Thymosin β4 prevents oxygen-glucose deprivation/reperfusion-induced injury in rat cortical neurons

References

• Philippart R, Brunet-Bernard A, Clementy N, et al. Oral anticoagulation, stroke and thromboembolism in patients with atrial fibrillation and valve bioprosthesis. The Loire Valley Atrial Fibrillation Project. Thromb Haemost. 2016;115(5):1056–1063. doi:10.1160/TH16-01-000726843425
   PubMed Web of Science ®Google Scholar
• Smith EE, Saposnik G, Biessels GJ, et al. Prevention of stroke in patients with silent cerebrovascular disease: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2017;48(2):e44–e71. doi:10.1161/STR.000000000000011627980126
   PubMed Web of Science ®Google Scholar
• Chong WC, Shastri MD, Eri R. Endoplasmic reticulum stress and oxidative stress: a vicious nexus implicated in bowel disease pathophysiology. Int J Mol Sci. 2017;18(4):E771.28379196
   PubMed Web of Science ®Google Scholar
• Shi B, Ding Q, He X, et al. Tbeta4-overexpression based on the piggyBac transposon system in cashmere goats alters hair fiber characteristics. Transgenic Res. 2017;26(1):77–85.27900536
   PubMed Web of Science ®Google Scholar
• Ziegler T, Bahr A, Howe A, et al. Tbeta4 increases neovascularization and cardiac function in chronic myocardial ischemia of normo- and hypercholesterolemic pigs. Mol Ther. 2018;26(7):1706–1714.29929787
   PubMed Web of Science ®Google Scholar
• Akpinar H, Naziroglu M, Ovey IS, Cig B, Akpinar O. The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: contribution of TRPM2 and TRPV1 channels. Sci Rep. 2016;6:37196.27872485
   PubMed Web of Science ®Google Scholar
• Morris DC, Cui Y, Cheung WL, et al. A dose-response study of thymosin beta4 for the treatment of acute stroke. J Neurol Sci. 2014;345(1–2):61–67.25060418
   PubMed Web of Science ®Google Scholar
• Morris DC, Cheung WL, Loi R, et al. Thymosin beta4 for the treatment of acute stroke in aged rats. Neurosci Lett. 2017;659:7–13.28864242
   PubMed Web of Science ®Google Scholar
• Ji H, Xu L, Wang Z, Fan X, Wu L. Effects of thymosin beta4 on oxygenglucose deprivation and reoxygenationinduced injury. Int J Mol Med. 2018;41(3):1749–1755.29328391
   PubMed Web of Science ®Google Scholar
• Song Z, Chen H, Xu W, Wu S, Zhu G. Basolateral amygdala calpain is required for extinction of contextual fear-memory. Neurobiol Learn Mem. 2018;155:180–188. doi:10.1016/j.nlm.2018.08.00430086394
   PubMed Web of Science ®Google Scholar
• Zhu G, Wang X, Wu S, Li Q. Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. Neurochem Int. 2012;60(4):400–408. doi:10.1016/j.neuint.2012.01.00322265823
   PubMed Web of Science ®Google Scholar
• Li J, Yang S, Zhu G. Postnatal calpain inhibition elicits cerebellar cell death and motor dysfunction. Oncotarget. 2017;8(50):87997–88007. doi:10.18632/oncotarget.2132429152136
   PubMedGoogle Scholar
• Trenkwalder T, Deindl E, Bongiovanni D, et al. Thymosin-beta4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway. Expert Opin Biol Ther. 2015;15(Suppl 1):S175–S185. doi:10.1517/14712598.2015.101112225652683
   PubMed Web of Science ®Google Scholar
• Pipes GT, Yang J. Cardioprotection by thymosin beta 4. Vitam Horm. 2016;102:209–226. doi:10.1016/bs.vh.2016.04.00427450736
   PubMed Web of Science ®Google Scholar
• Lee SI, Yi JK, Bae WJ, Lee S, Cha HJ, Kim EC. Thymosin beta-4 suppresses osteoclastic differentiation and inflammatory responses in human periodontal ligament cells. PLoS One. 2016;11(1):e0146708. doi:10.1371/journal.pone.014670826789270
   PubMed Web of Science ®Google Scholar
• Santra M, Chopp M, Santra S, et al. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. J Neurochem. 2016;136(1):118–132. doi:10.1111/jnc.1339426466330
   PubMed Web of Science ®Google Scholar
• Morris DC, Chopp M, Zhang L, Lu M, Zhang ZG. Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke. Neuroscience. 2010;169(2):674–682. doi:10.1016/j.neuroscience.2010.05.01720627173
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhang ZG, Li Y, et al. Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system. Neurobiol Dis. 2016;88:85–95. doi:10.1016/j.nbd.2016.01.01026805386
   PubMed Web of Science ®Google Scholar
• Qiu FY, Song XX, Zheng H, Zhao YB, Fu GS. Thymosin beta4 induces endothelial progenitor cell migration via PI3K/Akt/eNOS signal transduction pathway. J Cardiovasc Pharmacol. 2009;53(3):209–214. doi:10.1097/FJC.0b013e318199f32619247195
   PubMed Web of Science ®Google Scholar
• Seto SW, Chang D, Jenkins A, Bensoussan A, Kiat H. Angiogenesis in ischemic stroke and angiogenic effects of Chinese Herbal medicine. J Clin Med. 2016;5(6):E5627275837
   PubMed Web of Science ®Google Scholar
• Tan WKY, Purnamawati K, Pakkiri LS, et al. Sources of variability in quantifying circulating thymosin beta-4: literature review and recommendations. Expert Opin Biol Ther. 2018;18(sup1):141–147.29502471
   PubMed Web of Science ®Google Scholar
• Carthy CM, Yanagawa B, Luo H, et al. Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection. Virology. 2003;313(1):147–157.12951029
   PubMed Web of Science ®Google Scholar
• Um HD. Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: a review focusing on mitochondrial respiration and reactive oxygen species. Oncotarget. 2016;7(5):5193–5203.26621844
   PubMedGoogle Scholar
• Wang Q, Zhang L, Yuan X, et al. The relationship between the Bcl-2/Bax proteins and the mitochondria-mediated apoptosis pathway in the differentiation of adipose-derived stromal cells into neurons. PLoS One. 2016;11(10):e0163327.27706181
   PubMed Web of Science ®Google Scholar
• Terashi T, Otsuka S, Takada S, et al. Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats. Neurol Res. 2019;41:1–9.30296199
   PubMed Web of Science ®Google Scholar
• Liu Y, Wu X, An J, et al. Glaucocalyxin B protects against oxygen-glucose-deprivation/reperfusion-induced neuronal injury in PC-12 cells. J Cell Biochem. 2019;120(4):6137–6144.30304556
   PubMed Web of Science ®Google Scholar
• Lee AS. The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods. 2005;35(4):373–381.15804610
   PubMed Web of Science ®Google Scholar
• Ayaub EA, Kolb PS, Mohammed-Ali Z, et al. GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. J Pathol. 2016;239(4):411–425.27135434
   PubMed Web of Science ®Google Scholar
• Zhao Y, Han Y, Bu DF, et al. Reduced AKT phosphorylation contributes to endoplasmic reticulum stress-mediated hippocampal neuronal apoptosis in rat recurrent febrile seizure. Life Sci. 2016;153:153–162.27084529
   PubMed Web of Science ®Google Scholar
• Virrey JJ, Dong D, Stiles C, et al. Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res. 2008;6(8):1268–1275.18708359
   PubMed Web of Science ®Google Scholar
• Flodby P, Li C, Liu Y, et al. The 78-kD glucose-regulated protein regulates endoplasmic reticulum homeostasis and distal epithelial cell survival during lung development. Am J Respir Cell Mol Biol. 2016;55(1):135–149.26816051
   PubMed Web of Science ®Google Scholar
• Dong B, Zhang X, Fan Y, Cao S, Zhang X. GPR4 knockout improves renal ischemia-reperfusion injury and inhibits apoptosis via suppressing the expression of CHOP. Biochem J. 2017;474(24):4065–4074.29089376
   PubMed Web of Science ®Google Scholar