Critical appraisal of the role of glucosamine and chondroitin in the management of osteoarthritis of the knee

References

• Helmick CG, Felson DT, Lawrence RC, et al; for the National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008;58:15–25.
   PubMed Web of Science ®Google Scholar
• Lawrence RC, Felson DT, Helmick CG, et al; for the National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008;58:15–35.
   Google Scholar
• Frech TM, Clegg DO. The utility of nutraceuticals in the treatment of osteoarthritis. Curr Rheumatol Rep. 2007;9:25–30.
   PubMedGoogle Scholar
• Dieppe PA, Lohmander LS. Pathogenesis and management of pain in osteoarthritis. Lancet. 2005;365:965–973.
   PubMed Web of Science ®Google Scholar
• Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology. 2002;39:237–246.
   PubMed Web of Science ®Google Scholar
• Goldring MB, Otero M, Tsuchimochi K, et al. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis. 2008;67 Suppl 3:iii75-iii82.
   Web of Science ®Google Scholar
• Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000;43:1905–1915.
   PubMed Web of Science ®Google Scholar
• Huskisson EC. Glucosamine and chondroitin for osteoarthritis. J Int Med Res. 2008;36:1161–1179.
   PubMed Web of Science ®Google Scholar
• Vangsness CT Jr, Spiker W, Erickson J. A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. Arthroscopy. 2009;25:86–94.
   PubMed Web of Science ®Google Scholar
• Setnikar I, Rovati LC. Absorption, distribution, metabolism and excretion of glucosamine sulfate. A review. Arzneimittelforschung. 2001;51: 699–725.
   PubMed Web of Science ®Google Scholar
• Hochberg MC, Zhan M, Langenberg P. The rate of decline of joint space width in patients with osteoarthritis of the knee: a systematic review and meta-analysis of randomized placebo-controlled trials of chondroitin sulfate. Curr Med Res Opin. 2008;24:3029–3035.
   PubMed Web of Science ®Google Scholar
• Deal CL, Moskowitz RW. Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am. 1999;25:379–395.
   PubMed Web of Science ®Google Scholar
• Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15:1833–1840.
   PubMed Web of Science ®Google Scholar
• Lequesne MG, Mery C, Samson M, Gerard P. Indexes of severity for osteoarthritis of the hip and knee. Validation – value in comparison with other assessment tests. Scand J Rheumatol Suppl. 1987;65:85–89.
   PubMedGoogle Scholar
• Levels of Evidence. Oxford Centre for Evidence-based Medicine. URL: http://www.cebm.net/index.aspx?o=4590. Accessed 28 October, 2009.
   Google Scholar
• Müller-Fassbender H, Bach GL, Haase W, et al. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage. 1994;2:61–69.
   PubMedGoogle Scholar
• Noack W, Fischer M, Förster KK, et al. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage. 1994;2:51–59.
   PubMedGoogle Scholar
• Reginster JY, Derolsy R, Rovati LC, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: A randomized, placebo-controlled clinical trial. Lancet. 2001;357:251–256.
   PubMed Web of Science ®Google Scholar
• Bruyere O, Honore A, Ethgen O, et al. Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Osteoarthritis Cartilage. 2003;11:1–5.
   PubMed Web of Science ®Google Scholar
• Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis. Arch Intern Med. 2002;162:2113–2123.
   PubMed Web of Science ®Google Scholar
• Hughes R, Carr A. A randomized, double-blind, placebo controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford). 2002;41:279–284.
   PubMed Web of Science ®Google Scholar
• Cibere J, Kopec JA, Thorne A, et al. Randomized, double blind, placebocontrolled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum. 2004;51:738–745.
   PubMed Web of Science ®Google Scholar
• Herrero-Beaumont G, Ivorra JA, Del Carmen Trabada M, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis Rheum. 2007;56:555–567.
   PubMed Web of Science ®Google Scholar
• Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol. 1999;26:2423–2430.
   PubMed Web of Science ®Google Scholar
• McAlindon TE, Formica M, LaValley M, Lehmer M, Kabbara K. Effectiveness of glucosamine for symptoms of knee osteoarthritis: Results from an internet-based randomized double-blind controlled trial. Am J Med. 2004;117:643–649.
   PubMed Web of Science ®Google Scholar
• Morreale P, Manopulo R, Galati M, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol. 1996;23:1385–1391.
   PubMed Web of Science ®Google Scholar
• Bucsi L, Poór G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage. 1998; 6 Suppl A:31–46.
   Google Scholar
• Bourgeois P Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3 × 400 mg/day vs placebo. Osteoarthritis Cartilage. 1998;6:25–30.
   Web of Science ®Google Scholar
• Mazieres B, Combe B, Phan Van A, et al. Chondroitin sulfate in osteoarthritis of the knee: A prospective, double blind, placebo controlled multicenter clinical study. J Rheumatol. 2001;28:173–181.
   Google Scholar
• Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroi- tin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage. 1998;6 Suppl A:39–6.
   Google Scholar
• Uebelhart D, Malaise M, Marcolongo R, et al. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: A one year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage. 2004;12:269–276.
   PubMed Web of Science ®Google Scholar
• Michel BA, Stucki G, Frey D, et al. Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: A randomized, controlled trial. Arthritis Rheum. 2005;52:779–786.
   PubMed Web of Science ®Google Scholar
• Mazieres B, Hucher M, Zaim M, Garnero P. Effect of chondroitin sulfate in symptomatic knee osteoarthritis: A multicentre, randomised, doubleblind, placebo-controlled study. Ann Rheum Dis. 2007;66:639–645.
   PubMed Web of Science ®Google Scholar
• Kahan A, Uebelhart D, De Vathaire F, et al. Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2009;60:524–533.
   PubMed Web of Science ®Google Scholar
• Clegg D, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354:795–808.
   PubMed Web of Science ®Google Scholar
• Hochberg MC, Clegg DO. Potential effects of chondroitin sulfate on joint swelling: a GAIT report. Osteoarthritis Cartilage. 2008;16 Suppl 3: S22–S24.
   Google Scholar
• Sawitzke AD, Shi H, Finco MF, et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum. 2008;58:3183–3191.
   PubMed Web of Science ®Google Scholar
• Messier SP, Mihalko S, Loeser RF, et al. Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study. Osteoarthritis Cartilage. 2007;15:1256–1266.
   PubMed Web of Science ®Google Scholar
• Leffler CT, Philippi AF, Leffler SG, et al. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med. 1999;164:85–91.
   PubMed Web of Science ®Google Scholar
• Das A Jr., Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000;8:343–350.
   PubMed Web of Science ®Google Scholar
• McAlindon TE, LaValley MP, Gulin JP, et al. Glucosamine and chondroitin for treatment of osteoarthritis: A systematic quality assessment and meta-analysis. JAMA. 2000;283:1469–1475.
   PubMed Web of Science ®Google Scholar
• Richy F, Bruyere O, Ethgen O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: A comprehensive meta-analysis. Arch Intern Med. 2003;163:1514–1522.
   PubMed Web of Science ®Google Scholar
• Bjordal JM, Kloving A, Ljunggren AE, Slordal L. Short-term efficacy of pharmacotherapeutic interventions in osteoarthritic knee pain: A meta-analysis of randomized placebo-controlled trials. Eur J Pain. 2007;11:125–138.
   PubMed Web of Science ®Google Scholar
• Leeb BF, Schweitzer H, Montag K, Smolen JS. A meta-analysis of chondroitin sulfate in the treatment of osteoarthritis. J Rheumatol. 2000;27:205–211.
   PubMed Web of Science ®Google Scholar
• Reichenbach S, Sterchi R, Scherer M, et al. Meta-analysis: Chondroi- tin for osteoarthritis of the knee or hip. Ann Intern Med. 2007;146: 580–590.
   PubMed Web of Science ®Google Scholar
• Towheed TE, Maxwell L, Anastassiades TP, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005;2. Art. No: CD002946.
   Web of Science ®Google Scholar
• Jordan KM, Arden NK, Doherty M, et al. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2003;62:1145–1155.
   PubMed Web of Science ®Google Scholar
• Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16:137–162.
   PubMed Web of Science ®Google Scholar
• Osteoarthritis: National clinical guideline for care and management in adults. Royal College of Physicians. National Institute for Health and Clinical Excellence (NICE). 2008. URL: http://www.nice.org.uk/nicemedia/pdf/CG059FullGuideline.pdf. Accessed 30 October, 2009.
   Google Scholar
• Wluka AE, Wolfe R, Stuckey S, Cicuttini FM. How does tibial cartilage volume relate to symptoms in subjects with knee osteoarthritis? Ann Rheum Dis. 2004;63:264–268.
   PubMed Web of Science ®Google Scholar
• Cicuttini FM, Jones G, Forbes A, Wluka AE. Rate of cartilage loss at two years predicts subsequent total knee arthroplasty: a prospective study. Ann Rheum Dis. 2004;63:1124–1127.
   PubMed Web of Science ®Google Scholar
• Bruyere O, Richy F, Reginster JY. Three year joint space narrowing predicts long-term incidence of knee surgery in patients with osteoarthritis: an eight year prospective follow up study. Ann Rheum Dis. 2005;64:1727–1730.
   PubMed Web of Science ®Google Scholar
• Jones G, Ding C, Scott F, et al. Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females. Osteoarthritis Cartilage. 2004;12:169–174.
   PubMedGoogle Scholar
• Teichtahl AJ, Wluka AE, Davies-Tuck ML, Cicuttini FM. Imaging of knee osteoarthritis. Best Pract Res Clin Rheumatol. 2008;22:1061–1074.
   Web of Science ®Google Scholar
• Cicuttini FM, Wluka AE, Stuckey SL. Tibial and femoral cartilage changes in knee osteoarthritis. Ann Rheum Dis. 2001;60:977–980.
   PubMed Web of Science ®Google Scholar
• Bekelman JE, Li Y, Gross CP. Scope and impact of financial conflicts of interest in biomedical research: A systematic re-view. JAMA. 2003;289:454–465
   PubMed Web of Science ®Google Scholar
• Russell AS, Aghazadeh-Habashi A, Jamali F. Active ingredient consistency of commercially available glucosamine sulfate products. J Rheumatol. 2002;29:2407–2409.
   PubMed Web of Science ®Google Scholar
• Barnhill JG, Fye CL, Williams DW, et al. Chondroitin product selection for the glucosamine/chondroitin arthritis intervention trial. J Am Pharm Assoc. 2006;46:14–24.
   Google Scholar