Methylphenidate dose optimization for ADHD treatment: review of safety, efficacy, and clinical necessity

References

• MoffittTEHoutsRAshersonPIs Adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a four-decade longitudinal cohort studyAm J Psychiatry201517296797725998281
   PubMed Web of Science ®Google Scholar
• FaraoneSVAntshelKMDiagnosing and treating attention-deficit/hyperactivity disorder in adultsWorld Psychiatry20087313113618836579
   PubMed Web of Science ®Google Scholar
• PolanczykGVWillcuttEGSalumGAKielingCRohdeLAADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysisInt J Epidemiol201443243444224464188
   PubMed Web of Science ®Google Scholar
• HillJCSchoenerEPAge-dependent decline of attention deficit hyperactivity disorderAm J Psychiatry19961539114311468780416
   PubMed Web of Science ®Google Scholar
• TurgayAGoodmanDWAshersonPLifespan persistence of ADHD: the life transition model and its applicationJ Clin Psychiatry201273219220122313720
   PubMed Web of Science ®Google Scholar
• KooijSJBejerotSBlackwellAEuropean consensus statement on diagnosis and treatment of adult ADHD: the European Network Adult ADHDBMC Psychiatry2010106720815868
   PubMed Web of Science ®Google Scholar
• LaraCFayyadJde GraafRChildhood predictors of adult attention-deficit/hyperactivity disorder: results from the World Health Organization World Mental Health Survey InitiativeBiol Psychiatry2009651465419006789
   PubMed Web of Science ®Google Scholar
• European Medicines Agency EGuideline on the clinical investigation of medicinal products for the treatment of attention deficit hyperactivity disorder (ADHD)2008 Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2010/08/WC500095686.pdfAccessed February, 2016
   Google Scholar
• American Psychiatric AssociationDiagnostic and Statistical Manual of Mental Disorders5th edDSM-5. American Psychiatric Publishing2012 Available from: http://www.dsm5.orgAccessed February, 2017
   Google Scholar
• GoodmanDWThe consequences of attention-deficit/hyperactivity disorder in adultsJ Psychiatr Pract200713531832717890980
   PubMedGoogle Scholar
• BiedermanJFaraoneSVSpencerTJMickEMonuteauxMCAleardiMFunctional impairments in adults with self-reports of diagnosed ADHD: a controlled study of 1001 adults in the communityJ Clin Psychiatry200667452454016669717
   PubMed Web of Science ®Google Scholar
• MortonWAStocktonGGMethylphenidate abuse and psychiatric side effectsPrim Care Companion J Clin Psychiatry20002515916415014637
   PubMedGoogle Scholar
• SaferDJRecent trends in stimulant usageJ Atten Disord201620647147726486603
   PubMed Web of Science ®Google Scholar
• RenouxCShinJYDell’AnielloSFergussonESuissaSPrescribing trends of attention-deficit hyperactivity disorder (ADHD) medications in UK primary care, 1995–2015Br J Clin Pharmacol201682385886827145886
   PubMed Web of Science ®Google Scholar
• TrenqueTHerlemEAbou TaamMDrameMMethylphenidate off-label use and safetySpringerplus2014328625279275
   PubMedGoogle Scholar
• HodgkinsPShawMCoghillDHechtmanLAmfetamine and methylphenidate medications for attention-deficit/hyperactivity disorder: complementary treatment optionsEur Child Adolesc Psychiatry201221947749222763750
   PubMed Web of Science ®Google Scholar
• CastellsXRamos-QuirogaJARigauDEfficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysisCNS Drugs201125215716921254791
   PubMed Web of Science ®Google Scholar
• ChanEFoglerJMHammernessPGTreatment of attention-deficit/hyperactivity disorder in adolescents: a systematic reviewJAMA2016315181997200827163988
   PubMed Web of Science ®Google Scholar
• LichtensteinPHalldnerLZetterqvistJMedication for attention deficit-hyperactivity disorder and criminalityN Engl J Med20123672006201423171097
   PubMed Web of Science ®Google Scholar
• KonsteniusMJayaram-LindstromNGuterstamJBeckOPhilipsBFranckJMethylphenidate for attention deficit hyperactivity disorder and drug relapse in criminal offenders with substance dependence: a 24-week randomized placebo-controlled trialAddiction2014109344044924118269
   PubMed Web of Science ®Google Scholar
• ManKKChanEWCoghillDMethylphenidate and the risk of traumaPediatrics20151351404825511122
   PubMed Web of Science ®Google Scholar
• ShawMHodgkinsPCaciHA systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatmentBMC Med2012109922947230
   PubMed Web of Science ®Google Scholar
• MeszarosACzoborPBalintSKomlosiSSimonVBitterIPharmacotherapy of adult attention deficit hyperactivity disorder (ADHD): a metaanalysisInt J Neuropsychopharmacol20091281137114719580697
   PubMed Web of Science ®Google Scholar
• WilensTEDrug therapy for adults with attention-deficit hyperactivity disorderDrugs200363222395241114609347
   PubMed Web of Science ®Google Scholar
• FroehlichTEEpsteinJNNickTGPharmacogenetic predictors of methylphenidate dose-response in attention-deficit/hyperactivity disorderJ Am Acad Child Adolesc Psychiatry2011501111291139.e112222024001
   PubMed Web of Science ®Google Scholar
• GreenhillLLAbikoffHBArnoldLEMedication treatment strategies in the MTA Study: relevance to clinicians and researchersJ Am Acad Child Adolesc Psychiatry19963510130413138885584
   PubMed Web of Science ®Google Scholar
• VitielloBSevereJBGreenhillLLMethylphenidate dosage for children with ADHD over time under controlled conditions: lessons from the MTAJ Am Acad Child Adolesc Psychiatry200140218819611211367
   PubMed Web of Science ®Google Scholar
• CoghillDBanaschewskiTZuddasAPelazAGaglianoADoepfnerMLong-acting methylphenidate formulations in the treatment of attention-deficit/hyperactivity disorder: a systematic review of head-to-head studiesBMC Psychiatry20131323724074240
   PubMed Web of Science ®Google Scholar
• National Institute for Health and Care Excellence [NICE] guidelines for the treatment of adult ADHD2008 Available from: https://www.nice.org.uk/guidance/cg72Accessed February, 2016
   Google Scholar
• Canadian Attention Deficit Hyperactivity Disorder Resource Alliance (CADDRA): Canadian ADHD Practice Guidelines2014 Available from: https://caddra.ca/pdfs/caddraGuidelines2011.pdfAccessed February, 2016
   Google Scholar
• WolraichMBrownLBrownRTADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescentsPediatrics201112851007102222003063
   PubMed Web of Science ®Google Scholar
• American Psychiatric AssociationPractice Guideline for the Treatment of Patients with Major Depressive Disorder3rd ednWashington, DCAmerican Psychiatric Publishing2010
   Google Scholar
• AshersonPManorIHussMAttention-deficit/hyperactivity disorder in adults: update on clinical presentation and careNeuropsychiatry-Lond20144109128
   Google Scholar
• HussMGinsbergYTvedtenTMethylphenidate hydrochloride modified-release in adults with attention deficit hyperactivity disorder: a randomized double-blind placebo-controlled trialAdv Ther2014311446524371021
   PubMed Web of Science ®Google Scholar
• MedoriRRamos-QuirogaJACasasMA randomized, placebo-controlled trial of three fixed dosages of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorderBiol Psychiatry2008631098198918206857
   PubMed Web of Science ®Google Scholar
• SpencerTJAdlerLAMcGoughJJEfficacy and safety of dexmethylphenidate extended-release capsules in adults with attention-deficit/hyperactivity disorderBiol Psychiatry200761121380138717137560
   PubMed Web of Science ®Google Scholar
• SteinMASarampoteCSWaldmanIDA dose-response study of OROS methylphenidate in children with attention-deficit/hyperactivity disorderPediatrics20031125e40414595084
   PubMed Web of Science ®Google Scholar
• WigalSBNordbrockEAdjeiALChildressAKupperRJGreenhillLEfficacy of methylphenidate hydrochloride extended-release capsules (Aptensio XR™) in children and adolescents with attention-deficit/hyperactivity disorder: a phase III, randomized, double-blind studyCNS Drugs201529433134025877989
   PubMed Web of Science ®Google Scholar
• RapportMDDuPaulGJKellyKLAttention deficit hyperactivity disorder and methylphenidate: the relationship between gross body weight and drug response in childrenPsychopharmacol Bull19892522852902602521
   PubMedGoogle Scholar
• ChermaMDJosefssonMRydbergIMethylphenidate for treating ADHD: a naturalistic clinical study of methylphenidate blood concentrations in children and adults with optimized dosageEur J Drug Metab Pharmacokinet201742229530727220743
   PubMed Web of Science ®Google Scholar
• DouglasVIBarrRGAminKO’NeillMEBrittonBGDosage effects and individual responsivity to methylphenidate in attention deficit disorderJ Child Psychol Psychiatry19882944534753063718
   PubMed Web of Science ®Google Scholar
• Swedish Medical Products AgencyADHD drugs – treatment guide-linesThe Swedish Medical Products Agency201621324
   Google Scholar
• Ritalin LA [package insert]Novartis Pharmaceuticals CorporationEast Hanover, NJ62015 Available from: https://www.pharma.us.novartis.com/product/pi/pdf/ritalin_la.pdfAccessed February, 2016
   Google Scholar
• Aptensio XR [package insert]Patheon Manufacturing Services LLCGreenville, NC42015 Available from: http://www.aptensioxr.com/resources/full-prescribing-information.pdfAccessed February, 2016
   Google Scholar
• CONCERTA [package insert]ALZA CorporationMountain View, CA32007 Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021121s014lbl.pdfAccessed February, 2016
   Google Scholar
• Daytrana [package insert]Shire Pharmaceuticals Ireland Limited32007 Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021514s005lbl.pdfAccessed February, 2016
   Google Scholar
• Metadate ER [package insert]Mallinckrodt IncHazelwood, MO62015 Available from: www2.mallinckrodt.com/WorkArea/DownloadAsset.aspx?id=2147483760Accessed February, 2016
   Google Scholar
• Metadate CD [package insert]UCB, IncSmyrna, GA82008 http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021259s021lbl.pdfAccessed February, 2016
   Google Scholar
• Health NZMoNew Zealand Guidelines for the Assessment and Treatment of Attention-Deficit/Hyperactivity DisorderWellingtonMinistry of Health2001
   Google Scholar
• TakahashiNKohTTominagaYSaitoYKashimotoYMatsumuraTA randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of osmotic-controlled release oral delivery system methylphenidate HCl in adults with attention-deficit/hyperactivity disorder in JapanWorld J Biol Psychiatry20141548849824456065
   PubMed Web of Science ®Google Scholar
• GoodmanDWSurmanCBSchererPBSalinasGDBrownJJAssessment of physician practices in adult attention-deficit/hyperactivity disorderPrim Care Companion CNS Disord2012144
   Google Scholar
• EpsteinJNKelleherKJBaumRVariability in ADHD care in community-based pediatricsPediatrics201413461136114325367532
   PubMed Web of Science ®Google Scholar
• HussMGinsbergYArngrimTOpen-label dose optimization of methylphenidate modified release long acting (MPH-LA): a post hoc analysis of real-life titration from a 40-week randomized trialClin Drug Investig2014349639649
   Web of Science ®Google Scholar
• BuitelaarJKRamos-QuirogaJACasasMSafety and tolerability of flexible dosages of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorderNeuropsychiatr Dis Treat2009545746619777067
   PubMed Web of Science ®Google Scholar
• AdlerLAOrmanCStarrHLLong-term safety of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder: an open-label, dose-titration, 1-year studyJ Clin Psychopharmacol201131110811421192153
   PubMed Web of Science ®Google Scholar
• GreenhillLLSwansonJMVitielloBImpairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trialJ Am Acad Child Adolesc Psychiatry200140218018711211366
   PubMed Web of Science ®Google Scholar
• FredriksenMHalmoyAFaraoneSVHaavikJLong-term efficacy and safety of treatment with stimulants and atomoxetine in adult ADHD: a review of controlled and naturalistic studiesEur Neuropsychopharmacol201323650852722917983
   PubMed Web of Science ®Google Scholar
• BonviciniCFaraoneSVScassellatiCAttention-deficit hyperactivity disorder in adults: a systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studiesMol Psychiatry201621787288427217152
   PubMed Web of Science ®Google Scholar
• FredriksenMDahlAAMartinsenEWKlungsoyrOHaavikJPeleikisDEEffectiveness of one-year pharmacological treatment of adult attention-deficit/hyperactivity disorder (ADHD): an open-label prospective study of time in treatment, dose, side-effects and comorbidityEur Neuropsychopharmacol201424121873188425453480
   PubMed Web of Science ®Google Scholar
• GajriaKLuMSikiricaVAdherence, persistence, and medication discontinuation in patients with attention-deficit/hyperactivity disorder – a systematic literature reviewNeuropsychiatr Dis Treat2014101543156925187718
   PubMed Web of Science ®Google Scholar
• CorteseSPaneiPArcieriRSafety of methylphenidate and atomoxetine in children with attention-deficit/hyperactivity disorder (ADHD): data from the Italian National ADHD RegistryCNS Drugs20152986587726293742
   PubMed Web of Science ®Google Scholar
• MurrayMLInsukSBanaschewskiTAn inventory of European data sources for the long-term safety evaluation of methylphenidateEur Child Adolesc Psychiatry2013221060561823508655
   PubMed Web of Science ®Google Scholar
• GinsbergYArngrimTPhilipsenALong-term (1 year) safety and efficacy of methylphenidate modified-release long-acting formulation (MPH-LA) in adults with attention-deficit hyperactivity disorder: a 26-week, flexible-dose, open-label extension to a 40-week, double-blind, randomised, placebo-controlled core studyCNS Drugs2014281095196225183661
   PubMed Web of Science ®Google Scholar
• BuitelaarJKTrottGEHofeckerMLong-term efficacy and safety outcomes with OROS-MPH in adults with ADHDInt J Neuropsychopharmacol201215111321798108
   PubMed Web of Science ®Google Scholar
• FindlingRLWigalSBBuksteinOGLong-term tolerability of the methylphenidate transdermal system in pediatric attention-deficit/hyperactivity disorder: a multicenter, prospective, 12-month, open-label, uncontrolled, phase III extension of four clinical trialsClin Ther20093181844185519808143
   PubMed Web of Science ®Google Scholar
• ZhangSFariesDEVowlesMMichelsonDADHD Rating Scale IV: psychometric properties from a multinational study as a clinician-administered instrumentInt J Methods Psychiatr Res200514418620116395872
   PubMed Web of Science ®Google Scholar
• LeonACOlfsonMPorteraLFarberLSheehanDVAssessing psychiatric impairment in primary care with the Sheehan Disability ScaleInt J Psychiatry Med1997272931059565717
   PubMed Web of Science ®Google Scholar
• BuitelaarJKCasasMPhilipsenAFunctional improvement and correlations with symptomatic improvement in adults with attention deficit hyperactivity disorder receiving long-acting methylphenidatePsychol Med201242119520421733214
   PubMed Web of Science ®Google Scholar
• StoreboOJKroghHBRamstadEMethylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trialsBMJ2015351h520326608309
   PubMed Web of Science ®Google Scholar
• GinsbergYArngrimTPhilipsenASafety profile of methylphenidate hydrochloride-modified release (MPH-LA) in adults and children with attention deficit hyperactivity disorderEur Psychiat201429Suppl 11
   Google Scholar
• NuttDJFoneKAshersonPEvidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in adults: recommendations from the British Association for PsychopharmacologyJ Psychopharmacol2007211104117092962
   PubMed Web of Science ®Google Scholar
• Bolea-AlamanacBNuttDJAdamouMEvidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: update on recommendations from the British Association for PsychopharmacologyJ Psychopharmacol201428317920324526134
   PubMed Web of Science ®Google Scholar
• TaylorEDöpfnerMSergeantJEuropean clinical guidelines for hyperkinetic disorder–first upgradeEur Child Adolesc Psychiatry200413Suppl 11730
   Google Scholar
• LeeTCHashimAHKuanCSClinical practice guidelines. Management of attention deficit hyperactivity disorder in children and adolescents2008 Available from: http://www.acadmed.org.my/index.cfm?&menuid=67#Mental_Health
   Google Scholar
• National Health and Medical Research CouncilClinical Practice Points on the Diagnosis, Assessment and Management of Attention Deficit Hyperactivity Disorder in Children and AdolescentsCommonwealth of Australia2012
   Google Scholar
• Scottish Intercollegiate Guidelines NetworkManagement of Attention Deficit and Hyperactivity Disorders in Children and Young People – A National Clinical GuidelineScottish Intercollegiate Guidelines Network (SIGN)2009
   Google Scholar
• Development Group of the Clinical Practice Guideline on Attention Defi cit Hyperactivity Disorder (ADHD) in Children and Adolescents. Fundació Sant Joan de Déu, coordinator. Clinical Practice Guideline on Attention Deficit Hyperactivity Disorder (ADHD) in Children and AdolescentsQuality Plan for the National Health System of the Ministry of Health, Social Policies and Equality. Agència dinformació, Avaluació i Qualitat (AIAQS) of CataloniaClin Practice Guidelines Spanish NHS (SNS)2010
   Google Scholar