Betalain-rich red beet concentrate improves reduced knee discomfort and joint function: a double blind, placebo-controlled pilot clinical study

Refrences

• Steinbeck MJ, Nesti LJ, Sharkey PF, Parvizi J. Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the disease. J Orthop Res. 2007;25(9):1128–1135.
   PubMed Web of Science ®Google Scholar
• Katrantzis M, Baker MS, Handley CJ, Lowther DA. The oxidant hypochlorite (OCl-), a product of the myeloperoxidase system, degrades articular cartilage proteoglycan aggregate. Free Radic Biol Med. 1991;10(2):101–109.
   PubMed Web of Science ®Google Scholar
• Bush TM, Shlotzhauer TL, Imai K. Nonsteroidal anti-inflammatory drugs. Proposed guidelines for monitoring toxicity. The Western journal of medicine. 1991;155(1):39–42.
   Google Scholar
• Allegra M, Tesoriere L, Livrea MA. Betanin inhibits the myeloperoxidase/nitrite-induced oxidation of human low-density lipoproteins. Free Radic Res. 2007;41(3):335–341.
   PubMed Web of Science ®Google Scholar
• Zielinska-Przyjemska M, Olejnik A, Dobrowolska-Zachwieja A, Grajek W. In vitro effects of beetroot juice and chips on oxidative metabolism and apoptosis in neutrophils from obese individuals. Phytotherapy research: PTR. 2009;23(1):49–55.
   PubMed Web of Science ®Google Scholar
• Gentile C, Tesoriere L, Allegra M, Livrea MA, D’Alessio P. Antioxidant betalains from cactus pear (Opuntia ficus-indica) inhibit endothelial ICAM-1 expression. Ann N Y Acad S. 2004;1028:481–486.
   PubMed Web of Science ®Google Scholar
• Wybraniec S, Starzak K, Skopinska A, Nemzer B, Pietrzkowski Z, Michalowski T. Studies on nonenzymatic oxidation mechanisms in neobetanin, betanin, and decarboxylated betanins. J Agric Food Chem. 2013;61(26):6465–6476.
   PubMed Web of Science ®Google Scholar
• Nemzer B, Pietrzkowski Z, Spórna A, Stalica P, Thresher W, Michałowski T, et al. Betalainic and nutritional profiles of pigment-enriched red beet root (Beta vulgaris L.) dried extracts. Food chemistry. 2011;127(1):42–53.
   Web of Science ®Google Scholar
• Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15(12):1833–1840.
   PubMed Web of Science ®Google Scholar
• Lee S, Inglett GE, Carriere CJ. Effect of Nutrim Oat Bran and Flaxseed on Rheological Properties of Cakes. Cereal Chemistry. 2004;81(5):637–642.
   Web of Science ®Google Scholar
• Mohamed AA, Rayas-Duarte P, Xu J, Palmquist DE, Inglett G. Hard Red Winter Wheat/Nutrim-OB Alkaline Fresh Noodles: Processing and Texture Analysis. Journal of Food Science. 2005;70(1):S1–S7.
   Web of Science ®Google Scholar
• Melzack R. The McGill Pain Questionnaire: major properties and scoring methods. Pain. 1975;1(3):277–299.
   PubMed Web of Science ®Google Scholar
• Melzack R. The McGill pain questionnaire: from description to measurement. Anesthesiology. 2005;103(1):199–202.
   PubMed Web of Science ®Google Scholar
• Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, et al. Development of a fatigue scale. J Psychosom Res. 1993;37(2):147–153.
   PubMed Web of Science ®Google Scholar
• Gift AG. Visual analogue scales: measurement of subjective phenomena. Nurs Res. 1989;38(5):286–268.
   PubMed Web of Science ®Google Scholar
• Lee KA, Hicks G, Nino-Murcia G. Validity and reliability of a scale to assess fatigue. Psychiatry Res. 1991;36(3):291–298.
   PubMed Web of Science ®Google Scholar
• Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149–1160.
   PubMed Web of Science ®Google Scholar
• Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–191.
   PubMed Web of Science ®Google Scholar
• Erdfelder E, Faul F. [A class of information integration models for the Oppel-Kundt illusion]. Z Psychol Z Angew Psychol. 1994;202(2):133–160. German.
   Web of Science ®Google Scholar
• Pietrzkowski Z, Nemzer B, Michałowski T, Wybraniec S. Influence of betalain-rich extract on reduction of discomfort associated with osteoarthritis. 2010. Available from: http://www.betalainsources.com/Betalain_Study.pdf. Accessed February 18,2014.
   Google Scholar
• Gandhi R, Tsvetkov D, Dhottar H, Davey JR, Mahomed NN. Quantifying the pain experience in hip and knee osteoarthritis. Pain Res Manag. 2010;15(4):224–228.
   Web of Science ®Google Scholar
• Creamer P, Lethbridge-Cejku M, Hochberg MC. Determinants of pain severity in knee osteoarthritis: effect of demographic and psychosocial variables using 3 pain measures. J Rheumatol. 1999;26(8):1785–1792.
   Web of Science ®Google Scholar
• Creamer P, Lethbridge-Cejku M, Hochberg MC. Factors associated with functional impairment in symptomatic knee osteoarthritis. Rheumatology (Oxford). 2000;39(5):490–496.
   PubMed Web of Science ®Google Scholar
• Sharma L, Cahue S, Song J, Hayes K, Pai YC, Dunlop D. Physical functioning over three years in knee osteoarthritis: role of psychosocial, local mechanical, and neuromuscular factors. Arthritis Rheum. 2003;48(12):3359–3370.
   PubMedGoogle Scholar
• Netzel M, Stintzing F, Quaas D, Strass G, Carle R, Bitsch R, et al. Renal excretion of antioxidative constituents from red beet in humans. Food Res Int. 2005;38(8):1051–1058.
   Web of Science ®Google Scholar
• Stintzing FC, Herbach KM, Mosshammer MR, Carle R, Yi W, Sellappan S, et al. Color, betalain pattern, and antioxidant properties of cactus pear (Opuntia spp.) clones. J Agric Food Chem. 2005;53(2):442–451.
   PubMed Web of Science ®Google Scholar
• Allegra M, Furtmuller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, et al. Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid. Biochem Biophys Res Commun. 2005;332(3):837–844.
   Web of Science ®Google Scholar