Exercise training increases spatial memory via reducing contralateral hippocampal NMDAR subunits expression in intracerebral hemorrhage rats

References

• Springer MV, Schmidt JM, Wartenberg KE, et al. Predictors of global cognitive impairment 1 year after subarachnoid hemorrhage. Neurosurgery. 2009;65(6):1043–1051. doi:10.1227/01.NEU.0000359317.15269.2019934963
   PubMed Web of Science ®Google Scholar
• Shimada H, Hamakawa M, Ishida A, et al. Low-speed treadmill running exercise improves memory function after transient middle cerebral artery occlusion in rats. Behav Brain Res. 2013;243:21–27. doi:10.1016/j.bbr.2012.12.01823266325
   PubMed Web of Science ®Google Scholar
• Lin Y, Dong J, Yan T, et al. Involuntary, forced and voluntary exercises are equally capable of inducing hippocampal plasticity and the recovery of cognitive function after stroke. Neurol Res. 2015;37(10):893–901. doi:10.1179/1743132815Y.000000007426179091
   PubMed Web of Science ®Google Scholar
• Yang L, Zhang J, Deng Y, et al. The effects of early exercise on motor, sense, and memory recovery in rats with stroke. Am J Phys Med Rehabil. 2017;96(3):e36–e43. doi:10.1097/PHM.000000000000067027977432
   PubMed Web of Science ®Google Scholar
• Liu Z, Li R, Jiang C, et al. The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3β inhibition in intracerebral hemorrhage rats. Eur J Pharmacol. 2018;840:50–59. doi:10.1016/j.ejphar.2018.10.01930336136
   PubMed Web of Science ®Google Scholar
• Sharp F, Liu DZ, Zhan X, et al. Intracerebral hemorrhage injury mechanisms: glutamate neurotoxicity, thrombin, and Src. Acta Neurochir Suppl. 2008;105:43–46.19066080
   PubMedGoogle Scholar
• Jolly S, Bazargani N, Quiroga AC, et al. G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia. J Cell Physiol. 2018;66(1):47–61.
   Google Scholar
• Hardingham GE, Bading H. The Yin and Yang of NMDA receptor signalling. Trends Neurosci. 2003;26(2):81–89. doi:10.1016/S0166-2236(02)00040-112536131
   PubMed Web of Science ®Google Scholar
• Paoletti P, Bellone C, Zhou Q. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci. 2013;14(6):383–400. doi:10.1038/nrn350423686171
   PubMed Web of Science ®Google Scholar
• Mayor D, Tymianski M. Neurotransmitters in the mediation of cerebral ischemic injury. Neuropharmacology. 2018;134(Pt B):178–188.29203179
   PubMed Web of Science ®Google Scholar
• Jaenisch N, Liebmann L, Guenther M, et al. Reduced tonic inhibition after stroke promotes motor performance and epileptic seizures. Sci Rep. 2016;6:26173. doi:10.1038/srep2617327188341
   PubMed Web of Science ®Google Scholar
• Gogas KR. Glutamate-based therapeutic approaches: NR2B receptor antagonists. Curr Opin Pharmacol. 2006;6(1):68–74. doi:10.1016/j.coph.2006.06.00216376149
   PubMed Web of Science ®Google Scholar
• Huang M, Cheng G, Tan H, et al. Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol. 2017;295:66–76. doi:10.1016/j.expneurol.2017.05.00128479337
   PubMed Web of Science ®Google Scholar
• Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat. Rev Neurosci. 2009;10(12):861. doi:10.1038/nrn273519888284
   PubMed Web of Science ®Google Scholar
• Takatsuru Y, Fukumoto D, Yoshitomo M, et al. Neuronal circuit remodeling in the contralateral cortical hemisphere during functional recovery from cerebral infarction. J Neurosci. 2009;29(32):10081–10086. doi:10.1523/JNEUROSCI.1638-09.200919675241
   PubMed Web of Science ®Google Scholar
• Rehme AK, Fink GR, von Cramon DY, et al. The role of the contralesional motor cortex for motor recovery in the early days after stroke assessed with longitudinal FMRI. Cereb Cortex. 2011;21(4):756–768. doi:10.1093/cercor/bhq14020801897
   PubMed Web of Science ®Google Scholar
• Penner MR, Mizumori SJ. Age-associated changes in the hippocampal-ventral striatum-ventral tegmental loop that impact learning, prediction, and context discrimination. Front Aging Neurosci. 2012;4:22. doi:10.3389/fnagi.2012.0002222891060
   PubMed Web of Science ®Google Scholar
• Liu T, Zhou J, Cui H, et al. Quantitative proteomic analysis of intracerebral hemorrhage in rats with a focus on brain energy metabolism. Brain Behav. 2018;8(11):e01130.30307711
   PubMed Web of Science ®Google Scholar
• Xu CS, Liu AC, Chen J, et al. Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion. J Neurochem. 2015;134(3):566–577. doi:10.1111/jnc.1313425903928
   PubMed Web of Science ®Google Scholar
• Hashimoto M, Araki Y, Takashima Y, et al. Hippocampal atrophy and memory dysfunction associated with physical inactivity in community-dwelling elderly subjects: the Sefuri study. Brain Behav. 2017;7(2):e00620. doi:10.1002/brb3.62028239530
   PubMed Web of Science ®Google Scholar
• Weilinger NL, Lohman AW, Rakai BD, et al. Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity. Nat Neurosci. 2016;19(3):432–442.26854804
   PubMed Web of Science ®Google Scholar
• Wu QJ, Tymianski M. Targeting NMDA receptors in stroke: new hope in neuroprotection. Mol Brain. 2018;11(1):15. doi:10.1186/s13041-018-0357-829534733
   PubMed Web of Science ®Google Scholar
• Lee A, Lingwood BE, Bjorkman ST, et al. Rapid loss of glutamine synthetase from astrocytes in response to hypoxia: implications for excitotoxicity. J Chem Neuroanat. 2010;39(3):211–220. doi:10.1016/j.jchemneu.2009.12.00220034557
   PubMed Web of Science ®Google Scholar
• Hu J, Pang WS, Han J, et al. Gualou Guizhi decoction reverses brain damage with cerebral ischemic stroke, multi-component directed multi-target to screen calcium-overload inhibitors using combination of molecular docking and protein-protein docking. J Enzyme Inhib Med Chem. 2018;33(1):115–125. doi:10.1080/14756366.2017.139645729185359
   PubMed Web of Science ®Google Scholar
• Jie P, Lu Z, Hong Z, et al. Activation of transient receptor potential vanilloid 4 is involved in neuronal injury in middle cerebral artery occlusion in mice. Mol Neurobiol. 2016;53(1):8–17. doi:10.1007/s12035-014-8992-225399955
   PubMed Web of Science ®Google Scholar
• Fan M, Xu H, Wang L, et al. Tissue plasminogen activator neurotoxicity is neutralized by recombinant ADAMTS 13. Sci Rep. 2016;6:25971. doi:10.1038/srep2597127181025
   PubMed Web of Science ®Google Scholar
• Weng X, Tan Y, Chu X, et al. N-methyl-D-aspartic acid receptor 1 (NMDAR1) aggravates secondary inflammatory damage induced by hemin-NLRP3 pathway after intracerebral hemorrhage. Chin J Traumatol. 2015;18(5):254–258. doi:10.1016/j.cjtee.2015.11.01026777707
   PubMedGoogle Scholar
• Zerche M, Weissenborn K, Ott C, et al. Preexisting serum autoantibodies against the NMDAR subunit NR1 modulate evolution of lesion size in acute ischemic stroke. Stroke. 2015;46(5):1180–1186. doi:10.1161/STROKEAHA.114.00832325765725
   PubMed Web of Science ®Google Scholar
• During MJ, Symes CW, Lawlor PA, et al. An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy. Science. 2000;287(5457):1453–1460. doi:10.1126/science.287.5457.145310688787
   PubMed Web of Science ®Google Scholar
• Yun X, Maximov VD, Yu J, et al. Nanoparticles for targeted delivery of antioxidant enzymes to the brain after cerebral ischemia and reperfusion injury. J Cereb Blood Flow Metab. 2013;33(4):583–592. doi:10.1038/jcbfm.2012.20923385198
   PubMed Web of Science ®Google Scholar
• Gu J, Chen J, Yang N, et al. Combination of Ligusticum chuanxiong and Radix Paeoniae ameliorate focal cerebral ischemic in MCAO rats via endoplasmic reticulum stress-dependent apoptotic signaling pathway. Nat Neurosci. 2016;187:313–324.
   Google Scholar
• Balsara R, Dang A, Donahue DL, et al. Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke. PLoS One. 2015;10(3):e0122840. doi:10.1371/journal.pone.012284025822337
   PubMed Web of Science ®Google Scholar
• Jiang XF, Zhang T, Sy C, et al. Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study. Neurol Res. 2014;36(5):475–482. doi:10.1179/1743132814Y.000000035024649810
   PubMed Web of Science ®Google Scholar