References
- Rapin L, Gamaoun R, El Hage C, Arboleda MF, Prosk E. Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic. J Cannabis Res. 2021;3(1):19. doi:10.1186/s42238-021-00078-w
- James TR, Richards AA, Lowe DA, Reid WA, Watson CT, Pepple DJ. The in vitro effect of delta-9-tetrahydrocannabinol and cannabidiol on whole blood viscosity, elasticity and membrane integrity. J Cannabis Res. 2022;4(1):15. doi:10.1186/s42238-022-00126-z
- Khodadadi H, Salles EL, Jarrahi A, et al. Cannabidiol modulates cytokine storm in acute respiratory distress syndrome induced by simulated viral infection using synthetic RNA. Cannabis Cannabinoid Res. 2020;5(3):197–201. doi:10.1089/can.2020.0043
- Vuolo F, Abreu SC, Michels M, et al. Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma. Eur J Pharmacol. 2019;843:251–259. doi:10.1016/j.ejphar.2018.11.029
- Vuolo F, Petronilho F, Sonai B, et al. Evaluation of serum cytokines levels and the role of cannabidiol treatment in animal model of asthma. Mediators Inflamm. 2015;2015:538670. doi:10.1155/2015/538670
- Turner S, Barker VD, Adams AA. Effects of cannabidiol on the in vitro lymphocyte pro-inflammatory cytokine production of senior horses. J Equine Vet Sci. 2021;103:103668. doi:10.1016/j.jevs.2021.103668
- Chan JZ, Duncan RE. Regulatory effects of cannabidiol on mitochondrial functions: a review. Cells. 2021;10(5):1251. doi:10.3390/cells10051251
- Li Y, Li X, Cournoyer P, et al. Cannabidiol-induced transcriptomic changes and cellular senescence in human sertoli cells. Toxicol Sci. 2023;191(2):227–238. doi:10.1093/toxsci/kfac131
- Kumari R, Jat P. Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front Cell Dev Biol. 2021;9:645593. doi:10.3389/fcell.2021.645593
- Gerasymchuk M, Robinson GI, Groves A, et al. Phytocannabinoids stimulate rejuvenation and prevent cellular senescence in human dermal fibroblasts. Cells. 2022;11(23):3939. doi:10.3389/fcell.2021.645593
- Pandelides Z, Thornton C, Faruque AS, Whitehead AP, Willett KL, Ashpole NM. Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio). Geroscience. 2020;42(2):785–800. doi:10.1007/s11357-020-00182-4
- Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007;150(5):613–623. doi:10.1038/sj.bjp.0707133
- Cheng F Polypharmacology analysis of anti-osteoporosis agents and cannabinoid 2 receptor inverse agonists for osteoporosis drug research. [Master’s Thesis]. University of Pittsburgh; 2014. Available from: http://d-scholarship.pitt.edu/id/eprint/21179. Accessed November 1, 2023.
- Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol Cell. 2000;5(1):173–179. doi:10.1016/s1097-2765(00)80413-x
- Peres FF, Lima AC, Hallak JEC, Crippa JA, Silva RH, Abílio VC. Cannabidiol as a promising strategy to treat and prevent movement disorders? Front Pharmacol. 2018;9:482. doi:10.3389/fphar.2018.00482
- Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2^-DDCT Method. Methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262
- Trivedi MK, Mondal SC, Gangwar M, Jana S. Effect of a novel ashwagandha-based herbomineral formulation on pro-inflammatory cytokines expression in mouse splenocyte cells: a potential immunomodulator. Pharmacogn Mag. 2017;13(Suppl 1):S90–S94. doi:10.4103/0973-1296.197709
- Bao Z, Dai X, Wang P, Tao Y, Chai D. Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways. Cell Cycle. 2019;18(12):1379–1392. doi:10.1080/15384101.2019.1618119
- An D, Peigneur S, Hendrickx LA, Tytgat J. Targeting cannabinoid receptors: current status and prospects of natural products. Int J Mol Sci. 2020;21(14):5064. doi:10.3390/ijms21145064
- Henshaw FR, Dewsbury LS, Lim CK, Steiner GZ. The effects of cannabinoids on pro- and anti-inflammatory cytokines: a systematic review of in vivo studies. Cannabis Cannabinoid Res. 2021;6(3):177–195. doi:10.1089/can.2020.0105
- Aswad M, Hamza H, Pechkovsky A, et al. High-CBD extract (CBD-X) downregulates cytokine storm systemically and locally in inflamed lungs. Front Immunol. 2022;13:875546. doi:10.3389/fimmu.2022.875546
- Peyravian N, Deo S, Daunert S, Jimenez JJ. The anti-inflammatory effects of cannabidiol (CBD) on acne. J Inflamm Res. 2022;15:2795–2801. doi:10.2147/JIR.S355489
- Palmieri B, Laurino C, Vadalà M. A therapeutic effect of CBD-enriched ointment in inflammatory skin diseases and cutaneous scars. Clin Ter. 2019;170(2):e93–e99. doi:10.7417/CT.2019.2116
- Dobrev H. Clinical and instrumental study of the efficacy of a new sebum control cream. J Cosmet Dermatol. 2007;6(2):113–118. doi:10.1111/j.1473-2165.2007.00306.x
- Ghovanloo MR, Ruben PC. Cannabidiol and sodium channel pharmacology: general overview, mechanism, and clinical implications. Neuroscientist. 2022;28(4):318–334. doi:10.1177/10738584211017009
- Wang Z, Zheng P, Nagaratnam N, Solowij N, Huang X. Parkin mediates cannabidiol prevention of amyloid-beta-induced senescence in human astrocytes. Cannabis and Cannabinoid Res. 2023. doi:10.1089/can.2022.0186
- Gross C, Ramirez DA, McGrath S, Gustafson DL. Cannabidiol induces apoptosis and perturbs mitochondrial function in human and canine glioma cells. Front Pharmacol. 2021;12:725136. doi:10.3389/fphar.2021.725136
- Valvassori SS, Bavaresco DV, Scaini G, et al. Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain. Braz J Psychiatry. 2013;35(4):380–386. doi:10.1590/1516-4446-2012-0886
- Lu R, Zhang YG, Xia Y, et al. Paneth cell alertness to pathogens maintained by vitamin D receptors. Gastroenterology. 2021;160(4):1269–1283. doi:10.1053/j.gastro.2020.11.015
- Matos C, Mamilos A, Shah PN, et al. Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation. Front Immunol. 2022;13:1028850. doi:10.3389/fimmu.2022.1028850
- Trivedi MK, Mondal S, Jana S. Cannabidiol improves thyroid function via modulating vitamin D3 receptor in vitamin D3 deficiency diet-induced rat model. J Food Sci Technol. 2022;59(8):3237–3244. doi:10.1007/s13197-022-05492-3
- Navarrete F, García-Gutiérrez MS, Aracil-Fernández A, Lanciego JL, Manzanares J. Cannabinoid CB1 and CB2 receptors, and monoacylglycerol lipase gene expression alterations in the basal ganglia of patients with Parkinson’s disease. Neurotherapeutics. 2018;15(2):459–469. doi:10.1007/s13311-018-0603-x
- Navarro G, Carriba P, Gandı´a J, et al. Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer. Sci World J. 2008;8:1088–1097. doi:10.1100/tsw.2008.136