The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol

References

• Depression: “let’s Talk” Says WHO, as Depression Tops List of Causes of Ill Health [press Release]. Geneva: World Health Organisation 3032017.
   Google Scholar
• Walker E, McGee R, Druss B. Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psych. 2015;72:334–341. doi:10.1001/jamapsychiatry.2014.2502
   PubMed Web of Science ®Google Scholar
• Thornicroft G, Chatterji S, Evans-Lacko S, Gruber M. Undertreatment of people with major deperssive disorder in 21 countries. Brit J Psych. 2017;210:119–124. doi:10.1192/bjp.bp.116.188078
   Web of Science ®Google Scholar
• Rush A, Trivedi M, Wisniewski S, Nierenberg A, Stewart J, Warden D. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR* report. Am J Psychy. 2006;163:1905–1917. doi:10.1176/ajp.2006.163.11.1905
   PubMed Web of Science ®Google Scholar
• Insel T. Transforming diagnosis. 2013; Post Available from: www.nimh.nih.gov/about/director/2013/transforming-diagnosis-shtml. Accessed 527, 2013.
   Google Scholar
• Kapur S, Phillips A, Insel T. Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? Mol Psych. 2012;17:1174. doi:10.1038/mp.2012.105
   PubMed Web of Science ®Google Scholar
• Border R, Johnson E, Evans L, et al. No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples. Am J Psych. 2019. doi:10.1176/appi.ajp.2018.18070881
   Web of Science ®Google Scholar
• APA. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC: American Psychiatric Association; 2013.
   Google Scholar
• Sharpley C, Bitsika V. Differences in neurobiological pathways of four “clinical content” subtypes of depression. Behav Brain Res. 2013;256:368–376. doi:10.1016/j.bbr.2013.08.03023994546
   PubMed Web of Science ®Google Scholar
• Ostergaard S, Jensen S, Bech P. The heterogeneity of the depressive syndrome: when numbers get serious. Acta Psych Scand. 2011;124:495–496. doi:10.1111/j.1600-0447.2011.01744.x
   PubMed Web of Science ®Google Scholar
• Fried E, Nesse R. Depression is not a consistent syndrome: an investigation of unique symptom patterns in the STAR*D study. J Affective Dis. 2015;172:96–102. doi:10.1016/j.jad.2014.10.010
   PubMed Web of Science ®Google Scholar
• Fried E, Nesse R. Depression sum-scores don’t add up: why analyzing specific deperssion symptoms is essential. Cur Cont Psych. 2015;13.
   Google Scholar
• Koschera L, Hickie I, Hadzi-Pavlovic D, Wilson A, Lloyd A. Prolonged fatigue, anxiety and depression: exploring relationships in a primary care sample. ANZ J Psych. 1999;33:545–552.
   Google Scholar
• Wessely S, Chalder T, Hirsch S, Wallace P, Wright D. Psychological symptoms, somatic symptoms, and psychiatric disorder in chronic fatigue and chronic fatigue syndrome: a prospective study in the primary care setting. Am J Psych. 1996;153:1050–1059. doi:10.1176/ajp.153.8.1050
   PubMed Web of Science ®Google Scholar
• Bakshi R, Shaikh Z, Miletich R, et al. Fatigue in multiple sclerosis and its relationship to depression and neurologic disability. Mult Scler. 2000;6:181–185. doi:10.1177/13524585000060030810871830
   PubMed Web of Science ®Google Scholar
• Skapinakis P, Lewis G, Mavreas V. Temporal relations between unexplained fatigue and depression: longitudinal data from an international study in primary care. Psychosom Med. 2004;66:330–335.15184691
   PubMed Web of Science ®Google Scholar
• Lee K, Hicks G, Nino-Murcia G. Validity and reliability of a scale to asses fatigue. Psych Res. 1991;36:291–298. doi:10.1016/0165-1781(91)90027-M
   PubMed Web of Science ®Google Scholar
• Davis M, Zautra A, Younger J, Motivala S, Attrep J, Irwin M. Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: implications for fatigue. Brain Behav Immun. 2008;22(1):24–32. doi:10.1016/j.bbi.2007.06.01317706915
   PubMed Web of Science ®Google Scholar
• Chrousos G. Stress and disorders of the stress system. Nat Rev Endo. 2009;5:374–381. doi:10.1038/nrendo.2009.106
   PubMed Web of Science ®Google Scholar
• Pariante C, Lightman S. The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 2008;31:464–468. doi:10.1016/j.tins.2008.06.00618675469
   PubMed Web of Science ®Google Scholar
• Stetler C, Miller G. Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research. Psychosom Med. 2011;73:114–126. doi:10.1097/PSY.0b013e31820ad12b21257974
   PubMed Web of Science ®Google Scholar
• Bhagwagar Z, Hafizi S, Cowen P. Increase in concentration of waking cortisol in recovered patients with depression. Am J Psych. 2003;160:1890–1891.
   PubMed Web of Science ®Google Scholar
• Bhagwagar Z, Hafizi S, Cowen P. Increased salivary cortisol after waking in depression. Psychopharmacol. 2005;182:54–57. doi:10.1007/s00213-005-0062-z
   PubMed Web of Science ®Google Scholar
• Black P, Garbutt L. Stress, inflammation and cardiovascular disease. J Psychosom Res. 2002;52(1):1–23. doi:10.1016/S0022-3999(01)00302-611801260
   PubMed Web of Science ®Google Scholar
• Black S, Kushner I, Samols D. C-reactive protein. J Biol Chem. 2004;279:48478–48490. doi:10.1074/jbc.R400025200
   Web of Science ®Google Scholar
• Volanakis J. Human C-reactive protein: expression, structure, and function. Mol Immun. 2001;38:189–197. doi:10.1016/S0161-5890(01)00042-6
   PubMed Web of Science ®Google Scholar
• Wysokinski A, Margulska A, Strzelecki D, Kloszewska I. Levels of C-reactive protein (CRP) in patients with schizophrenia, unipolar depression and bipolar disorder. Nordic J Psych. 2015;69:346–353. doi:10.3109/08039488.2014.984755
   PubMed Web of Science ®Google Scholar
• Chang H, Wang T-H, Lee I, et al. C-reactive protein: a differential biomarker for major depressive disorder and bipolar II disorder. World J Biol Psych. 2017;18(1):63–70. doi:10.3109/15622975.2016.1155746
   PubMed Web of Science ®Google Scholar
• Karlović D, Serretti A, Vrkić N, Martinac M, Marčinko D. Serum concentrations of CRP, IL-6, TNF-α and cortisol in major depressive disorder with melancholic or atypical features. Psych Res. 2012;198(1):74–80. doi:10.1016/j.psychres.2011.12.007
   PubMed Web of Science ®Google Scholar
• Lamers F, Vogelzangs N, Merikangas K, de Jonge P, Beekman A, Penninx B. Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Mol Psych. 2013;18:692–699. doi:10.1038/mp.2012.144
   PubMed Web of Science ®Google Scholar
• Katon W, Lin E, Kroenke K. The association of depression and anxiety with medical symtpkm burden in patients with chronic medical illness. Gen Hosp Psych. 2007;29:147–155. doi:10.1016/j.genhosppsych.2006.11.005
   PubMed Web of Science ®Google Scholar
• Willner P. The chronic mild stress (CMS) model of depression: history, evaluation and usage. Neurobiol Stress. 2017;6:78–93. doi:10.1016/j.ynstr.2016.08.00228229111
   PubMed Web of Science ®Google Scholar
• De Vries J. Vermoeidheidsschaal [Fatigue Scale]. Tilburg, Netherlands: Tilburg University; 1998.
   Google Scholar
• Van Veldhoven M, Meijman T. Het Meten Van Psychosociale Arbeidsbelasting Met Een Vragenlijst: De Vragenlijst Beleving En Beoordeling Van De Arbeid (VBBA). Amsterdam: NIA; 1995.
   Google Scholar
• Clow A, Hucklebridge F, Stalder T, Evans P, Thorn L. The cortisol awakening response: more than a measure of HPA axis function. Neurosci Biobehav Rev. 2010;35:97–103. doi:10.1016/j.neubiorev.2009.12.01120026350
   PubMed Web of Science ®Google Scholar
• Holsboer F. The corticosteroid hypothesis of depression. Neuropsychopharm. 2000;23:477–501. doi:10.1016/S0893-133X(00)00159-7
   PubMed Web of Science ®Google Scholar
• Young E, Korszun A. Sex, trauma, stress hormones and depression. Mol Psych. 2010;15:23–28. doi:10.1038/mp.2009.94
   PubMed Web of Science ®Google Scholar
• Suarez E, Sundy J. The Cortisol: C-reactiveprotein ratio and negative affect reactivity in depressed adults. Health Psychol. 2017;36:852–862. doi:10.1037/hea000051728650200
   PubMed Web of Science ®Google Scholar
• Suarez E, Sundy J, Erkanli A. Depressogenic vulnerability and gender-specific patterns of neuroimmune dysregulation: what the ratio of cortisol to C-reactive protein can tell us about loss of normal regulatory control. Brain Behav Immun. 2015;44:137–147. doi:10.1016/j.bbi.2014.09.00825241020
   PubMed Web of Science ®Google Scholar
• Tsigos C, Papanicolaou D, Defensor R, Mitsiadis C, Kyrou I, Chrousos G. Dose effects of recombinant human lnterleukin-6 on pituitary hormone secretion and energy expenditure. Neuroendocrin. 1997;66(1):54–62. doi:10.1159/000127219
   PubMed Web of Science ®Google Scholar
• Miller G, Rohleder N, Stetler C, Kirschbaum C. Clinical depression and regulation of the inflammatory response during acute stress. Psychosom Med. 2005;67:679–687. doi:10.1097/01.psy.0000174172.82428.ce16204423
   PubMed Web of Science ®Google Scholar
• Zung W. A self-rating depression scale. Arch Gen Psych. 1965;12:63–70. doi:10.1001/archpsyc.1965.01720310065008
   PubMed Web of Science ®Google Scholar
• APA. Diagnostic and Statistical Manual of Mental Disorders (4th Ed, Text Revision). Washington, DC: American Psychiatric Association; 2000.
   Google Scholar
• Zung W. From art to science: the diagnosis and treatment of depression. Arch Gen Psych. 1973;29:328–337. doi:10.1001/archpsyc.1973.04200030026004
   PubMed Web of Science ®Google Scholar
• DeJonge J, Baneke J. The Zung self-rating depression scale: a replication study on reliability, validity and prediction. Psychol Rep. 1989;64:833–834. doi:10.2466/pr0.1989.64.3.833
   Web of Science ®Google Scholar
• Gabrys J, Peters K. Reliability, discriminant and predictive validity of the Zung self-rating depression scale. Psychol Reps. 1985;57:1091–1096. doi:10.2466/pr0.1985.57.3f.1091
   PubMed Web of Science ®Google Scholar
• Schaefer A, Brown J, Watson C, et al. Comparison of the validities of the Beck, Zung and MMPI depression scales. J Cons Clin Psychol. 1985;53:415–418. doi:10.1037/0022-006X.53.3.415
   PubMed Web of Science ®Google Scholar
• Sharpley C, Bitsika V, Christie D. Understanding the causes of depression among prostate cancer patients: development of the effects of prostate cancer on lifestyle questionnaire. Psycho-Oncol. 2009;18:162–168. doi:10.1002/pon.1382
   PubMed Web of Science ®Google Scholar
• Cohen J. Statistical Power for the Behavioural Sciences. Hillsdale, NJ: Erlbaun; 1988.
   Google Scholar
• Sharpley C, Bitsika V, Agnew L, Andronicos N. Eight-month test–retest agreement in morning salivary cortisol, self- and parent-rated anxiety in boys with an autism spectrum disorder. Physiol Behav. 2015;151:207–212. doi:10.1016/j.physbeh.2015.07.02726220465
   PubMed Web of Science ®Google Scholar
• Ho S, Rohan K, Parent J, Tager F, McKinley P. A longitudinal study of depression, fatigue, and sleep disturbances as a symptom cluster in women with breast cancer. J Pain Sympt Manag. 2015;49(4):707–715. doi:10.1016/j.jpainsymman.2014.09.009
   PubMed Web of Science ®Google Scholar
• Bortolato B, Hyphantis T, Valpione S, et al. Depression in cancer: the many biobehavioral pathways driving tumor progression. Cancer Treat Rev. 2017;52:58–70. doi:10.1016/j.ctrv.2016.11.00427894012
   PubMed Web of Science ®Google Scholar
• van Dam A. Subgroup analysis in burnout: relations between fatigue, anxiety, and depression. Front Psychol. 2016;7:90. doi:10.3389/fpsyg.2016.0009026869983
   PubMed Web of Science ®Google Scholar
• Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From information to sickness and depression: when the immune system subjugates the brain. Nature Rev Neurosci. 2007;9:45–56.
   Web of Science ®Google Scholar
• Bolling M, Kohlenberg R, Parker C. Behavior analysis and depression In: Dougher MJ, editor. Clinical Behavior Analysis. Reno, Nevada: Context Press; 1999:127–153.
   Google Scholar
• Hart BL. Biological basis of the behavior of sick animals. Neurosci Biobehav Rev. 1988;12(2):123–137. doi:10.1016/S0149-7634(88)80004-63050629
   PubMed Web of Science ®Google Scholar
• Dunn A. The cytokines and depression hypothesis: an evaluation. NeuroImmune Biol. 2008;6:485–506.
   Google Scholar
• Dunn A, Swiergiel A, de Beaurepaire R. Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev. 2005;29(4):891–909. doi:10.1016/j.neubiorev.2005.03.02315885777
   PubMed Web of Science ®Google Scholar
• Köhler O, Benros M, Nordentoft M, et al. Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials. JAMA Psych. 2014;71:1381–1391. doi:10.1001/jamapsychiatry.2014.1611
   PubMed Web of Science ®Google Scholar
• Kappelmann N, Lewis G, Dantzer R, Jones P, Khandaker G. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol Psych. 2016;23:335. doi:10.1038/mp.2016.167
   Web of Science ®Google Scholar