C, Phillips SM. Nutritional interventions to augment resistance training-induced skeletal muscle hypertrophy. Front Physiol. 2015;6:245. doi:10.3389/fphys.2015.00245
   PubMed Web of Science ®Google Scholar
• Jager R, Kerksick CM, Campbell BI, et al. International society of sports nutrition position stand: protein and exercise. J Int Soc Sport Nutr. 2017;14:20. doi:10.1186/s12970-017-0177-8
   PubMed Web of Science ®Google Scholar
• Moore RD, Robinson MJ, Fry JL, et al. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr. 2009;89:161–168. doi:10.3945/ajcn.2008.26401
   PubMed Web of Science ®Google Scholar
• Tang JE, Manolakos JJ, Kujbida GW, Lysecki PJ, Moore DR, Phillips SM. Minimal whey protein with carbohydrate stimulates muscle protein synthesis following resistance exercise in trained young men. Appl Physiol Nutr Metab. 2007;32(6):1132–1138. doi:10.1139/H07-076
   PubMed Web of Science ®Google Scholar
• Trommelen J, Betz MW, van Loon LJC. The muscle protein synthetic response to meal ingestion following resistance-type exercise. Sport Med. 2019;49:185–197. doi:10.1007/s40279-019-01053-5
   PubMed Web of Science ®Google Scholar
• Bilsborough S, Mann N. A review of issue of dietary protein intake in humans. Int J Sport Nutr Exc Metab. 2006;16:129–152. doi:10.1123/ijsnem.16.2.129
   PubMed Web of Science ®Google Scholar
• Norton L, Wilson GJ. Optimal protein intake to maximize muscle protein synthesis. AgroFood Ind Hi-tech. 2009;20:54–57.
   Google Scholar
• Reitelseder S, Agergaard J, Doessing S, et al. Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion. Am J Physiol Endocrinol Metab. 2011;300(1):E231–42. doi:10.1152/ajpendo.00513.2010
   PubMed Web of Science ®Google Scholar
• Hulmi JJ, Lockwood CM, Stout JR. Effect of protein/essential amino acids and resistance training on skeletal muscle hypertrophy: A case for whey protein. Nutr Metab. 2010;7:51. doi:10.1186/1743-7075-7-51
   Google Scholar
• Churchward-Venne TA, Burd NA, Mitchell CJ, et al. Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J Physiol. 2012;590(Pt 11):2751–2765. doi:10.1113/jphysiol.2012.228833
   Web of Science ®Google Scholar
• Mitchell CJ, Zeng N, D’Souza RF, et al. Minimal dose of milk protein concentrate to enhance the anabolic signalling response to a single bout of resistance exercise; A randomised controlled trial. J Int Soc Sports Nutr. 2017;14:17. doi:10.1186/s12970-017-0175-x
   Web of Science ®Google Scholar
• Burd NA, Holwerda AM, Selby KC, et al. Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men. J Physiol. 2010;15(588):3119–3130. doi:10.1113/jphysiol.2010.192856
   Google Scholar
• Macnaughton LS, Wardle SL, Witard OC, et al. The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein. Physiol Rep. 2016;4:15. doi:10.14814/phy2.12893
   Google Scholar
• Haun CT, Vann CG, Mobley CB, et al. Effects of graded whey supplementation during extreme-volume resistance training. Front Nutr. 2018;5:84. doi:10.3389/fnut.2018.00084
   Web of Science ®Google Scholar
• Kerksick CM, Rasmussen CJ, Lancaster SL, et al. The effects of protein and amino acid supplementation on performance and training adaptations during ten weeks of resistance training. J Strength Cond Res. 2006;20(3):643–653. doi:10.1519/R-17695.1
   PubMed Web of Science ®Google Scholar
• Hoffman JR, Ratamess NA, Kang J, Falvo MJ, Faigenbaum AD. Effects of protein supplementation on muscular performance and resting hormonal changes in college football players. J Sport Sci Med. 2007;6(1):85–92.
   Web of Science ®Google Scholar
• Hoffman JR, Ratamess NA, Tranchina CP, Rashti SL, Kang J, Faigenbaum AD. Effect of protein-supplement timing on strength, power, and body-composition Changes in resistance-trained men. Int J Sport Nutr Exerc Metab. 2009;19(2):172–184. doi:10.1123/ijsnem.19.2.172
   Web of Science ®Google Scholar
• Jeacocke NA, Burke LM. Methods to standardize dietary intake before performance testing. Int J Sport Nutr Exerc Metab. 2010;20(2):87–103.
   PubMed Web of Science ®Google Scholar
• Cribb PJ, Williams AD, Carey MF, Hayes A. The effect of whey isolate and resistance training on strength, body composition, and plasma glutamine. Int J Sport Nutr Exerc Metab. 2006;16:494–509. doi:10.1123/ijsnem.16.5.494
   PubMed Web of Science ®Google Scholar
• Cooper R, Naclerio F, Allgrove J, Jimenez A. Creatine supplementation with specific view to exercise/sports performance: an update. J Int Soc Sports Nutr. 2012;9. doi:10.1186/1550-2783-9-33.
   Web of Science ®Google Scholar
• Kreider RB, Earnest CP, Lundberg J, et al. Effects of ingesting protein with various forms of carbohydrate following resistance-exercise on substrate availability and markers of anabolism, catabolism, and immunity. J Int Soc Sport Nutr. 2007;4:18. doi:10.1186/1550-2783-4-18
   Web of Science ®Google Scholar
• Hulmi JJ, Laakso M, Mero AA, Häkkinen K, Ahtiainen JP, Peltonen H. The effects of whey protein with or without carbohydrates on resistance training adaptations. J Int Soc Sports Nutr. 2015;12:48. doi:10.1186/s12970-015-0109-4
   Web of Science ®Google Scholar
• Kerksick CM, Rasmussen C, Lancaster S, et al. Impact of differing protein sources and a creatine containing nutritional formula after 12 weeks of resistance training. Nutrition. 2007;23(9):647–656. doi:10.1016/j.nut.2007.06.015
   PubMed Web of Science ®Google Scholar
• Naclerio F, Larumbe-Zabala E, Larrosa M, Centeno A, Esteve-Lanao J, Moreno-Perez D. Intake of animal protein blend plus carbohydrate improves body composition with no impact on performance in endurance athletes. Int J Sport Nutr Exerc Metab. 2019;1–7. doi:10.1123/ijsnem.2018-0359
   Web of Science ®Google Scholar
• Willoughby DS, Stout JR, Wilborn CD. Effects of resistance training and protein plus amino acid supplementation on muscle anabolic, mass, and strength. Amin Acids. 2007;32:467–477. doi:10.1007/s00726-006-0398-7
   PubMed Web of Science ®Google Scholar
• Jakubowski JS, Wong EPT, Nunes EA, et al. Equivalent Hypertrophy and Strength Gains in HMB- or Leucine-supplemented Men. Med Sci Sport Exerc. 2019;51(1):65–74. doi:10.1249/MSS.0000000000001752
   PubMed Web of Science ®Google Scholar
• Cooper R, Naclerio F, Larumbe-Zabala E, Chassin C, Allgrove A, Jimenez A. Effects of a carbohydrate-protein-creatine supplement on strength performance and body composition in recreationally resistance trained young Men. JOEP Online. 2013;16(1):72–85.
   Google Scholar
• Willems ME, Sallis CW, Haskell JA. Effects of multi-ingredient supplementation on resistance training in young males. J Hum Kinet. 2012;33:91–101. doi:10.2478/v10078-012-0048-y
   PubMed Web of Science ®Google Scholar
• Tipton KD, Wolf R. Exercise, protein metabolism and muscle growth. Int J Sport Nutr Exc Metab. 2001;11(1):109–132. doi:10.1123/ijsnem.11.1.109
   PubMed Web of Science ®Google Scholar
• Breen L, Philp A, Witard OC, et al. The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis. J Physiol. 2011;589:4011–4025. doi:10.1113/jphysiol.2011.211888
   PubMed Web of Science ®Google Scholar
• Greenhaff PL, Karagounis LG, Peirce N, et al. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am J Physiol Endocrinol Metab. 2008;295:E595–E604. doi:10.1152/ajpendo.90411.2008
   Web of Science ®Google Scholar
• Glynn EL, Fry CS, Drummond MJ, et al. Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. Am J Physiol Integr Comp Physiol. 2010;299:R533–R540. doi:10.1152/ajpregu.00077.2010
   PubMed Web of Science ®Google Scholar
• Cribb PJ, Williams AD, Stathis CG, Carey MF, Hayes A. Effects of whey isolate, creatine, and resistance training on muscle hypertrophy. Med Sci Sport Exerc. 2007;39(2):298–307. doi:10.1249/01.mss.0000247002.32589.ef
   PubMed Web of Science ®Google Scholar
• Kerksick CM, Arent S, Schoenfeld BJ, et al. International society of sports nutrition position stand: nutrient timing. J Int Soc Sport Nutr. 2017;14:33. doi:10.1186/s12970-017-0189-4
   PubMed Web of Science ®Google Scholar
• Naclerio F, Seijo-Bujia M, Larumbe-Zabala E, Earnest CP. Carbohydrates alone or mixing with beef or whey protein promote similar training outcomes in resistance training males: a double-blind, randomized controlled clinical trial. Int J Sport Nutr Exerc Metab. 2017;27(5):408–420. doi:10.1123/ijsnem.2017-0003
   PubMed Web of Science ®Google Scholar
• Churchward-Venne TA, Pinckaers PJM, van Loon JJA, van Loon LJC. Consideration of insects as a source of dietary protein for human consumption. Nutr Rev. 2017;75(12):1035–1045. doi:10.1093/nutrit/nux057
   PubMed Web of Science ®Google Scholar