Exercise is medicine for patients with major depressive disorders: but only if the “pill” is taken!

References

• KesslerRCBerglundPDemlerONational Comorbidity Survey ReplicationThe epidemiology of major depressive disorder. Results from the national comorbidity survey replicationJAMA200318233095310512813115
   PubMed Web of Science ®Google Scholar
• KesslerRCBerglundPDemlerOJinRMerikangasKRWaltersEELifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replicationArch Gen Psychiatry200562659360215939837
   PubMed Web of Science ®Google Scholar
• MurrayCJLopezADGlobal mortality, disability, and the contribution of risk factors: global burden of disease studyLancet19973499063143614429164317
   PubMed Web of Science ®Google Scholar
• LépineJ-PBrileyMThe increasing burden of depressionNeuropsychiatr Dis Treat20117suppl 13721750622
   PubMedGoogle Scholar
• World Health OrganizationThe World Health Report 2001-Mental Health: New Understanding, New HopeGenevaWorld Health Organization2001
   Google Scholar
• BlumenthalJASmithPJHoffmanBMIs exercise a viable treatment for depression?ACSMs Health Fit J2012164142123750100
   PubMed Web of Science ®Google Scholar
• VancampfortDMitchellAJDe HertMType 2 diabetes in patients with major depressive disorder: a meta-analysis of prevalence estimates and predictorsDepress Anxiety2015321076377326114259
   PubMed Web of Science ®Google Scholar
• LuppinoFSde WitLMBouvyPFOverweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studiesArch Gen Psychiatry201067322022920194822
   PubMed Web of Science ®Google Scholar
• PanASunQOkerekeOIRexrodeKMHuFBDepression and risk of stroke morbidity and mortality: a meta-analysis and systematic reviewJAMA2011306111241124921934057
   PubMed Web of Science ®Google Scholar
• DharAKBartonADDepression and the link with cardiovascular diseaseFront Psychiatry201671926903886
   PubMed Web of Science ®Google Scholar
• GoldsteinBICarnethonMRMatthewsKAAmerican Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Disease in the YoungMajor depressive disorder and bipolar disorder predispose youth to accelerated atherosclerosis and early cardiovascular disease: a scientific statement from the American Heart AssociationCirculation20151321096598626260736
   PubMed Web of Science ®Google Scholar
• CuijpersPVogelzangsNTwiskJKleiboerALiJPenninxBWDifferential mortality rates in major and subthreshold depression: meta-analysis of studies that measured bothBr J Psychiatry20132021222723284149
   PubMed Web of Science ®Google Scholar
• WalkerERMcGeeREDrussBGMortality in mental disorders and global disease burden implications: a systematic review and meta-analysisJAMA Psychiatry201572433434125671328
   PubMed Web of Science ®Google Scholar
• ThornicroftGPhysical health disparities and mental illness: the scandal of premature mortalityBr J Psychiatry2011199644144222130744
   PubMed Web of Science ®Google Scholar
• SmithDDempsterCGlanvilleJFeemantleNAndersonIEfficacy and tolerability of venlafaxine compared with selective serotonin re-uptake inhabitors and other antidepresssants: a meta-analysisBr J Psychiatry200218039640411983635
   PubMed Web of Science ®Google Scholar
• TrivediMHDalyEJTreatment strategies to improve and sustain remission in major depressive disorderDialogues Clin Neurosci200810437738419170395
   PubMedGoogle Scholar
• NemeroffCBPrevalence and management of treatment-resistant depressionJ Clin Psychiatry200768suppl 8172517640154
   PubMed Web of Science ®Google Scholar
• TrivediMHFavaMWisniewskiSRSTAR*D Study TeamMedication augmentation after the failure of SSRIs for depressionN Engl J Med2006354121243125216554526
   PubMed Web of Science ®Google Scholar
• DunnALTrivediMHKampertJBClarkCGChamblissHOExercise treatment for depression: efficacy and dose responseAm J Prev Med20052811815626549
   PubMed Web of Science ®Google Scholar
• RethorstCDWipfliBMLandersDMThe antidepressive effects of exercise: a meta-analysis of randomized trialsSports Med200939649151119453207
   PubMed Web of Science ®Google Scholar
• LawlorDAHopkerSWThe effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trialsBMJ2001322728976376711282860
   PubMed Web of Science ®Google Scholar
• KroghJNordentoftMSterneJALawlorDAThe effect of exercise in clinically depressed adults: systematic review and meta-analysis of randomized controlled trialsJ Clin Psychiatry201172452953821034688
   PubMed Web of Science ®Google Scholar
• CraftLLLandersDMThe effect of exercise on clinical depression and depression resulting from mental illness: a meta-analysisJ Sport Exerc Psychol199820339357
   Web of Science ®Google Scholar
• StathopoulouGPowersMBBerryACSmitsJAJOttoMWExercise interventions for mental health: a quantitative and qualitative reviewClin Psychol Sci Pract2006132179193
   Web of Science ®Google Scholar
• MeadGEMorleyDCampbellPGreigCAMcMurdoMETLawlorDAExercise for depressionCochrane Database Syst Rev20094CD004366.pub3
   Google Scholar
• SchuchFBVancampfortDRichardsJRosenbaumSWardPBStubbsBExercise as a treatment for depression: a meta-analysis adjusting for publication biasJ Psychiatr Res201677425126978184
   PubMed Web of Science ®Google Scholar
• CooneyGMDwanKGreigCAExercise for depressionCochrane Database Syst Rev20139CD004366.pub624026850
   PubMed Web of Science ®Google Scholar
• JosefssonTLindwallMArcherTPhysical exercise intervention in depressive disorders: meta-analysis and systematic reviewScand J Med Sci Sports201424225927223362828
   PubMed Web of Science ®Google Scholar
• SchuchFBVasconcelos-MorenoMPBorowskyCZimmermannABRochaNSFleckMPExercise and severe major depression: effect on symptom severity and quality of life at discharge in an inpatient cohortJ Psychiatr Res201561253225439084
   PubMed Web of Science ®Google Scholar
• Mota-PereiraJSilverioJCarvalhoSRibeiroJCFonteDRamosJModerate exercise improves depression parameters in treatment-resistant patients with major depressive disorderJ Psychiatr Res20114581005101121377690
   PubMed Web of Science ®Google Scholar
• SchuchFBDeslandesACStubbsBGosmannNPSilvaCTFleckMPNeurobiological effects of exercise on major depressive disorder: a systematic reviewNeurosci Biobehav Rev20166111126657969
   PubMed Web of Science ®Google Scholar
• StubbsBRosenbaumSVancampfortDWardPBSchuchFBExercise improves cardiorespiratory fitness in people with depression: a meta-analysis of randomized controlled trialsJ Affect Disord201619024925326523669
   PubMed Web of Science ®Google Scholar
• KodamaSSaitoKTanakaSCardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysisJAMA2009301192024203519454641
   PubMed Web of Science ®Google Scholar
• BlumenthalJABabyakMAMooreKAEffects of exercise training on older patients with major depressionArch Intern Med1999159192349235610547175
   PubMed Web of Science ®Google Scholar
• BlumenthalJABabyakMADoraiswamyPMExercise and pharmacotherapy in the treatment of major depressive disorderPsychosom Med200769758759617846259
   PubMed Web of Science ®Google Scholar
• HoffmanBMBabyakMACraigheadWEExercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE studyPsychosom Med201173212713321148807
   PubMed Web of Science ®Google Scholar
• BabyakMBlumenthalJAHermanSExercise treatment for major depression: maintenance of therapeutic benefit at 10 monthsPsychosom Med200062563363811020092
   PubMed Web of Science ®Google Scholar
• SchuchFBVasconcelos-MorenoMPBorowskyCFleckMPExercise and severe depression: preliminary results of an add-on studyJ Affect Disord2011133361561821616540
   PubMed Web of Science ®Google Scholar
• BrandSColledgeFBeelerNThe current state of physical activity and exercise programs in German-speaking, Swiss psychiatric hospitals: results from a brief online surveyNeuropsychiatr Dis Treat2016121309131727350748
   PubMed Web of Science ®Google Scholar
• KrämerLHelmesAWBengelJUnderstanding activity limitations in depression: integrating the concepts of motivation and volition from health psychology into clinical psychologyEur Psychol2014194278288
   Web of Science ®Google Scholar
• KrämerLVHelmesAWSeeligHFuchsRBengelJCorrelates of reduced exercise behaviour in depression: the role of motivational and volitional deficitsPsychol Health201429101206122524785393
   PubMed Web of Science ®Google Scholar
• FuchsRGöhnerWSeeligHEffects of a standardized group intervention on physical exercise and health: the MoVo-conceptJ Phys Act Health20118679480321832294
   PubMed Web of Science ®Google Scholar
• GerberMFuchsRPühseUDer Einfluss eines Kurz-Interventionsprogramms (MoVo-Lisa) auf das Bewegungsverhalten und die Determinanten köperlich-sportlicher Aktivität bei übergewichtigen und fettleibigen Personen [Effects of a short exercise-intervention on sport participation and cognitive-behavioral antecedents of sport participation in a sample of overweight and obese individuals]Z Gesundheitspsychol201018159169
   Google Scholar
• SniehottaFFScholzUSchwarzerRFuhrmannBKiwusUVöllerHLong-term effects of two psychological interventions on physical exercise and self-regulation following coronary rehabilitationInt J Behav Med200512424425516262543
   PubMed Web of Science ®Google Scholar
• LippkeSZiegelmannJPSchwarzerRBehavioral intentions and action plans promote physical exercise: a longitudinal study with orthopedic rehabilitation patientsJ Sport Exerc Psychol2004263470483
   Web of Science ®Google Scholar
• SinghNAStavrinosTMScarbeckYGalambosGLiberCFiatarone SinghMAA randomized controlled trial of high versus low intensity weight training versus general practitioner care for clinical depression in older adultsJ Gerontol A Biol Sci Med Sci200560676877615983181
   PubMed Web of Science ®Google Scholar
• EkkekakisPHallEEPetruzzelloSJVariation and homogeneity in affective responses to physical activity of varying intensities: an alternative perspective on dose-response based on evolutionary considerationsJ Sports Sci200523547750016194996
   PubMed Web of Science ®Google Scholar
• SchneiderMDunnACooperDAffect, exercise, and physical activity among healthy adolescentsJ Sport Exerc Psychol200931670672320384008
   PubMed Web of Science ®Google Scholar
• MarkowitzSMArentSMThe exercise and affect relationship: evidence for the dual-mode model and a modified opponent process theoryJ Sport Exerc Psychol201032571173020980712
   PubMed Web of Science ®Google Scholar
• BluemkeMBrandRSchweizerGKahlertDExercise might be good for me, but I don’t feel good about it: do automatic associations predict exercise behavior?J Sport Exerc Psychol201032213715320479475
   PubMed Web of Science ®Google Scholar
• ConroyDEHydeALDoerksenSERibeiroNFImplicit attitudes and explicit motivation prospectively predict physical activityAnn Behav Med201039211211820140542
   PubMed Web of Science ®Google Scholar
• BiddleSJBatterhamAMHigh-intensity interval exercise training for public health: a big HIT or shall we HIT it on the head?Int J Behav Nutr Phys Act20151219526187579
   PubMed Web of Science ®Google Scholar