Empathy In Neurodegenerative Diseases: A Systematic Review

References

• Gray HM, Tickle-Degnen L. A meta-analysis of performance on emotion recognition tasks in parkinson’s disease. Neuropsychology. 2010;24(2):176–191. doi:10.1037/a001810420230112
   PubMed Web of Science ®Google Scholar
• Kleinbub JR, Palmieri A, Broggio A, et al. Hypnosis-based psychodynamic treatment in ALS: a longitudinal study on patients and their caregivers. Front Psychol. 2015;6:822. doi:10.3389/fpsyg.2015.0082226136710
   PubMed Web of Science ®Google Scholar
• Bartochowski Z, Gatla S, Khoury R, Al-Dahhak R, Grossberg GT. Empathy changes in neurocognitive disorders: a review. Ann Clin Psychiatry. 2018;30(3):220–232.30028897
   PubMed Web of Science ®Google Scholar
• Kennedy DP, Adolphs R. The social brain in psychiatric and neurological disorders. Trends Cogn Sci. 2012;16(11):559–572. doi:10.1016/J.TICS.2012.09.00623047070
   PubMed Web of Science ®Google Scholar
• Kemp J, Després O, Sellal F, Dufour A. Theory of Mind in normal ageing and neurodegenerative pathologies. Ageing Res Rev. 2012;11(2):199–219. doi:10.1016/J.ARR.2011.12.00122186031
   PubMed Web of Science ®Google Scholar
• Strikwerda-Brown C, Ramanan S, Irish M. Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach. Neuropsychiatr Dis Treat. 2019;15:557–573. doi:10.2147/NDT.S15899630863078
   PubMed Web of Science ®Google Scholar
• Fischer A, Landeira-Fernandez J, Sollero de Campos F, Mograbi DC. Empathy in Alzheimer’s Disease: review of findings and proposed model. J Alzheimer’s Dis. 2019;69(4):921–933. doi:10.3233/JAD-18073031104016
   PubMed Web of Science ®Google Scholar
• Fittipaldi S, Ibanez A, Baez S, Manes F, Sedeno L, Garcia AM. More than words: social cognition across variants of primary progressive aphasia. Neurosci Biobehav Rev. 2019;100:263–284. doi:10.1016/j.neubiorev.2019.02.02030876954
   PubMed Web of Science ®Google Scholar
• Elamin M, Pender N, Hardiman O, Abrahams S. Social cognition in neurodegenerative disorders: a systematic review. J Neurol Neurosurg Psychiatry. 2012;83(11):1071–1079. doi:10.1136/jnnp-2012-30281722869923
   PubMed Web of Science ®Google Scholar
• Poletti M, Enrici I, Bonuccelli U, Adenzato M. Theory of mind in Parkinson’s disease. Behav Brain Res. 2011;219(2):342–350. doi:10.1016/J.BBR.2011.01.01021238496
   PubMed Web of Science ®Google Scholar
• Kipps CM, Hodges JR. Theory of mind in frontotemporal dementia. Soc Neurosci. 2006;1(3–4):235–244. doi:10.1080/1747091060098984718633790
   PubMed Web of Science ®Google Scholar
• Carr AR, Mendez MF. Affective empathy in behavioral variant frontotemporal dementia: a meta-analysis. Front Neurol. 2018;9:417. doi:10.3389/fneur.2018.0041729946291
   PubMed Web of Science ®Google Scholar
• Bora E, Velakoulis D, Walterfang M. Social cognition in Huntington’s disease: a meta-analysis. Behav Brain Res. 2016;297:131–140. doi:10.1016/J.BBR.2015.10.00126455876
   PubMed Web of Science ®Google Scholar
• Bora E, Walterfang M, Velakoulis D. Theory of mind in Parkinson’s disease: a meta-analysis. Behav Brain Res. 2015;292:515–520. doi:10.1016/j.bbr.2015.07.01226166188
   PubMed Web of Science ®Google Scholar
• Bora E, Walterfang M, Velakoulis D. Theory of mind in behavioural-variant frontotemporal dementia and Alzheimer’s disease: a meta-analysis. J Neurol Neurosurg Psychiatry. 2015;86:714–719. doi:10.1136/jnnp-2014-30944525595152
   PubMed Web of Science ®Google Scholar
• Bora E. Meta-analysis of social cognition in amyotrophic lateral sclerosis. Cortex. 2017;88:1–7. doi:10.1016/j.cortex.2016.11.01228002755
   PubMed Web of Science ®Google Scholar
• Bora E, Velakoulis D, Walterfang M. Meta-analysis of facial emotion recognition in behavioral variant frontotemporal dementia: comparison With Alzheimer disease and healthy controls. J Geriatr Psychiatry Neurol. 2016;29(4):205–211. doi:10.1177/089198871664037527056068
   PubMed Web of Science ®Google Scholar
• Decety J, Jackson PL. The functional architecture of human empathy. Behav Cogn Neurosci Rev. 2004;3(2):71–100. doi:10.1177/153458230426718715537986
   PubMedGoogle Scholar
• Zaki J, Ochsner KN. The neuroscience of empathy: progress, pitfalls and promise. Nat Neurosci. 2012;15(5):675–680. doi:10.1038/nn.308522504346
   PubMed Web of Science ®Google Scholar
• Davis MH. A multidimensional approach to individual differences in empathy. JSAS Cat Sel Doc Psychol. 1980;10(85):1–17.
   Google Scholar
• Baron-Cohen S, Leslie AM, Frith U. Does the autistic child have a “theory of mind”? Cognition. 1985;21(1):37–46. doi:10.1016/0010-0277(85)90022-82934210
   PubMed Web of Science ®Google Scholar
• Cuff BMP, Brown SJ, Taylor L, Howat DJ. Empathy: a review of the concept. Emot Rev. 2016;8(2):144–153. doi:10.1177/1754073914558466
   Web of Science ®Google Scholar
• Neumann DL, Chan RCK, Boyle GJ, Wang Y, Rae Westbury H. Measures of empathy: self-report, behavioral, and neuroscientific approaches In: Boyle GJ, Saklofske DH, Matthews G, editors. Measures of Personality and Social Psychological Constructs. Cambridge, MA: Academic Press; 2015:257–289. doi:10.1016/B978-0-12-386915-9.00010-3
   Google Scholar
• Kleinbub JR, Palmieri A, Orsucci FF, et al. Measuring empathy: a statistical physics grounded approach. Phys A Stat Mech Its Appl. 2019;526. doi:10.1016/j.physa.2019.04.215
   Web of Science ®Google Scholar
• Shamay-Tsoory SG. The neural bases for empathy. Neurosci. 2011;17(1):18–24. doi:10.1177/1073858410379268
   Web of Science ®Google Scholar
• Sessa P, Meconi F, Han S. Double dissociation of neural responses supporting perceptual and cognitive components of social cognition: evidence from processing of others’ pain. Sci Rep. 2014;4:7424. doi:10.1038/srep0742425502570
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. doi:10.1136/bmj.b2535.19622551
   PubMed Web of Science ®Google Scholar
• Angelini C, Battistin L, eds. Neurologia Clinica. Bologna, IT: Società Editrice Esculapio; 2014.
   Google Scholar
• Tramèr MR, Reynolds DJ, Moore RA, McQuay HJ. Impact of covert duplicate publication on meta-analysis: a case study. BMJ. 1997;315(7109):635–640. doi:10.1136/bmj.315.7109.6359310564
   PubMed Web of Science ®Google Scholar
• Mayeux R. Alzheimer’s disease: epidemiology In: Duyckaerts C, Litvan I editors, Handbook of Clinical Neurology. Vol. 89 Elsevier; 2008:195–205. doi:10.1016/S0072-9752(07)01218-318631744
   PubMedGoogle Scholar
• Reitz C, Mayeux R. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol. 2014;88(4):640–651. doi:10.1016/j.bcp.2013.12.02424398425
   PubMed Web of Science ®Google Scholar
• Whitwell JL, Shiung MM, Przybelski SA, et al. MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment. Neurology. 2008;70(7):512–520. doi:10.1212/01.WNL.0000280575.77437.A217898323
   PubMed Web of Science ®Google Scholar
• Nestor PJ, Fryer TD, Ikeda M, Hodges JR. Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer’s disease). Eur J Neurosci. 2003;18(9):2663–2667. doi:10.1046/j.1460-9568.2003.02999.x14622168
   PubMed Web of Science ®Google Scholar
• Fernandez-Duque D, Hodges SD, Baird JA, Black SE. Empathy in frontotemporal dementia and Alzheimer’s disease. J Clin Exp Neuropsychol. 2010;32(3):289–298. doi:10.1080/1380339090300219119544133
   PubMed Web of Science ®Google Scholar
• Narme P, Mouras H, Roussel M, Devendeville A, Godefroy O. Assessment of socioemotional processes facilitates the distinction between frontotemporal lobar degeneration and Alzheimer’s disease. J Clin Exp Neuropsychol. 2013;35(7):728–744. doi:10.1080/13803395.2013.82391123930667
   PubMed Web of Science ®Google Scholar
• Sturm VE, Yokoyama JS, Seeley WW, Kramer JH, Miller BL, Rankin KP. Heightened emotional contagion in mild cognitive impairment and Alzheimer’s disease is associated with temporal lobe degeneration. Proc Natl Acad Sci. 2013;110(24):9944–9949. doi:10.1073/pnas.130111911023716653
   PubMed Web of Science ®Google Scholar
• Dermody N, Wong S, Ahmed R, Piguet O, Hodges JR, Irish M. Uncovering the neural bases of cognitive and affective empathy deficits in Alzheimer’s disease and the behavioral-variant of frontotemporal dementia. Knopman D, ed. J Alzheimer’s Dis. 2016;53(3):801–816. doi:10.3233/JAD-16017527258418
   PubMed Web of Science ®Google Scholar
• Nash S, Henry JD, McDonald S, Martin I, Brodaty H, Peek-O’Leary M-A. Cognitive disinhibition and socioemotional functioning in Alzheimer’s disease. J Int Neuropsychol Soc. 2007;13(6):1060–1064. doi:10.1017/S135561770707118417942023
   PubMed Web of Science ®Google Scholar
• Rankin KP, Kramer JH, Miller BL. Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cogn Behav Neurol. 2005;18(1):28–36. doi:10.1097/01.wnn.0000152225.05377.ab15761274
   PubMed Web of Science ®Google Scholar
• Siegler IC, Dawson DV, Welsh KA. Caregiver ratings of personality change in Alzheimer’s disease patients: a replication. Psychol Aging. 1994;9(3):464–466. doi:10.1037/0882-7974.9.3.4647999331
   PubMed Web of Science ®Google Scholar
• Rankin KP, Gorno-Tempini ML, Allison SC, et al. Structural anatomy of empathy in neurodegenerative disease. Brain. 2006;129(11):2945–2956. doi:10.1093/brain/awl25417008334
   PubMed Web of Science ®Google Scholar
• Lee TMC, Sun D, Leung M-K, Chu L-W, Keysers C. Neural activities during affective processing in people with Alzheimer’s disease. Neurobiol Aging. 2013;34(3):706–715. doi:10.1016/j.neurobiolaging.2012.06.01822840336
   PubMed Web of Science ®Google Scholar
• Mar RA. The neural bases of social cognition and story comprehension. Annu Rev Psychol. 2011;62(1):103–134. doi:10.1146/annurev-psych-120709-14540621126178
   PubMed Web of Science ®Google Scholar
• Martinez M, Multani N, Anor CJ, et al. Emotion detection deficits and decreased empathy in patients with Alzheimer’s disease and Parkinson’s disease affect caregiver mood and burden. Front Aging Neurosci. 2018;10:120. doi:10.3389/fnagi.2018.0012029740312
   PubMed Web of Science ®Google Scholar
• Olney NT, Spina S, Miller BL. Frontotemporal Dementia. Neurol Clin. 2017;35(2):339–374. doi:10.1016/j.ncl.2017.01.00828410663
   PubMed Web of Science ®Google Scholar
• Onyike CU, Diehl-Schmid J. The epidemiology of frontotemporal dementia. Int Rev Psychiatry. 2013;25(2):130–137. doi:10.3109/09540261.2013.77652323611343
   PubMed Web of Science ®Google Scholar
• Rosen HJ, Allison SC, Schauer GF, Gorno-Tempini ML, Weiner MW, Miller BL. Neuroanatomical correlates of behavioural disorders in dementia. Brain. 2005;128(11):2612–2625. doi:10.1093/brain/awh62816195246
   PubMed Web of Science ®Google Scholar
• Seeley WW, Crawford R, Rascovsky K, et al. Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia. Arch Neurol. 2008;65(2):249–255. doi:10.1001/archneurol.2007.3818268196
   PubMedGoogle Scholar
• Varma AR, Adams W, Lloyd JJ, et al. Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer’s disease, frontotemporal dementia and vascular dementia. Acta Neurol Scand. 2002;105(4):261–269. doi:10.1034/j.1600-0404.2002.1o148.x11939938
   PubMed Web of Science ®Google Scholar
• Rascovsky K, Hodges JR, Knopman DS, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain a J Neurol. 2011;134(9):2456–2477. doi:10.1093/brain/awr179
   Web of Science ®Google Scholar
• Lough S, Kipps CM, Treise C, Watson P, Blair JR, Hodges JR. Social reasoning, emotion and empathy in frontotemporal dementia. Neuropsychologia. 2006;44(6):950–958. doi:10.1016/j.neuropsychologia.2005.08.00916198378
   PubMed Web of Science ®Google Scholar
• Hua AY, Sible IJ, Perry DC, et al. Enhanced positive emotional reactivity undermines empathy in behavioral variant frontotemporal dementia. Front Neurol. 2018;9:402. doi:10.3389/fneur.2018.0040229915557
   PubMed Web of Science ®Google Scholar
• Eslinger PJ, Moore P, Anderson C, Grossman M. Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2011;23(1):74–82. doi:10.1176/jnp.23.1.jnp7421304142
   PubMed Web of Science ®Google Scholar
• Eslinger PJ, Moore P, Troiani V, et al. Oops! Resolving social dilemmas in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2007;78:457–460. doi:10.1136/jnnp.2006.09822817012339
   PubMed Web of Science ®Google Scholar
• Baez S, Manes F, Huepe D, et al. Primary empathy deficits in frontotemporal dementia. Front Aging Neurosci. 2014;6(262). doi:10.3389/fnagi.2014.00262
   Web of Science ®Google Scholar
• Cerami C, Dodich A, Canessa N, et al. Neural correlates of empathic impairment in the behavioral variant of frontotemporal dementia. Alzheimer’s Dement. 2014;10(6):827–834. doi:10.1016/j.jalz.2014.01.00524589435
   PubMed Web of Science ®Google Scholar
• Caminiti SP, Canessa N, Cerami C, et al. Affective mentalizing and brain activity at rest in the behavioral variant of frontotemporal dementia. Neuroimage. 2015;9:484–497. doi:10.1016/j.nicl.2015.08.01226594631
   PubMed Web of Science ®Google Scholar
• Kamminga J, Kumfor F, Burrell JR. Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: an examination of clinical characteristics and emotion processing. J Neurol Neurosurg Psychiatry. 2015;86:1082–1088. doi:10.1136/jnnp-2014-30912025511791
   PubMed Web of Science ®Google Scholar
• Baez S, Morales JP, Slachevsky A, et al. Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia. Cortex. 2016;75:20–32. doi:10.1016/J.CORTEX.2015.11.00726707083
   PubMed Web of Science ®Google Scholar
• Oliver LD, Mitchell DGV, Dziobek I, et al. Parsing cognitive and emotional empathy deficits for negative and positive stimuli in frontotemporal dementia. Neuropsychologia. 2015;67:14–26. doi:10.1016/J.NEUROPSYCHOLOGIA.2014.11.02225438032
   PubMed Web of Science ®Google Scholar
• Rabinovici GD, Rascovsky K, Miller BL. Frontotemporal lobar degeneration: clinical and pathologic overview. Handb Clin Neurol. 2008;89:343–364. doi:10.1016/S0072-9752(07)01233-X18631759
   PubMedGoogle Scholar
• Hodges JR, Patterson K, Oxbury S, Funnell E. Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain. 1992;115(Pt 6):1783–1806. doi:10.1093/brain/115.6.17831486461
   PubMed Web of Science ®Google Scholar
• Narme P, Mouras H, Roussel M, Duru C, Krystkowiak P, Godefroy O. Emotional and cognitive social processes are impaired in Parkinson’s disease and are related to behavioral disorders. Neuropsychology. 2013;27(2):182–192. doi:10.1037/a003152223527646
   PubMed Web of Science ®Google Scholar
• Grossman M. The non-fluent/agrammatic variant of primary progressive aphasia. Lancet Neurol. 2012;11(6):545–555. doi:10.1016/S1474-4422(12)70099-622608668
   PubMed Web of Science ®Google Scholar
• Montembeault M, Brambati SM, Gorno-Tempini ML, Migliaccio R. Clinical, anatomical, and pathological features in the three variants of primary progressive aphasia: a review. Front Neurol. 2018;9:692. doi:10.3389/fneur.2018.0069230186225
   PubMed Web of Science ®Google Scholar
• Rabinovici GD, Jagust WJ, Furst AJ, et al. Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol. 2008;64(4):388–401. doi:10.1002/ana.2145118991338
   PubMed Web of Science ®Google Scholar
• Ascherio A, Schwarzschild MA. The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol. 2016;15(12):1257–1272. doi:10.1016/S1474-4422(16)30230-727751556
   PubMed Web of Science ®Google Scholar
• Forno LS. Neuropathology of Parkinsonʼs Disease. J Neuropathol Exp Neurol. 1996;55(3):259–272. doi:10.1097/00005072-199603000-000018786384
   PubMed Web of Science ®Google Scholar
• Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord. 2015;30(12):1591–1601. doi:10.1002/mds.2642426474316
   PubMed Web of Science ®Google Scholar
• Dubois B, Burn DJ, Goetz CG, et al. Diagnostic procedures for Parkinson’s disease dementia: recommendations from the movement disorder society task force. Mov Disord. 2007;22(16):2314–2324. doi:10.1002/mds.2184418098298
   PubMed Web of Science ®Google Scholar
• Verbaan D, Marinus J, Visser M, et al. Cognitive impairment in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2007;78(11):1182–1187. doi:10.1136/jnnp.2006.11236717442759
   PubMed Web of Science ®Google Scholar
• Burton EJ, McKeith IG, Burn DJ, Williams ED, O’Brien JT. Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls. Brain. 2004;127(4):791–800. doi:10.1093/brain/awh08814749292
   PubMed Web of Science ®Google Scholar
• Antonini A, De Notaris R, Benti R, De Gaspari D, Pezzoli G. Perfusion ECD/SPECT in the characterization of cognitive deficits in Parkinson’s disease. Neurol Sci. 2001;22(1):45–46. doi:10.1007/s10072017003911487194
   PubMed Web of Science ®Google Scholar
• Kay C, Hayden MR, Leavitt BR. Epidemiology of Huntington disease In: Feigin AS, Anderson KE editors, Handbook of Clinical Neurology. Vol. 144 Elsevier B.V.; 2017:31–46. doi:10.1016/B978-0-12-801893-4.00003-128947124
   PubMedGoogle Scholar
• Pringsheim T, Wiltshire K, Day L, Dykeman J, Steeves T, Jetté N. The incidence and prevalence of Huntington’s disease: a systematic review and meta-analysis. Mov Disord. 2012;27(9):1083–1091. doi:10.1002/mds.2507522692795
   PubMed Web of Science ®Google Scholar
• Van Den Bogaard SJA, Dumas EM, Acharya P, et al. Early atrophy of pallidum and accumbens nucleus in Huntington’s disease. J Neurol. 2011;258:412–420. doi:10.1007/s00415-010-5768-020936300
   PubMed Web of Science ®Google Scholar
• Aylward EH, Brandt J, Codori AM, Mangus RS, Barta PE, Harris GJ. Reduced basal ganglia volume associated with the gene for Huntington’s disease in asymptomatic at-risk persons. Neurology. 1994;44(5):823–828. doi:10.1212/WNL.44.5.8238190282
   PubMed Web of Science ®Google Scholar
• Tabrizi SJ, Scahill RI, Owen G, et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington’s disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol. 2013;12(7):637–649. doi:10.1016/S1474-4422(13)70088-723664844
   PubMed Web of Science ®Google Scholar
• Paulsen JS, Nopoulos PC, Aylward EH, et al. Striatal and white matter predictors of estimated diagnosis for Huntington disease. Brain Res Bull. 2010;82(3–4):201–207. doi:10.1016/j.brainresbull.2010.04.00320385209
   PubMed Web of Science ®Google Scholar
• Rosas HD, Reuter M, Doros G, et al. A tale of two factors: what determines the rate of progression in Huntington’s disease? A longitudinal MRI study. Mov Disord. 2011;26(9):1691–1697. doi:10.1002/mds.2376221611979
   PubMed Web of Science ®Google Scholar
• Ciarmiello A, Cannella M, Lastoria S, et al. Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington’s disease. J Nucl Med. 2006;47(2):215–222.16455626
   PubMed Web of Science ®Google Scholar
• Trinkler I, Cleret de Langavant L, Bachoud-Lévi A-C. Joint recognition-expression impairment of facial emotions in Huntington’s disease despite intact understanding of feelings. Cortex. 2013;49(2):549–558. doi:10.1016/j.cortex.2011.12.00322244587
   PubMed Web of Science ®Google Scholar
• Adjeroud N, Besnard J, El Massioui N, et al. Theory of mind and empathy in preclinical and clinical Huntington’s disease. Soc Cogn Affect Neurosci. 2016;11(1):89–99. doi:10.1093/scan/nsv09326211015
   PubMed Web of Science ®Google Scholar
• Maurage P, Lahaye M, Grynberg D, et al. Dissociating emotional and cognitive empathy in pre-clinical and clinical Huntington’s disease. Psychiatry Res. 2016;237:103–108. doi:10.1016/j.psychres.2016.01.07026869362
   PubMed Web of Science ®Google Scholar
• Eddy CM, Rickards HE. Theory of mind can be impaired prior to motor onset in Huntington’s disease. Neuropsychology. 2015;29(5):792–798. doi:10.1037/neu000019025664466
   PubMed Web of Science ®Google Scholar
• Baez S, Herrera E, Gershanik O, et al. Impairments in negative emotion recognition and empathy for pain in Huntington’s disease families. Neuropsychologia. 2015;68:158–167. doi:10.1016/j.neuropsychologia.2015.01.01225582408
   PubMed Web of Science ®Google Scholar
• Trinkler I, Devignevielle S, Achaibou A, et al. Embodied emotion impairment in Huntington’s Disease. Cortex. 2017;92:44–56. doi:10.1016/j.cortex.2017.02.01928399433
   PubMed Web of Science ®Google Scholar
• Adolphs R, Damasio H, Tranel D, Cooper G, Damasio AR. A role for somatosensory cortices in the visual recognition of emotion as revealed by three-dimensional lesion mapping. J Neurosci. 2000;20(7):2683–2690. doi:10.1523/JNEUROSCI.20-07-02683.200010729349
   PubMed Web of Science ®Google Scholar
• Logroscino G, Traynor BJ, Hardiman O, et al. Incidence of amyotrophic lateral sclerosis in Europe. J Neurol Neurosurg Psychiatry. 2010;81(4):385–390. doi:10.1136/jnnp.2009.18352519710046
   PubMed Web of Science ®Google Scholar
• Rowland LP, Shneider NA. Amyotrophic Lateral Sclerosis. N Engl J Med. 2001;344(22):1688–1700. doi:10.1056/NEJM20010531344220711386269
   PubMed Web of Science ®Google Scholar
• Goldstein LH, Abrahams S. Changes in cognition and behaviour in amyotrophic lateral sclerosis: nature of impairment and implications for assessment. Lancet Neurol. 2013;12(4):368–380. doi:10.1016/S1474-4422(13)70026-723518330
   PubMed Web of Science ®Google Scholar
• Palmieri A, Sorarù G, Albertini E, et al. Psychopathological features and suicidal ideation in amyotrophic lateral sclerosis patients. Neurol Sci. 2010;31(6):735–740. doi:10.1007/s10072-010-0332-320521074
   PubMed Web of Science ®Google Scholar
• Shen D, Cui L, Fang J, Cui B, Li D, Tai H. Voxel-wise meta-analysis of gray matter changes in amyotrophic lateral sclerosis. Front Aging Neurosci. 2016;8:64. doi:10.3389/fnagi.2016.0006427065078
   PubMed Web of Science ®Google Scholar
• Matías-Guiu JA, Pytel V, Cabrera-Martín MN, et al. Amyloid- and FDG-PET imaging in amyotrophic lateral sclerosis. Eur J Nucl Med Mol Imaging. 2016;43(11):2050–2060. doi:10.1007/s00259-016-3434-127262702
   PubMed Web of Science ®Google Scholar
• Cerami C, Dodich A, Canessa N, et al. Emotional empathy in amyotrophic lateral sclerosis: a behavioural and voxel-based morphometry study. Amyotroph Lateral Scler Front Degener. 2014;15(1–2):21–29. doi:10.3109/21678421.2013.785568
   PubMed Web of Science ®Google Scholar
• van der Hulst E-J, Bak TH, Abrahams S. Impaired affective and cognitive theory of mind and behavioural change in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2015;86:1208–1215. doi:10.1136/jnnp-2014-30929025476003
   PubMed Web of Science ®Google Scholar
• Watermeyer TJ, Brown RG, Sidle KCL, et al. Executive dysfunction predicts social cognition impairment in amyotrophic lateral sclerosis. J Neurol. 2015;262(7):1681–1690. doi:10.1007/s00415-015-7761-025957636
   PubMed Web of Science ®Google Scholar
• Guidetti D, Sabadini R, Ferlini A, Torrente I. Epidemiological survey of X-linked bulbar and spinal muscular atrophy, or Kennedy disease, in the province of Reggio Emilia, Italy. Eur J Epidemiol. 2001;17(6):587–591. doi:10.1023/A:101458021976111949733
   PubMed Web of Science ®Google Scholar
• Finsterer J, Sorarù G. onset manifestations of spinal and bulbar muscular atrophy (Kennedy’s Disease). J Mol Neurosci. 2016;58(3):321–329. doi:10.1007/s12031-015-0663-x26482145
   PubMed Web of Science ®Google Scholar
• Fratta P, Nirmalananthan N, Masset L, et al. Correlation of clinical and molecular features in spinal bulbar muscular atrophy. Neurology. 2014;82(23):2077–2084. doi:10.1212/WNL.000000000000050724814851
   PubMed Web of Science ®Google Scholar
• Kennedy WR, Alter M, Sung JH. Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait. Neurology. 1968;18(7):671–680. doi:10.1212/WNL.18.7.6714233749
   PubMed Web of Science ®Google Scholar
• Di Rosa E, Sorarù G, Kleinbub JR, et al. Theory of mind, empathy and neuropsychological functioning in X-linked Spinal and Bulbar Muscular Atrophy: a controlled study of 20 patients. J Neurol. 2015;262(2):394–401. doi:10.1007/s00415-014-7567-525408365
   PubMed Web of Science ®Google Scholar
• Marcato S, Kleinbub JR, Querin G, et al. Unimpaired neuropsychological performance and enhanced memory recall in patients with Sbma: a large sample comparative study. Sci Rep. 2018;8(1):13627. doi:10.1038/s41598-018-32062-530206283
   PubMed Web of Science ®Google Scholar
• Soukup GR, Sperfeld AD, Uttner I, et al. Frontotemporal cognitive function in X-linked spinal and bulbar muscular atrophy (SBMA): a controlled neuropsychological study of 20 patients. J Neurol. 2009;256(11):1869–1875. doi:10.1007/s00415-009-5212-519572162
   PubMed Web of Science ®Google Scholar
• Guidetti D, Vescovini E, Motti L, et al. X-linked bulbar and spinal muscular atrophy, or Kennedy disease: clinical, neurophysiological, neuropathological, neuropsychological and molecular study of a large family. J Neurol Sci. 1996;135(2):140–148. doi:10.1016/0022-510X(95)00283-88867070
   PubMed Web of Science ®Google Scholar
• Kasper E, Wegrzyn M, Marx I, et al. Minor cognitive disturbances in X-linked spinal and bulbar muscular atrophy, Kennedy’s disease. Amyotroph Lateral Scler Frontotemporal Degener. 2014;15(1–2):15–20. doi:10.3109/21678421.2013.83792724200287
   PubMed Web of Science ®Google Scholar
• Kassubek J, Juengling FD, Sperfeld AD. Widespread white matter changes in Kennedy disease: a voxel based morphometry study. J Neurol Neurosurg Psychiatry. 2007;78(11):1209–1212. doi:10.1136/jnnp.2006.11253217332050
   PubMed Web of Science ®Google Scholar
• Pieper CC, Konrad C, Sommer J, Teismann I, Schiffbauer H. Structural changes of central white matter tracts in Kennedy’s disease - a diffusion tensor imaging and voxel-based morphometry study. Acta Neurol Scand. 2013;127(5):323–328. doi:10.1111/ane.1201823216624
   PubMed Web of Science ®Google Scholar
• Lai T-H, Liu R-S, Yang B-H, et al. Cerebral involvement in spinal and bulbar muscular atrophy (Kennedy’s disease): a pilot study of PET. J Neurol Sci. 2013;335(1–2):139–144. doi:10.1016/J.JNS.2013.09.01624120273
   PubMed Web of Science ®Google Scholar
• Adenzato M, Poletti M. Theory of Mind abilities in neurodegenerative diseases: an update and a call to introduce mentalizing tasks in standard neuropsychological assessments. Clin Neuropsychiatry. 2013;10(5):226–234.
   Google Scholar
• Russell J. How executive disorders can bring about an inadequate “theory of mind.” In: Autism as an Executive Disorder. New York, NY: Oxford University Press; 1997:256–304.
   Google Scholar
• van Honk J, Schutter DJ, Bos PA, Kruijt A-W, Lentjes EG, Baron-Cohen S. Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratio. Proc Natl Acad Sci U S A. 2011;108(8):3448–3452. doi:10.1073/pnas.101189110821300863
   PubMed Web of Science ®Google Scholar
• Miller DI, Halpern DF. The new science of cognitive sex differences. Trends Cogn Sci. 2014;18(1):37–45. doi:10.1016/J.TICS.2013.10.01124246136
   PubMed Web of Science ®Google Scholar
• Bremner JD, Soufer R, McCarthy G, et al. Gender differences in cognitive and neural correlates of remembrance of emotional words. Psychopharmacol Bull. 2001;35(3):55–78.12397879
   PubMedGoogle Scholar
• Baron-cohen S. The extreme male brain theory of autism. Trends Cogn Sci. 2002;6(6):248–254. doi:10.1016/S1364-6613(02)01904-612039606
   PubMed Web of Science ®Google Scholar
• Emery AEH. Population frequencies of inherited neuromuscular diseases—A world survey. Neuromuscul Disord. 1991;1(1):19–29. doi:10.1016/0960-8966(91)90039-U1822774
   PubMedGoogle Scholar
• Mahadevan M, Tsilfidis C, Sabourin L, et al. Myotonic dystrophy mutation: an unstable CTG repeat in the 3ʹ untranslated region of the gene. Science. 1992;255(5049):1253–1255. doi:10.1126/science.15463251546325
   PubMed Web of Science ®Google Scholar
• Harper PS. Myotonic Dystrophy: Major Problems in Neurology. 3rd ed. London, UK: WB Saunders; 2001.
   Google Scholar
• Peric S, Rakocevic Stojanovic V, Mandic Stojmenovic G, et al. Clusters of cognitive impairment among different phenotypes of myotonic dystrophy type 1 and type 2. Neurol Sci. 2017;38:415–423. doi:10.1007/s10072-016-2778-427896491
   PubMed Web of Science ®Google Scholar
• Romeo V, Pegoraro E, Ferrati C, et al. Brain involvement in myotonic dystrophies: neuroimaging and neuropsychological comparative study in DM1 and DM2. J Neurol. 2010;257(8):1246–1255. doi:10.1007/s00415-010-5498-320221771
   PubMed Web of Science ®Google Scholar
• Modoni A, Silvestri G, Vita MG, Quaranta D, Tonali PA, Marra C. Cognitive impairment in myotonic dystrophy type 1 (DM1). J Neurol. 2008;255(11):1737–1742. doi:10.1007/s00415-008-0017-518821050
   PubMed Web of Science ®Google Scholar
• Sistiaga A, Urreta I, Jodar M, et al. Cognitive/personality pattern and triplet expansion size in adult myotonic dystrophy type 1 (DM1): CTG repeats, cognition and personality in DM1. Psychol Med. 2010;40(3):487. doi:10.1017/S003329170999060219627641
   PubMed Web of Science ®Google Scholar
• Labayru G, Arenzana I, Aliri J, Zulaica M, López de Munain A, Sistiaga AA. Social cognition in myotonic dystrophy type 1: specific or secondary impairment? PLoS One. 2018;13(9):e0204227. doi:10.1371/journal.pone.020422730248121
   PubMed Web of Science ®Google Scholar
• Serra L, Cercignani M, Bruschini M, et al. “I know that you know that i know”: neural substrates associated with social cognition deficits in DM1 patients. PLoS One. 2016;11(6):e0156901. doi:10.1371/journal.pone.015690127258100
   PubMed Web of Science ®Google Scholar
• Fuertes JN, Toporovsky A, Reyes M, Osborne JB. The physician-patient working alliance: theory, research, and future possibilities. Patient Educ Couns. 2017;100(4):610–615. doi:10.1016/J.PEC.2016.10.01827773600
   PubMed Web of Science ®Google Scholar
• Kelley JM, Kraft-Todd G, Schapira L, Kossowsky J, Riess H. The Influence of the patient-clinician relationship on healthcare outcomes: a systematic review and meta-analysis of randomized controlled trials. Timmer A, ed. PLoS One. 2014;9(4):e94207. doi:10.1371/journal.pone.009420724718585
   PubMed Web of Science ®Google Scholar
• Hojat M, Louis DZ, Markham FW, Wender R, Rabinowitz C, Gonnella JS. Physiciansʼ empathy and clinical outcomes for diabetic patients. Acad Med. 2011;86(3):359–364. doi:10.1097/ACM.0b013e3182086fe121248604
   PubMed Web of Science ®Google Scholar
• Di Blasi Z, Harkness E, Ernst E, Georgiou A, Kleijnen J. Influence of context effects on health outcomes: a systematic review. Lancet. 2001;357(9258):757–762. doi:10.1016/S0140-6736(00)04169-611253970
   PubMed Web of Science ®Google Scholar
• Calvo V, Palmieri A, Marinelli S, Bianco F, Kleinbub JR. Reciprocal empathy and working alliance in terminal oncological illness: the crucial role of patients’ attachment style. J Psychosoc Oncol. 2014;32(5):517–534. doi:10.1080/07347332.2014.93665124988462
   PubMed Web of Science ®Google Scholar
• Andersen PM, Abrahams S, Borasio GD, et al. EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) - revised report of an EFNS task force. Eur J Neurol. 2012;19(3):360–375. doi:10.1111/j.1468-1331.2011.03501.x21914052
   PubMed Web of Science ®Google Scholar
• Sorbi S, Hort J, Erkinjuntti T, et al. EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia. Eur J Neurol. 2012;19(9):1159–1179. doi:10.1111/j.1468-1331.2012.03784.x22891773
   PubMed Web of Science ®Google Scholar
• Boffo M, Mannarini S, Munari C. Exploratory structure equation modeling of the UCLA loneliness scale: a contribution to the Italian adaptation. TPM - Testing, Psychom Methodol Appl Psychol. 2012;19(4):345–363. doi:10.4473/TPM19.4.7
   Google Scholar
• Roter DL, Hall JA, Merisca R, Nordstrom B, Cretin D, Svarstad B. Effectiveness of interventions to improve patient compliance: a meta-analysis. Med Care. 1998;36(8):1138–1161. doi:10.1097/00005650-199808000-000049708588
   PubMed Web of Science ®Google Scholar
• Kleinbub JR. State of the art of interpersonal physiology in psychotherapy: a systematic review. Front Psychol. 2017;8:2053. doi:10.3389/fpsyg.2017.0205329225589
   PubMed Web of Science ®Google Scholar
• Fonagy P, Allison E. The role of mentalizing and epistemic trust in the therapeutic relationship. Psychother. 2014;51(3):372–380. doi:10.1037/a0036505
   PubMed Web of Science ®Google Scholar
• National Institute for Health and Clinical Excellence. NICE SCIE guideline to improve care of people with dementia. Available from: https://www.nice.org.uk/guidance?action=download&o=30323&r=true. 2006 Accessed March 14, 2019.
   Google Scholar
• Mehrabian A, Epstein N. A measure of emotional empathy. J Pers. 1972;40(4):525–543. doi:10.1111/j.1467-6494.1972.tb00078.x4642390
   PubMed Web of Science ®Google Scholar
• Jolliffe D, Farrington DP. Development and validation of the basic empathy scale. J Adolesc. 2006;29(4):589–611. doi:10.1016/J.ADOLESCENCE.2005.08.01016198409
   PubMed Web of Science ®Google Scholar
• Decety J, Michalska KJ, Kinzler KD. The contribution of emotion and cognition to moral sensitivity: a neurodevelopmental study. Cereb Cortex. 2012;22(1):209–220. doi:10.1093/cercor/bhr11121616985
   PubMed Web of Science ®Google Scholar
• Baron-Cohen S, Wheelwright S. The empathy quotient: an investigation of adults with asperger syndrome or high functioning autism, and normal sex differences. J Autism Dev Disord. 2004;34(2):163–175. doi:10.1023/B:JADD.0000022607.19833.0015162935
   PubMed Web of Science ®Google Scholar
• Stone VE, Baron-Cohen S, Knight RT. Frontal lobe contributions to theory of mind. J Cogn Neurosci. 1998;10(5):640–656. doi:10.1162/0898929985629429802997
   PubMed Web of Science ®Google Scholar
• O’Sullivan M, Guilford J. Tests of Social Intelligence. Palo Alto, CA: Consulting Psychologists Press; 1965.
   Google Scholar
• Dziobek I, Rogers K, Fleck S, et al. Dissociation of cognitive and emotional empathy in adults with asperger syndrome using the Multifaceted Empathy Test (MET). J Autism Dev Disord. 2008;38(3):464–473. doi:10.1007/s10803-007-0486-x17990089
   PubMed Web of Science ®Google Scholar
• Ekman P, Friesen W. Pictures of Facial Affect. Palo Alto, CA: Consulting Psychologists Press; 1976.
   Google Scholar
• Baron-Cohen S, Jolliffe T, Mortimore C, Robertson M. Another advanced test of theory of mind: evidence from very high functioning adults with autism or asperger syndrome. J Child Psychol Psychiatry. 1997;38(7):813–822. doi:10.1111/jcpp.1997.38.issue-79363580
   PubMed Web of Science ®Google Scholar
• McDonald S, Flanagan S, Rollins J, Kinch J. TASIT: a new clinical tool for assessing social perception after traumatic brain injury. J Head Trauma Rehabil. 2003;18(3):219–238. doi:10.1097/00001199-200305000-0000112802165
   PubMed Web of Science ®Google Scholar
• Lopez-Pérez B, Fernaéndez-Pinto I, Abad F. TECA: Test De Empatia Cognitiva Y Afectiva. Madrid, ES: TEA Ediciones; 2008.
   Google Scholar
• Crespi C, Cerami C, Dodich A, et al. Microstructural correlates of emotional attribution impairment in non-demented patients with amyotrophic lateral sclerosis. PLoS One. 2016;11:e0161034. doi:10.1371/journal.pone.016103427513746
   PubMed Web of Science ®Google Scholar